{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:52:30Z","timestamp":1784253150346,"version":"3.55.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB-1350"],"award-info":[{"award-number":["SFB-1350"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidneys are thought to express eight different connexin isoforms (i.e., Cx 26, 30, 32, 37, 40, 43, 45, and 46), which form either hemichannels or gap junctions serving to intercellular communication and functional synchronization. Proper function of connexins has already been shown to be crucial for regulation of renal hemodynamics and renin secretion, and there is also growing evidence for connexins to play a role in pathologic conditions such as renal fibrosis or diabetic nephropathy. Therefore, exact intrarenal localization of the different connexin isoforms gains particular interest. Until now intrarenal expression of connexins has mainly been examined by immunohistochemistry, which in part generated conflicting results depending on antibodies and fixation protocols used. In this work, we used fluorescent RNAscope as an alternative technical approach to localize renal connexin mRNAs in healthy mouse kidneys. Addition of RNAscope probes for cell type specific mRNAs was used to assign connexin mRNA signals to specific cell types. We hereby found Cx26 mRNA strongly expressed in proximal tubules, Cx30 mRNA was selectively detected in the urothelium, and Cx32 mRNA was found in proximal tubules and to a lesser extent also in collecting ducts. Cx37 mRNA was mainly associated with vascular endothelium, Cx40 mRNA was largely found in glomerular mesangial and less in vascular endothelial cells, Cx43 mRNA was sparsely expressed by interstitial cells of all kidney zones, and Cx45 mRNA was predominantly found in smooth muscle cell layers of both blood vessels and ureter as well as in mesangial and interstitial (fibroblastic) cells. Cx46 mRNA could not be detected. In summary our results essentially confirm previous data on connexin expression in the renal vasculature and in glomeruli. In addition, they demonstrate strong connexin gene expression in proximal tubules, and they suggest significant connexin expression in resident tubulointerstitial cells.<\/jats:p>","DOI":"10.1007\/s00424-021-02608-0","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T23:07:48Z","timestamp":1628377668000},"page":"1737-1747","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Connexin mRNA distribution in adult mouse kidneys"],"prefix":"10.1007","volume":"473","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-3713","authenticated-orcid":false,"given":"Lisa","family":"Geis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Fabian","family":"Boudriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"2608_CR1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1681\/ASN.2008090943","volume":"20","author":"A Just","year":"2009","unstructured":"Just A, Kurtz L, de Wit C, Wagner C, Kurtz A, Arendshorst WJ (2009) Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation [eng]. J Am Soc Nephrol: JASN 20:1577\u20131585","journal-title":"J Am Soc Nephrol: JASN"},{"key":"2608_CR2","doi-asserted-by":"publisher","first-page":"F855","DOI":"10.1152\/ajprenal.00026.2012","volume":"303","author":"CM Sorensen","year":"2012","unstructured":"Sorensen CM, Giese I, Braunstein TH, Brasen JC, Salomonsson M, Holstein-Rathlou N-H (2012) Role of connexin40 in the autoregulatory response of the afferent arteriole [eng]. Am J Physiol Ren Physiol 303:F855\u2013F863","journal-title":"Am J Physiol Ren Physiol"},{"key":"2608_CR3","doi-asserted-by":"publisher","first-page":"R371","DOI":"10.1152\/ajpregu.00468.2007","volume":"295","author":"F Hanner","year":"2008","unstructured":"Hanner F, von Maltzahn J, Maxeiner S, Toma I, Sipos A, Kr\u00fcger O, Willecke K, Peti-Peterdi J (2008) Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure [eng]. Am J Physiol Regul Integr Comp Physiol 295:R371\u2013R380","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2608_CR4","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/sj.ki.5002423","volume":"72","author":"N Krattinger","year":"2007","unstructured":"Krattinger N, Capponi A, Mazzolai L, Aubert J-F, Caille D, Nicod P, Waeber G, Meda P, Haefliger J-A (2007) Connexin40 regulates renin production and blood pressure [eng]. Kidney Int 72:814\u2013822","journal-title":"Kidney Int"},{"key":"2608_CR5","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1161\/01.RES.0000258856.19922.45","volume":"100","author":"C Wagner","year":"2007","unstructured":"Wagner C, de Wit C, Kurtz L, Gr\u00fcnberger C, Kurtz A, Schweda F (2007) Connexin40 is essential for the pressure control of renin synthesis and secretion [eng]. Circ Res 100:556\u2013563","journal-title":"Circ Res"},{"key":"2608_CR6","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/sj.ki.5002720","volume":"73","author":"C Wagner","year":"2008","unstructured":"Wagner C (2008) Function of connexins in the renal circulation [eng]. Kidney Int 73:547\u2013555","journal-title":"Kidney Int"},{"key":"2608_CR7","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.bbamem.2011.05.023","volume":"1818","author":"A Kurtz","year":"2012","unstructured":"Kurtz A (2012) Renal connexins and blood pressure [eng]. Biochim Biophys Acta 1818:1903\u20131908","journal-title":"Biochim Biophys Acta"},{"key":"2608_CR8","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1002\/cphy.c110051","volume":"2","author":"MS Nielsen","year":"2012","unstructured":"Nielsen MS, Axelsen LN, Sorgen PL, Verma V, Delmar M, Holstein-Rathlou N-H (2012) Gap junctions [eng]. Compr Physiol 2:1981\u20132035","journal-title":"Compr Physiol"},{"key":"2608_CR9","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","volume":"83","author":"JC Saez","year":"2003","unstructured":"Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC (2003) Plasma membrane channels formed by connexins: their regulation and functions [eng]. Physiol Rev 83:1359\u20131400","journal-title":"Physiol Rev"},{"key":"2608_CR10","doi-asserted-by":"publisher","first-page":"R1143","DOI":"10.1152\/ajpregu.00808.2009","volume":"298","author":"F Hanner","year":"2010","unstructured":"Hanner F, Sorensen CM, Holstein-Rathlou N-H, Peti-Peterdi J (2010) Connexins and the kidney [eng]. Am J Physiol Regul Integr Comp Physiol 298:R1143\u2013R1155","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2608_CR11","first-page":"193","volume":"160","author":"K K\u00fchn","year":"1975","unstructured":"K\u00fchn K, Reale E (1975) Junctional complexes of the tubular cells in the human kidney as revealed with freeze-fracture [eng]. Cell Tissue Res 160:193\u2013205","journal-title":"Cell Tissue Res"},{"key":"2608_CR12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1083\/jcb.47.2.513","volume":"47","author":"FJ Silverblatt","year":"1970","unstructured":"Silverblatt FJ, Bulger RE (1970) Gap junctions occur in vertebrate renal proximal tubule cells [eng]. J Cell Biol 47:513\u2013515","journal-title":"J Cell Biol"},{"key":"2608_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11302-013-9400-5","volume":"10","author":"G Burnstock","year":"2014","unstructured":"Burnstock G, Evans LC, Bailey MA (2014) Purinergic signalling in the kidney in health and disease [eng]. Purinergic Signal 10:71\u2013101","journal-title":"Purinergic Signal"},{"key":"2608_CR14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/15419060802013836","volume":"15","author":"F Hanner","year":"2008","unstructured":"Hanner F, Schnichels M, Zheng-Fischh\u00f6fer Q, Yang LE, Toma I, Willecke K, McDonough AA, Peti-Peterdi J (2008) Connexin 30.3 is expressed in the kidney but not regulated by dietary salt or high blood pressure [eng]. Cell Commun Adhes 15:219\u2013230","journal-title":"Cell Commun Adhes"},{"key":"2608_CR15","doi-asserted-by":"publisher","first-page":"F1304","DOI":"10.1152\/ajprenal.00203.2005","volume":"289","author":"F McCulloch","year":"2005","unstructured":"McCulloch F, Chambrey R, Eladari D, Peti-Peterdi J (2005) Localization of connexin 30 in the luminal membrane of cells in the distal nephron [eng]. Am J Physiol Ren Physiol 289:F1304\u2013F1312","journal-title":"Am J Physiol Ren Physiol"},{"key":"2608_CR16","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1681\/ASN.2008101099","volume":"20","author":"A Sipos","year":"2009","unstructured":"Sipos A, Vargas SL, Toma I, Hanner F, Willecke K, Peti-Peterdi J (2009) Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis [eng]. J Am Soc Nephrol JASN 20:1724\u20131732","journal-title":"J Am Soc Nephrol JASN"},{"key":"2608_CR17","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/ki.2014.108","volume":"86","author":"A Abed","year":"2014","unstructured":"Abed A, Toubas J, Kavvadas P, Authier F, Cathelin D, Alfieri C, Boffa J-J, Dussaule J-C, Chatziantoniou C, Chadjichristos CE (2014) Targeting connexin 43 protects against the progression of experimental chronic kidney disease in mice [eng]. Kidney Int 86:768\u2013779","journal-title":"Kidney Int"},{"key":"2608_CR18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/bph.14853","volume":"177","author":"Z Chen","year":"2020","unstructured":"Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H (2020) Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation [eng]. Br J Pharmacol 177:145\u2013160","journal-title":"Br J Pharmacol"},{"key":"2608_CR19","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00125-014-3427-1","volume":"58","author":"CE Hills","year":"2015","unstructured":"Hills CE, Price GW, Squires PE (2015) Mind the gap: connexins and cell-cell communication in the diabetic kidney [eng]. Diabetologia 58:233\u2013241","journal-title":"Diabetologia"},{"key":"2608_CR20","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1159\/000488185","volume":"45","author":"C Hills","year":"2018","unstructured":"Hills C, Price GW, Wall MJ, Kaufmann TJ, Chi-Wai Tang S, Yiu WH, Squires PE (2018) Transforming growth factor beta 1 drives a switch in connexin mediated cell-to-cell communication in tubular cells of the diabetic kidney [eng]. Cell Physiol Biochem Intl J Exp Cell Physiol Biochem Pharmacol 45:2369\u20132388","journal-title":"Cell Physiol Biochem Intl J Exp Cell Physiol Biochem Pharmacol"},{"key":"2608_CR21","doi-asserted-by":"publisher","first-page":"F24","DOI":"10.1152\/ajprenal.00255.2010","volume":"301","author":"J Toubas","year":"2011","unstructured":"Toubas J, Beck S, Pageaud A-L, Huby A-C, Mael-Ainin M, Dussaule J-C, Chatziantoniou C, Chadjichristos CE (2011) Alteration of connexin expression is an early signal for chronic kidney disease [eng]. Am J Physiol Ren Physiol 301:F24\u2013F32","journal-title":"Am J Physiol Ren Physiol"},{"key":"2608_CR22","first-page":"500","volume":"122","author":"F Chatelet","year":"1986","unstructured":"Chatelet F, Brianti E, Ronco P, Roland J, Verroust P (1986) Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution [eng]. Am J Pathol 122:500\u2013511","journal-title":"Am J Pathol"},{"key":"2608_CR23","doi-asserted-by":"publisher","first-page":"5557","DOI":"10.1073\/pnas.79.18.5557","volume":"79","author":"D Kerjaschki","year":"1982","unstructured":"Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border [eng]. Proc Natl Acad Sci U S A 79:5557\u20135561","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2608_CR24","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/361549a0","volume":"361","author":"K Fushimi","year":"1993","unstructured":"Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S (1993) Cloning and expression of apical membrane water channel of rat kidney collecting tubule [eng]. Nature 361:549\u2013552","journal-title":"Nature"},{"key":"2608_CR25","doi-asserted-by":"publisher","first-page":"6037","DOI":"10.1073\/pnas.0511324103","volume":"103","author":"A Rojek","year":"2006","unstructured":"Rojek A, F\u00fcchtbauer E-M, Kwon T-H, Fr\u00f8kiaer J, Nielsen S (2006) Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice [eng]. Proc Natl Acad Sci U S A 103:6037\u20136042","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2608_CR26","doi-asserted-by":"publisher","first-page":"11300","DOI":"10.1016\/S0021-9258(17)39180-9","volume":"260","author":"JA van Mourik","year":"1985","unstructured":"van Mourik JA, Leeksma OC, Reinders JH, de Groot PG, Zandbergen-Spaargaren J (1985) Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa [eng]. J Biol Chem 260:11300\u201311306","journal-title":"J Biol Chem"},{"key":"2608_CR27","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1172\/JCI111185","volume":"73","author":"G Gabbiani","year":"1984","unstructured":"Gabbiani G, Kocher O, Bloom WS, Vandekerckhove J, Weber K (1984) Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media [eng]. J Clin Invest 73:148\u2013152","journal-title":"J Clin Invest"},{"key":"2608_CR28","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/ki.1992.300","volume":"42","author":"CE Alpers","year":"1992","unstructured":"Alpers CE, Seifert RA, Hudkins KL, Johnson RJ, Bowen-Pope DF (1992) Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis [eng]. Kidney Int 42:390\u2013399","journal-title":"Kidney Int"},{"key":"2608_CR29","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/sj.ki.5001567","volume":"70","author":"TJ Soos","year":"2006","unstructured":"Soos TJ, Sims TN, Barisoni L, Lin K, Littman DR, Dustin ML, Nelson PJ (2006) CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney [eng]. Kidney Int 70:591\u2013596","journal-title":"Kidney Int"},{"key":"2608_CR30","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1177\/43.11.7560895","volume":"43","author":"T Kren\u00e1cs","year":"1995","unstructured":"Kren\u00e1cs T, Rosendaal M (1995) Immunohistological detection of gap junctions in human lymphoid tissue: connexin43 in follicular dendritic and lymphoendothelial cells [eng]. J Histochem Cytochem Official J Histochem Soc 43:1125\u20131137","journal-title":"J Histochem Cytochem Official J Histochem Soc"},{"key":"2608_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ydbio.2019.06.013","volume":"454","author":"DM Mokhtar","year":"2019","unstructured":"Mokhtar DM, Hussein MM (2019) Morphological characteristic and functional dependencies of dendritic cell in developing rabbit lung during fetal and neonatal life [eng]. Dev Biol 454:29\u201343","journal-title":"Dev Biol"},{"key":"2608_CR32","doi-asserted-by":"crossref","unstructured":"Tittarelli A, Navarrete M, Gleisner MA, Gebicke-Haerter P, Salazar-Onfray F (2020) Connexin-Mediated signaling at the immunological synapse [eng]. Int J Mol Sci 21","DOI":"10.3390\/ijms21103736"},{"key":"2608_CR33","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF00235134","volume":"141","author":"A Butterweck","year":"1994","unstructured":"Butterweck A, Gergs U, Elfgang C, Willecke K, Traub O (1994) Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells [eng]. J Membr Biol 141:247\u2013256","journal-title":"J Membr Biol"},{"key":"2608_CR34","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1242\/dev.115.3.827","volume":"115","author":"K Sainio","year":"1992","unstructured":"Sainio K, Gilbert SF, Lehtonen E, Nishi M, Kumar NM, Gilula NB, Sax\u00e9n L (1992) Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes [eng]. Development (Cambridge, England) 115:827\u2013837","journal-title":"Development (Cambridge, England)"},{"key":"2608_CR35","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1126\/science.1176488","volume":"326","author":"CE Holt","year":"2009","unstructured":"Holt CE, Bullock SL (2009) Subcellular mRNA localization in animal cells and why it matters [eng]. Science (New York, NY) 326:1212\u20131216","journal-title":"Science (New York, NY)"},{"key":"2608_CR36","first-page":"286","volume":"30","author":"C Pricam","year":"1974","unstructured":"Pricam C, Humbert F, Perrelet A, Orci L (1974) A freeze-etch study of the tight junctions of the rat kidney tubules [eng]. Laboratory Investigation; a Journal of Technical Methods and Pathology 30:286\u2013291","journal-title":"Laboratory Investigation; a Journal of Technical Methods and Pathology"},{"key":"2608_CR37","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1242\/dev.127.19.4179","volume":"127","author":"O Kr\u00fcger","year":"2000","unstructured":"Kr\u00fcger O, Plum A, Kim JS, Winterhager E, Maxeiner S, Hallas G, Kirchhoff S, Traub O, Lamers WH, Willecke K (2000) Defective vascular development in connexin 45-deficient mice [eng]. Development (Cambridge, England) 127:4179\u20134193","journal-title":"Development (Cambridge, England)"},{"key":"2608_CR38","doi-asserted-by":"publisher","first-page":"F216","DOI":"10.1152\/ajprenal.00295.2009","volume":"298","author":"A Stoessel","year":"2010","unstructured":"Stoessel A, Himmerkus N, Bleich M, Bachmann S, Theilig F (2010) Connexin 37 is localized in renal epithelia and responds to changes in dietary salt intake [eng]. Am J Physiol Ren Physiol 298:F216\u2013F223","journal-title":"Am J Physiol Ren Physiol"},{"key":"2608_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/sj.ki.5002673","volume":"73","author":"T Takenaka","year":"2008","unstructured":"Takenaka T, Inoue T, Kanno Y, Okada H, Meaney KR, Hill CE, Suzuki H (2008) Expression and role of connexins in the rat renal vasculature [eng]. Kidney Int 73:415\u2013422","journal-title":"Kidney Int"},{"key":"2608_CR40","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/j.1523-1755.2005.00509.x","volume":"68","author":"J Zhang","year":"2005","unstructured":"Zhang J, Hill CE (2005) Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes [eng]. Kidney Int 68:1171\u20131185","journal-title":"Kidney Int"},{"key":"2608_CR41","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/mvre.1999.2216","volume":"59","author":"K Hwan Seul","year":"2000","unstructured":"Hwan Seul K, Beyer EC (2000) Heterogeneous localization of connexin40 in the renal vasculature [eng]. Microvasc Res 59:140\u2013148","journal-title":"Microvasc Res"},{"key":"2608_CR42","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1681\/ASN.2008030252","volume":"20","author":"L Kurtz","year":"2009","unstructured":"Kurtz L, Janssen-Bienhold U, Kurtz A, Wagner C (2009) Connexin expression in renin-producing cells [eng]. J Am Soc Nephrol: JASN 20:506\u2013512","journal-title":"J Am Soc Nephrol: JASN"},{"key":"2608_CR43","doi-asserted-by":"publisher","first-page":"F743","DOI":"10.1152\/ajprenal.00647.2010","volume":"300","author":"B Kurt","year":"2011","unstructured":"Kurt B, Kurtz L, Sequeira-Lopez ML, Gomez RA, Willecke K, Wagner C, Kurtz A (2011) Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells [eng]. Am J Physiol Ren Physiol 300:F743\u2013F748","journal-title":"Am J Physiol Ren Physiol"},{"key":"2608_CR44","doi-asserted-by":"publisher","first-page":"F17","DOI":"10.1152\/ajprenal.00453.2020","volume":"320","author":"Y Xu","year":"2021","unstructured":"Xu Y, Hu J, Yilmaz DE, Bachmann S (2021) Connexin43 is differentially distributed within renal vasculature and mediates profibrotic differentiation in medullary fibroblasts [eng]. Am J Physiol Ren Physiol 320:F17\u2013F30","journal-title":"Am J Physiol Ren Physiol"},{"key":"2608_CR45","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s004180100275","volume":"115","author":"B Arensbak","year":"2001","unstructured":"Arensbak B, Mikkelsen HB, Gustafsson F, Christensen T, Holstein-Rathlou NH (2001) Expression of connexin 37, 40, and 43 mRNA and protein in renal preglomerular arterioles [eng]. Histochem Cell Biol 115:479\u2013487","journal-title":"Histochem Cell Biol"},{"key":"2608_CR46","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00424-009-0707-6","volume":"459","author":"C Wagner","year":"2009","unstructured":"Wagner C, Kurtz L, Schweda F, Simon AM, Kurtz A (2009) Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney [eng]. Pflugers Arch - Eur J Physiol 459:151\u2013158","journal-title":"Pflugers Arch - Eur J Physiol"},{"key":"2608_CR47","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10157-012-0687-2","volume":"17","author":"T Morioka","year":"2013","unstructured":"Morioka T, Okada S, Nameta M, Kamal F, Yanakieva-Georgieva NT, Yao J, Sato A, Piao H, Oite T (2013) Glomerular expression of connexin 40 and connexin 43 in rat experimental glomerulonephritis [eng]. Clin Exp Nephrol 17:191\u2013204","journal-title":"Clin Exp Nephrol"},{"key":"2608_CR48","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/S0002-9440(10)64438-0","volume":"161","author":"E Yaoita","year":"2002","unstructured":"Yaoita E, Yao J, Yoshida Y, Morioka T, Nameta M, Takata T (2002) Kamiie J-i, Fujinaka H, Oite T, Yamamoto T. Up-regulation of connexin43 in glomerular podocytes in response to injury [eng]. Am J Pathol 161:1597\u20131606","journal-title":"Am J Pathol"},{"key":"2608_CR49","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.febslet.2014.01.011","volume":"588","author":"MJ Meens","year":"2014","unstructured":"Meens MJ, Sabine A, Petrova TV, Kwak BR (2014) Connexins in lymphatic vessel physiology and disease [eng]. FEBS Lett 588:1271\u20131277","journal-title":"FEBS Lett"},{"key":"2608_CR50","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12964-020-00558-1","volume":"18","author":"GW Price","year":"2020","unstructured":"Price GW, Chadjichristos CE, Kavvadas P, Tang SCW, Yiu WH, Green CR, Potter JA, Siamantouras E, Squires PE, Hills CE (2020) Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease [eng]. Cell Commun Signaling: CCS 18:79","journal-title":"Cell Commun Signaling: CCS"},{"key":"2608_CR51","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1369\/0022155419849386","volume":"67","author":"N Prakoura","year":"2019","unstructured":"Prakoura N, Hadchouel J, Chatziantoniou C (2019) Novel targets for therapy of renal fibrosis [eng]. J Histochem Cytochem Official J Histochem Soc 67:701\u2013715","journal-title":"J Histochem Cytochem Official J Histochem Soc"},{"key":"2608_CR52","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911021","volume":"12","author":"EM Buhl","year":"2020","unstructured":"Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P (2020) Dysregulated mesenchymal PDGFR-\u03b2 drives kidney fibrosis [eng]. EMBO Mol Med 12:e11021","journal-title":"EMBO Mol Med"},{"key":"2608_CR53","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41586-020-2941-1","volume":"589","author":"C Kuppe","year":"2021","unstructured":"Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Pat\u00f3n J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R (2021) Decoding myofibroblast origins in human kidney fibrosis [eng]. Nature 589:281\u2013286","journal-title":"Nature"},{"key":"2608_CR54","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1681\/ASN.2016111211","volume":"28","author":"P Kavvadas","year":"2017","unstructured":"Kavvadas P, Abed A, Poulain C, Authier F, Lab\u00e9jof L-P, Calmont A, Afieri C, Prakoura N, Dussaule J-C, Chatziantoniou C, Chadjichristos CE (2017) Decreased expression of connexin 43 blunts the progression of experimental GN [eng]. J Am Soc Nephrol: JASN 28:2915\u20132930","journal-title":"J Am Soc Nephrol: JASN"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-021-02608-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-021-02608-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-021-02608-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T09:27:12Z","timestamp":1635240432000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-021-02608-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["2608"],"URL":"https:\/\/doi.org\/10.1007\/s00424-021-02608-0","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"27 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}