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Nevertheless, mechanisms underlying Cnidarians\u2019 neural signalling and behaviour and their (possible) alterations due to the world ocean acidification remain poorly understood. Here we researched for the first time modulation of GABA<jats:sub>A<\/jats:sub> receptors (GABA<jats:sub>A<\/jats:sub>Rs) in <jats:italic>Actinia equina<\/jats:italic> (Cnidaria: Anthozoa) by pH fluctuations within a range predicted by the world ocean acidification scenarios for the next 80\u2013100\u00a0years and by selective pharmacological activation. We found that in line with earlier studies on vertebrates, both changes of pH and activation of GABA<jats:sub>A<\/jats:sub>Rs with a selective allosteric agonist (diazepam) modulate electrical charge transfer through GABA<jats:sub>A<\/jats:sub>R and the whole-cell excitability. On top of that, diazepam modifies the animal behavioural reaction on startle response. However, despite behavioural reactions displayed by living animals are controlled by GABA<jats:sub>A<\/jats:sub>Rs, changes of pH do not alter them significantly. Possible mechanisms underlying the species resistance to acidification impact are discussed.<\/jats:p>","DOI":"10.1007\/s00424-021-02628-w","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T07:30:48Z","timestamp":1633937448000},"page":"1851-1858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidification"],"prefix":"10.1007","volume":"473","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-2519","authenticated-orcid":false,"given":"Sergii","family":"Snigirov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1358-0601","authenticated-orcid":false,"given":"Sergiy","family":"Sylantyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"2628_CR1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.cbd.2009.07.001","volume":"4","author":"M Anctil","year":"2009","unstructured":"Anctil M (2009) Chemical transmission in the sea anemone Nematostella vectensis: a genomic perspective. 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