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An elegant way to bridge this divide is the exploitation of human-induced pluripotent stem cell (iPSC) reprogramming into human iPSC-derived nociceptors (iDNs). Several protocols were developed and optimized to model nociceptive processes in health and disease. Here we provide an overview of the different approaches and summarize the knowledge obtained from such models on pain pathologies associated with monogenetic sensory disorders so far. In addition, novel perspectives offered by increasing the complexity of the model systems further to better reflect the natural environment of nociceptive neurons by involving other cell types in 3D model systems are described.<\/jats:p>","DOI":"10.1007\/s00424-022-02707-6","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T21:02:38Z","timestamp":1654203758000},"page":"965-978","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Towards bridging the translational gap by improved modeling of human nociception in health and disease"],"prefix":"10.1007","volume":"474","author":[{"given":"Maximilian","family":"Zeidler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai K.","family":"Kummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"2707_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1399-6576.1982.tb01838.x","volume":"74","author":"KL Casey","year":"1982","unstructured":"Casey KL (1982) Neural mechanisms of pain: an overview. 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