{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:01:24Z","timestamp":1740106884001,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Augsburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Established risk factors for the metabolic syndrome as diabetes and arterial hypertension are believed to be the cause of arteriosclerosis and subsequently following diseases like coronary heart disease, apoplexy, or chronic renal failure. Based on broad evidence from the already available experimental literature and clinical experience, an alternative hypothesis is presented that puts an increased vessel and organ stiffness to the beginning of the pathophysiological scenario. The stiffness itself is caused by a persistent activation of mechano-sensitive cation channels like the epithelial\/endothelial sodium channel. A further enhancement takes place by proteins like JACD and RhoA coupled phospholipase C coupled G-protein receptors and integrins. A self-enhancing positive feedback loop by activation of YAP\/TAZ signaling is a further central pillar of this theory. Further investigations are necessary to verify this hypothesis. If this hypothesis could be confirmed fundamental changes regarding the pharmacologic therapy of the diseases that are currently summarizes as metabolic syndrome would be the\u00a0consequence.<\/jats:p>","DOI":"10.1007\/s00424-022-02749-w","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T20:19:28Z","timestamp":1663964368000},"page":"1323-1326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of progredient vessel and tissue stiffening for the development of metabolic syndrome"],"prefix":"10.1007","volume":"474","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-6612","authenticated-orcid":false,"given":"Clemens","family":"Loracher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-850X","authenticated-orcid":false,"given":"Bruno","family":"M\u00e4rkl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alois","family":"Loracher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"2749_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/HYPERTENSIONAHA.121.18449","volume":"79","author":"AO Agbaje","year":"2022","unstructured":"Agbaje AO, Barker AR, Tuomainen TP (2022) Effects of arterial stiffness and carotid intima-media thickness progression on the risk of overweight\/obesity and elevated blood pressure\/hypertension: a cross-lagged cohort study. 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Ethical approval and\/or consent are therefore not necessary.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable \u2014 This work does not include any original data or patient\/person or animal data. Ethical approval and\/or consent are therefore not necessary.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal ethics"}},{"value":"Not applicable \u2014 This work does not include any original data or patient\/person or animal data. Ethical approval and\/or consent are therefore not necessary.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}