{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:19:16Z","timestamp":1777623556637,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s00424-023-02789-w","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T23:01:52Z","timestamp":1674860512000},"page":"477-488","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle"],"prefix":"10.1007","volume":"475","author":[{"given":"Haruka","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuki","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakako","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Someya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyohiko","family":"Shindoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"2789_CR1","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1172\/JCI25371","volume":"115","author":"FG Akar","year":"2005","unstructured":"Akar FG, Aon MA, Tomaselli GF, O\u2019Rourke B (2005) The mitochondrial origin of postischemic arrhythmias. J Clin Invest 115:3527\u20133535. https:\/\/doi.org\/10.1172\/JCI25371","journal-title":"J Clin Invest"},{"key":"2789_CR2","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1113\/jphysiol.2010.202838","volume":"589","author":"DC Andersson","year":"2011","unstructured":"Andersson DC, Fauconnier J, Yamada T, Lacampagne A, Zhang SJ, Katz A, Westerblad H (2011) Mitochondrial production of reactive oxygen species contributes to the \u03b2-adrenergic stimulation of mouse cardiomyocytes. J Physiol 589:1791\u20131801. https:\/\/doi.org\/10.1113\/jphysiol.2010.202838","journal-title":"J Physiol"},{"key":"2789_CR3","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1111\/j.1582-4934.2011.01516.x","volume":"16","author":"K Boengler","year":"2012","unstructured":"Boengler K, Ruiz-Meana M, Gent S, Ungefug E, Soetkamp D, Miro-Casas E, Cabestrero A, Fernandez-Sanz C, Semenzato M, Di Lisa F, Rohrbach S, Garcia-Dorado D, Heusch G, Schulz R (2012) Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J Cell Mol Med 16:1649\u20131655. https:\/\/doi.org\/10.1111\/j.1582-4934.2011.01516.x","journal-title":"J Cell Mol Med"},{"key":"2789_CR4","doi-asserted-by":"publisher","first-page":"H1215","DOI":"10.1152\/ajpheart.00124.2018","volume":"315","author":"K Boengler","year":"2018","unstructured":"Boengler K, Lochnit G, Schulz R (2018) Mitochondria \u201cTHE\u201d target of myocardial conditioning. Am J Physiol Heart Circ Physiol 315:H1215\u2013H1231. https:\/\/doi.org\/10.1152\/ajpheart.00124.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2789_CR5","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0006-3495(02)75194-1","volume":"83","author":"R Brandes","year":"2002","unstructured":"Brandes R, Bers DM (2002) Simultaneous measurements of mitochondrial NADH and Ca2+ during increased work in intact rat heart trabeculae. Biophys J 83:587\u2013604. https:\/\/doi.org\/10.1016\/S0006-3495(02)75194-1","journal-title":"Biophys J"},{"key":"2789_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.yjmcc.2009.11.011","volume":"48","author":"DA Brown","year":"2010","unstructured":"Brown DA, Aon MA, Frasier CR, Sloan RC, Maloney AH, Anderson EJ, O\u2019Rourke B (2010) Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. J Mol Cell Cardiol 48:673\u2013679. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.11.011","journal-title":"J Mol Cell Cardiol"},{"key":"2789_CR7","doi-asserted-by":"publisher","first-page":"15363","DOI":"10.1073\/pnas.2002250117","volume":"117","author":"JD Chavez","year":"2020","unstructured":"Chavez JD, Tang X, Campbell MD, Reyes G, Kramer PA, Stuppard R, Keller A, Zhang H, Rabinovitch PS, Marcinek DJ, Bruce JE (2020) Mitochondrial protein interaction landscape of SS-31. Proc Natl Acad Sci USA 117:15363\u201315373. https:\/\/doi.org\/10.1073\/pnas.2002250117","journal-title":"Proc Natl Acad Sci USA"},{"key":"2789_CR8","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1152\/japplphysiol.01471.2012","volume":"115","author":"F Chen","year":"2013","unstructured":"Chen F, Hadfield JM, Berzingi C, Hollander JM, Miller DB, Nichols CE, Finkel MS (2013) N-acetylcysteine reverses cardiac myocyte dysfunction in a rodent model of behavioral stress. J Appl Physiol 115:514\u2013524. https:\/\/doi.org\/10.1152\/japplphysiol.01471.2012","journal-title":"J Appl Physiol"},{"key":"2789_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.pharmthera.2013.06.007","volume":"140","author":"WA Coetzee","year":"2013","unstructured":"Coetzee WA (2013) Multiplicity of effectors of the cardioprotective agent, diazoxide. Pharmacol Ther 140:167\u2013175. https:\/\/doi.org\/10.1016\/j.pharmthera.2013.06.007","journal-title":"Pharmacol Ther"},{"key":"2789_CR10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/cyto.a.21061","volume":"79","author":"C Cottet-Rousselle","year":"2011","unstructured":"Cottet-Rousselle C, Ronot X, Leverve X, Mayol JF (2011) Cytometric assessment of mitochondria using fluorescent probes. Cytometry A 79:405\u2013425. https:\/\/doi.org\/10.1002\/cyto.a.21061","journal-title":"Cytometry A"},{"key":"2789_CR11","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1161\/01.RES.0000148664.33695.2a","volume":"95","author":"SB Danik","year":"2004","unstructured":"Danik SB, Liu F, Zhang J, Suk HJ, Morley GE, Fishman GI, Gutstein DE (2004) Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res 95:1035\u20131041. https:\/\/doi.org\/10.1161\/01.RES.0000148664.33695.2a","journal-title":"Circ Res"},{"key":"2789_CR12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ceca.2009.07.002","volume":"46","author":"E De Vuyst","year":"2009","unstructured":"De Vuyst E, Wang N, Decrock E, de Bock M, Vinken M, van Moorhem M, Lai C, Culot M, Rogiers V, Cecchelli R, Naus CC, Evans WH, Leybaert L (2009) Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells. Cell Calcium 46:176\u2013187. https:\/\/doi.org\/10.1016\/j.ceca.2009.07.002","journal-title":"Cell Calcium"},{"key":"2789_CR13","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1172\/JCI119367","volume":"99","author":"PA Guerrero","year":"1997","unstructured":"Guerrero PA, Schuessler RB, Davis LM, Beyer EC, Johnson CM, Yamada KA, Saffitz JE (1997) Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J Clin Invest 99:1991\u20131998. https:\/\/doi.org\/10.1172\/JCI119367","journal-title":"J Clin Invest"},{"key":"2789_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1161\/01.RES.0000181171.65293.65","volume":"97","author":"FR Heinzel","year":"2005","unstructured":"Heinzel FR, Luo Y, Li X, Boengler K, Buechert A, Garc\u00eda-Dorado D, Di Lisa F, Schulz R, Heusch G (2005) Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res 97:583\u2013586. https:\/\/doi.org\/10.1161\/01.RES.0000181171.65293.65","journal-title":"Circ Res"},{"key":"2789_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12576-012-0206-y","volume":"62","author":"C Jin","year":"2012","unstructured":"Jin C, Wu J, Watanabe M, Okada T, Iesaki T (2012) Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts. J Physiol Sci 62:325\u2013332. https:\/\/doi.org\/10.1007\/s12576-012-0206-y","journal-title":"J Physiol Sci"},{"key":"2789_CR16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1124\/mol.53.3.497","volume":"53","author":"M Kawakami","year":"1998","unstructured":"Kawakami M, Okabe E (1998) Superoxide anion radical-triggered Ca2+ release from cardiac sarcoplasmic reticulum through ryanodine receptor Ca2+ channel. Mol Pharmacol 53:497\u2013503. https:\/\/doi.org\/10.1124\/mol.53.3.497","journal-title":"Mol Pharmacol"},{"key":"2789_CR17","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1161\/CIRCULATIONAHA.119.039710","volume":"140","author":"JC Kim","year":"2019","unstructured":"Kim JC, P\u00e9rez-Hern\u00e1ndez M, Alvarado FJ, Maurya SR, Montnach J, Yin Y, Zhang M, Lin X, Vasquez C, Heguy A, Liang FX, Woo SH, Morley GE, Rothenberg E, Lundby A, Valdivia HH, Cerrone M, Delmar M (2019) Disruption of Ca2+i homeostasis and connexin 43 hemichannel function in the right ventricle precedes overt arrhythmogenic cardiomyopathy in plakophilin-2-deficient mice. Circulation 140:1015\u20131030. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.039710","journal-title":"Circulation"},{"key":"2789_CR18","doi-asserted-by":"publisher","first-page":"9989","DOI":"10.1073\/pnas.171305298","volume":"98","author":"Y Liao","year":"2001","unstructured":"Liao Y, Day KH, Damon DN, Duling BR (2001) Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc Natl Acad Sci USA 98:9989\u20139994. https:\/\/doi.org\/10.1073\/pnas.171305298","journal-title":"Proc Natl Acad Sci USA"},{"key":"2789_CR19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/cvr\/cvq293","volume":"88","author":"G Lu","year":"2010","unstructured":"Lu G, Haider HKh, Porollo A, Ashraf M (2010) Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovasc Res 88:277\u2013286. https:\/\/doi.org\/10.1093\/cvr\/cvq293","journal-title":"Cardiovasc Res"},{"key":"2789_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.33549\/physiolres.931317","volume":"58","author":"J Matej\u00edkov\u00e1","year":"2009","unstructured":"Matej\u00edkov\u00e1 J, Kucharsk\u00e1 J, Pint\u00e9rov\u00e1 M, Pancza D, Ravingerov\u00e1 T (2009) Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: involvement of mitochondrial KATP channels and reactive oxygen species. Physiol Res 58:9\u201319. https:\/\/doi.org\/10.33549\/physiolres.931317","journal-title":"Physiol Res"},{"key":"2789_CR21","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/cvr\/cvp157","volume":"83","author":"E Miro-Casas","year":"2009","unstructured":"Miro-Casas E, Ruiz-Meana M, Agullo E, Stahlhofen S, Rodr\u00edguez-Sinovas A, Cabestrero A, Jorge I, Torre I, Vazquez J, Boengler K, Schulz R, Heusch G, Garcia-Dorado D (2009) Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc Res 83:747\u2013756. https:\/\/doi.org\/10.1093\/cvr\/cvp157","journal-title":"Cardiovasc Res"},{"key":"2789_CR22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/cvr\/cvn162","volume":"80","author":"M Miura","year":"2008","unstructured":"Miura M, Wakayama Y, Endoh H, Nakano M, Sugai Y, Hirose M, ter Keurs HEDJ, Shimokawa H (2008) Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic delayed afterdepolarizations in rat cardiac muscle. Cardiovasc Res 80:55\u201361. https:\/\/doi.org\/10.1093\/cvr\/cvn162","journal-title":"Cardiovasc Res"},{"key":"2789_CR23","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1253\/circj.CJ-15-0401","volume":"80","author":"M Miura","year":"2016","unstructured":"Miura M, Nagano T, Murai N, Taguchi Y, Handoh T, Satoh M, Miyata S, Miller L, Shindoh C, Stuyvers BD (2016) Effect of carbenoxolone on arrhythmogenesis in rat ventricular muscle. Circ J 80:76\u201384. https:\/\/doi.org\/10.1253\/circj.CJ-15-0401","journal-title":"Circ J"},{"key":"2789_CR24","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s00424-018-2152-x","volume":"470","author":"M Miura","year":"2018","unstructured":"Miura M, Taguchi Y, Handoh T, Hasegawa T, Takahashi Y, Morita N, Matsumoto A, Sato H, Shindoh C (2018) Regional increase in ROS within stretched region exacerbates arrhythmias in rat trabeculae with nonuniform contraction. Pfl\u00fcgers Arch 470:1349\u20131357. https:\/\/doi.org\/10.1007\/s00424-018-2152-x","journal-title":"Pfl\u00fcgers Arch"},{"key":"2789_CR25","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1007\/s00380-020-01726-6","volume":"36","author":"M Miura","year":"2021","unstructured":"Miura M, Hasegawa T, Matsumoto A, Nishiyama M, Someya Y, Satoh W, Kumasaka K, Shindoh C, Sato H (2021) Effect of transient elevation of glucose on contractile properties in non-diabetic rat cardiac muscle. Heart Vessels 36:568\u2013576. https:\/\/doi.org\/10.1007\/s00380-020-01726-6","journal-title":"Heart Vessels"},{"key":"2789_CR26","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1093\/cvr\/cvaa221","volume":"117","author":"Y Monma","year":"2021","unstructured":"Monma Y, Shindo T, Eguchi K, Kurosawa R, Kagaya Y, Ikumi Y, Ichijo S, Nakata T, Miyata S, Matsumoto A, Sato H, Miura M, Kanai H, Shimokawa H (2021) Low-intensity pulsed ultrasound ameliorates cardiac diastolic dysfunction in mice: a possible novel therapy for heart failure with preserved left ventricular ejection fraction. Cardiovasc Res 117:1325\u20131338. https:\/\/doi.org\/10.1093\/cvr\/cvaa221","journal-title":"Cardiovasc Res"},{"key":"2789_CR27","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1111\/j.1540-8167.1999.tb00192.x","volume":"10","author":"GE Morley","year":"1999","unstructured":"Morley GE, Vaidya D, Samie FH, Lo C, Delmar M, Jalife J (1999) Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. J Cardiovasc Electrophysiol 10:1361\u20131375. https:\/\/doi.org\/10.1111\/j.1540-8167.1999.tb00192.x","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2789_CR28","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s00395-008-0731-2","volume":"103","author":"J Mykytenko","year":"2008","unstructured":"Mykytenko J, Reeves JG, Kin H, Wang NP, Zatta AJ, Jiang R, Guyton RA, Vinten-Johansen J, Zhao ZQ (2008) Persistent beneficial effect of postconditioning against infarct size: role of mitochondrial KATP channels during reperfusion. Basic Res Cardiol 103:472\u2013484. https:\/\/doi.org\/10.1007\/s00395-008-0731-2","journal-title":"Basic Res Cardiol"},{"key":"2789_CR29","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41586-019-1498-3","volume":"572","author":"A Paggio","year":"2019","unstructured":"Paggio A, Checchetto V, Campo A, Menab\u00f2 R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D (2019) Identification of an ATP-sensitive potassium channel in mitochondria. Nature 572:609\u2013613. https:\/\/doi.org\/10.1038\/s41586-019-1498-3","journal-title":"Nature"},{"key":"2789_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1749-6632.2010.05634.x","volume":"1201","author":"TI Peng","year":"2010","unstructured":"Peng TI, Jou MJ (2010) Oxidative stress caused by mitochondrial calcium overload. Ann N Y Acad Sci 1201:183\u2013188. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05634.x","journal-title":"Ann N Y Acad Sci"},{"key":"2789_CR31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12013-011-9165-9","volume":"61","author":"I Pinz","year":"2011","unstructured":"Pinz I, Zhu M, Mende U, Ingwall JS (2011) An improved isolation procedure for adult mouse cardiomyocyte. Cell Biochem Biophys 61:93\u2013101. https:\/\/doi.org\/10.1007\/s12013-011-9165-9","journal-title":"Cell Biochem Biophys"},{"key":"2789_CR32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/01.RES.0000230315.56904.de","volume":"99","author":"A Rodriguez-Sinovas","year":"2006","unstructured":"Rodriguez-Sinovas A, Boengler K, Cabestrero A, Gres P, Morente M, Ruiz-Meana M, Konietzka I, Mir\u00f3 E, Totzeck A, Heusch G, Schulz R, Garcia-Dorado D (2006) Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res 99:93\u2013101. https:\/\/doi.org\/10.1161\/01.RES.0000230315.56904.de","journal-title":"Circ Res"},{"key":"2789_CR33","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1172\/JCI40927","volume":"120","author":"D Rottlaender","year":"2010","unstructured":"Rottlaender D, Boengler K, Wolny M, Michels G, Endres-Becker J, Motloch LJ, Schwaiger A, Buechert A, Schulz R, Heusch G, Hoppe UC (2010) Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. J Clin Invest 120:1441\u20131453. https:\/\/doi.org\/10.1172\/JCI40927","journal-title":"J Clin Invest"},{"key":"2789_CR34","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/cvr\/cvm062","volume":"77","author":"M Ruiz-Meana","year":"2008","unstructured":"Ruiz-Meana M, Rodr\u00edguez-Sinovas A, Cabestrero A, Boengler K, Heusch G, Garcia-Dorado D (2008) Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury. Cardiovasc Res 77:325\u2013333. https:\/\/doi.org\/10.1093\/cvr\/cvm062","journal-title":"Cardiovasc Res"},{"key":"2789_CR35","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1016\/j.yexcr.2010.05.026","volume":"316","author":"JC S\u00e1ez","year":"2010","unstructured":"S\u00e1ez JC, Schalper KA, Retamal MA, Orellana JA, Shoji KF, Bennett MV (2010) Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res 316:2377\u20132389. https:\/\/doi.org\/10.1016\/j.yexcr.2010.05.026","journal-title":"Exp Cell Res"},{"key":"2789_CR36","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00424-021-02657-5","volume":"474","author":"H Sato","year":"2022","unstructured":"Sato H, Nagano T, Satoh W, Kumasaka K, Shindoh C, Miura M (2022) Roles of stretch-activated channels and NADPH oxidase 2 in the induction of twitch contraction by muscle stretching in rat ventricular muscle. Pfl\u00fcgers Arch 474:355\u2013363. https:\/\/doi.org\/10.1007\/s00424-021-02657-5","journal-title":"Pfl\u00fcgers Arch"},{"key":"2789_CR37","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.pharmthera.2015.06.005","volume":"153","author":"R Schulz","year":"2015","unstructured":"Schulz R, G\u00f6rge PM, G\u00f6rbe A, Ferdinandy P, Lampe PD, Leybaert L (2015) Connexin 43 is an emerging therapeutic target in ischemia\/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther 153:90\u2013106. https:\/\/doi.org\/10.1016\/j.pharmthera.2015.06.005","journal-title":"Pharmacol Ther"},{"key":"2789_CR38","doi-asserted-by":"publisher","first-page":"H1740","DOI":"10.1152\/ajpheart.00442.2002","volume":"283","author":"U Schwanke","year":"2002","unstructured":"Schwanke U, Konietzka I, Duschin A, Li X, Schulz R, Heusch G (2002) No ischemic preconditioning in heterozygous connexin43-deficient mice. Am J Physiol Heart Circ Physiol 283:H1740\u2013H1742. https:\/\/doi.org\/10.1152\/ajpheart.00442.2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2789_CR39","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00395-014-0433-x","volume":"109","author":"D Soetkamp","year":"2014","unstructured":"Soetkamp D, Nguyen TT, Menazza S, Hirschh\u00e4user C, Hendgen-Cotta UB, Rassaf T, Schl\u00fcter KD, Boengler K, Murphy E, Schulz R (2014) S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function. Basic Res Cardiol 109:433. https:\/\/doi.org\/10.1007\/s00395-014-0433-x","journal-title":"Basic Res Cardiol"},{"key":"2789_CR40","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1161\/CIRCEP.112.976787","volume":"6","author":"AA Sovari","year":"2013","unstructured":"Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS, Dudley SC Jr (2013) Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death. Circ Arrhythm Electrophysiol 6:623\u2013631. https:\/\/doi.org\/10.1161\/CIRCEP.112.976787","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2789_CR41","doi-asserted-by":"publisher","first-page":"E7129","DOI":"10.1073\/pnas.1721298115","volume":"115","author":"S Sunamura","year":"2018","unstructured":"Sunamura S, Satoh K, Kurosawa R, Ohtsuki T, Kikuchi N, Elias-Al-Mamun M, Shimizu T, Ikeda S, Suzuki K, Satoh T, Omura J, Nogi M, Numano K, Siddique MAH, Miyata S, Miura M, Shimokawa H (2018) Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice. Proc Natl Acad Sci USA 115:E7129-7138. https:\/\/doi.org\/10.1073\/pnas.1721298115","journal-title":"Proc Natl Acad Sci USA"},{"key":"2789_CR42","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1111\/bph.12461","volume":"171","author":"HH Szeto","year":"2014","unstructured":"Szeto HH (2014) First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol 171:2029\u20132050. https:\/\/doi.org\/10.1111\/bph.12461","journal-title":"Br J Pharmacol"},{"key":"2789_CR43","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1152\/physrev.00011.2006","volume":"87","author":"HEDJ Ter Keurs","year":"2007","unstructured":"Ter Keurs HEDJ, Boyden PA (2007) Calcium and arrhythmogenesis. Physiol Rev 87:457\u2013506. https:\/\/doi.org\/10.1152\/physrev.00011.2006","journal-title":"Physiol Rev"},{"key":"2789_CR44","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1161\/01.res.68.6.1638","volume":"68","author":"MJ Van Kempen","year":"1991","unstructured":"Van Kempen MJ, Fromaget C, Gros D, Moorman AF, Lamers WH (1991) Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart. Circ Res 68:1638\u20131651. https:\/\/doi.org\/10.1161\/01.res.68.6.1638","journal-title":"Circ Res"},{"key":"2789_CR45","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1074\/jbc.M412749200","volume":"280","author":"J Thimm","year":"2005","unstructured":"Thimm J, Mechler A, Lin H, Rhee S, Lal R (2005) Calcium-dependent open\/closed conformations and interfacial energy maps of reconstituted hemichannels. J Biol Chem 280:10646\u201310654. https:\/\/doi.org\/10.1074\/jbc.M412749200","journal-title":"J Biol Chem"},{"key":"2789_CR46","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1161\/CIRCRESAHA.110.221911","volume":"108","author":"S Wagner","year":"2011","unstructured":"Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS (2011) Reactive oxygen species-activated Ca\/calmodulin kinase II\u03b4 is required for late INa augmentation leading to cellular Na and Ca overload. Circ Res 108:555\u2013565. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.221911","journal-title":"Circ Res"},{"key":"2789_CR47","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1161\/01.res.79.6.1077","volume":"79","author":"YM Zhang","year":"1996","unstructured":"Zhang YM, Miura M, ter Keurs HEDJ (1996) Triggered propagated contractions in rat cardiac trabeculae. Inhibition by octanol and heptanol. Circ Res 79:1077\u20131085. https:\/\/doi.org\/10.1161\/01.res.79.6.1077","journal-title":"Circ Res"},{"key":"2789_CR48","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.cardiores.2006.02.019","volume":"71","author":"AV Zima","year":"2006","unstructured":"Zima AV, Blatter LA (2006) Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71:310\u2013321. https:\/\/doi.org\/10.1016\/j.cardiores.2006.02.019","journal-title":"Cardiovasc Res"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02789-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-023-02789-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02789-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:04:10Z","timestamp":1678683850000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-023-02789-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,28]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["2789"],"URL":"https:\/\/doi.org\/10.1007\/s00424-023-02789-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2043097\/v1","asserted-by":"object"}]},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,28]]},"assertion":[{"value":"7 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were approved by the Ethics Review Board of Tohoku University (approval reference number: 2017MdLM0-102, 2020 MdLM0-041).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have read the manuscript and gave explicit consent to submit. All authors are completely satisfied with its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}