{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:50:20Z","timestamp":1792176620282,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00424-023-02808-w","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T15:03:08Z","timestamp":1680534188000},"page":"711-718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Electrophysiological characterization of a CaV3.1 calcium channel mutation linked to trigeminal neuralgia"],"prefix":"10.1007","volume":"475","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-3648","authenticated-orcid":false,"given":"Abdulaziz M.","family":"Alaklabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-9110","authenticated-orcid":false,"given":"Eder","family":"Gambeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-9066","authenticated-orcid":false,"given":"Gerald W.","family":"Zamponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"2808_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR (2010) A method and server for predicting damaging missense mutations. Nat Methods 7:248\u2013249. https:\/\/doi.org\/10.1038\/nmeth0410-248","journal-title":"Nat Methods"},{"key":"2808_CR2","doi-asserted-by":"publisher","first-page":"8136","DOI":"10.1074\/jbc.M708761200","volume":"283","author":"O Arias II","year":"2008","unstructured":"Arias O II, Vitko I, Fortuna M, Baumgart JP, Sokolova S, Shumilin IA, Van Deusen A, Soriano-Garcia M, Gomora JC, Perez-Reyes E (2008) Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels. J Biol Chem 283:8136\u20138144. https:\/\/doi.org\/10.1074\/jbc.M708761200","journal-title":"J Biol Chem"},{"key":"2808_CR3","doi-asserted-by":"publisher","first-page":"e2976","DOI":"10.1371\/journal.pone.0002976","volume":"3","author":"JP Baumgart","year":"2008","unstructured":"Baumgart JP, Vitko I, Bidaud I, Kondratskyi A, Lory P, Perez-Reyes E (2008) I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One 3:e2976. https:\/\/doi.org\/10.1371\/journal.pone.0002976","journal-title":"PLoS One"},{"key":"2808_CR4","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S1474-4422(20)30233-7","volume":"19","author":"L Bendtsen","year":"2020","unstructured":"Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S (2020) Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia. Lancet Neurol 19:784\u2013796. https:\/\/doi.org\/10.1016\/S1474-4422(20)30233-7","journal-title":"Lancet Neurol"},{"key":"2808_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4161\/chan.4.6.14106","volume":"4","author":"SM Cain","year":"2010","unstructured":"Cain SM, Snutch TP (2010) Contributions of T-type calcium channel isoforms to neuronal firing. Channels (Austin) 4:475\u2013482. https:\/\/doi.org\/10.4161\/chan.4.6.14106","journal-title":"Channels (Austin)"},{"key":"2808_CR6","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/S0006-3495(01)76100-0","volume":"80","author":"J Chemin","year":"2001","unstructured":"Chemin J, Monteil A, Bourinet E, Nargeot J, Lory P (2001) Alternatively spliced alpha(1G) (Ca(V)3.1) intracellular loops promote specific T-type Ca(2+) channel gating properties. Biophys J 80:1238\u20131250. https:\/\/doi.org\/10.1016\/S0006-3495(01)76100-0","journal-title":"Biophys J"},{"key":"2808_CR7","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1093\/brain\/awy145","volume":"141","author":"J Chemin","year":"2018","unstructured":"Chemin J, Siquier-Pernet K, Nicouleau M, Barcia G, Ahmad A, Medina-Cano D, Hanein S, Altin N, Hubert L, Bole-Feysot C, Fourage C, Nitschke P, Thevenon J, Rio M, Blanc P, Vidal C, Bahi-Buisson N, Desguerre I, Munnich A et al (2018) De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene. Brain 141:1998\u20132013. https:\/\/doi.org\/10.1093\/brain\/awy145","journal-title":"Brain"},{"key":"2808_CR8","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1073\/pnas.1600418113","volume":"113","author":"S Choi","year":"2016","unstructured":"Choi S, Yu E, Hwang E, Llinas RR (2016) Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain. Proc Natl Acad Sci U S A 113:2270\u20132275. https:\/\/doi.org\/10.1073\/pnas.1600418113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2808_CR9","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1212\/WNL.0000000000002840","volume":"87","author":"G Cruccu","year":"2016","unstructured":"Cruccu G, Finnerup NB, Jensen TS, Scholz J, Sindou M, Svensson P, Treede RD, Zakrzewska JM, Nurmikko T (2016) Trigeminal neuralgia: new classification and diagnostic grading for practice and research. Neurology 87:220\u2013228. https:\/\/doi.org\/10.1212\/WNL.0000000000002840","journal-title":"Neurology"},{"key":"2808_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00002508-200201000-00002","volume":"18","author":"M Devor","year":"2002","unstructured":"Devor M, Amir R, Rappaport ZH (2002) Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin J Pain 18:4\u201313. https:\/\/doi.org\/10.1097\/00002508-200201000-00002","journal-title":"Clin J Pain"},{"key":"2808_CR11","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1177\/0333102419897623","volume":"40","author":"G Di Stefano","year":"2020","unstructured":"Di Stefano G, Yuan JH, Cruccu G, Waxman SG, Dib-Hajj SD, Truini A (2020) Familial trigeminal neuralgia\u2014a systematic clinical study with a genomic screen of the neuronal electrogenisome. Cephalalgia 40:767\u2013777. https:\/\/doi.org\/10.1177\/0333102419897623","journal-title":"Cephalalgia"},{"key":"2808_CR12","doi-asserted-by":"publisher","first-page":"101552","DOI":"10.1016\/j.isci.2020.101552","volume":"23","author":"W Dong","year":"2020","unstructured":"Dong W, Jin SC, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo LE, Islam B, Brindle G, Bachand K, Hu J, Sularz A, Gaillard J, Choi J, Dunbar A, Nelson-Williams C, Kiziltug E, Furey CG et al (2020) Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal neuralgia. iScience 23:101552. https:\/\/doi.org\/10.1016\/j.isci.2020.101552","journal-title":"iScience"},{"key":"2808_CR13","doi-asserted-by":"publisher","first-page":"120101","DOI":"10.1016\/j.jns.2021.120101","volume":"434","author":"PK Eide","year":"2022","unstructured":"Eide PK (2022) Familial occurrence of classical and idiopathic trigeminal neuralgia. J Neurol Sci 434:120101. https:\/\/doi.org\/10.1016\/j.jns.2021.120101","journal-title":"J Neurol Sci"},{"key":"2808_CR14","doi-asserted-by":"publisher","first-page":"174480692090189","DOI":"10.1177\/1744806920901890","volume":"16","author":"E Gambeta","year":"2020","unstructured":"Gambeta E, Chichorro JG, Zamponi GW (2020) Trigeminal neuralgia: an overview from pathophysiology to pharmacological treatments. Mol Pain 16:1744806920901890. https:\/\/doi.org\/10.1177\/1744806920901890","journal-title":"Mol Pain"},{"key":"2808_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13041-020-00725-y","volume":"14","author":"E Gambeta","year":"2021","unstructured":"Gambeta E, Gandini MA, Souza IA, Ferron L, Zamponi GW (2021) A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels. Mol. Brain 14:4. https:\/\/doi.org\/10.1186\/s13041-020-00725-y","journal-title":"Brain"},{"key":"2808_CR16","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1097\/j.pain.0000000000002651","volume":"163","author":"E Gambeta","year":"2022","unstructured":"Gambeta E, Gandini MA, Souza IA, Zamponi GW (2022) Ca V 3.2 calcium channels contribute to trigeminal neuralgia. Pain 163:2315\u20132325. https:\/\/doi.org\/10.1097\/j.pain.0000000000002651","journal-title":"Pain"},{"key":"2808_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13041-022-00923-w","volume":"15","author":"EK Harding","year":"2022","unstructured":"Harding EK, Zamponi GW (2022) Central and peripheral contributions of T-type calcium channels in pain. Mol Brain 15:39. https:\/\/doi.org\/10.1186\/s13041-022-00923-w","journal-title":"Mol Brain"},{"key":"2808_CR18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.tips.2008.10.004","volume":"30","author":"MC Iftinca","year":"2009","unstructured":"Iftinca MC, Zamponi GW (2009) Regulation of neuronal T-type calcium channels. Trends Pharmacol Sci 30:32\u201340. https:\/\/doi.org\/10.1016\/j.tips.2008.10.004","journal-title":"Trends Pharmacol Sci"},{"key":"2808_CR19","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/head.14144","volume":"61","author":"S Maarbjerg","year":"2021","unstructured":"Maarbjerg S, Benoliel R (2021) The changing face of trigeminal neuralgia\u2014a narrative review. Headache 61:817\u2013837. https:\/\/doi.org\/10.1111\/head.14144","journal-title":"Headache"},{"key":"2808_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neuroscience.2016.06.034","volume":"331","author":"A Marchenkova","year":"2016","unstructured":"Marchenkova A, van den Maagdenberg AM, Nistri A (2016) Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. Neuroscience 331:197\u2013205. https:\/\/doi.org\/10.1016\/j.neuroscience.2016.06.034","journal-title":"Neuroscience"},{"key":"2808_CR21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0896-6273(91)90080-j","volume":"7","author":"DP McCobb","year":"1991","unstructured":"McCobb DP, Beam KG (1991) Action potential waveform voltage-clamp commands reveal striking differences in calcium entry via low and high voltage-activated calcium channels. Neuron 7:119\u2013127. https:\/\/doi.org\/10.1016\/0896-6273(91)90080-j","journal-title":"Neuron"},{"key":"2808_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13041-015-0180-4","volume":"8","author":"H Morino","year":"2015","unstructured":"Morino H, Matsuda Y, Muguruma K, Miyamoto R, Ohsawa R, Ohtake T, Otobe R, Watanabe M, Maruyama H, Hashimoto K, Kawakami H (2015) A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. Mol Brain 8:89. https:\/\/doi.org\/10.1186\/s13041-015-0180-4","journal-title":"Mol Brain"},{"key":"2808_CR23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1152\/physrev.00018.2002","volume":"83","author":"E Perez-Reyes","year":"2003","unstructured":"Perez-Reyes E (2003) Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 83:117\u2013161. https:\/\/doi.org\/10.1152\/physrev.00018.2002","journal-title":"Physiol Rev"},{"key":"2808_CR24","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1152\/jn.1989.62.3.810","volume":"62","author":"E Puil","year":"1989","unstructured":"Puil E, Miura RM, Spigelman I (1989) Consequences of 4-aminopyridine applications to trigeminal root ganglion neurons. J Neurophysiol 62:810\u2013820. https:\/\/doi.org\/10.1152\/jn.1989.62.3.810","journal-title":"J Neurophysiol"},{"key":"2808_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0304-3959(94)90086-8","volume":"56","author":"ZH Rappaport","year":"1994","unstructured":"Rappaport ZH, Devor M (1994) Trigeminal neuralgia: the role of self-sustaining discharge in the trigeminal ganglion. Pain 56:127\u2013138. https:\/\/doi.org\/10.1016\/0304-3959(94)90086-8","journal-title":"Pain"},{"key":"2808_CR26","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1016\/j.febslet.2008.10.013","volume":"582","author":"A Shcheglovitov","year":"2008","unstructured":"Shcheglovitov A, Vitko I, Bidaud I, Baumgart JP, Navarro-Gonzalez MF, Grayson TH, Lory P, Hill CE, Perez-Reyes E (2008) Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels. FEBS Lett 582:3765\u20133770. https:\/\/doi.org\/10.1016\/j.febslet.2008.10.013","journal-title":"FEBS Lett"},{"key":"2808_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","volume":"82","author":"BA Simms","year":"2014","unstructured":"Simms BA, Zamponi GW (2014) Neuronal voltage-gated calcium channels: structure, function, and dysfunction. Neuron 82:24\u201345. https:\/\/doi.org\/10.1016\/j.neuron.2014.03.016","journal-title":"Neuron"},{"key":"2808_CR28","doi-asserted-by":"publisher","first-page":"16051","DOI":"10.1523\/JNEUROSCI.1828-12.2012","volume":"32","author":"WT Tseng","year":"2012","unstructured":"Tseng WT, Tsai ML, Iwata K, Yen CT (2012) Long-term changes in trigeminal ganglionic and thalamic neuronal activities following inferior alveolar nerve transection in behaving rats. J Neurosci 32:16051\u201316063. https:\/\/doi.org\/10.1523\/JNEUROSCI.1828-12.2012","journal-title":"J Neurosci"},{"key":"2808_CR29","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1523\/JNEUROSCI.1817-06.2007","volume":"27","author":"I Vitko","year":"2007","unstructured":"Vitko I, Bidaud I, Arias JM, Mezghrani A, Lory P, Perez-Reyes E (2007) The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations. J Neurosci 27:322\u2013330. https:\/\/doi.org\/10.1523\/JNEUROSCI.1817-06.2007","journal-title":"J Neurosci"},{"key":"2808_CR30","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00424-013-1259-3","volume":"465","author":"N Weiss","year":"2013","unstructured":"Weiss N, Black SA, Bladen C, Chen L, Zamponi GW (2013) Surface expression and function of Cav3.2 T-type calcium channels are controlled by asparagine-linked glycosylation. Pflugers Arch 465:1159\u20131170. https:\/\/doi.org\/10.1007\/s00424-013-1259-3","journal-title":"Pflugers Arch"},{"key":"2808_CR31","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1074\/jbc.M111.290882","volume":"287","author":"N Weiss","year":"2012","unstructured":"Weiss N, Hameed S, Fernandez-Fernandez JM, Fablet K, Karmazinova M, Poillot C, Proft J, Chen L, Bidaud I, Monteil A, Huc-Brandt S, Lacinova L, Lory P, Zamponi GW, De Waard M (2012) A Ca(v)3.2\/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis. J Biol Chem 287:2810\u20132818. https:\/\/doi.org\/10.1074\/jbc.M111.290882","journal-title":"J Biol Chem"},{"key":"2808_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jmedgenet-2019-106163","volume":"57","author":"N Weiss","year":"2020","unstructured":"Weiss N, Zamponi GW (2020) Genetic T-type calcium channelopathies. J Med Genet 57:1\u201310. https:\/\/doi.org\/10.1136\/jmedgenet-2019-106163","journal-title":"J Med Genet"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02808-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-023-02808-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02808-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:08:05Z","timestamp":1684195685000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-023-02808-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["2808"],"URL":"https:\/\/doi.org\/10.1007\/s00424-023-02808-w","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"13 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}