{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:58:04Z","timestamp":1770271084153,"version":"3.49.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["219S713"],"award-info":[{"award-number":["219S713"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["219S713"],"award-info":[{"award-number":["219S713"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["219S713"],"award-info":[{"award-number":["219S713"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["219S713"],"award-info":[{"award-number":["219S713"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["219S713"],"award-info":[{"award-number":["219S713"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Asperglaucide (ASP) is an aurantiamide, an effective constituent of purslane (<jats:italic>Portulaca oleracea<\/jats:italic>L.), a safe to eat greenery. Effects of ASP on endothelial function, endothelial nitric oxide synthase (eNOS) expression, vascular fluidity, renal and vascular reactive oxygen, and nitrogen species (ROS\/RNS) production was examined in the two-kidney one-clip (2\u00a0K-1C) rat model of renovascular arterial hypertension. ASP toxicity, dose dependent eNOS gene expression and protein levels were also analyzed in human umbilical vein endothelial cells (HUVEC). The 2\u00a0K-1C model of hypertension was created via surgery and mean blood pressure (MBP) was measured by tail-cuff method during four weeks of ASP treatment. Erythrocyte deformability was monitored by rotational ektacytometry, while vascular constrictor and dilator responses were determined in organ baths. eNOS gene expression and protein levels were assessed in thoracic aorta and HUVEC. MBP was significantly decreased in hypertensive rats treated with ASP. Endothelium dependent vascular dilator and constrictor responses were also considerably improved following ASP treatment. There was a notable increase in red blood cell deformability in hypertensive rats treated with ASP as compared to hypertensive rats alone. A significant increase was observed in eNOS gene expression and protein levels in both normotensive and hypertensive rats treated with ASP. Treatment of HUVEC with 3\u00a0\u00b5M ASP notably increased eNOS mRNA and protein levels. In conclusion, ASP lowered blood pressure, improved endothelium-mediated relaxation, decreased renovascular ROS\/RNS production in hypertensive rats. ASP also increased eNOS protein expression in aorta and HUVEC at nontoxic doses. ASP may have future potential as an anti-hypertensive agent.<\/jats:p>","DOI":"10.1007\/s00424-023-02850-8","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T16:01:40Z","timestamp":1692115300000},"page":"1177-1192","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of aurantiamide on a rat model of renovascular arterial hypertension"],"prefix":"10.1007","volume":"475","author":[{"given":"Mutay","family":"Aslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz","family":"Basral\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"\u00dclker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerrin","family":"Barut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fatay","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011f\u00e7e","family":"\u00c7eker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"\u00d6zen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleyna","family":"\u00d6zt\u00fcz\u00fcn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Elpek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"2850_CR1","doi-asserted-by":"publisher","first-page":"101430","DOI":"10.1016\/j.redox.2020.101430","volume":"30","author":"E Af\u015far","year":"2020","unstructured":"Af\u015far E, K\u0131r\u0131ml\u0131oglu E, \u00c7eker T, Y\u0131lmaz \u00c7, Demir N, Aslan M (2020) Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells. Redox Biol 30:101430. https:\/\/doi.org\/10.1016\/j.redox.2020.101430","journal-title":"Redox Biol"},{"issue":"6","key":"2850_CR2","first-page":"397","volume":"17","author":"RS Ajmani","year":"1997","unstructured":"Ajmani RS (1997) Hypertension and hemorheology. Clin Hemorheol Microcirc 17(6):397\u2013420","journal-title":"Clin Hemorheol Microcirc"},{"issue":"1","key":"2850_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s40199-020-00385-2","volume":"29","author":"B Akg\u00fcl","year":"2021","unstructured":"Akg\u00fcl B, Aycan \u0130\u00d6, Hidi\u015fo\u011flu E, Af\u015far E, Y\u0131ld\u0131r\u0131m S, Tanr\u0131\u00f6ver G, Co\u015fkunf\u0131rat N, Sanl\u0131 S, Aslan M (2021) Alleviation of prilocaine-induced epileptiform activity and cardiotoxicity by thymoquinone. Daru 29(1):85\u201399. https:\/\/doi.org\/10.1007\/s40199-020-00385-2","journal-title":"Daru"},{"issue":"5 Pt 2","key":"2850_CR4","doi-asserted-by":"publisher","first-page":"H1509","DOI":"10.1152\/ajpheart.1989.256.5.H1509","volume":"256","author":"N Aoki","year":"1989","unstructured":"Aoki N, Siegfried M, Lefer AM (1989) Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries. Am J Physiol 256(5 Pt 2):H1509\u2013H1512. https:\/\/doi.org\/10.1152\/ajpheart.1989.256.5.H1509","journal-title":"Am J Physiol"},{"key":"2850_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.niox.2019.02.004","volume":"86","author":"AV Ara\u00fajo","year":"2019","unstructured":"Ara\u00fajo AV, Andrade FA, Paulo M, de Paula TD, Potje SR, Pereira AC, Bendhack LM (2019) NO donors induce vascular relaxation by different cellular mechanisms in hypertensive and normotensive rats. Nitric Oxide 86:12\u201320. https:\/\/doi.org\/10.1016\/j.niox.2019.02.004","journal-title":"Nitric Oxide"},{"issue":"11","key":"2850_CR6","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.freeradbiomed.2007.08.014","volume":"43","author":"M Aslan","year":"2007","unstructured":"Aslan M, Freeman BA (2007) Redox-dependent impairment of vascular function in sickle cell disease. Free Radic Biol Med 43(11):1469\u20131483. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.08.014","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"2850_CR7","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.taap.2014.08.026","volume":"280","author":"M Aslan","year":"2014","unstructured":"Aslan M, Basaranlar G, Unal M, Ciftcioglu A, Derin N, Mutus B (2014) Inhibition of neutral sphingomyelinase decreases elevated levels of inducible nitric oxide synthase and apoptotic cell death in ocular hypertensive rats. Toxicol Appl Pharmacol 280(3):389\u2013398. https:\/\/doi.org\/10.1016\/j.taap.2014.08.026","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"2850_CR8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1177\/0960327120949619","volume":"40","author":"M Aslan","year":"2021","unstructured":"Aslan M, Elpek \u00d6, Akkaya B, Balaban HT, Af\u015far E (2021) Organ function, sphingolipid levels and inflammation in tunicamycin induced endoplasmic reticulum stress in male rats. Hum Exp Toxicol 40(2):259\u2013273. https:\/\/doi.org\/10.1177\/0960327120949619","journal-title":"Hum Exp Toxicol"},{"issue":"9","key":"2850_CR9","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/0031-9422(81)80116-1","volume":"20","author":"A Banerji","year":"1981","unstructured":"Banerji A, Ray R (1981) Aurantiamides: a new class of modified dipeptides from Piper aurantiacum. Phytochemistry 20(9):2217\u20132220. https:\/\/doi.org\/10.1016\/0031-9422(81)80116-1","journal-title":"Phytochemistry"},{"issue":"2","key":"2850_CR10","doi-asserted-by":"publisher","first-page":"R438","DOI":"10.1152\/ajpregu.00590.2007","volume":"294","author":"LM Bivol","year":"2008","unstructured":"Bivol LM, Berge RK, Iversen BM (2008) Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension. Am J Physiol Regul Integr Comp Physiol 294(2):R438\u2013R447. https:\/\/doi.org\/10.1152\/ajpregu.00590.2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"2850_CR11","first-page":"267","volume":"22","author":"M Bor-K\u00fc\u00e7\u00fckatay","year":"2000","unstructured":"Bor-K\u00fc\u00e7\u00fckatay M, Yal\u00e7in O, G\u00f6kalp O, Kipmen-Korgun D, Yesilkaya A, Baykal A, Ispir M, Senturk UK, Kaputlu I, Ba\u015fkurt OK (2000) Red blood cell rheological alterations in hypertension induced by chronic inhibition of nitric oxide synthesis in rats. Clin Hemorheol Microcirc 22(4):267\u2013275","journal-title":"Clin Hemorheol Microcirc"},{"issue":"12","key":"2850_CR12","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.phymed.2013.04.021","volume":"20","author":"YJ Cao","year":"2013","unstructured":"Cao YJ, He X, Wang N, He LC (2013) Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. Phytomedicine 20(12):1048\u20131054. https:\/\/doi.org\/10.1016\/j.phymed.2013.04.021","journal-title":"Phytomedicine"},{"key":"2850_CR13","doi-asserted-by":"publisher","unstructured":"\u00c7eker T, Y\u0131lmaz \u00c7, K\u0131r\u0131ml\u0131oglu E, Aslan M (2022) Endoplasmic-reticulum-stress-induced lipotoxicity in human kidney epithelial cells. Toxicol Res (Camb). tfac041. https:\/\/doi.org\/10.1093\/toxres\/tfac041","DOI":"10.1093\/toxres\/tfac041"},{"issue":"17","key":"2850_CR14","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1021\/acs.jafc.6b00470","volume":"64","author":"L Chen","year":"2016","unstructured":"Chen L, Liu Y, Jia D, Yang J, Zhao J, Chen C, Liu H, Liang X (2016) Pharmacokinetics and biodistribution of aurantiamide and aurantiamide acetate in rats after oral administration of Portulaca oleracea L. Extracts J Agric Food Chem 64(17):3445\u20133455. https:\/\/doi.org\/10.1021\/acs.jafc.6b00470","journal-title":"Extracts J Agric Food Chem"},{"key":"2850_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev.ph.49.030187.001141","volume":"49","author":"S Chien","year":"1987","unstructured":"Chien S (1987) Red cell deformability and its relevance to blood flow. Annu Rev Physiol 49:177\u2013192. https:\/\/doi.org\/10.1146\/annurev.ph.49.030187.001141","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"2850_CR16","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s11906-010-0150-2","volume":"12","author":"K Dharmashankar","year":"2010","unstructured":"Dharmashankar K, Widlansky ME (2010) Vascular endothelial function and hypertension: insights and directions. Curr Hypertens Rep 12(6):448\u2013455. https:\/\/doi.org\/10.1007\/s11906-010-0150-2","journal-title":"Curr Hypertens Rep"},{"issue":"5","key":"2850_CR17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1557\/mrs2010.571","volume":"35","author":"M Diez-Silva","year":"2010","unstructured":"Diez-Silva M, Dao M, Han J, Lim CT, Suresh S (2010) Shape and biomechanical characteristics of human red blood cells in health and disease. MRS Bull 35(5):382\u2013388. https:\/\/doi.org\/10.1557\/mrs2010.571","journal-title":"MRS Bull"},{"issue":"3","key":"2850_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/life11030208","volume":"11","author":"L Dobrek","year":"2021","unstructured":"Dobrek L (2021) An outline of renal artery stenosis pathophysiology-a narrative review. Life (Basel) 11(3):208. https:\/\/doi.org\/10.3390\/life11030208","journal-title":"Life (Basel)"},{"key":"2850_CR19","doi-asserted-by":"publisher","first-page":"3510423","DOI":"10.1155\/2022\/3510423","volume":"2022","author":"Z Fang","year":"2022","unstructured":"Fang Z, Fang J, Gao C, Wu Y, Yu W (2022) Aurantiamide acetate ameliorates lung inflammation in lipopolysaccharide-induced acute lung injury in mice. Biomed Res Int 2022:3510423. https:\/\/doi.org\/10.1155\/2022\/3510423","journal-title":"Biomed Res Int"},{"issue":"2","key":"2850_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1476-5381.2010.01196.x.PMID:21198553;PMCID:PMC3174401","volume":"164","author":"U F\u00f6rstermann","year":"2011","unstructured":"F\u00f6rstermann U, Li H (2011) Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. Br J Pharmacol 164(2):213\u2013223. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.01196.x.PMID:21198553;PMCID:PMC3174401","journal-title":"Br J Pharmacol"},{"issue":"9","key":"2850_CR21","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1161\/CIRCULATIONAHA.104.492348","volume":"112","author":"VD Garovic","year":"2005","unstructured":"Garovic VD, Textor SC (2005) Renovascular hypertension and ischemic nephropathy. Circulation 112(9):1362\u20131374. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.104.492348","journal-title":"Circulation"},{"issue":"3","key":"2850_CR22","first-page":"266","volume":"42","author":"MR Haydari","year":"2017","unstructured":"Haydari MR, Panjeshahin MR, Mashghoolozekr E, Nekooeian AA (2017) Antihypertensive effects of hydroalcoholic extract of crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension: an experimental mechanistic study. Iran J Med Sci 42(3):266\u2013274","journal-title":"Iran J Med Sci"},{"issue":"10","key":"2850_CR23","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1097\/00004872-199310000-00003","volume":"11","author":"S Holmer","year":"1993","unstructured":"Holmer S, Eckardt KU, Aedtner O, LeHir M, Schricker K, Hamann M, G\u00f6tz K, Riegger G, Moll W, Kurtz A (1993) Which factor mediates reno-renal control of renin gene expression? J Hypertens 11(10):1011\u20131019. https:\/\/doi.org\/10.1097\/00004872-199310000-00003","journal-title":"J Hypertens"},{"issue":"7","key":"2850_CR24","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3390\/foods10071571","volume":"10","author":"EW Jeong","year":"2021","unstructured":"Jeong EW, Park SY, Yang YS, Baek YJ, Yun DM, Kim HJ, Go GW, Lee HG (2021) Black soybean and adzuki bean extracts lower blood pressure by modulating the renin-angiotensin system in spontaneously hypertensive rats. Foods 10(7):1571. https:\/\/doi.org\/10.3390\/foods10071571","journal-title":"Foods"},{"issue":"7","key":"2850_CR25","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3109\/10641963.2013.764887","volume":"35","author":"P Kalaivani","year":"2013","unstructured":"Kalaivani P, Saranya RB, Ramakrishnan G, Ranju V, Sathiya S, Gayathri V, Thiyagarajan LK, Venkhatesh JR, Babu CS, Thanikachalam S (2013) Cuminum cyminum, a dietary spice, attenuates hypertension via endothelial nitric oxide synthase and NO pathway in renovascular hypertensive rats. Clin Exp Hypertens 35(7):534\u2013542. https:\/\/doi.org\/10.3109\/10641963.2013.764887","journal-title":"Clin Exp Hypertens"},{"key":"2850_CR26","doi-asserted-by":"publisher","first-page":"6618061","DOI":"10.1155\/2021\/6618061","volume":"2021","author":"F Karimi","year":"2021","unstructured":"Karimi F, Nematbakhsh M (2021) Mas receptor blockade promotes renal vascular response to Ang II after Partial kidney ischemia\/reperfusion in a two-kidney-one-clip hypertensive rats model. Int J Nephrol 2021:6618061. https:\/\/doi.org\/10.1155\/2021\/6618061","journal-title":"Int J Nephrol"},{"issue":"6","key":"2850_CR27","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1093\/cvr\/cvy268","volume":"115","author":"WS Korim","year":"2019","unstructured":"Korim WS, Elsaafien K, Basser JR, Setiadi A, May CN, Yao ST (2019) In renovascular hypertension, TNF-\u03b1 type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure. Cardiovasc Res 115(6):1092\u20131101. https:\/\/doi.org\/10.1093\/cvr\/cvy268","journal-title":"Cardiovasc Res"},{"issue":"21","key":"2850_CR28","doi-asserted-by":"publisher","first-page":"11471","DOI":"10.1021\/jf102538g","volume":"58","author":"H Li","year":"2010","unstructured":"Li H, Aluko RE (2010) Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J Agric Food Chem 58(21):11471\u201311476. https:\/\/doi.org\/10.1021\/jf102538g","journal-title":"J Agric Food Chem"},{"issue":"27","key":"2850_CR29","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.2174\/138161209789058002","volume":"15","author":"H Li","year":"2009","unstructured":"Li H, F\u00f6rstermann U (2009) Prevention of atherosclerosis by interference with the vascular nitric oxide system. Curr Pharm Des 15(27):3133\u20133145. https:\/\/doi.org\/10.2174\/138161209789058002","journal-title":"Curr Pharm Des"},{"issue":"1","key":"2850_CR30","first-page":"31","volume":"17","author":"G Mchedlishvili","year":"1997","unstructured":"Mchedlishvili G, Tsinamdzvrishvili B, Beritashvili N, Gobejishvili L, Ilencko V (1997) New evidence for involvement of blood rheological disorders in rise of peripheral resistance in essential hypertension. Clin Hemorheol Microcirc 17(1):31\u201339","journal-title":"Clin Hemorheol Microcirc"},{"issue":"15","key":"2850_CR31","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.3390\/ijms20153775","volume":"20","author":"CA Meza","year":"2019","unstructured":"Meza CA, La Favor JD, Kim DH, Hickner RC (2019) Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS? Int J Mol Sci 20(15):3775. https:\/\/doi.org\/10.3390\/ijms20153775","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2850_CR32","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1161\/01.atv.15.1.52","volume":"15","author":"F Mohamed","year":"1995","unstructured":"Mohamed F, Monge JC, Gordon A, Cernacek P, Blais D, Stewart DJ (1995) Lack of role for nitric oxide (NO) in the selective destabilization of endothelial NO synthase mRNA by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol 15(1):52\u201357. https:\/\/doi.org\/10.1161\/01.atv.15.1.52","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"2850_CR33","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1440-1681.1995.tb02085.x","volume":"22","author":"R Morishita","year":"1995","unstructured":"Morishita R, Higaki J, Nakamura Y, Aoki M, Yamada K, Moriguchi A, Rakugi H, Tomita N, Tomita S, Yu H et al (1995) Effect of an antihypertensive drug on brain angiotensin II levels in renal and spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 22(9):665\u2013669. https:\/\/doi.org\/10.1111\/j.1440-1681.1995.tb02085.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"3","key":"2850_CR34","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/10641963.2017.1368540","volume":"40","author":"N \u00d6zen","year":"2018","unstructured":"\u00d6zen N, Nas\u0131rc\u0131lar \u00dclker S, \u00dclker P, \u00d6zcan F, Aslan M, \u015eent\u00fcrk \u00dcK, Basral\u0131 F (2018) Effect of 20-HETE inhibition on L-NAME-induced hypertension in rats. Clin Exp Hypertens 40(3):292\u2013302. https:\/\/doi.org\/10.1080\/10641963.2017.1368540","journal-title":"Clin Exp Hypertens"},{"issue":"Suppl 1","key":"2850_CR35","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.33549\/physiolres.933402","volume":"65","author":"J Radosinska","year":"2016","unstructured":"Radosinska J, Vrbjar N (2016) The role of red blood cell deformability and Na, K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia. Physiol Res 65(Suppl 1):S43\u2013S54. https:\/\/doi.org\/10.33549\/physiolres.933402","journal-title":"Physiol Res"},{"issue":"21","key":"2850_CR36","doi-asserted-by":"publisher","first-page":"11924","DOI":"10.3390\/ijms222111924","volume":"22","author":"J Radosinska","year":"2021","unstructured":"Radosinska J, Vrbjar N (2021) Erythrocyte deformability and Na, K-ATPase activity in various pathophysiological situations and their protection by selected nutritional antioxidants in humans. Int J Mol Sci 22(21):11924. https:\/\/doi.org\/10.3390\/ijms222111924. (Published 2021 Nov 3)","journal-title":"Int J Mol Sci"},{"issue":"3\u20134","key":"2850_CR37","first-page":"179","volume":"21","author":"B Sandhagen","year":"1999","unstructured":"Sandhagen B (1999) Red cell fluidity in hypertension. Clin Hemorheol Microcirc 21(3\u20134):179\u2013181","journal-title":"Clin Hemorheol Microcirc"},{"issue":"1","key":"2850_CR38","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.ejmech.2007.12.018","volume":"44","author":"KV Sashidhara","year":"2009","unstructured":"Sashidhara KV, Rosaiah JN, Tyagi E, Shukla R, Raghubir R, Rajendran SM (2009) Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. Eur J Med Chem 44(1):432\u2013436. https:\/\/doi.org\/10.1016\/j.ejmech.2007.12.018","journal-title":"Eur J Med Chem"},{"issue":"5","key":"2850_CR39","doi-asserted-by":"publisher","first-page":"C803","DOI":"10.1152\/ajpcell.00457.2005","volume":"291","author":"CD Searles","year":"2006","unstructured":"Searles CD (2006) Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression. Am J Physiol Cell Physiol 291(5):C803\u2013C816. https:\/\/doi.org\/10.1152\/ajpcell.00457.2005","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"2850_CR40","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1161\/01.hyp.31.2.649","volume":"31","author":"DH Sigmon","year":"1998","unstructured":"Sigmon DH, Beierwaltes WH (1998) Influence of nitric oxide in the chronic phase of two-kidney, one clip renovascular hypertension. Hypertension 31(2):649\u2013656. https:\/\/doi.org\/10.1161\/01.hyp.31.2.649","journal-title":"Hypertension"},{"issue":"2\u20133","key":"2850_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3233\/BIR-140653","volume":"51","author":"MJ Simmonds","year":"2014","unstructured":"Simmonds MJ, Detterich JA, Connes P (2014) Nitric oxide, vasodilation and the red blood cell. Biorheology 51(2\u20133):121\u2013134. https:\/\/doi.org\/10.3233\/BIR-140653","journal-title":"Biorheology"},{"issue":"5","key":"2850_CR42","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/j.1747-0285.2012.01331.x","volume":"79","author":"R Suhas","year":"2012","unstructured":"Suhas R, Channe GD (2012) Structure-based rationale design and synthesis of aurantiamide acetate analogues - towards a new class of potent analgesic and anti-inflammatory agents. Chem Biol Drug Des 79(5):850\u2013862. https:\/\/doi.org\/10.1111\/j.1747-0285.2012.01331.x","journal-title":"Chem Biol Drug Des"},{"issue":"1","key":"2850_CR43","doi-asserted-by":"publisher","first-page":"012011","DOI":"10.1088\/1755-1315\/755\/1\/012011","volume":"755","author":"AB Sutjiatmo","year":"2021","unstructured":"Sutjiatmo AB, Vikasari SN, Bintussolihah F (2021) antihypertensive effects of purslane (Portulaca oleracea) extract in animal model of hypertension. IOP Conf Ser Earth Environ Sci 755(1):012011. https:\/\/doi.org\/10.1088\/1755-1315\/755\/1\/012011","journal-title":"IOP Conf Ser Earth Environ Sci"},{"issue":"1","key":"2850_CR44","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/157016112798829760","volume":"10","author":"D Tousoulis","year":"2012","unstructured":"Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C (2012) The role of nitric oxide on endothelial function. Curr Vasc Pharmacol 10(1):4\u201318. https:\/\/doi.org\/10.2174\/157016112798829760","journal-title":"Curr Vasc Pharmacol"},{"issue":"4","key":"2850_CR45","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s00726-011-0833-2","volume":"42","author":"CC Udenigwe","year":"2012","unstructured":"Udenigwe CC, Li H, Aluko RE (2012) Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides. Amino Acids 42(4):1379\u20131386. https:\/\/doi.org\/10.1007\/s00726-011-0833-2","journal-title":"Amino Acids"},{"issue":"3\u20134","key":"2850_CR46","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3233\/BIR-16096","volume":"53","author":"P Ulker","year":"2016","unstructured":"Ulker P (2016) The effect of acute and short term normobaric hyperoxia on hemorheologic parameters. Biorheology 53(3\u20134):171\u2013177. https:\/\/doi.org\/10.3233\/BIR-16096","journal-title":"Biorheology"},{"issue":"4","key":"2850_CR47","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/cbdd.13809","volume":"97","author":"H Wang","year":"2021","unstructured":"Wang H, Gao S, Li J, Ma X, Liu W, Qian S (2021) Hybrids of aurantiamide acetate and isopropylated genipin as potential anti-inflammatory agents: the design, synthesis, and biological evaluation. Chem Biol Drug Des 97(4):797\u2013808. https:\/\/doi.org\/10.1111\/cbdd.13809","journal-title":"Chem Biol Drug Des"},{"issue":"4","key":"2850_CR48","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1161\/STROKEAHA.121.035852","volume":"53","author":"X Wang","year":"2022","unstructured":"Wang X, Carcel C, Woodward M, Schutte AE (2022) Blood pressure and stroke: a review of sex- and ethnic\/racial-specific attributes to the epidemiology, pathophysiology, and management of raised blood pressure. Stroke 53(4):1114\u20131133. https:\/\/doi.org\/10.1161\/STROKEAHA.121.035852","journal-title":"Stroke"},{"issue":"4","key":"2850_CR49","doi-asserted-by":"publisher","first-page":"34","DOI":"10.5494\/wjh.v2.i4.34","volume":"2","author":"H Wen","year":"2012","unstructured":"Wen H, Gwathmey JK, Xie LH (2012) Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens 2(4):34\u201344. https:\/\/doi.org\/10.5494\/wjh.v2.i4.34","journal-title":"World J Hypertens"},{"issue":"24","key":"2850_CR50","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.1113\/JP272927","volume":"594","author":"C Wilson","year":"2016","unstructured":"Wilson C, Lee MD, McCarron JG (2016) Acetylcholine released by endothelial cells facilitates flow-mediated dilatation. J Physiol 594(24):7267\u20137307. https:\/\/doi.org\/10.1113\/JP272927","journal-title":"J Physiol"},{"issue":"2","key":"2850_CR51","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1124\/jpet.107.128009","volume":"325","author":"P Wohlfart","year":"2008","unstructured":"Wohlfart P, Xu H, Endlich A, Habermeier A, Closs EI, H\u00fcbschle T, Mang C, Strobel H, Suzuki T, Kleinert H, F\u00f6rstermann U, Ruetten H, Li H (2008) Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling. J Pharmacol Exp Ther 325(2):370\u2013379. https:\/\/doi.org\/10.1124\/jpet.107.128009","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"2850_CR52","doi-asserted-by":"crossref","first-page":"358","DOI":"10.7883\/yoken.JJID.2005.358","volume":"58","author":"M Yapar","year":"2005","unstructured":"Yapar M, Aydogan H, Pahsa A, Besirbellioglu BA, Bodur H, Basustaoglu AC, Guney C, Avci IY, Sener K, Setteh MH, Kubar A (2005) Rapid and quantitative detection of Crimean-Congo hemorrhagic fever virus by one-step real-time reverse transcriptase-PCR. Jpn J Infect Dis 58(6):358\u2013362","journal-title":"Jpn J Infect Dis"},{"issue":"2","key":"2850_CR53","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.intimp.2014.10.006","volume":"23","author":"CS Yoon","year":"2014","unstructured":"Yoon CS, Kim DC, Lee DS, Kim KS, Ko W, Sohn JH, Yim JH, Kim YC, Oh H (2014) Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-\u03baB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells. Int Immunopharmacol. 23(2):568\u201374. https:\/\/doi.org\/10.1016\/j.intimp.2014.10.006","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"2850_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1161\/01.res.73.1.205","volume":"73","author":"M Yoshizumi","year":"1993","unstructured":"Yoshizumi M, Perrella MA, Burnett JC Jr, Lee ME (1993) Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 73(1):205\u2013209. https:\/\/doi.org\/10.1161\/01.res.73.1.205","journal-title":"Circ Res"},{"issue":"9","key":"2850_CR55","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.visres.2004.11.018","volume":"45","author":"I Y\u00fccel","year":"2005","unstructured":"Y\u00fccel I, Akar Y, Y\u00fccel G, Cift\u00e7io\u011flu MA, Kele\u015f N, Aslan M (2005) Effect of hypercholesterolemia on inducible nitric oxide synthase expression in a rat model of elevated intraocular pressure. Vision Res 45(9):1107\u20131114. https:\/\/doi.org\/10.1016\/j.visres.2004.11.018","journal-title":"Vision Res"},{"issue":"2","key":"2850_CR56","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pharmthera.2010.09.004","volume":"129","author":"K Yuhki","year":"2011","unstructured":"Yuhki K, Kojima F, Kashiwagi H, Kawabe J, Fujino T, Narumiya S, Ushikubi F (2011) Roles of prostanoids in the pathogenesis of cardiovascular diseases: novel insights from knockout mouse studies. Pharmacol Ther 129(2):195\u2013205. https:\/\/doi.org\/10.1016\/j.pharmthera.2010.09.004","journal-title":"Pharmacol Ther"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02850-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-023-02850-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02850-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T05:48:09Z","timestamp":1729921689000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-023-02850-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,15]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["2850"],"URL":"https:\/\/doi.org\/10.1007\/s00424-023-02850-8","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,15]]},"assertion":[{"value":"15 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols carried out on rats were executed in agreement with the principles set up by the Institutional Animal Care and Use Committee at Akdeniz University (Decision No:153-Date: 11.11.2019).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors report no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}