{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:47Z","timestamp":1786980167843,"version":"build-2736575974"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s00424-023-02897-7","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T21:03:56Z","timestamp":1702933436000},"page":"533-543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pendrin: linking acid base to blood pressure"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-4389","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Brazier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-5638","authenticated-orcid":false,"given":"Nicolas","family":"Corni\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1695-3389","authenticated-orcid":false,"given":"Nicolas","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4704-8098","authenticated-orcid":false,"given":"R\u00e9gine","family":"Chambrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1067-0844","authenticated-orcid":false,"given":"Dominique","family":"Eladari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"2897_CR1","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.1073\/pnas.86.14.5429","volume":"86","author":"SL Alper","year":"1989","unstructured":"Alper SL, Natale J, Gluck S, Lodish HF, Brown D (1989) Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A 86:5429\u20135433. https:\/\/doi.org\/10.1073\/pnas.86.14.5429","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR2","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1681\/ASN.0000000000000173","volume":"34","author":"P Berg","year":"2023","unstructured":"Berg P, Jensen T, Andersen JF, Svendsen SL, Modvig IM, Wang T, Frische S, Chow BKC, Malte H, Holst JJ, Sorensen MV, Leipziger J (2023) Loss of the secretin receptor impairs renal bicarbonate excretion and aggravates metabolic alkalosis in mice during acute base-loading. J Am Soc Nephrol 34:1329\u20131342. https:\/\/doi.org\/10.1681\/ASN.0000000000000173","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR3","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.7326\/M22-1741","volume":"175","author":"P Berg","year":"2022","unstructured":"Berg P, Sorensen MV, Rousing AQ, Vebert Olesen H, Jensen-Fangel S, Jeppesen M, Leipziger J (2022) Challenged urine bicarbonate excretion as a measure of cystic fibrosis transmembrane conductance regulator function in cystic fibrosis. Ann Intern Med 175:1543\u20131551. https:\/\/doi.org\/10.7326\/M22-1741","journal-title":"Ann Intern Med"},{"key":"2897_CR4","doi-asserted-by":"publisher","first-page":"e13591","DOI":"10.1111\/apha.13591","volume":"231","author":"P Berg","year":"2021","unstructured":"Berg P, Svendsen SL, Hoang TTL, Praetorius HA, Sorensen MV, Leipziger J (2021) Impaired renal HCO(3)(-) secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading. Acta Physiol (Oxford) 231:e13591. https:\/\/doi.org\/10.1111\/apha.13591","journal-title":"Acta Physiol (Oxford)"},{"key":"2897_CR5","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1681\/ASN.2020010053","volume":"31","author":"P Berg","year":"2020","unstructured":"Berg P, Svendsen SL, Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J (2020) Impaired renal HCO(3)(-) excretion in cystic fibrosis. J Am Soc Nephrol 31:1711\u20131727. https:\/\/doi.org\/10.1681\/ASN.2020010053","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR6","first-page":"395","volume":"56","author":"RS Berghoff","year":"1929","unstructured":"Berghoff RS, Geraci AS (1929) The influence of sodium chloride on blood pressure. IMJ 56:395\u2013397","journal-title":"IMJ"},{"key":"2897_CR7","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1126\/science.127.3290.146","volume":"127","author":"KH Beyer Jr","year":"1958","unstructured":"Beyer KH Jr, Baer JE, Russo HF, Noll R (1958) Electrolyte excretion as influenced by chlorothiazide. Science 127:146\u2013147. https:\/\/doi.org\/10.1126\/science.127.3290.146","journal-title":"Science"},{"key":"2897_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/MNH.0000000000000669","volume":"30","author":"S Bourgeois","year":"2021","unstructured":"Bourgeois S, Wagner CA (2021) Regulation of renal pendrin activity by aldosterone. Curr Opin Nephrol Hypertens 30:131\u2013137. https:\/\/doi.org\/10.1097\/MNH.0000000000000669","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2897_CR9","doi-asserted-by":"publisher","first-page":"25290","DOI":"10.1074\/jbc.M803931200","volume":"283","author":"MD Carattino","year":"2008","unstructured":"Carattino MD, Hughey RP, Kleyman TR (2008) Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. J Biol Chem 283:25290\u201325295. M803931200 [pii]. https:\/\/doi.org\/10.1074\/jbc.M803931200","journal-title":"J Biol Chem"},{"key":"2897_CR10","doi-asserted-by":"publisher","unstructured":"Carrisoza-Gaytan R, Ray EC, Flores D, Marciszyn AL, Wu P, Liu L, Subramanya AR, Wang W, Sheng S, Nkashama LJ, Chen J, Jackson EK, Mutchler SM, Heja S, Kohan DE, Satlin LM, Kleyman TR (2020) Intercalated cell BKalpha subunit is required for flow-induced K+ secretion. JCI Insight 5. https:\/\/doi.org\/10.1172\/jci.insight.130553","DOI":"10.1172\/jci.insight.130553"},{"key":"2897_CR11","doi-asserted-by":"publisher","first-page":"7928","DOI":"10.1073\/pnas.1221496110","volume":"110","author":"R Chambrey","year":"2013","unstructured":"Chambrey R, Kurth I, Peti-Peterdi J, Houillier P, Purkerson JM, Leviel F, Hentschke M, Zdebik AA, Schwartz GJ, Hubner CA, Eladari D (2013) Renal intercalated cells are rather energized by a proton than a sodium pump. Proc Natl Acad Sci U S A 110:7928\u20137933. https:\/\/doi.org\/10.1073\/pnas.1221496110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR12","doi-asserted-by":"publisher","first-page":"E9989","DOI":"10.1073\/pnas.1710964114","volume":"114","author":"L Chen","year":"2017","unstructured":"Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Paunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA (2017) Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq. Proc Natl Acad Sci U S A 114:E9989\u2013E9998. https:\/\/doi.org\/10.1073\/pnas.1710964114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR13","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1681\/ASN.2015121312","volume":"27","author":"O Cil","year":"2016","unstructured":"Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS (2016) Small-molecule inhibitors of pendrin potentiate the diuretic action of furosemide. J Am Soc Nephrol 27:3706\u20133714. https:\/\/doi.org\/10.1681\/ASN.2015121312","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR14","doi-asserted-by":"publisher","first-page":"F1256","DOI":"10.1152\/ajprenal.00220.2006","volume":"292","author":"S de Seigneux","year":"2007","unstructured":"de Seigneux S, Malte H, Dimke H, Frokiaer J, Nielsen S, Frische S (2007) Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule. Am J Physiol Renal Physiol 292:F1256\u2013F1266. https:\/\/doi.org\/10.1152\/ajprenal.00220.2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR15","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.cmet.2011.03.022","volume":"13","author":"IE Deyev","year":"2011","unstructured":"Deyev IE, Sohet F, Vassilenko KP, Serova OV, Popova NV, Zozulya SA, Burova EB, Houillier P, Rzhevsky DI, Berchatova AA, Murashev AN, Chugunov AO, Efremov RG, Nikol'sky NN, Bertelli E, Eladari D, Petrenko AG (2011) Insulin receptor-related receptor as an extracellular alkali sensor. Cell Metab 13:679\u2013689. https:\/\/doi.org\/10.1016\/j.cmet.2011.03.022","journal-title":"Cell Metab"},{"key":"2897_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1146\/annurev-physiol-020911-153225","volume":"74","author":"D Eladari","year":"2012","unstructured":"Eladari D, Chambrey R, Peti-Peterdi J (2012) A new look at electrolyte transport in the distal tubule. Annu Rev Physiol 74:325\u2013349. https:\/\/doi.org\/10.1146\/annurev-physiol-020911-153225","journal-title":"Annu Rev Physiol"},{"key":"2897_CR17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1161\/HYPERTENSIONAHA.109.129171","volume":"54","author":"DH Ellison","year":"2009","unstructured":"Ellison DH, Loffing J (2009) Thiazide effects and adverse effects: insights from molecular genetics. Hypertension 54:196\u2013202. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.109.129171","journal-title":"Hypertension"},{"key":"2897_CR18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ng1297-411","volume":"17","author":"LA Everett","year":"1997","unstructured":"Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, Green ED (1997) Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 17:411\u2013422. https:\/\/doi.org\/10.1038\/ng1297-411","journal-title":"Nat Genet"},{"key":"2897_CR19","doi-asserted-by":"publisher","first-page":"F584","DOI":"10.1152\/ajprenal.00254.2002","volume":"284","author":"S Frische","year":"2003","unstructured":"Frische S, Kwon TH, Frokiaer J, Madsen KM, Nielsen S (2003) Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Am J Physiol Renal Physiol 284:F584\u2013F593. https:\/\/doi.org\/10.1152\/ajprenal.00254.2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR20","doi-asserted-by":"publisher","first-page":"17713","DOI":"10.1016\/S0021-9258(17)32499-7","volume":"269","author":"G Gamba","year":"1994","unstructured":"Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC (1994) Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269:17713\u201317722","journal-title":"J Biol Chem"},{"key":"2897_CR21","doi-asserted-by":"publisher","first-page":"F205","DOI":"10.1152\/ajprenal.1985.249.2.F205","volume":"249","author":"J Garcia-Austt","year":"1985","unstructured":"Garcia-Austt J, Good DW, Burg MB, Knepper MA (1985) Deoxycorticosterone-stimulated bicarbonate secretion in rabbit cortical collecting ducts: effects of luminal chloride removal and in vivo acid loading. Am J Phys 249:F205\u2013F212. https:\/\/doi.org\/10.1152\/ajprenal.1985.249.2.F205","journal-title":"Am J Phys"},{"key":"2897_CR22","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1073\/pnas.1421441112","volume":"112","author":"Y Gong","year":"2015","unstructured":"Gong Y, Wang J, Yang J, Gonzales E, Perez R, Hou J (2015) KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A 112:4340\u20134345. https:\/\/doi.org\/10.1073\/pnas.1421441112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR23","doi-asserted-by":"publisher","first-page":"E3766","DOI":"10.1073\/pnas.1406741111","volume":"111","author":"Y Gong","year":"2014","unstructured":"Gong Y, Yu M, Yang J, Gonzales E, Perez R, Hou M, Tripathi P, Hering-Smith KS, Hamm LL, Hou J (2014) The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation. Proc Natl Acad Sci U S A 111:E3766\u2013E3774. https:\/\/doi.org\/10.1073\/pnas.1406741111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev.ph.50.030188.000551","volume":"50","author":"R Greger","year":"1988","unstructured":"Greger R (1988) Chloride transport in thick ascending limb, distal convolution, and collecting duct. Annu Rev Physiol 50:111\u2013122. https:\/\/doi.org\/10.1146\/annurev.ph.50.030188.000551","journal-title":"Annu Rev Physiol"},{"key":"2897_CR25","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1172\/JCI78558","volume":"125","author":"PR Grimm","year":"2015","unstructured":"Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA (2015) Integrated compensatory network is activated in the absence of NCC phosphorylation. J Clin Invest 125:2136\u20132150. https:\/\/doi.org\/10.1172\/JCI78558","journal-title":"J Clin Invest"},{"key":"2897_CR26","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1172\/JCI63492","volume":"123","author":"V Gueutin","year":"2013","unstructured":"Gueutin V, Vallet M, Jayat M, Peti-Peterdi J, Corniere N, Leviel F, Sohet F, Wagner CA, Eladari D, Chambrey R (2013) Renal beta-intercalated cells maintain body fluid and electrolyte balance. J Clin Invest 123:4219\u20134231. https:\/\/doi.org\/10.1172\/JCI63492","journal-title":"J Clin Invest"},{"key":"2897_CR27","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1096\/fj.201600223R","volume":"30","author":"PM Haggie","year":"2016","unstructured":"Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS (2016) Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J 30:2187\u20132197. https:\/\/doi.org\/10.1096\/fj.201600223R","journal-title":"FASEB J"},{"key":"2897_CR28","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/emmm.201201527","volume":"4","author":"JC Hennings","year":"2012","unstructured":"Hennings JC, Picard N, Huebner AK, Stauber T, Maier H, Brown D, Jentsch TJ, Vargas-Poussou R, Eladari D, Hubner CA (2012) A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule. EMBO Mol Med 4:1057\u20131071. https:\/\/doi.org\/10.1002\/emmm.201201527","journal-title":"EMBO Mol Med"},{"key":"2897_CR29","doi-asserted-by":"publisher","first-page":"36117","DOI":"10.1074\/jbc.M608853200","volume":"281","author":"J Hou","year":"2006","unstructured":"Hou J, Gomes AS, Paul DL, Goodenough DA (2006) Study of claudin function by RNA interference. J Biol Chem 281:36117\u201336123. M608853200 [pii]. https:\/\/doi.org\/10.1074\/jbc.M608853200","journal-title":"J Biol Chem"},{"key":"2897_CR30","doi-asserted-by":"publisher","first-page":"18010","DOI":"10.1073\/pnas.1009399107","volume":"107","author":"J Hou","year":"2010","unstructured":"Hou J, Renigunta A, Yang J, Waldegger S (2010) Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A 107:18010\u201318015. 1009399107 [pii]. https:\/\/doi.org\/10.1073\/pnas.1009399107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR31","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1681\/ASN.2012080787","volume":"24","author":"T Jacques","year":"2013","unstructured":"Jacques T, Picard N, Miller RL, Riemondy KA, Houillier P, Sohet F, Ramakrishnan SK, Busst CJ, Jayat M, Corniere N, Hassan H, Aronson PS, Hennings JC, Hubner CA, Nelson RD, Chambrey R, Eladari D (2013) Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension. J Am Soc Nephrol 24:1104\u20131113. ASN.2012080787 [pii]. https:\/\/doi.org\/10.1681\/ASN.2012080787","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR32","doi-asserted-by":"publisher","first-page":"14877","DOI":"10.1073\/pnas.0406172101","volume":"101","author":"KT Kahle","year":"2004","unstructured":"Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP (2004) Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci U S A 101:14877\u201314882","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR33","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1530\/EJE-11-0101","volume":"165","author":"N Kandasamy","year":"2011","unstructured":"Kandasamy N, Fugazzola L, Evans M, Chatterjee K, Karet F (2011) Life-threatening metabolic alkalosis in Pendred syndrome. Eur J Endocrinol 165:167\u2013170. https:\/\/doi.org\/10.1530\/EJE-11-0101","journal-title":"Eur J Endocrinol"},{"key":"2897_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/cge.12789","volume":"91","author":"BG Kim","year":"2017","unstructured":"Kim BG, Yoo TH, Yoo JE, Seo YJ, Jung J, Choi JY (2017) Resistance to hypertension and high Cl(-) excretion in humans with SLC26A4 mutations. Clin Genet 91:448\u2013452. https:\/\/doi.org\/10.1111\/cge.12789","journal-title":"Clin Genet"},{"key":"2897_CR35","doi-asserted-by":"publisher","first-page":"F744","DOI":"10.1152\/ajprenal.00037.2002","volume":"283","author":"YH Kim","year":"2002","unstructured":"Kim YH, Kwon TH, Frische S, Kim J, Tisher CC, Madsen KM, Nielsen S (2002) Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol 283:F744\u2013F754. https:\/\/doi.org\/10.1152\/ajprenal.00037.2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR36","doi-asserted-by":"publisher","first-page":"F1314","DOI":"10.1152\/ajprenal.00155.2007","volume":"293","author":"YH Kim","year":"2007","unstructured":"Kim YH, Pech V, Spencer KB, Beierwaltes WH, Everett LA, Green ED, Shin W, Verlander JW, Sutliff RL, Wall SM (2007) Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice. Am J Physiol Renal Physiol 293:F1314\u2013F1324. https:\/\/doi.org\/10.1152\/ajprenal.00155.2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR37","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1681\/ASN.V134875","volume":"13","author":"Y Kiuchi-Saishin","year":"2002","unstructured":"Kiuchi-Saishin Y, Gotoh S, Furuse M, Takasuga A, Tano Y, Tsukita S (2002) Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J Am Soc Nephrol 13:875\u2013886. https:\/\/doi.org\/10.1681\/ASN.V134875","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR38","doi-asserted-by":"publisher","first-page":"F870","DOI":"10.1152\/ajprenal.1985.249.6.F870","volume":"249","author":"MA Knepper","year":"1985","unstructured":"Knepper MA, Good DW, Burg MB (1985) Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro. Am J Phys 249:F870\u2013F877. https:\/\/doi.org\/10.1152\/ajprenal.1985.249.6.F870","journal-title":"Am J Phys"},{"key":"2897_CR39","doi-asserted-by":"publisher","first-page":"5662","DOI":"10.1093\/emboj\/cdf580","volume":"21","author":"SB Ko","year":"2002","unstructured":"Ko SB, Shcheynikov N, Choi JY, Luo X, Ishibashi K, Thomas PJ, Kim JY, Kim KH, Lee MG, Naruse S, Muallem S (2002) A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J 21:5662\u20135672. https:\/\/doi.org\/10.1093\/emboj\/cdf580","journal-title":"EMBO J"},{"key":"2897_CR40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/ncb1115","volume":"6","author":"SB Ko","year":"2004","unstructured":"Ko SB, Zeng W, Dorwart MR, Luo X, Kim KH, Millen L, Goto H, Naruse S, Soyombo A, Thomas PJ, Muallem S (2004) Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 6:343\u2013350. https:\/\/doi.org\/10.1038\/ncb1115","journal-title":"Nat Cell Biol"},{"key":"2897_CR41","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1056\/NEJM198710223171702","volume":"317","author":"TW Kurtz","year":"1987","unstructured":"Kurtz TW, Al-Bander HA, Morris RC Jr (1987) \u201cSalt-sensitive\u201d essential hypertension in men. Is the sodium ion alone important? N Engl J Med 317:1043\u20131048","journal-title":"N Engl J Med"},{"key":"2897_CR42","doi-asserted-by":"crossref","first-page":"S371","DOI":"10.1097\/00004872-198402040-00008","volume":"2","author":"TW Kurtz","year":"1984","unstructured":"Kurtz TW, Morris RC Jr (1984) Dietary chloride and bicarbonate as determinants of desoxycorticosterone hypertension. J Hypertens Suppl 2:S371\u2013S373","journal-title":"J Hypertens Suppl"},{"key":"2897_CR43","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.kint.2019.12.022","volume":"97","author":"S Lemoine","year":"2020","unstructured":"Lemoine S, Eladari D, Juillard L, Bonnefond A, Froguel P, Dubourg L (2020) The Case | Hypokalemia and severe renal loss of sodium. Kidney Int 97:1305\u20131306. https:\/\/doi.org\/10.1016\/j.kint.2019.12.022","journal-title":"Kidney Int"},{"key":"2897_CR44","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI40145","volume":"120","author":"F Leviel","year":"2010","unstructured":"Leviel F, Hubner CA, Houillier P, Morla L, El Moghrabi S, Brideau G, Hassan H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM et al (2010) The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest 120:1627\u20131635. 40145 [pii]. https:\/\/doi.org\/10.1172\/JCI40145","journal-title":"J Clin Invest"},{"key":"2897_CR45","doi-asserted-by":"publisher","first-page":"C507","DOI":"10.1152\/ajpcell.00197.2021","volume":"321","author":"S Lewis","year":"2021","unstructured":"Lewis S, Chen L, Raghuram V, Khundmiri SJ, Chou CL, Yang CR, Knepper MA (2021) \u201cSLC-omics\u201d of the kidney: solute transporters along the nephron. Am J Physiol Cell Physiol 321:C507\u2013C518. https:\/\/doi.org\/10.1152\/ajpcell.00197.2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"2897_CR46","doi-asserted-by":"publisher","first-page":"F628","DOI":"10.1152\/ajprenal.00217.2002","volume":"284","author":"J Loffing","year":"2003","unstructured":"Loffing J, Kaissling B (2003) Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol 284:F628\u2013F643. https:\/\/doi.org\/10.1152\/ajprenal.00217.2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR47","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.kint.2018.05.001","volume":"94","author":"KI Lopez-Cayuqueo","year":"2018","unstructured":"Lopez-Cayuqueo KI, Chavez-Canales M, Pillot A, Houillier P, Jayat M, Baraka-Vidot J, Trepiccione F, Baudrie V, Busst C, Soukaseum C, Kumai Y, Jeunemaitre X, Hadchouel J, Eladari D, Chambrey R (2018) A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis. Kidney Int 94:514\u2013523. https:\/\/doi.org\/10.1016\/j.kint.2018.05.001","journal-title":"Kidney Int"},{"key":"2897_CR48","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1097\/00004872-199007000-00010","volume":"8","author":"FC Luft","year":"1990","unstructured":"Luft FC, Zemel MB, Sowers JA, Fineberg NS, Weinberger MH (1990) Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man. J Hypertens 8:663\u2013670","journal-title":"J Hypertens"},{"key":"2897_CR49","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/jmg.2008.063610","volume":"46","author":"AC Madeo","year":"2009","unstructured":"Madeo AC, Manichaikul A, Pryor SP, Griffith AJ (2009) Do mutations of the Pendred syndrome gene, SLC26A4, confer resistance to asthma and hypertension? J Med Genet 46:405\u2013406. https:\/\/doi.org\/10.1136\/jmg.2008.063610","journal-title":"J Med Genet"},{"key":"2897_CR50","doi-asserted-by":"publisher","first-page":"F251","DOI":"10.1152\/ajprenal.00471.2013","volume":"309","author":"M Nanami","year":"2015","unstructured":"Nanami M, Lazo-Fernandez Y, Pech V, Verlander JW, Agazatian D, Weinstein AM, Bao HF, Eaton DC, Wall SM (2015) ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion. Am J Physiol Renal Physiol 309:F251\u2013F258. https:\/\/doi.org\/10.1152\/ajprenal.00471.2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR51","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2215\/CJN.12391213","volume":"10","author":"LG Palmer","year":"2015","unstructured":"Palmer LG, Schnermann J (2015) Integrated control of Na transport along the nephron. Clin J Am Soc Nephrol 10:676\u2013687. https:\/\/doi.org\/10.2215\/CJN.12391213","journal-title":"Clin J Am Soc Nephrol"},{"key":"2897_CR52","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00424-017-2049-0","volume":"470","author":"G Pathare","year":"2018","unstructured":"Pathare G, Dhayat N, Mohebbi N, Wagner CA, Cheval L, Neuhaus TJ, Fuster DG (2018) Acute regulated expression of pendrin in human urinary exosomes. Pflugers Arch 470:427\u2013438. https:\/\/doi.org\/10.1007\/s00424-017-2049-0","journal-title":"Pflugers Arch"},{"key":"2897_CR53","doi-asserted-by":"publisher","first-page":"F914","DOI":"10.1152\/ajprenal.00361.2006","volume":"292","author":"V Pech","year":"2007","unstructured":"Pech V, Kim YH, Weinstein AM, Everett LA, Pham TD, Wall SM (2007) Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism. Am J Physiol Renal Physiol 292:F914\u2013F920. https:\/\/doi.org\/10.1152\/ajprenal.00361.2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR54","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1681\/ASN.2009121257","volume":"21","author":"V Pech","year":"2010","unstructured":"Pech V, Pham TD, Hong S, Weinstein AM, Spencer KB, Duke BJ, Walp E, Kim YH, Sutliff RL, Bao HF, Eaton DC, Wall SM (2010) Pendrin modulates ENaC function by changing luminal HCO3. J Am Soc Nephrol 21:1928\u20131941. https:\/\/doi.org\/10.1681\/ASN.2009121257","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR55","doi-asserted-by":"publisher","first-page":"F45","DOI":"10.1152\/ajprenal.00030.2012","volume":"303","author":"V Pech","year":"2012","unstructured":"Pech V, Thumova M, Kim YH, Agazatian D, Hummler E, Rossier BC, Weinstein AM, Nanami M, Wall SM (2012) ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism. Am J Physiol Renal Physiol 303:F45\u2013F55. ajprenal.00030.2012 [pii]. https:\/\/doi.org\/10.1152\/ajprenal.00030.2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR56","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1172\/JCI83942","volume":"126","author":"L Pei","year":"2016","unstructured":"Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS (2016) Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest 126:2509\u20132518. https:\/\/doi.org\/10.1172\/JCI83942","journal-title":"J Clin Invest"},{"key":"2897_CR57","doi-asserted-by":"publisher","first-page":"450","DOI":"10.5414\/cnp69450","volume":"69","author":"I Pela","year":"2008","unstructured":"Pela I, Bigozzi M, Bianchi B (2008) Profound hypokalemia and hypochloremic metabolic alkalosis during thiazide therapy in a child with Pendred syndrome. Clin Nephrol 69:450\u2013453. https:\/\/doi.org\/10.5414\/cnp69450","journal-title":"Clin Nephrol"},{"key":"2897_CR58","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/S0140-6736(01)74403-0","volume":"148","author":"V Pendred","year":"1896","unstructured":"Pendred V (1896) Deaf-Mutism and goitre. Lancet 148:532","journal-title":"Lancet"},{"key":"2897_CR59","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1016\/j.bbapap.2012.11.011","volume":"1834","author":"AG Petrenko","year":"2013","unstructured":"Petrenko AG, Zozulya SA, Deyev IE, Eladari D (2013) Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. Biochim Biophys Acta 1834:2170\u20132175. https:\/\/doi.org\/10.1016\/j.bbapap.2012.11.011","journal-title":"Biochim Biophys Acta"},{"key":"2897_CR60","doi-asserted-by":"publisher","first-page":"F103","DOI":"10.1152\/ajprenal.00205.2002","volume":"284","author":"S Petrovic","year":"2003","unstructured":"Petrovic S, Wang Z, Ma L, Soleimani M (2003) Regulation of the apical Cl-\/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis. Am J Physiol Renal Physiol 284:F103\u2013F112. https:\/\/doi.org\/10.1152\/ajprenal.00205.2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR61","doi-asserted-by":"publisher","first-page":"F486","DOI":"10.1152\/ajprenal.00378.2021","volume":"322","author":"TD Pham","year":"2022","unstructured":"Pham TD, Elengickal AJ, Verlander JW, Al-Qusairi L, Chen C, Abood DC, King SA, Loffing J, Welling PA, Wall SM (2022) Pendrin-null mice develop severe hypokalemia following dietary Na(+) and K(+) restriction: role of ENaC. Am J Physiol Renal Physiol 322:F486\u2013F497. https:\/\/doi.org\/10.1152\/ajprenal.00378.2021","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR62","doi-asserted-by":"publisher","first-page":"F1179","DOI":"10.1152\/ajprenal.00211.2004","volume":"287","author":"F Quentin","year":"2004","unstructured":"Quentin F, Chambrey R, Trinh-Trang-Tan MM, Fysekidis M, Cambillau M, Paillard M, Aronson PS, Eladari D (2004) The Cl-\/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol Renal Physiol 287:F1179\u2013F1188. https:\/\/doi.org\/10.1152\/ajprenal.00211.2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR63","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.coph.2013.11.010","volume":"15","author":"BC Rossier","year":"2014","unstructured":"Rossier BC (2014) Epithelial sodium channel (ENaC) and the control of blood pressure. Curr Opin Pharmacol 15:33\u201346. https:\/\/doi.org\/10.1016\/j.coph.2013.11.010","journal-title":"Curr Opin Pharmacol"},{"key":"2897_CR64","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1073\/pnas.071516798","volume":"98","author":"IE Royaux","year":"2001","unstructured":"Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED (2001) Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A 98:4221\u20134226. https:\/\/doi.org\/10.1073\/pnas.071516798","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR65","first-page":"F291","volume":"247","author":"SC Sansom","year":"1984","unstructured":"Sansom SC, Weinman EJ, O'Neil RG (1984) Microelectrode assessment of chloride-conductive properties of cortical collecting duct. Am J Phys 247:F291\u2013F302","journal-title":"Am J Phys"},{"key":"2897_CR66","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/ki.1981.72","volume":"19","author":"M Schambelan","year":"1981","unstructured":"Schambelan M, Sebastian A, Rector FC Jr (1981) Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int 19:716\u2013727","journal-title":"Kidney Int"},{"key":"2897_CR67","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/BF00370998","volume":"417","author":"E Schlatter","year":"1990","unstructured":"Schlatter E, Greger R, Schafer JA (1990) Principal cells of cortical collecting ducts of the rat are not a route of transepithelial Cl- transport. Pflugers Arch 417:317\u2013323. https:\/\/doi.org\/10.1007\/BF00370998","journal-title":"Pflugers Arch"},{"key":"2897_CR68","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1161\/01.HYP.0000164628.46415.66","volume":"45","author":"O Schmidlin","year":"2005","unstructured":"Schmidlin O, Tanaka M, Bollen AW, Yi SL, Morris RC Jr (2005) Chloride-dominant salt sensitivity in the stroke-prone spontaneously hypertensive rat. Hypertension 45:867\u2013873","journal-title":"Hypertension"},{"key":"2897_CR69","first-page":"131","volume":"14","author":"U Schorr","year":"1996","unstructured":"Schorr U, Distler A, Sharma AM (1996) Effect of sodium chloride- and sodium bicarbonate-rich mineral water on blood pressure and metabolic parameters in elderly normotensive individuals: a randomized double-blind crossover trial. J Hypertens 14:131\u2013135","journal-title":"J Hypertens"},{"key":"2897_CR70","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/7783","volume":"21","author":"DA Scott","year":"1999","unstructured":"Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP (1999) The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet 21:440\u2013443. https:\/\/doi.org\/10.1038\/7783","journal-title":"Nat Genet"},{"key":"2897_CR71","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1172\/JCI108490","volume":"58","author":"A Sebastian","year":"1976","unstructured":"Sebastian A, McSherry E, Morris RC Jr (1976) Impaired renal conservation of sodium and chloride during sustained correction of systemic acidosis in patients with type 1, classic renal tubular acidosis. J Clin Invest 58:454\u2013469. https:\/\/doi.org\/10.1172\/JCI108490","journal-title":"J Clin Invest"},{"key":"2897_CR72","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1681\/ASN.2015070734","volume":"28","author":"A Sinning","year":"2017","unstructured":"Sinning A, Radionov N, Trepiccione F, Lopez-Cayuqueo KI, Jayat M, Baron S, Corniere N, Alexander RT, Hadchouel J, Eladari D, Hubner CA, Chambrey R (2017) Double knockout of the Na+-driven Cl-\/HCO3- exchanger and Na+\/Cl- cotransporter induces hypokalemia and volume depletion. J Am Soc Nephrol 28:130\u2013139. https:\/\/doi.org\/10.1681\/ASN.2015070734","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR73","doi-asserted-by":"publisher","first-page":"13368","DOI":"10.1073\/pnas.1202671109","volume":"109","author":"M Soleimani","year":"2012","unstructured":"Soleimani M, Barone S, Xu J, Shull GE, Siddiqui F, Zahedi K, Amlal H (2012) Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure. Proc Natl Acad Sci U S A 109:13368\u201313373. https:\/\/doi.org\/10.1073\/pnas.1202671109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR74","doi-asserted-by":"publisher","first-page":"F356","DOI":"10.1152\/ajprenal.2001.280.2.F356","volume":"280","author":"M Soleimani","year":"2001","unstructured":"Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE (2001) Pendrin: an apical Cl-\/OH-\/HCO3- exchanger in the kidney cortex. Am J Physiol Renal Physiol 280:F356\u2013F364. https:\/\/doi.org\/10.1152\/ajprenal.2001.280.2.F356","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR75","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1172\/JCI112067","volume":"76","author":"RA Star","year":"1985","unstructured":"Star RA, Burg MB, Knepper MA (1985) Bicarbonate secretion and chloride absorption by rabbit cortical collecting ducts. Role of chloride\/bicarbonate exchange. J Clin Invest 76:1123\u20131130. https:\/\/doi.org\/10.1172\/JCI112067","journal-title":"J Clin Invest"},{"key":"2897_CR76","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1056\/NEJM199102143240707","volume":"324","author":"C Take","year":"1991","unstructured":"Take C, Ikeda K, Kurasawa T, Kurokawa K (1991) Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism. N Engl J Med 324:472\u2013476","journal-title":"N Engl J Med"},{"key":"2897_CR77","doi-asserted-by":"publisher","first-page":"14748","DOI":"10.1073\/pnas.94.26.14748","volume":"94","author":"M Tanaka","year":"1997","unstructured":"Tanaka M, Schmidlin O, Yi SL, Bollen AW, Morris RC Jr (1997) Genetically determined chloride-sensitive hypertension and stroke. Proc Natl Acad Sci U S A 94:14748\u201314752","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR78","doi-asserted-by":"publisher","first-page":"F24","DOI":"10.1152\/ajprenal.00450.2009","volume":"298","author":"R Tatum","year":"2010","unstructured":"Tatum R, Zhang Y, Salleng K, Lu Z, Lin JJ, Lu Q, Jeansonne BG, Ding L, Chen YH (2010) Renal salt wasting and chronic dehydration in claudin-7-deficient mice. Am J Physiol Renal Physiol 298:F24\u2013F34. 00450.2009 [pii]. https:\/\/doi.org\/10.1152\/ajprenal.00450.2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR79","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1681\/ASN.V72260","volume":"7","author":"P Teng-umnuay","year":"1996","unstructured":"Teng-umnuay P, Verlander JW, Yuan W, Tisher CC, Madsen KM (1996) Identification of distinct subpopulations of intercalated cells in the mouse collecting duct. J Am Soc Nephrol 7:260\u2013274. https:\/\/doi.org\/10.1681\/ASN.V72260","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR80","first-page":"F519","volume":"259","author":"Y Terada","year":"1990","unstructured":"Terada Y, Knepper MA (1990) Thiazide-sensitive NaCl absorption in rat cortical collecting duct. Am J Phys 259:F519\u2013F528","journal-title":"Am J Phys"},{"key":"2897_CR81","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1172\/JCI112268","volume":"77","author":"K Tomita","year":"1986","unstructured":"Tomita K, Pisano JJ, Burg MB, Knepper MA (1986) Effects of vasopressin and bradykinin on anion transport by the rat cortical collecting duct. Evidence for an electroneutral sodium chloride transport pathway. J Clin Invest 77:136\u2013141. https:\/\/doi.org\/10.1172\/JCI112268","journal-title":"J Clin Invest"},{"key":"2897_CR82","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1172\/JCI111935","volume":"76","author":"K Tomita","year":"1985","unstructured":"Tomita K, Pisano JJ, Knepper MA (1985) Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone. J Clin Invest 76:132\u2013136. https:\/\/doi.org\/10.1172\/JCI111935","journal-title":"J Clin Invest"},{"key":"2897_CR83","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1681\/ASN.2015080915","volume":"27","author":"F Trepiccione","year":"2016","unstructured":"Trepiccione F, Gerber SD, Grahammer F, Lopez-Cayuqueo KI, Baudrie V, Paunescu TG, Capen DE, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D, Simons M (2016) Renal Atp6ap2\/(Pro)renin receptor is required for normal vacuolar H+-ATPase function but not for the renin-angiotensin system. J Am Soc Nephrol 27:3320\u20133330. https:\/\/doi.org\/10.1681\/ASN.2015080915","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR84","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1093\/ndt\/gfw393","volume":"32","author":"F Trepiccione","year":"2017","unstructured":"Trepiccione F, Soukaseum C, Baudrie V, Kumai Y, Teulon J, Villoutreix B, Corniere N, Wangemann P, Griffith AJ, Byung Choi Y, Hadchouel J, Chambrey R, Eladari D (2017) Acute genetic ablation of pendrin lowers blood pressure in mice. Nephrol Dial Transplant 32:1137\u20131145. https:\/\/doi.org\/10.1093\/ndt\/gfw393","journal-title":"Nephrol Dial Transplant"},{"key":"2897_CR85","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.kint.2021.06.020","volume":"100","author":"F Trepiccione","year":"2021","unstructured":"Trepiccione F, Suzumoto Y, Perna A, Capasso G (2021) Pure Gitelman-like syndrome secondary to SLC26A4 (pendrin) mutation. Kidney Int 100:947\u2013948. https:\/\/doi.org\/10.1016\/j.kint.2021.06.020","journal-title":"Kidney Int"},{"key":"2897_CR86","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1681\/ASN.2005101054","volume":"17","author":"M Vallet","year":"2006","unstructured":"Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschenes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D (2006) Pendrin regulation in mouse kidney primarily is chloride-dependent. J Am Soc Nephrol 17:2153\u20132163. https:\/\/doi.org\/10.1681\/ASN.2005101054","journal-title":"J Am Soc Nephrol"},{"key":"2897_CR87","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1161\/01.HYP.0000088321.67254.B7","volume":"42","author":"JW Verlander","year":"2003","unstructured":"Verlander JW, Hassell KA, Royaux IE, Glapion DM, Wang ME, Everett LA, Green ED, Wall SM (2003) Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension 42:356\u2013362. https:\/\/doi.org\/10.1161\/01.HYP.0000088321.67254.B7","journal-title":"Hypertension"},{"key":"2897_CR88","doi-asserted-by":"publisher","first-page":"F833","DOI":"10.1152\/ajprenal.00474.2005","volume":"291","author":"JW Verlander","year":"2006","unstructured":"Verlander JW, Kim YH, Shin W, Pham TD, Hassell KA, Beierwaltes WH, Green ED, Everett L, Matthews SW, Wall SM (2006) Dietary Cl(-) restriction upregulates pendrin expression within the apical plasma membrane of type B intercalated cells. Am J Physiol Renal Physiol 291:F833\u2013F839. https:\/\/doi.org\/10.1152\/ajprenal.00474.2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR89","first-page":"889","volume-title":"The kidney: physiology and pathophysiology","author":"F Verrey","year":"2008","unstructured":"Verrey F, Hummler E, Schild L, Rossier BC (2008) Mineralocorticoid action in the aldosterone-sensitive distal nephron. In: Alpern RJ, Hebert SC (eds) The kidney: physiology and pathophysiology, 4th edn. Academic, Burlington, MA, pp 889\u2013924","edition":"4"},{"key":"2897_CR90","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1038\/s41467-023-38562-x","volume":"14","author":"H Vitzthum","year":"2023","unstructured":"Vitzthum H, Koch M, Eckermann L, Svendsen SL, Berg P, Hubner CA, Wagner CA, Leipziger J, Meyer-Schwesinger C, Ehmke H (2023) The AE4 transporter mediates kidney acid-base sensing. Nat Commun 14:3051. https:\/\/doi.org\/10.1038\/s41467-023-38562-x","journal-title":"Nat Commun"},{"key":"2897_CR91","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1046\/j.1523-1755.2002.00671.x","volume":"62","author":"CA Wagner","year":"2002","unstructured":"Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP (2002) Regulation of the expression of the Cl-\/anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int 62:2109\u20132117. https:\/\/doi.org\/10.1046\/j.1523-1755.2002.00671.x","journal-title":"Kidney Int"},{"key":"2897_CR92","doi-asserted-by":"publisher","first-page":"F229","DOI":"10.1152\/ajprenal.00147.2002","volume":"284","author":"SM Wall","year":"2003","unstructured":"Wall SM, Hassell KA, Royaux IE, Green ED, Chang JY, Shipley GL, Verlander JW (2003) Localization of pendrin in mouse kidney. Am J Physiol Renal Physiol 284:F229\u2013F241. https:\/\/doi.org\/10.1152\/ajprenal.00147.2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"2897_CR93","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/01.HYP.0000145863.96091.89","volume":"44","author":"SM Wall","year":"2004","unstructured":"Wall SM, Kim YH, Stanley L, Glapion DM, Everett LA, Green ED, Verlander JW (2004) NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: role in Cl- conservation. Hypertension 44:982\u2013987. https:\/\/doi.org\/10.1161\/01.HYP.0000145863.96091.89","journal-title":"Hypertension"},{"key":"2897_CR94","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1152\/physrev.00011.2019","volume":"100","author":"SM Wall","year":"2020","unstructured":"Wall SM, Verlander JW, Romero CA (2020) The renal physiology of pendrin-positive intercalated cells. Physiol Rev 100:1119\u20131147. https:\/\/doi.org\/10.1152\/physrev.00011.2019","journal-title":"Physiol Rev"},{"key":"2897_CR95","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s41594-023-00974-0","volume":"30","author":"L Wang","year":"2023","unstructured":"Wang L, Hall C, Li J, Choi E, Bai XC (2023) Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat Struct Mol Biol 30:661\u2013669. https:\/\/doi.org\/10.1038\/s41594-023-00974-0","journal-title":"Nat Struct Mol Biol"},{"key":"2897_CR96","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1126\/science.6322303","volume":"223","author":"SA Whitescarver","year":"1984","unstructured":"Whitescarver SA, Ott CE, Jackson BA, Guthrie GP Jr, Kotchen TA (1984) Salt-sensitive hypertension: contribution of chloride. Science 223:1430\u20131432","journal-title":"Science"},{"key":"2897_CR97","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1159\/000494596","volume":"50","author":"J Xu","year":"2018","unstructured":"Xu J, Barone S, Zahedi K, Brooks M, Soleimani M (2018) Slc4a8 in the kidney: expression, subcellular localization and role in salt reabsorption. Cell Physiol Biochem 50:1361\u20131375. https:\/\/doi.org\/10.1159\/000494596","journal-title":"Cell Physiol Biochem"},{"key":"2897_CR98","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1073\/pnas.0306924101","volume":"101","author":"K Yamauchi","year":"2004","unstructured":"Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S (2004) Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A 101:4690\u20134694","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02897-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-023-02897-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-023-02897-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:02:11Z","timestamp":1712707331000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-023-02897-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":98,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["2897"],"URL":"https:\/\/doi.org\/10.1007\/s00424-023-02897-7","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"24 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments shown in Fig.\n                      \n                      conformed to the Protocol of Animal Welfare (Amsterdam Treaty;\n                      \n                      ) and were approved by the ethical committee (agreement no. A75\u201315\u201332 to R\u00e9gine Chambrey).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}