{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:32:52Z","timestamp":1782387172482,"version":"3.54.5"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/19249-0 and 2019\/24478-3"],"award-info":[{"award-number":["2017\/19249-0 and 2019\/24478-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["431339\/2018-0 and 304484\/2022-9"],"award-info":[{"award-number":["431339\/2018-0 and 304484\/2022-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s00424-024-02904-5","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T02:02:30Z","timestamp":1705456950000},"page":"351-364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of corticotropin-releasing factor neurotransmission in the lateral hypothalamus on baroreflex impairment evoked by chronic variable stress in rats"],"prefix":"10.1007","volume":"476","author":[{"given":"Lucas","family":"Barretto-de-Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Benini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian L.","family":"Reis-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Busnardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos C.","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"2904_CR1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3109\/10253890.2015.1038993","volume":"18","author":"J Almeida","year":"2015","unstructured":"Almeida J, Duarte JO, Oliveira LA, Crestani CC (2015) Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. Stress 18:462\u2013474. https:\/\/doi.org\/10.3109\/10253890.2015.1038993","journal-title":"Stress"},{"key":"2904_CR2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1146\/annurev.pharmtox.44.101802.121410","volume":"44","author":"TL Bale","year":"2004","unstructured":"Bale TL, Vale WW (2004) CRF and CRF receptors\u202f: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44:525\u2013557. https:\/\/doi.org\/10.1146\/annurev.pharmtox.44.101802.121410","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2904_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.brainresbull.2020.11.010","volume":"166","author":"L Barretto-de-souza","year":"2021","unstructured":"Barretto-de-souza L, Benini R, Reis-silva LL, Crestani CC (2021) Corticotropin-releasing factor neurotransmission in the lateral hypothalamus modulates the tachycardiac response during acute emotional stress in rats. Brain Res Bull 166:102\u2013109. https:\/\/doi.org\/10.1016\/j.brainresbull.2020.11.010","journal-title":"Brain Res Bull"},{"key":"2904_CR4","doi-asserted-by":"publisher","first-page":"109061","DOI":"10.1016\/j.neuropharm.2022.109061","volume":"212","author":"L Barretto-de-Souza","year":"2022","unstructured":"Barretto-de-Souza L, Benini R, Reis-Silva LL, Crestani CC (2022) Role of CRF1 and CRF2 receptors in the lateral hypothalamus in cardiovascular and anxiogenic responses evoked by restraint stress in rats: evaluation of acute and chronic exposure. Neuropharmacology 212:109061. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109061","journal-title":"Neuropharmacology"},{"key":"2904_CR5","doi-asserted-by":"publisher","first-page":"113013","DOI":"10.1016\/J.PHYSBEH.2020.113013","volume":"223","author":"T Batschauer","year":"2020","unstructured":"Batschauer T, Cordeiro JM, Simas BB, Brunetta HS, Souza RM, Nunes EA, Reis WL, Moreira ELG, Crestani CC, Santos ARS, Speretta GF (2020) Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet. Physiol Behav 223:113013. https:\/\/doi.org\/10.1016\/J.PHYSBEH.2020.113013","journal-title":"Physiol Behav"},{"key":"2904_CR6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/(SICI)1096-9861(19991220)415:3<285::AID-CNE1>3.0.CO;2-0","volume":"415","author":"JC Bittencourt","year":"1999","unstructured":"Bittencourt JC, Vaughan J, Arias C, Rissman RA, Vale WW, Sawchenko PE (1999) Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol 415:285\u2013312. https:\/\/doi.org\/10.1002\/(SICI)1096-9861(19991220)415:3%3c285::AID-CNE1%3e3.0.CO;2-0","journal-title":"J Comp Neurol"},{"key":"2904_CR7","doi-asserted-by":"publisher","first-page":"6443","DOI":"10.1113\/JP271946","volume":"594","author":"P Bonnavion","year":"2016","unstructured":"Bonnavion P, Mickelsen LE, Fujita A, de Lecea L, Jackson AC (2016) Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour. J Physiol 594:6443. https:\/\/doi.org\/10.1113\/JP271946","journal-title":"J Physiol"},{"key":"2904_CR8","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neubiorev.2016.11.006","volume":"76","author":"L Carnevali","year":"2017","unstructured":"Carnevali L, Montano N, Statello R, Sgoifo A (2017) Rodent models of depression-cardiovascular comorbidity: bridging the known to the new. Neurosci Biobehav Rev 76:144\u2013153. https:\/\/doi.org\/10.1016\/j.neubiorev.2016.11.006","journal-title":"Neurosci Biobehav Rev"},{"key":"2904_CR9","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.regpep.2010.11.006","volume":"167","author":"SL Chagra","year":"2011","unstructured":"Chagra SL, Zavala JK, Hall MV, Gosselink KL (2011) Acute and repeated restraint differentially activate orexigenic pathways in the rat hypothalamus. Regul Pept 167:70\u201378. https:\/\/doi.org\/10.1016\/j.regpep.2010.11.006","journal-title":"Regul Pept"},{"key":"2904_CR10","doi-asserted-by":"publisher","unstructured":"Chitravanshi VC, Kawabe K, Sapru HN (2012) Bradycardic effects of microinjections of urocortin 3 into the nucleus ambiguus of the rat. Am J Physiol - Regul Integr Comp Physiol 303. https:\/\/doi.org\/10.1152\/ajpregu.00224.2012","DOI":"10.1152\/ajpregu.00224.2012"},{"key":"2904_CR11","doi-asserted-by":"publisher","unstructured":"Chitravanshi VC, Sapru HN (2011) Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia. Am J Physiol - Hear Circ Physiol 300. https:\/\/doi.org\/10.1152\/ajpheart.00391.2010","DOI":"10.1152\/ajpheart.00391.2010"},{"key":"2904_CR12","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1093\/ajh\/hpv047","volume":"28","author":"BE Cohen","year":"2015","unstructured":"Cohen BE, Edmondson D, Kronish IM (2015) State of the art review: depression, stress, anxiety, and cardiovascular disease. Am J Hypertens 28:1295\u20131302. https:\/\/doi.org\/10.1093\/ajh\/hpv047","journal-title":"Am J Hypertens"},{"key":"2904_CR13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3389\/fphar.2016.00262","volume":"7","author":"W Costa-Ferreira","year":"2016","unstructured":"Costa-Ferreira W, Vieira JO, Almeida J, Gomes-de-Souza L, Crestani CC (2016) Involvement of type 1 angiontensin II receptor (AT1) in cardiovascular changes induced by chronic emotional stress: comparison between homotypic and heterotypic stressors. Front Pharmacol 7:262. https:\/\/doi.org\/10.3389\/fphar.2016.00262","journal-title":"Front Pharmacol"},{"key":"2904_CR14","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3389\/fphys.2016.00251","volume":"7","author":"CC Crestani","year":"2016","unstructured":"Crestani CC (2016) Emotional stress and cardiovascular complications in animal models: a review of the influence of stress type. Front Physiol 7:251. https:\/\/doi.org\/10.3389\/fphys.2016.00251","journal-title":"Front Physiol"},{"key":"2904_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.neures.2010.05.001","volume":"67","author":"CC Crestani","year":"2010","unstructured":"Crestani CC, Alves FHF, Busnardo C, Resstel LBM, Correa FMA (2010) N-Methyl-d-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats. Neurosci Res 67:317\u2013326. https:\/\/doi.org\/10.1016\/j.neures.2010.05.001","journal-title":"Neurosci Res"},{"key":"2904_CR16","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1440-1681.2009.05191.x","volume":"36","author":"CC Crestani","year":"2009","unstructured":"Crestani CC, Deolindo MV, Alves FH, Resstel LB, Correa FM (2009) Non- N -methyl-d-aspartate glutamate receptors in the lateral hypothalamus modulate cardiac baroreflex responses in conscious rats. Clin Exp Pharmacol Physiol 36:1079\u20131085. https:\/\/doi.org\/10.1111\/j.1440-1681.2009.05191.x","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2904_CR17","doi-asserted-by":"publisher","first-page":"R429","DOI":"10.1152\/ajpregu.00051.2015","volume":"309","author":"RAL Dampney","year":"2015","unstructured":"Dampney RAL (2015) Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal. Am J Physiol - Regul Integr Comp Physiol 309:R429\u2013R443. https:\/\/doi.org\/10.1152\/ajpregu.00051.2015","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"2904_CR18","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/1874467210666170302104053","volume":"11","author":"N Dedic","year":"2018","unstructured":"Dedic N, Chen A, Deussing JM (2018) The CRF family of neuropeptides and their receptors - mediators of the central stress response. Curr Mol Pharmacol 11:4\u201331. https:\/\/doi.org\/10.2174\/1874467210666170302104053","journal-title":"Curr Mol Pharmacol"},{"key":"2904_CR19","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1111\/ejn.12246","volume":"38","author":"MV Deolindo","year":"2013","unstructured":"Deolindo MV, Reis DG, Crestani CC, Tavares RF, Resstel LBM, Corr\u00eaa FMA (2013) NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats. Eur J Neurosci 38:2374\u20132381. https:\/\/doi.org\/10.1111\/ejn.12246","journal-title":"Eur J Neurosci"},{"key":"2904_CR20","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1152\/physrev.00042.2017","volume":"98","author":"JM Deussing","year":"2018","unstructured":"Deussing JM, Chen A (2018) The corticotropin-releasing factor family: physiology of the stress response. Physiol Rev 98:2225\u20132286. https:\/\/doi.org\/10.1152\/physrev.00042.2017","journal-title":"Physiol Rev"},{"key":"2904_CR21","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1159\/000126303","volume":"56","author":"M Diamant","year":"1992","unstructured":"Diamant M, Kashtanov SI, Fodor M, de Wied D (1992) Corticotropin-releasing factor induces differential behavioral and cardiovascular effects after intracerebroventricular and lateral hypothalamic\/perifornical injections in rats. Neuroendocrinology 56:750\u2013760. https:\/\/doi.org\/10.1159\/000126303","journal-title":"Neuroendocrinology"},{"key":"2904_CR22","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/PSY.0000000000000141","volume":"77","author":"JO Duarte","year":"2015","unstructured":"Duarte JO, Cruz FC, Le\u00e3o RM, Planeta CS, Crestani CC (2015) Stress vulnerability during adolescence. Psychosom Med 77:186\u2013199. https:\/\/doi.org\/10.1097\/PSY.0000000000000141","journal-title":"Psychosom Med"},{"key":"2904_CR23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ijdevneu.2014.11.004","volume":"40","author":"JO Duarte","year":"2015","unstructured":"Duarte JO, Planeta CS, Crestani CC (2015) Immediate and long-term effects of psychological stress during adolescence in cardiovascular function: comparison of homotypic vs heterotypic stress regimens. Int J Dev Neurosci 40:52\u201359. https:\/\/doi.org\/10.1016\/j.ijdevneu.2014.11.004","journal-title":"Int J Dev Neurosci"},{"key":"2904_CR24","doi-asserted-by":"publisher","first-page":"e0146974","DOI":"10.1371\/journal.pone.0146974","volume":"11","author":"SA Engi","year":"2016","unstructured":"Engi SA, Planeta CS, Crestani CC (2016) Effect of voluntary ethanol consumption combined with testosterone treatment on cardiovascular function in rats: influence of exercise training. PLoS ONE 11:e0146974. https:\/\/doi.org\/10.1371\/journal.pone.0146974","journal-title":"PLoS ONE"},{"key":"2904_CR25","doi-asserted-by":"publisher","unstructured":"Firmino EMS, Kuntze LB, Lagatta DC, Dias DPM, Resstel LBM (2019) Effect of chronic stress on cardiovascular and ventilatory responses activated by both chemoreflex and baroreflex in rats. J Exp Biol 222:jeb204883. https:\/\/doi.org\/10.1242\/jeb.204883","DOI":"10.1242\/jeb.204883"},{"key":"2904_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.npep.2019.03.006","volume":"75","author":"H-R Gao","year":"2019","unstructured":"Gao H-R, Gao H-Y (2019) Cardiovascular functions of central corticotropin-releasing factor related peptides system. Neuropeptides 75:18\u201324. https:\/\/doi.org\/10.1016\/j.npep.2019.03.006","journal-title":"Neuropeptides"},{"key":"2904_CR27","doi-asserted-by":"publisher","unstructured":"Gao HR, Zhuang QX, Li B, Li HZ, Chen ZP, Wang JJ, Zhu JN (2016) Corticotropin releasing factor excites neurons of posterior hypothalamic nucleus to produce tachycardia in rats. Sci Rep 6. https:\/\/doi.org\/10.1038\/srep20206","DOI":"10.1038\/srep20206"},{"key":"2904_CR28","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/s41593-018-0198-x","volume":"21","author":"WJ Giardino","year":"2018","unstructured":"Giardino WJ, Eban-Rothschild A, Christoffel DJ, Li S-B, Malenka RC, de Lecea L (2018) Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci 21:1084\u20131095. https:\/\/doi.org\/10.1038\/s41593-018-0198-x","journal-title":"Nat Neurosci"},{"key":"2904_CR29","doi-asserted-by":"publisher","first-page":"H1476","DOI":"10.1152\/ajpheart.00859.2014","volume":"308","author":"S Golbidi","year":"2015","unstructured":"Golbidi S, Frisbee JC, Laher I (2015) Chronic stress impacts the cardiovascular system: animal models and clinical outcomes. Am J Physiol Circ Physiol 308:H1476\u2013H1498. https:\/\/doi.org\/10.1152\/ajpheart.00859.2014","journal-title":"Am J Physiol Circ Physiol"},{"key":"2904_CR30","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.euroneuro.2019.03.001","volume":"29","author":"L Gomes-de-Souza","year":"2019","unstructured":"Gomes-de-Souza L, Benini R, Costa-Ferreira W, Crestani CC (2019) GABAA but not GABAB receptors in the lateral hypothalamus modulate the tachycardic response to emotional stress in rats. Eur Neuropsychopharmacol 29:672\u2013680. https:\/\/doi.org\/10.1016\/j.euroneuro.2019.03.001","journal-title":"Eur Neuropsychopharmacol"},{"key":"2904_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/J.1476-5381.2011.01631.X","volume":"166","author":"DK Grammatopoulos","year":"2012","unstructured":"Grammatopoulos DK (2012) Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction. Br J Pharmacol 166:85. https:\/\/doi.org\/10.1111\/J.1476-5381.2011.01631.X","journal-title":"Br J Pharmacol"},{"key":"2904_CR32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/J.JASH.2016.02.015","volume":"10","author":"G Grassi","year":"2016","unstructured":"Grassi G, Ram VS (2016) Evidence for a critical role of the sympathetic nervous system in hypertension. J Am Soc Hypertens 10:457\u2013466. https:\/\/doi.org\/10.1016\/J.JASH.2016.02.015","journal-title":"J Am Soc Hypertens"},{"key":"2904_CR33","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/PSY.0b013e31816ff7dd","volume":"70","author":"AJ Grippo","year":"2008","unstructured":"Grippo AJ, Moffitt JA, Johnson AK (2008) Evaluation of baroreceptor reflex function in the chronic mild stress rodent model of depression. Psychosom Med 70:435\u2013443. https:\/\/doi.org\/10.1097\/PSY.0b013e31816ff7dd","journal-title":"Psychosom Med"},{"key":"2904_CR34","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nrn.2016.94","volume":"17","author":"MJAG Henckens","year":"2016","unstructured":"Henckens MJAG, Deussing JM, Chen A (2016) Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci 17:636\u2013651. https:\/\/doi.org\/10.1038\/nrn.2016.94","journal-title":"Nat Rev Neurosci"},{"key":"2904_CR35","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/cphy.c150015","volume":"6","author":"JP Herman","year":"2016","unstructured":"Herman JP, McKlveen JM, Ghosal S, Kopp B, Wulsin A, Makinson R, Scheimann J, Myers B (2016) Regulation of the hypothalamic-pituitary- adrenocortical stress response. Compr Physiol 6:603\u2013621. https:\/\/doi.org\/10.1002\/cphy.c150015","journal-title":"Compr Physiol"},{"key":"2904_CR36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuroscience.2014.06.043","volume":"277","author":"E Horjales-Araujo","year":"2014","unstructured":"Horjales-Araujo E, Hellysaz A, Broberger C (2014) Lateral hypothalamic thyrotropin-releasing hormone neurons: distribution and relationship to histochemically defined cell populations in the rat. Neuroscience 277:87\u2013102. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.06.043","journal-title":"Neuroscience"},{"key":"2904_CR37","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.1716","author":"N Ito","year":"2009","unstructured":"Ito N, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T (2009) A possible mechanism underlying an antidepressive-like effect of kososan, a kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice. Biol Pharm Bull. https:\/\/doi.org\/10.1248\/bpb.32.1716","journal-title":"Biol Pharm Bull"},{"key":"2904_CR38","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nrn2632","volume":"10","author":"M Jo\u00ebls","year":"2009","unstructured":"Jo\u00ebls M, Baram TZ (2009) The neuro-symphony of stress. Nat Rev Neurosci 10:459\u2013466. https:\/\/doi.org\/10.1038\/nrn2632","journal-title":"Nat Rev Neurosci"},{"key":"2904_CR39","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nrcardio.2017.189","volume":"15","author":"M Kivim\u00e4ki","year":"2018","unstructured":"Kivim\u00e4ki M, Steptoe A (2018) Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol 15:215\u2013229. https:\/\/doi.org\/10.1038\/nrcardio.2017.189","journal-title":"Nat Rev Cardiol"},{"key":"2904_CR40","doi-asserted-by":"publisher","unstructured":"Komnenov D, Quaal H, Rossi NF (2021) V1aand V1bvasopressin receptors within the paraventricular nucleus contribute to hypertension in male rats exposed to chronic mild unpredictable stress. Am J Physiol - Regul Integr Comp Physiol 320. https:\/\/doi.org\/10.1152\/AJPREGU.00245.2020","DOI":"10.1152\/AJPREGU.00245.2020"},{"key":"2904_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00366-4","author":"D Lin","year":"2002","unstructured":"Lin D, Bruijnzeel AW, Schmidt P, Markou A (2002) Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine. Neuroscience. https:\/\/doi.org\/10.1016\/S0306-4522(02)00366-4","journal-title":"Neuroscience"},{"key":"2904_CR42","doi-asserted-by":"publisher","first-page":"4871","DOI":"10.1007\/S12035-021-02470-2\/FIGURES\/7","volume":"58","author":"MB Malta","year":"2021","unstructured":"Malta MB, Martins J, Novaes LS, dos Santos NB, Sita L, Camarini R, Scavone C, Bittencourt J, Munhoz CD (2021) Norepinephrine and glucocorticoids modulate chronic unpredictable stress-induced increase in the type 2 CRF and glucocorticoid receptors in brain structures related to the HPA axis activation. Mol Neurobiol 58:4871\u20134885. https:\/\/doi.org\/10.1007\/S12035-021-02470-2\/FIGURES\/7","journal-title":"Mol Neurobiol"},{"key":"2904_CR43","doi-asserted-by":"publisher","first-page":"247054701769232","DOI":"10.1177\/2470547017692328","volume":"1","author":"BS McEwen","year":"2017","unstructured":"McEwen BS (2017) Neurobiological and systemic effects of chronic stress. Chronic Stress 1:247054701769232. https:\/\/doi.org\/10.1177\/2470547017692328","journal-title":"Chronic Stress"},{"key":"2904_CR44","doi-asserted-by":"publisher","unstructured":"Nakamura T, Sapru HN (2009) Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. Am J Physiol - Hear Circ Physiol 296. https:\/\/doi.org\/10.1152\/ajpheart.00191.2009","DOI":"10.1152\/ajpheart.00191.2009"},{"key":"2904_CR45","doi-asserted-by":"publisher","first-page":"102946","DOI":"10.1016\/J.AUTNEU.2022.102946","volume":"238","author":"L Norcliffe-Kaufmann","year":"2022","unstructured":"Norcliffe-Kaufmann L (2022) Stress and the baroreflex. Auton Neurosci 238:102946. https:\/\/doi.org\/10.1016\/J.AUTNEU.2022.102946","journal-title":"Auton Neurosci"},{"key":"2904_CR46","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.phrs.2015.03.012","volume":"95\u201396","author":"LA Oliveira","year":"2015","unstructured":"Oliveira LA, Almeida J, Benini R, Crestani CC (2015) CRF 1 and CRF 2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats. Pharmacol Res 95\u201396:53\u201362. https:\/\/doi.org\/10.1016\/j.phrs.2015.03.012","journal-title":"Pharmacol Res"},{"key":"2904_CR47","doi-asserted-by":"publisher","first-page":"110009","DOI":"10.1016\/j.pnpbp.2020.110009","volume":"105","author":"LA Oliveira","year":"2021","unstructured":"Oliveira LA, Gomes-de-Souza L, Benini R, Wood SK, Crestani CC (2021) Both CRF1 and CRF2 receptors in the bed nucleus of stria terminalis are involved in baroreflex impairment evoked by chronic stress in rats. Prog Neuro-Psychopharmacol Biol Psychiatr 105:110009. https:\/\/doi.org\/10.1016\/j.pnpbp.2020.110009","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatr"},{"key":"2904_CR48","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3109\/10253890802641966","volume":"12","author":"MM Ostrander","year":"2009","unstructured":"Ostrander MM, Ulrich-Lai YM, Choi DC, Flak JN, Richtand NM, Herman JP (2009) Chronic stress produces enduring decreases in novel stress-evoked c-fos mRNA expression in discrete brain regions of the rat. Stress 12:469\u2013477. https:\/\/doi.org\/10.3109\/10253890802641966","journal-title":"Stress"},{"key":"2904_CR49","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1997","unstructured":"Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates. Sidney, Australia"},{"key":"2904_CR50","doi-asserted-by":"publisher","first-page":"147195","DOI":"10.1016\/j.brainres.2020.147195","volume":"1751","author":"LL Reis-Silva","year":"2021","unstructured":"Reis-Silva LL, Barretto-de-Souza L, Benini R, Crestani CC (2021) CRF1 and CRF2 receptors in the lateral hypothalamus differently modulate the baroreflex function in unanesthetized rats. Brain Res 1751:147195. https:\/\/doi.org\/10.1016\/j.brainres.2020.147195","journal-title":"Brain Res"},{"key":"2904_CR51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1471-4892(01)00117-5","volume":"2","author":"JMHM Reul","year":"2002","unstructured":"Reul JMHM, Holsboer F (2002) Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol 2:23\u201333. https:\/\/doi.org\/10.1016\/S1471-4892(01)00117-5","journal-title":"Curr Opin Pharmacol"},{"key":"2904_CR52","doi-asserted-by":"publisher","first-page":"R744","DOI":"10.1152\/ajpregu.2001.280.3.R744","volume":"280","author":"M Di Rienzo","year":"2001","unstructured":"Di Rienzo M, Parati G, Castiglioni P, Tordi R, Mancia G, Pedotti A (2001) Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life. Am J Physiol Integr Comp Physiol 280:R744\u2013R751. https:\/\/doi.org\/10.1152\/ajpregu.2001.280.3.R744","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"2904_CR53","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.neuroscience.2017.08.016","volume":"361","author":"ZJ Rosinger","year":"2017","unstructured":"Rosinger ZJ, Jacobskind JS, Park SG, Justice NJ, Zuloaga DG (2017) Distribution of corticotropin-releasing factor receptor 1 in the developing mouse forebrain: a novel sex difference revealed in the rostral periventricular hypothalamus. Neuroscience 361:167\u2013178. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.08.016","journal-title":"Neuroscience"},{"key":"2904_CR54","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3389\/FPHYS.2022.820398\/BIBTEX","volume":"13","author":"D Schaeuble","year":"2022","unstructured":"Schaeuble D, Myers B (2022) Cortical\u2013hypothalamic integration of autonomic and endocrine stress responses. Front Physiol 13:151. https:\/\/doi.org\/10.3389\/FPHYS.2022.820398\/BIBTEX","journal-title":"Front Physiol"},{"key":"2904_CR55","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00213-004-2015-3","volume":"178","author":"V Sergeyev","year":"2005","unstructured":"Sergeyev V, Fetissov S, Math\u00e9 AA, Jimenez PA, Bartfai T, Mortas P, Gaudet L, Moreau JL, H\u00f6kfelt T (2005) Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology 178:115\u2013124. https:\/\/doi.org\/10.1007\/s00213-004-2015-3","journal-title":"Psychopharmacology"},{"key":"2904_CR56","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neubiorev.2013.12.005","volume":"39","author":"A Sgoifo","year":"2014","unstructured":"Sgoifo A, Carnevali L, Grippo AJ (2014) The socially stressed heart. Insights from studies in rodents. Neurosci Biobehav Rev 39:51\u201360. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.12.005","journal-title":"Neurosci Biobehav Rev"},{"key":"2904_CR57","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1124\/MOL.116.104927","volume":"90","author":"PG Slater","year":"2016","unstructured":"Slater PG, Yarur HE, Gysling K (2016) Corticotropin-releasing factor receptors and their interacting proteins: functional consequences. Mol Pharmacol 90:627\u2013632. https:\/\/doi.org\/10.1124\/MOL.116.104927","journal-title":"Mol Pharmacol"},{"key":"2904_CR58","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1210\/endo.136.9.7649080","volume":"136","author":"MA Smith","year":"1995","unstructured":"Smith MA, Makino S, Kim SY, Kvetnansky R (1995) Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology 136:3743\u20133750. https:\/\/doi.org\/10.1210\/endo.136.9.7649080","journal-title":"Endocrinology"},{"key":"2904_CR59","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1258\/ebm.2010.009347","volume":"235","author":"A Stengel","year":"2010","unstructured":"Stengel A, Tach\u00e9 Y (2010) Corticotropin-releasing factor signaling and visceral response to stress. Exp Biol Med (Maywood) 235:1168\u20131178. https:\/\/doi.org\/10.1258\/ebm.2010.009347","journal-title":"Exp Biol Med (Maywood)"},{"key":"2904_CR60","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.physbeh.2011.06.004","volume":"106","author":"P Sterling","year":"2012","unstructured":"Sterling P (2012) Allostasis: a model of predictive regulation. Physiol Behav 106:5\u201315. https:\/\/doi.org\/10.1016\/j.physbeh.2011.06.004","journal-title":"Physiol Behav"},{"key":"2904_CR61","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1111\/j.1460-9568.2012.08262.x","volume":"36","author":"AP Ventura-Silva","year":"2012","unstructured":"Ventura-Silva AP, P\u00eago JM, Sousa JC, Marques AR, Rodrigues AJ, Marques F, Cerqueira JJ, Almeida OFX, Sousa N (2012) Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode. Eur J Neurosci 36:3396\u20133406. https:\/\/doi.org\/10.1111\/j.1460-9568.2012.08262.x","journal-title":"Eur J Neurosci"},{"key":"2904_CR62","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.pnpbp.2017.08.014","volume":"81","author":"JO Vieira","year":"2018","unstructured":"Vieira JO, Duarte JO, Costa-Ferreira W, Morais-Silva G, Marin MT, Crestani CC (2018) Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats. Prog Neuro-Psychopharmacol Biol Psychiatr 81:426\u2013437. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.08.014","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatr"},{"key":"2904_CR63","doi-asserted-by":"publisher","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","volume":"24","author":"R Winsky-Sommerer","year":"2004","unstructured":"Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, De Lecea L (2004) Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci 24:11439. https:\/\/doi.org\/10.1523\/JNEUROSCI.3459-04.2004","journal-title":"J Neurosci"},{"key":"2904_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyg.2014.00950","volume":"5","author":"SK Wood","year":"2014","unstructured":"Wood SK (2014) Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers. Front Psychol 5:1\u20138. https:\/\/doi.org\/10.3389\/fpsyg.2014.00950","journal-title":"Front Psychol"},{"key":"2904_CR65","doi-asserted-by":"publisher","DOI":"10.1039\/d2mo00332e","author":"H Zhao","year":"2023","unstructured":"Zhao H, Wu Q, Li N, Chen Y (2023) The mechanism of chronic unpredictable mild stress induced high blood pressure in rats: a proteomic and targeted metabolomic analysis. Mol Omi. https:\/\/doi.org\/10.1039\/d2mo00332e","journal-title":"Mol Omi"},{"key":"2904_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18388\/abp.2010_2366","volume":"57","author":"MA \u1e92mijewski","year":"2010","unstructured":"\u1e92mijewski MA, Slominski AT, Biochim A, Author P (2010) Emerging role of alternative splicing of CRF1 receptor in CRF signaling. Acta Biochim Pol 57:1. https:\/\/doi.org\/10.18388\/abp.2010_2366","journal-title":"Acta Biochim Pol"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-024-02904-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-024-02904-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-024-02904-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:03:22Z","timestamp":1707271402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-024-02904-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["2904"],"URL":"https:\/\/doi.org\/10.1007\/s00424-024-02904-5","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"5 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were approved by the Ethics Committee on the Use of Animals of the School of Pharmaceutical Sciences\/UNESP (approval no. 23\/2018), which complies with Brazilian and international guidelines for animal use and welfare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}