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Claudin-3 (<jats:italic>Cldn3<\/jats:italic>), a tight junction protein present along the whole intestine in mice, has been proposed to tighten the paracellular pathway for phosphate. The aim of this work was to characterize the phosphate-related phenotype of <jats:italic>Cldn3<\/jats:italic>-deficient mice. <jats:italic>Cldn3<\/jats:italic>-deficient mice and wildtype littermates were fed standard diet or challenged for 3\u00a0days with high dietary phosphate. Feces, urine, blood, intestinal segments and kidneys were collected. Measurements included fecal, urinary, and plasma concentrations of phosphate and calcium, plasma levels of phosphate-regulating hormones, evaluation of trans- and paracellular phosphate transport across jejunum and ileum, and analysis of intestinal phosphate and calcium permeabilities. Fecal and urinary excretion of phosphate as well as its plasma concentration was similar in both genotypes, under standard and high-phosphate diet. However, <jats:italic>Cldn3<\/jats:italic>-deficient mice challenged with high dietary phosphate had a reduced urinary calcium excretion and increased plasma levels of calcitriol. Intact FGF23 concentration was also similar in both groups, regardless of the dietary conditions. We found no differences either in intestinal phosphate transport (trans- or paracellular) and phosphate and calcium permeabilities between genotypes. The intestinal expression of claudin-7 remained unaltered in <jats:italic>Cldn3<\/jats:italic>-deficient mice. Our data do not provide evidence for a decisive role of <jats:italic>Cldn3<\/jats:italic> for intestinal phosphate absorption and phosphate homeostasis. In addition, our data suggest a novel role of <jats:italic>Cldn3<\/jats:italic> in regulating calcitriol levels.<\/jats:p>","DOI":"10.1007\/s00424-024-02998-x","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:01:58Z","timestamp":1723093318000},"page":"1597-1612","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Absence of claudin-3 does not alter intestinal absorption of phosphate in mice"],"prefix":"10.1007","volume":"476","author":[{"given":"Zsuzsa","family":"Radv\u00e1nyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Schnitzbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Maria","family":"Pastor-Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"H\u00f6lker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Himmerkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Breiderhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nati","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten A.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"2998_CR1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1681\/ASN.2008040349","volume":"20","author":"KL Adeney","year":"2009","unstructured":"Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR (2009) Association of serum phosphate with vascular and valvular calcification in moderate CKD. 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