{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:01:35Z","timestamp":1740106895135,"version":"3.37.3"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100008353","name":"Funda\u00e7\u00e3o de Apoio ao Ensino, Pesquisa e Assist\u00eancia do Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s00424-024-03011-1","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T03:16:11Z","timestamp":1725246971000},"page":"1743-1760","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune-mediated impairment of tonic immobility defensive behavior in an experimental model of colonic inflammation"],"prefix":"10.1007","volume":"476","author":[{"given":"Leda","family":"Menescal-de-Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariulza Rocha","family":"Brentegani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Pincelli","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto","family":"Giusti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Simone","family":"Saia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"3011_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13030-014-0028-7","volume":"9","author":"A Agostini","year":"2015","unstructured":"Agostini A, Campieri M, Bertani A, Scarcelli A, Ballotta D, Calabrese C, Rizzello F, Gionchetti P, Nichelli P, Benuzzi F (2015) Absence of change in the gray matter volume of patients with ulcerative colitis in remission: a voxel based morphometry study. BioPsychoSocial medicine 9:1. https:\/\/doi.org\/10.1186\/s13030-014-0028-7","journal-title":"BioPsychoSocial medicine"},{"key":"3011_CR2","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1002\/ibd.21549","volume":"17","author":"A Agostini","year":"2011","unstructured":"Agostini A, Filippini N, Cevolani D, Agati R, Leoni C, Tambasco R, Calabrese C, Rizzello F, Gionchetti P, Ercolani M, Leonardi M, Campieri M (2011) Brain functional changes in patients with ulcerative colitis: a functional magnetic resonance imaging study on emotional processing. Inflamm Bowel Dis 17:1769\u20131777. https:\/\/doi.org\/10.1002\/ibd.21549","journal-title":"Inflamm Bowel Dis"},{"key":"3011_CR3","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/ibd.20753","volume":"15","author":"P Alex","year":"2009","unstructured":"Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, Centola M, Li X (2009) Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis 15:341\u2013352. https:\/\/doi.org\/10.1002\/ibd.20753","journal-title":"Inflamm Bowel Dis"},{"key":"3011_CR4","first-page":"988","volume":"259","author":"WA Banks","year":"1991","unstructured":"Banks WA, Ortiz L, Plotkin SR, Kastin AJ (1991) Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259:988\u2013996","journal-title":"J Pharmacol Exp Ther"},{"key":"3011_CR5","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.neuroscience.2009.07.050","volume":"163","author":"S Bhatt","year":"2009","unstructured":"Bhatt S, Bhatt RS, Zalcman SS, Siegel A (2009) Peripheral and central mediators of lipopolysaccharide induced suppression of defensive rage behavior in the cat. Neuroscience 163:1002\u20131011. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.07.050","journal-title":"Neuroscience"},{"key":"3011_CR6","doi-asserted-by":"publisher","unstructured":"Bluthe RM, Laye S, Michaud B, Combe C, Dantzer R, Parnet P (2000) Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur J Neurosci 12:4447\u20134456. https:\/\/doi.org\/10.1111\/j.1460-9568.2000.01348.x","DOI":"10.1111\/j.1460-9568.2000.01348.x"},{"key":"3011_CR7","doi-asserted-by":"crossref","unstructured":"Carrive P, Lee J, Su A (2000) Lidocaine blockade of amygdala output in fear-conditioned rats reduces Fos expression in the ventrolateral periaqueductal gray. Neuroscience 95:1071\u20131080","DOI":"10.1016\/S0306-4522(99)00488-1"},{"key":"3011_CR8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1136\/gut.46.4.487","volume":"46","author":"E Carty","year":"2000","unstructured":"Carty E, De Brabander M, Feakins RM, Rampton DS (2000) Measurement of in vivo rectal mucosal cytokine and eicosanoid production in ulcerative colitis using filter paper. Gut 46:487\u2013492. https:\/\/doi.org\/10.1136\/gut.46.4.487","journal-title":"Gut"},{"key":"3011_CR9","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","volume":"383","author":"JT Chang","year":"2020","unstructured":"Chang JT (2020) Pathophysiology of inflammatory bowel diseases. N Engl J Med 383:2652\u20132664. https:\/\/doi.org\/10.1056\/NEJMra2002697","journal-title":"N Engl J Med"},{"key":"3011_CR10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/apha.12489","volume":"214","author":"A Chytilova","year":"2015","unstructured":"Chytilova A, Borchert GH, Mandikova-Alanova P, Hlavackova M, Kopkan L, Khan MA, Imig JD, Kolar F, Neckar J (2015) Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia. Acta Physiol 214:97\u2013108. https:\/\/doi.org\/10.1111\/apha.12489","journal-title":"Acta Physiol"},{"key":"3011_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12974-022-02431-z","volume":"19","author":"NL Cluny","year":"2022","unstructured":"Cluny NL, Nyuyki KD, Almishri W, Griffin L, Lee BH, Hirota SA, Pittman QJ, Swain MG, Sharkey KA (2022) Recruitment of alpha4beta7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior. J Neuroinflammation 19:73. https:\/\/doi.org\/10.1186\/s12974-022-02431-z","journal-title":"J Neuroinflammation"},{"key":"3011_CR12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12974-021-02354-1","volume":"19","author":"CF Craig","year":"2022","unstructured":"Craig CF, Filippone RT, Stavely R, Bornstein JC, Apostolopoulos V, Nurgali K (2022) Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease. J Neuroinflammation 19:4. https:\/\/doi.org\/10.1186\/s12974-021-02354-1","journal-title":"J Neuroinflammation"},{"key":"3011_CR13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1054\/npep.2000.0819","volume":"34","author":"C Cutrufo","year":"2000","unstructured":"Cutrufo C, Evangelista S, Cirillo R, Ciucci A, Conte B, Lopez G, Manzini S, Maggi CA (2000) Protective effect of the tachykinin NK2 receptor antagonist nepadutant in acute rectocolitis induced by diluted acetic acid in guinea-pigs. Neuropeptides 34:355\u2013359. https:\/\/doi.org\/10.1054\/npep.2000.0819","journal-title":"Neuropeptides"},{"key":"3011_CR14","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.physbeh.2006.01.019","volume":"87","author":"LF da Silva","year":"2006","unstructured":"da Silva LF, Menescal-de-Oliveira L (2006) Cholinergic modulation of tonic immobility and nociception in the NRM of guinea pig. Physiol Behav 87:821\u2013827. https:\/\/doi.org\/10.1016\/j.physbeh.2006.01.019","journal-title":"Physiol Behav"},{"key":"3011_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neulet.2012.12.031","volume":"535","author":"LF da Silva","year":"2013","unstructured":"da Silva LF, Coimbra NC, Menescal-de-Oliveira L (2013) Rostral ventromedial medulla connections in Cavia porcellus and their relation with tonic immobility defensive behavior: a biotinylated dextran amine neurotracing study. Neurosci Lett 535:116\u2013121. https:\/\/doi.org\/10.1016\/j.neulet.2012.12.031","journal-title":"Neurosci Lett"},{"key":"3011_CR16","doi-asserted-by":"crossref","unstructured":"de Oliveira L, Hoffmann A, Menescal-de-Oliveira L (1997) The lateral hypothalamus in the modulation of tonic immobility in guinea pigs. NeuroReport 8:3489\u20133493","DOI":"10.1097\/00001756-199711100-00015"},{"key":"3011_CR17","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.bbi.2019.05.007","volume":"80","author":"E Dempsey","year":"2019","unstructured":"Dempsey E, Abautret-Daly A, Docherty NG, Medina C, Harkin A (2019) Persistent central inflammation and region specific cellular activation accompany depression- and anxiety-like behaviours during the resolution phase of experimental colitis. Brain Behav Immun 80:616\u2013632. https:\/\/doi.org\/10.1016\/j.bbi.2019.05.007","journal-title":"Brain Behav Immun"},{"key":"3011_CR18","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jpsychires.2009.05.010","volume":"43","author":"FS Dhabhar","year":"2009","unstructured":"Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM (2009) Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression. J Psychiatr Res 43:962\u2013969. https:\/\/doi.org\/10.1016\/j.jpsychires.2009.05.010","journal-title":"J Psychiatr Res"},{"key":"3011_CR19","doi-asserted-by":"publisher","first-page":"422","DOI":"10.9758\/cpn.2018.16.4.422","volume":"16","author":"J Do","year":"2018","unstructured":"Do J, Woo J (2018) From gut to brain: alteration in inflammation markers in the brain of dextran sodium sulfate-induced colitis model mice. Clin Psychopharmacol Neurosci 16:422\u2013433. https:\/\/doi.org\/10.9758\/cpn.2018.16.4.422","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"3011_CR20","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.4049\/jimmunol.160.4.1944","volume":"160","author":"LC Ehrlich","year":"1998","unstructured":"Ehrlich LC, Hu S, Sheng WS, Sutton RL, Rockswold GL, Peterson PK, Chao CC (1998) Cytokine regulation of human microglial cell IL-8 production. J Immunol 160:1944\u20131948","journal-title":"J Immunol"},{"key":"3011_CR21","doi-asserted-by":"publisher","first-page":"15952","DOI":"10.1523\/JNEUROSCI.1609-13.2013","volume":"33","author":"LN Eidson","year":"2013","unstructured":"Eidson LN, Murphy AZ (2013) Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. J Neurosci 33:15952\u201315963. https:\/\/doi.org\/10.1523\/JNEUROSCI.1609-13.2013","journal-title":"J Neurosci"},{"key":"3011_CR22","doi-asserted-by":"publisher","unstructured":"El-Akabawy G, El-Sherif NM (2019) Zeaxanthin exerts protective effects on acetic acid-induced colitis in rats via modulation of pro-inflammatory cytokines and oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 111:841\u2013851. https:\/\/doi.org\/10.1016\/j.biopha.2019.01.001","DOI":"10.1016\/j.biopha.2019.01.001"},{"key":"3011_CR23","doi-asserted-by":"publisher","first-page":"G989","DOI":"10.1152\/ajpgi.00086.2016","volume":"310","author":"JR Emge","year":"2016","unstructured":"Emge JR, Huynh K, Miller EN, Kaur M, Reardon C, Barrett KE, Gareau MG (2016) Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 310:G989-998. https:\/\/doi.org\/10.1152\/ajpgi.00086.2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3011_CR24","doi-asserted-by":"publisher","first-page":"706439","DOI":"10.3389\/fphar.2021.706439","volume":"12","author":"AM Espinosa-Oliva","year":"2021","unstructured":"Espinosa-Oliva AM, Garcia-Miranda P, Alonso-Bellido IM, Carvajal AE, Gonzalez-Rodriguez M, Carrillo-Jimenez A, Temblador AJ, Felices-Navarro M, Garcia-Dominguez I, Roca-Ceballos MA, Vazquez-Carretero MD, Garcia-Revilla J, Santiago M, Peral MJ, Venero JL, de Pablos RM (2021) Galectin-3 deletion reduces LPS and acute colitis-induced pro-inflammatory microglial activation in the ventral mesencephalon. Front Pharmacol 12:706439. https:\/\/doi.org\/10.3389\/fphar.2021.706439","journal-title":"Front Pharmacol"},{"key":"3011_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1159\/000129209","volume":"24","author":"R Fabia","year":"1992","unstructured":"Fabia R, Willen R, Ar\u2019Rajab A, Andersson R, Ahren B, Bengmark S (1992) Acetic acid-induced colitis in the rat: a reproducible experimental model for acute ulcerative colitis. European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes 24:211\u2013225. https:\/\/doi.org\/10.1159\/000129209","journal-title":"European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes"},{"key":"3011_CR26","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1136\/gutjnl-2021-325985","volume":"71","author":"KM Fairbrass","year":"2022","unstructured":"Fairbrass KM, Lovatt J, Barberio B, Yuan Y, Gracie DJ, Ford AC (2022) Bidirectional brain-gut axis effects influence mood and prognosis in IBD: a systematic review and meta-analysis. Gut 71:1773\u20131780. https:\/\/doi.org\/10.1136\/gutjnl-2021-325985","journal-title":"Gut"},{"key":"3011_CR27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fnhum.2019.00107","volume":"13","author":"W Fan","year":"2019","unstructured":"Fan W, Zhang S, Hu J, Liu B, Wen L, Gong M, Wang G, Yang L, Chen Y, Chen H, Guo H, Zhang D (2019) Aberrant brain function in active-stage ulcerative colitis patients: a resting-state functional MRI study. Front Hum Neurosci 13:107. https:\/\/doi.org\/10.3389\/fnhum.2019.00107","journal-title":"Front Hum Neurosci"},{"key":"3011_CR28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","volume":"246","author":"JC Felger","year":"2013","unstructured":"Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199\u2013229. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.04.060","journal-title":"Neuroscience"},{"key":"3011_CR29","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.physbeh.2012.01.005","volume":"106","author":"MD Ferreira","year":"2012","unstructured":"Ferreira MD, Menescal-de-Oliveira L (2012) Opioidergic, GABAergic and serotonergic neurotransmission in the dorsal raphe nucleus modulates tonic immobility in guinea pigs. Physiol Behav 106:109\u2013116. https:\/\/doi.org\/10.1016\/j.physbeh.2012.01.005","journal-title":"Physiol Behav"},{"key":"3011_CR30","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","volume":"50","author":"M Friedrich","year":"2019","unstructured":"Friedrich M, Pohin M, Powrie F (2019) Cytokine networks in the pathophysiology of inflammatory bowel disease. Immunity 50:992\u20131006. https:\/\/doi.org\/10.1016\/j.immuni.2019.03.017","journal-title":"Immunity"},{"key":"3011_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.isci.2019.05.012","volume":"16","author":"VM Gadotti","year":"2019","unstructured":"Gadotti VM, Andonegui G, Zhang Z, M\u2019Dahoma S, Baggio CH, Chen L, Basso L, Altier C, MacNaughton WK, Kubes P, Zamponi GW (2019) Neuroimmune responses mediate depression-related behaviors following acute colitis. iScience 16:12\u201321. https:\/\/doi.org\/10.1016\/j.isci.2019.05.012","journal-title":"iScience"},{"key":"3011_CR32","doi-asserted-by":"publisher","unstructured":"Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S (2016) Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. eLife 5. https:\/\/doi.org\/10.7554\/eLife.14137","DOI":"10.7554\/eLife.14137"},{"key":"3011_CR33","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/ibd.20873","volume":"15","author":"LA Graff","year":"2009","unstructured":"Graff LA, Walker JR, Bernstein CN (2009) Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management. Inflamm Bowel Dis 15:1105\u20131118. https:\/\/doi.org\/10.1002\/ibd.20873","journal-title":"Inflamm Bowel Dis"},{"key":"3011_CR34","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.cgh.2006.09.027","volume":"4","author":"LA Graff","year":"2006","unstructured":"Graff LA, Walker JR, Lix L, Clara I, Rawsthorne P, Rogala L, Miller N, Jakul L, McPhail C, Ediger J, Bernstein CN (2006) The relationship of inflammatory bowel disease type and activity to psychological functioning and quality of life. Clin Gastroenterol Hepatol 4:1491\u20131501. https:\/\/doi.org\/10.1016\/j.cgh.2006.09.027","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3011_CR35","unstructured":"Guide for the care and use of laboratory animals: eighth edition (2011). The National Academies Press,"},{"key":"3011_CR36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejphar.2009.03.076","volume":"612","author":"JY Guo","year":"2009","unstructured":"Guo JY, Li CY, Ruan YP, Sun M, Qi XL, Zhao BS, Luo F (2009) Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain. Eur J Pharmacol 612:54\u201360. https:\/\/doi.org\/10.1016\/j.ejphar.2009.03.076","journal-title":"Eur J Pharmacol"},{"key":"3011_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2005.04.086","volume":"1048","author":"M Hassanain","year":"2005","unstructured":"Hassanain M, Bhatt S, Zalcman S, Siegel A (2005) Potentiating role of interleukin-1beta (IL-1beta) and IL-1beta type 1 receptors in the medial hypothalamus in defensive rage behavior in the cat. Brain Res 1048:1\u201311. https:\/\/doi.org\/10.1016\/j.brainres.2005.04.086","journal-title":"Brain Res"},{"key":"3011_CR38","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.bbi.2010.10.020","volume":"25","author":"S Heinisch","year":"2011","unstructured":"Heinisch S, Palma J, Kirby LG (2011) Interactions between chemokine and mu-opioid receptors: anatomical findings and electrophysiological studies in the rat periaqueductal grey. Brain Behav Immun 25:360\u2013372. https:\/\/doi.org\/10.1016\/j.bbi.2010.10.020","journal-title":"Brain Behav Immun"},{"key":"3011_CR39","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.pain.2004.04.026","volume":"110","author":"MM Heinricher","year":"2004","unstructured":"Heinricher MM, Martenson ME, Neubert MJ (2004) Prostaglandin E2 in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla. Pain 110:419\u2013426. https:\/\/doi.org\/10.1016\/j.pain.2004.04.026","journal-title":"Pain"},{"key":"3011_CR40","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1038\/nn.3480","volume":"16","author":"DJ Hermanson","year":"2013","unstructured":"Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S (2013) Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. Nat Neurosci 16:1291\u20131298. https:\/\/doi.org\/10.1038\/nn.3480","journal-title":"Nat Neurosci"},{"key":"3011_CR41","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","volume":"12","author":"IC Hoogland","year":"2015","unstructured":"Hoogland IC, Houbolt C, van Westerloo DJ, van Gool WA, van de Beek D (2015) Systemic inflammation and microglial activation: systematic review of animal experiments. J Neuroinflammation 12:114. https:\/\/doi.org\/10.1186\/s12974-015-0332-6","journal-title":"J Neuroinflammation"},{"issue":"Suppl 1","key":"3011_CR42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000051906","volume":"63","author":"K Ishizuka","year":"2001","unstructured":"Ishizuka K, Sugimura K, Homma T, Matsuzawa J, Mochizuki T, Kobayashi M, Suzuki K, Otsuka K, Tashiro K, Yamaguchi O, Asakura H (2001) Influence of interleukin-10 on the interleukin-1 receptor antagonist\/interleukin-1 beta ratio in the colonic mucosa of ulcerative colitis. Digestion 63(Suppl 1):22\u201327. https:\/\/doi.org\/10.1159\/000051906","journal-title":"Digestion"},{"key":"3011_CR43","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1073\/pnas.93.6.2317","volume":"93","author":"WE Kaufmann","year":"1996","unstructured":"Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P (1996) COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci USA 93:2317\u20132321. https:\/\/doi.org\/10.1073\/pnas.93.6.2317","journal-title":"Proc Natl Acad Sci USA"},{"key":"3011_CR44","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1210\/endo.139.5.5982","volume":"139","author":"MC Keightley","year":"1998","unstructured":"Keightley MC, Curtis AJ, Chu S, Fuller PJ (1998) Structural determinants of cortisol resistance in the guinea pig glucocorticoid receptor. Endocrinology 139:2479\u20132485. https:\/\/doi.org\/10.1210\/endo.139.5.5982","journal-title":"Endocrinology"},{"key":"3011_CR45","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/B978-0-12-512504-8.50011-1","volume":"4","author":"WR Klemm","year":"1971","unstructured":"Klemm WR (1971) Neurophysiologic studies of the immobility reflex (\u201canimal hypnosis\u201d). Neurosci Res (N Y) 4:165\u2013212","journal-title":"Neurosci Res (N Y)"},{"key":"3011_CR46","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/ecco-jcc\/jjy035","volume":"12","author":"PJ Koelink","year":"2018","unstructured":"Koelink PJ, Wildenberg ME, Stitt LW, Feagan BG, Koldijk M, van \u2019t Wout AB, Atreya R, Vieth M, Brandse JF, Duijst S, Te Velde AA, D\u2019Haens G, Levesque BG, van den Brink GR, (2018) Development of reliable, valid and responsive scoring systems for endoscopy and histology in animal models for inflammatory bowel disease. J Crohns Colitis 12:794\u2013803. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjy035","journal-title":"J Crohns Colitis"},{"key":"3011_CR47","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/HRP.0000000000000065","volume":"23","author":"K Kozlowska","year":"2015","unstructured":"Kozlowska K, Walker P, McLean L, Carrive P (2015) Fear and the defense cascade: clinical implications and management. Harv Rev Psychiatry 23:263\u2013287. https:\/\/doi.org\/10.1097\/HRP.0000000000000065","journal-title":"Harv Rev Psychiatry"},{"key":"3011_CR48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41398-021-01268-z","volume":"11","author":"JL Kruse","year":"2021","unstructured":"Kruse JL, Vasavada MM, Olmstead R, Hellemann G, Wade B, Breen EC, Brooks JO, Congdon E, Espinoza R, Narr KL, Irwin MR (2021) Depression treatment response to ketamine: sex-specific role of interleukin-8, but not other inflammatory markers. Transl Psychiatry 11:167. https:\/\/doi.org\/10.1038\/s41398-021-01268-z","journal-title":"Transl Psychiatry"},{"key":"3011_CR49","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/s0165-0327(00)00182-8","volume":"63","author":"M Kubera","year":"2001","unstructured":"Kubera M, Maes M, Holan V, Basta-Kaim A, Roman A, Shani J (2001) Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL\/6 mice subjected to the chronic mild stress model of depression. J Affect Disord 63:171\u2013178. https:\/\/doi.org\/10.1016\/s0165-0327(00)00182-8","journal-title":"J Affect Disord"},{"key":"3011_CR50","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00228-012-1389-0","volume":"69","author":"D Lacruz-Guzman","year":"2013","unstructured":"Lacruz-Guzman D, Torres-Moreno D, Pedrero F, Romero-Cara P, Garcia-Tercero I, Trujillo-Santos J, Conesa-Zamora P (2013) Influence of polymorphisms and TNF and IL1beta serum concentration on the infliximab response in Crohn\u2019s disease and ulcerative colitis. Eur J Clin Pharmacol 69:431\u2013438. https:\/\/doi.org\/10.1007\/s00228-012-1389-0","journal-title":"Eur J Clin Pharmacol"},{"key":"3011_CR51","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.bja.2017.11.103","volume":"120","author":"QB Li","year":"2018","unstructured":"Li QB, Chang L, Ye F, Luo QH, Tao YX, Shu HH (2018) Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats. Br J Anaesth 120:827\u2013835. https:\/\/doi.org\/10.1016\/j.bja.2017.11.103","journal-title":"Br J Anaesth"},{"key":"3011_CR52","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jpsychires.2009.08.005","volume":"44","author":"AA Lima","year":"2010","unstructured":"Lima AA, Fiszman A, Marques-Portella C, Mendlowicz MV, Coutinho ES, Maia DC, Berger W, Rocha-Rego V, Volchan E, Mari JJ, Figueira I (2010) The impact of tonic immobility reaction on the prognosis of posttraumatic stress disorder. J Psychiatr Res 44:224\u2013228. https:\/\/doi.org\/10.1016\/j.jpsychires.2009.08.005","journal-title":"J Psychiatr Res"},{"key":"3011_CR53","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.2147\/DDDT.S40107","volume":"7","author":"D Low","year":"2013","unstructured":"Low D, Nguyen DD, Mizoguchi E (2013) Animal models of ulcerative colitis and their application in drug research. Drug Des Dev Ther 7:1341\u20131357. https:\/\/doi.org\/10.2147\/DDDT.S40107","journal-title":"Drug Des Dev Ther"},{"key":"3011_CR54","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/s0006-8993(00)03124-3","volume":"889","author":"Y Lu","year":"2001","unstructured":"Lu Y, Westlund KN (2001) Effects of baclofen on colon inflammation-induced Fos, CGRP and SP expression in spinal cord and brainstem. Brain Res 889:118\u2013130. https:\/\/doi.org\/10.1016\/s0006-8993(00)03124-3","journal-title":"Brain Res"},{"key":"3011_CR55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainresbull.2022.02.002","volume":"182","author":"OA Lyubashina","year":"2022","unstructured":"Lyubashina OA, Sivachenko IB, Mikhalkin AA (2022) Impaired visceral pain-related functions of the midbrain periaqueductal gray in rats with colitis. Brain Res Bull 182:12\u201325. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.02.002","journal-title":"Brain Res Bull"},{"key":"3011_CR56","doi-asserted-by":"publisher","first-page":"16066","DOI":"10.1073\/pnas.0504908102","volume":"102","author":"Y Matsuoka","year":"2005","unstructured":"Matsuoka Y, Furuyashiki T, Yamada K, Nagai T, Bito H, Tanaka Y, Kitaoka S, Ushikubi F, Nabeshima T, Narumiya S (2005) Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proc Natl Acad Sci USA 102:16066\u201316071. https:\/\/doi.org\/10.1073\/pnas.0504908102","journal-title":"Proc Natl Acad Sci USA"},{"key":"3011_CR57","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.bbr.2010.01.040","volume":"209","author":"R Medeiros","year":"2010","unstructured":"Medeiros R, Figueiredo CP, Pandolfo P, Duarte FS, Prediger RD, Passos GF, Calixto JB (2010) The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide. Behav Brain Res 209:165\u2013173. https:\/\/doi.org\/10.1016\/j.bbr.2010.01.040","journal-title":"Behav Brain Res"},{"key":"3011_CR58","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1210\/endo.139.4.5917","volume":"139","author":"OC Meijer","year":"1998","unstructured":"Meijer OC, de Lange EC, Breimer DD, de Boer AG, Workel JO, de Kloet ER (1998) Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139:1789\u20131793. https:\/\/doi.org\/10.1210\/endo.139.4.5917","journal-title":"Endocrinology"},{"key":"3011_CR59","doi-asserted-by":"crossref","unstructured":"Menescal-de-Oliveira L, Hoffmann A (1993) The parabrachial region as a possible region modulating simultaneously pain and tonic immobility. Behav Brain Res 56:127\u2013132","DOI":"10.1016\/0166-4328(93)90030-T"},{"key":"3011_CR60","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jpsychires.2008.02.004","volume":"43","author":"AR Mesquita","year":"2008","unstructured":"Mesquita AR, Correia-Neves M, Roque S, Castro AG, Vieira P, Pedrosa J, Palha JA, Sousa N (2008) IL-10 modulates depressive-like behavior. J Psychiatr Res 43:89\u201397. https:\/\/doi.org\/10.1016\/j.jpsychires.2008.02.004","journal-title":"J Psychiatr Res"},{"key":"3011_CR61","first-page":"721","volume":"68","author":"J Mokry","year":"2017","unstructured":"Mokry J, Urbanova A, Medvedova I, Kertys M, Mikolka P, Kosutova P, Mokra D (2017) Effects of tadalafil (PDE5 inhibitor) and roflumilast (PDE4 inhibitor) on airway reactivity and markers of inflammation in ovalbumin-induced airway hyperresponsiveness in guinea pigs. J Physiol Pharmacol 68:721\u2013730","journal-title":"J Physiol Pharmacol"},{"key":"3011_CR62","doi-asserted-by":"crossref","unstructured":"Monassi CR, Hoffmann A, Menescal-de-Oliveira L (1997) Involvement of the cholinergic system and periaqueductal gray matter in the modulation of tonic immobility in the guinea pig. Physiol Behav 62:53\u201359","DOI":"10.1016\/S0031-9384(97)00134-0"},{"key":"3011_CR63","doi-asserted-by":"crossref","unstructured":"Monassi CR, Leite-Panissi CR, Menescal-de-Oliveira L (1999) Ventrolateral periaqueductal gray matter and the control of tonic immobility. Brain Res Bull 50:201\u2013208","DOI":"10.1016\/S0361-9230(99)00192-6"},{"key":"3011_CR64","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.brainres.2004.02.061","volume":"1009","author":"CR Monassi","year":"2004","unstructured":"Monassi CR, Menescal-de-Oliveira L (2004) Serotonin 5-HT2 and 5-HT1A receptors in the periaqueductal gray matter differentially modulate tonic immobility in guinea pig. Brain Res 1009:169\u2013180. https:\/\/doi.org\/10.1016\/j.brainres.2004.02.061","journal-title":"Brain Res"},{"key":"3011_CR65","doi-asserted-by":"publisher","first-page":"112024","DOI":"10.1016\/j.bbr.2019.112024","volume":"372","author":"S Munshi","year":"2019","unstructured":"Munshi S, Parrilli V, Rosenkranz JA (2019) Peripheral anti-inflammatory cytokine Interleukin-10 treatment mitigates interleukin-1beta - induced anxiety and sickness behaviors in adult male rats. Behav Brain Res 372:112024. https:\/\/doi.org\/10.1016\/j.bbr.2019.112024","journal-title":"Behav Brain Res"},{"key":"3011_CR66","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-2982.2005.00654.x","volume":"17","author":"SS Natah","year":"2005","unstructured":"Natah SS, Mouihate A, Pittman QJ, Sharkey KA (2005) Disruption of the blood-brain barrier during TNBS colitis. Neurogastroenterol Motil 17:433\u2013446. https:\/\/doi.org\/10.1111\/j.1365-2982.2005.00654.x","journal-title":"Neurogastroenterol Motil"},{"key":"3011_CR67","doi-asserted-by":"publisher","first-page":"101952","DOI":"10.1016\/j.pneurobio.2020.101952","volume":"199","author":"RR Patel","year":"2021","unstructured":"Patel RR, Wolfe SA, Bajo M, Abeynaike S, Pahng A, Borgonetti V, D\u2019Ambrosio S, Nikzad R, Edwards S, Paust S, Roberts AJ, Roberto M (2021) IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. Prog Neurobiol 199:101952. https:\/\/doi.org\/10.1016\/j.pneurobio.2020.101952","journal-title":"Prog Neurobiol"},{"key":"3011_CR68","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1152\/jn.00251.2021","volume":"126","author":"D Pati","year":"2021","unstructured":"Pati D, Kash TL (2021) Tumor necrosis factor-alpha modulates GABAergic and dopaminergic neurons in the ventrolateral periaqueductal gray of female mice. J Neurophysiol 126:2119\u20132129. https:\/\/doi.org\/10.1152\/jn.00251.2021","journal-title":"J Neurophysiol"},{"key":"3011_CR69","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/s41598-017-01169-6","volume":"7","author":"X Peng","year":"2017","unstructured":"Peng X, Li J, Tan S, Xu M, Tao J, Jiang J, Liu H, Wu B (2017) COX-1\/PGE(2)\/EP4 alleviates mucosal injury by upregulating beta-arr1-mediated Akt signaling in colitis. Sci Rep 7:1055. https:\/\/doi.org\/10.1038\/s41598-017-01169-6","journal-title":"Sci Rep"},{"key":"3011_CR70","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.physbeh.2008.02.013","volume":"94","author":"M Ramos Coutinho","year":"2008","unstructured":"Ramos Coutinho M, da Silva LF, Menescal-de-Oliveira L (2008) Modulation of tonic immobility in guinea pig PAG by homocysteic acid, a glutamate agonist. Physiol Behav 94:468\u2013473. https:\/\/doi.org\/10.1016\/j.physbeh.2008.02.013","journal-title":"Physiol Behav"},{"key":"3011_CR71","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/apha.12729","volume":"218","author":"AB Ribeiro","year":"2016","unstructured":"Ribeiro AB, de Barcellos-Filho PC, Franci CR, Menescal-de-Oliveira L, Saia RS (2016) Pro-inflammatory cytokines, IL-1beta and TNF-alpha, produce persistent compromise in tonic immobility defensive behaviour in endotoxemia guinea-pigs. Acta Physiol 218:123\u2013135. https:\/\/doi.org\/10.1111\/apha.12729","journal-title":"Acta Physiol"},{"key":"3011_CR72","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1002\/ibd.22865","volume":"18","author":"ML Rodriguez-Peralvarez","year":"2012","unstructured":"Rodriguez-Peralvarez ML, Garcia-Sanchez V, Villar-Pastor CM, Gonzalez R, Iglesias-Flores E, Muntane J, Gomez-Camacho F (2012) Role of serum cytokine profile in ulcerative colitis assessment. Inflamm Bowel Dis 18:1864\u20131871. https:\/\/doi.org\/10.1002\/ibd.22865","journal-title":"Inflamm Bowel Dis"},{"key":"3011_CR73","doi-asserted-by":"publisher","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","volume":"114","author":"DT Rubin","year":"2019","unstructured":"Rubin DT, Ananthakrishnan AN, Siegel CA, Sauer BG, Long MD (2019) ACG Clinical Guideline: ulcerative colitis in adults. Am J Gastroenterol 114:384\u2013413. https:\/\/doi.org\/10.14309\/ajg.0000000000000152","journal-title":"Am J Gastroenterol"},{"key":"3011_CR74","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/bdd.435","volume":"26","author":"MN Samtani","year":"2005","unstructured":"Samtani MN, Jusko WJ (2005) Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration. Biopharm Drug Dispos 26:85\u201391. https:\/\/doi.org\/10.1002\/bdd.435","journal-title":"Biopharm Drug Dispos"},{"key":"3011_CR75","doi-asserted-by":"publisher","unstructured":"Shin MC, Jang MH, Chang HK, Kim YJ, Kim EH, Kim CJ (2003) Modulation of cyclooxygenase-2 on glycine- and glutamate-induced ion currents in rat periaqueductal gray neurons. Brain Res Bull 59:251\u2013256. https:\/\/doi.org\/10.1016\/S0361-9230(02)00872-9","DOI":"10.1016\/S0361-9230(02)00872-9"},{"key":"3011_CR76","doi-asserted-by":"publisher","first-page":"175628482110337","DOI":"10.1177\/17562848211033763","volume":"14","author":"AR Siebenhuner","year":"2021","unstructured":"Siebenhuner AR, Rossel JB, Schreiner P, Butter M, Greuter T, Krupka N, Jordi SBU, Biedermann L, Rogler G, Misselwitz B, von Kanel R (2021) Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis. Ther Adv Gastroenterol 14:17562848211033764. https:\/\/doi.org\/10.1177\/17562848211033763","journal-title":"Ther Adv Gastroenterol"},{"key":"3011_CR77","doi-asserted-by":"publisher","first-page":"20217","DOI":"10.1038\/s41598-019-56859-0","volume":"9","author":"HM Sroor","year":"2019","unstructured":"Sroor HM, Hassan AM, Zenz G, Valadez-Cosmes P, Farzi A, Holzer P, El-Sharif A, Gomaa FAM, Kargl J, Reichmann F (2019) Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers. Sci Rep 9:20217. https:\/\/doi.org\/10.1038\/s41598-019-56859-0","journal-title":"Sci Rep"},{"key":"3011_CR78","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jneuroim.2008.11.007","volume":"207","author":"S Sugama","year":"2009","unstructured":"Sugama S, Takenouchi T, Fujita M, Conti B, Hashimoto M (2009) Differential microglial activation between acute stress and lipopolysaccharide treatment. J Neuroimmunol 207:24\u201331. https:\/\/doi.org\/10.1016\/j.jneuroim.2008.11.007","journal-title":"J Neuroimmunol"},{"key":"3011_CR79","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00005-009-0031-z","volume":"57","author":"A Szkaradkiewicz","year":"2009","unstructured":"Szkaradkiewicz A, Marciniak R, Chudzicka-Strugala I, Wasilewska A, Drews M, Majewski P, Karpinski T, Zwozdziak B (2009) Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients. Arch Immunol Ther Exp 57:291\u2013294. https:\/\/doi.org\/10.1007\/s00005-009-0031-z","journal-title":"Arch Immunol Ther Exp"},{"key":"3011_CR80","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12974-019-1580-7","volume":"16","author":"K Takahashi","year":"2019","unstructured":"Takahashi K, Nakagawasai O, Nemoto W, Odaira T, Sakuma W, Onogi H, Nishijima H, Furihata R, Nemoto Y, Iwasa H, Tan-No K, Tadano T (2019) Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain-gut axis. J Neuroinflammation 16:201. https:\/\/doi.org\/10.1186\/s12974-019-1580-7","journal-title":"J Neuroinflammation"},{"key":"3011_CR81","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1177\/0023677219883319","volume":"54","author":"SR Talbot","year":"2020","unstructured":"Talbot SR, Biernot S, Bleich A, van Dijk RM, Ernst L, Hager C, Helgers SOA, Koegel B, Koska I, Kuhla A, Miljanovic N, Muller-Graff FT, Schwabe K, Tolba R, Vollmar B, Weegh N, Wolk T, Wolf F, Wree A, Zieglowski L, Potschka H, Zechner D (2020) Defining body-weight reduction as a humane endpoint: a critical appraisal. Lab Anim 54:99\u2013110. https:\/\/doi.org\/10.1177\/0023677219883319","journal-title":"Lab Anim"},{"key":"3011_CR82","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s12974-021-02317-6","volume":"18","author":"S Talley","year":"2021","unstructured":"Talley S, Valiauga R, Anderson L, Cannon AR, Choudhry MA, Campbell EM (2021) DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod. J Neuroinflammation 18:263. https:\/\/doi.org\/10.1186\/s12974-021-02317-6","journal-title":"J Neuroinflammation"},{"key":"3011_CR83","doi-asserted-by":"publisher","unstructured":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017 (2020). The lancet Gastroenterology & hepatology 5:17\u201330. https:\/\/doi.org\/10.1016\/S2468-1253(19)30333-4","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"3011_CR84","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.2147\/JIR.S355669","volume":"15","author":"Z Tian","year":"2022","unstructured":"Tian Z, Shofer FS, Sandroni AZ, Zhao L, Scanzello CR, Zhang Y (2022) Expression of human interleukin 8 in mice alters their natural behaviors. J Inflamm Res 15:2413\u20132424. https:\/\/doi.org\/10.2147\/JIR.S355669","journal-title":"J Inflamm Res"},{"key":"3011_CR85","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/glia.23961","volume":"69","author":"AD Umpierre","year":"2021","unstructured":"Umpierre AD, Wu LJ (2021) How microglia sense and regulate neuronal activity. Glia 69:1637\u20131653. https:\/\/doi.org\/10.1002\/glia.23961","journal-title":"Glia"},{"key":"3011_CR86","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/s41386-020-00939-7","volume":"46","author":"HA Vecchiarelli","year":"2021","unstructured":"Vecchiarelli HA, Morena M, Keenan CM, Chiang V, Tan K, Qiao M, Leitl K, Santori A, Pittman QJ, Sharkey KA, Hill MN (2021) Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase. Neuropsychopharmacol 46:992\u20131003. https:\/\/doi.org\/10.1038\/s41386-020-00939-7","journal-title":"Neuropsychopharmacol"},{"key":"3011_CR87","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.bbr.2010.07.013","volume":"216","author":"EB Vieira","year":"2011","unstructured":"Vieira EB, Menescal-de-Oliveira L, Leite-Panissi CR (2011) Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs. Behav Brain Res 216:94\u201399. https:\/\/doi.org\/10.1016\/j.bbr.2010.07.013","journal-title":"Behav Brain Res"},{"key":"3011_CR88","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1111\/j.1572-0241.2008.01980.x","volume":"103","author":"JR Walker","year":"2008","unstructured":"Walker JR, Ediger JP, Graff LA, Greenfeld JM, Clara I, Lix L, Rawsthorne P, Miller N, Rogala L, McPhail CM, Bernstein CN (2008) The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders. Am J Gastroenterol 103:1989\u20131997. https:\/\/doi.org\/10.1111\/j.1572-0241.2008.01980.x","journal-title":"Am J Gastroenterol"},{"key":"3011_CR89","doi-asserted-by":"publisher","first-page":"7850324","DOI":"10.1155\/2019\/7850324","volume":"2019","author":"G Wang","year":"2019","unstructured":"Wang G, Xu B, Shi F, Du M, Li Y, Yu T, Chen L (2019) Protective effect of methane-rich saline on acetic acid-induced ulcerative colitis via blocking the TLR4\/NF-kappaB\/MAPK pathway and promoting IL-10\/JAK1\/STAT3-mediated anti-inflammatory response. Oxid Med Cell Longev 2019:7850324. https:\/\/doi.org\/10.1155\/2019\/7850324","journal-title":"Oxid Med Cell Longev"},{"key":"3011_CR90","doi-asserted-by":"publisher","first-page":"R281","DOI":"10.1152\/ajpregu.00279.2002","volume":"283","author":"World Medical Association","year":"2002","unstructured":"World Medical Association (2002) Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283:R281-283. https:\/\/doi.org\/10.1152\/ajpregu.00279.2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"3011_CR91","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12974-020-01922-1","volume":"17","author":"RJ Worthen","year":"2020","unstructured":"Worthen RJ, Garzon Zighelboim SS, Torres Jaramillo CS, Beurel E (2020) Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice. J Neuroinflammation 17:246. https:\/\/doi.org\/10.1186\/s12974-020-01922-1","journal-title":"J Neuroinflammation"},{"key":"3011_CR92","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/ibd\/izab252","volume":"28","author":"S Zhang","year":"2022","unstructured":"Zhang S, Chen F, Wu J, Liu C, Yang G, Piao R, Geng B, Xu K, Liu P (2022) Regional gray matter volume changes in brains of patients with ulcerative colitis. Inflamm Bowel Dis 28:599\u2013610. https:\/\/doi.org\/10.1093\/ibd\/izab252","journal-title":"Inflamm Bowel Dis"},{"key":"3011_CR93","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12974-015-0281-0","volume":"12","author":"S Zonis","year":"2015","unstructured":"Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V (2015) Chronic intestinal inflammation alters hippocampal neurogenesis. J Neuroinflammation 12:65. https:\/\/doi.org\/10.1186\/s12974-015-0281-0","journal-title":"J Neuroinflammation"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-024-03011-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-024-03011-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-024-03011-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T18:07:47Z","timestamp":1728410867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-024-03011-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":93,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["3011"],"URL":"https:\/\/doi.org\/10.1007\/s00424-024-03011-1","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"type":"print","value":"0031-6768"},{"type":"electronic","value":"1432-2013"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"30 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}