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Signaling occurs by engaging five G protein-coupled receptors (S1P<jats:sub>1-5<\/jats:sub>) or intracellular pathways. While the extensively studied S1P\u00a0with a chain length of 18 carbon atoms (d18:1 S1P)\u00a0affects lymphocyte trafficking, immune cell survival and inflammatory responses, the biological implication of atypical S1Ps such as d16:1 or d20:1 remains elusive. As S1P lipids have far-reaching implications in health and disease states in mammalian organisms, the previous contrasting results may be attributed to differences in S1P\u2019s alkyl chain length. Current research is beginning to appreciate these less abundant atypical S1P moieties. 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