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Previous work has shown that deletion of S1P lyase caused a chronic elevation of cytosolic [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and enhanced Ca<jats:sup>2+<\/jats:sup> storage in mouse embryonic fibroblasts. Here, we studied the role of sphingosine kinase (SphK)-1 in Ca<jats:sup>2+<\/jats:sup> signaling, using two independently generated EA.hy926 cell lines with stable knockdown of SphK1 (SphK1-KD1\/2). Resting [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and thapsigargin-induced [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> increases were reduced in both SphK1-KD1 and -KD2 cells. Agonist-induced [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> increases, measured in SphK1-KD1, were blunted. In the absence of extracellular Ca<jats:sup>2+<\/jats:sup>, thapsigargin-induced [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> increases declined rapidly, indicating enhanced removal of Ca<jats:sup>2+<\/jats:sup> from the cytosol. In agreement, plasma membrane Ca<jats:sup>2+<\/jats:sup> ATPase (PMCA)-1 and -4 and their auxiliary subunit, basigin, were strongly upregulated. Activation of S1P-GPCR by specific agonists or extracellular S1P did not rescue the effects of SphK1 knockdown, indicating that S1P-GPCR were not involved. Lipid measurements indicated that not only S1P but also dihydro-sphingosine, ceramides, and lactosylceramides were markedly depleted in SphK1-KD2 cells. SphK2 and S1P lyase were upregulated, suggesting enhanced flux via the sphingolipid degradation pathway. Finally, histone acetylation was enhanced in SphK1-KD2 cells, and the histone deacetylase inhibitor, vorinostat, induced upregulation of PMCA1 and basigin on mRNA and protein levels in EA.hy926 cells. These data show for the first time a transcriptional regulation of PMCA1 and basigin by S1P metabolism. It is concluded that SphK1 knockdown in EA.hy926 cells caused long-term alterations in cellular Ca<jats:sup>2+<\/jats:sup> homeostasis by upregulating PMCA via increased histone acetylation.<\/jats:p>","DOI":"10.1007\/s00424-024-03027-7","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T05:01:54Z","timestamp":1728622914000},"page":"1895-1911","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1"],"prefix":"10.1007","volume":"476","author":[{"given":"Luisa Michelle","family":"Volk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Erik","family":"Bruun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Trautmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Schwalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Pfeilschifter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar Meyer","family":"zu Heringdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"3027_CR1","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nbt.2017","volume":"29","author":"T Anastassiadis","year":"2011","unstructured":"Anastassiadis T, Deacon SW, Devarajan K et al (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. 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