{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:08:27Z","timestamp":1787620107117,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["288034826 - IRTG 2251"],"award-info":[{"award-number":["288034826 - IRTG 2251"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["288034826 - IRTG 2251"],"award-info":[{"award-number":["288034826 - IRTG 2251"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["288034826 - IRTG 2251"],"award-info":[{"award-number":["288034826 - IRTG 2251"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Medicine Carl Gustav Carus of TUD Dresden University of Technology","award":["Carus Promotionskolleg"],"award-info":[{"award-number":["Carus Promotionskolleg"]}]},{"name":"Faculty of Medicine Carl Gustav Carus of TUD Dresden University of Technology","award":["Carus Promotionskolleg"],"award-info":[{"award-number":["Carus Promotionskolleg"]}]},{"name":"TUD Dresden University of Technology","award":["Open Access Funding by Publication Fund"],"award-info":[{"award-number":["Open Access Funding by Publication Fund"]}]},{"DOI":"10.13039\/501100002957","name":"Technische Universit\u00e4t Dresden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gestational diabetes mellitus is one of the most common complications during pregnancy. Its prevalence is rapidly increasing worldwide. Gestational diabetes mellitus is leading to an elevated risk for the development of endothelial dysfunction and cardiovascular diseases both in the mother and the child in later life. The underlying pathophysiological mechanisms are not well-understood. Therefore, we aimed to characterize the endothelial function in fetal placental vessels from mothers with gestational diabetes mellitus. In this study, we distinguished between insulin-treated and diet-controlled gestational diabetes mothers and compared them to a normoglycemic control group. The clinical data confirmed pre-conceptional overweight as a risk factor in women with insulin-treated gestational diabetes mellitus. The insulin-treated gestational diabetes group was also characterized by a recent family history of diabetes compared to mothers of the control or diet-controlled gestational diabetes group. Analyses of blood serum from umbilical cords suggested a reduced fetal insulin metabolism in the insulin-treated gestational diabetes group. Vascular function analysis in fetal placental vessels revealed an altered substance P-induced vasorelaxation in vessels from patients with insulin-dependent gestational diabetes. Inhibition of nitric oxide synthase affected only fetal vessel segments from the control group or diet-controlled gestational diabetes group, but not from insulin-dependent gestational diabetes. Finally, we found a significantly decreased substance P receptor (<jats:italic>TACR1<\/jats:italic>) mRNA expression in fetal vessel segments from patients with insulin-treated gestational diabetes. In conclusion, we provide evidence that different pathophysiological mechanisms might be responsible for the development of insulin-treated versus diet-controlled gestational diabetes. Only in fetal vessels from patients with insulin-treated gestational diabetes were we able to detect an endothelial dysfunction and a reduced fetal insulin conversion. This provides novel insights into the pathophysiology of the subtypes of gestational diabetes.<\/jats:p>","DOI":"10.1007\/s00424-024-03028-6","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T22:02:04Z","timestamp":1728511324000},"page":"67-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of human placental fetal vessels in gestational diabetes mellitus"],"prefix":"10.1007","volume":"477","author":[{"given":"Philine S.","family":"Carstens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-1807","authenticated-orcid":false,"given":"Heike","family":"Brendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Leyre","family":"Villar-Ballesteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mittag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Hengst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coy","family":"Brunssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cahit","family":"Birdir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-2821","authenticated-orcid":false,"given":"Lucilla","family":"Poston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-9736","authenticated-orcid":false,"given":"Henning","family":"Morawietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"3028_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0140-6736(24)00825-0","volume":"404","author":"A Sweeting","year":"2024","unstructured":"Sweeting A, Hannah W, Backman H, Catalano P, Feghali M, Herman WH, Hivert MF, Immanuel J, Meek C, Oppermann ML, Nolan CJ, Ram U, Schmidt MI, Simmons D, Chivese T, Benhalima K (2024) Epidemiology and management of gestational diabetes. Lancet 404:175\u2013192. https:\/\/doi.org\/10.1016\/S0140-6736(24)00825-0","journal-title":"Lancet"},{"key":"3028_CR2","doi-asserted-by":"publisher","first-page":"109050","DOI":"10.1016\/j.diabres.2021.109050","volume":"183","author":"H Wang","year":"2022","unstructured":"Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, Hoegfeldt CA, Elise Powe C, Immanuel J, Karuranga S, Divakar H, Levitt N, Li C, Simmons D, Yang X, IDF Diabetes Atlas Committee Hyperglycaemia in Pregnancy Special Interest Group (2022) IDF diabetes atlas: estimation of global and regional gestational diabetes mellitus prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group\u2019s Criteria. Diabetes Res Clin Pract 183:109050. https:\/\/doi.org\/10.1016\/j.diabres.2021.109050","journal-title":"Diabetes Res Clin Pract"},{"key":"3028_CR3","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.3390\/ijms19113342","volume":"19","author":"JF Plows","year":"2018","unstructured":"Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH (2018) The pathophysiology of gestational diabetes mellitus. Int J Mol Sci 19:3342. https:\/\/doi.org\/10.3390\/ijms19113342","journal-title":"Int J Mol Sci"},{"key":"3028_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000115355","volume":"36","author":"JA Armitage","year":"2008","unstructured":"Armitage JA, Poston L, Taylor PD (2008) Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity. Front Horm Res 36:73\u201384. https:\/\/doi.org\/10.1159\/000115355","journal-title":"Front Horm Res"},{"key":"3028_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13098-015-0038-z","volume":"7","author":"T Vilmi-Kerala","year":"2015","unstructured":"Vilmi-Kerala T, Palomaki O, Vainio M, Uotila J, Palomaki A (2015) The risk of metabolic syndrome after gestational diabetes mellitus - a hospital-based cohort study. Diabetol Metab Syndr 7:43. https:\/\/doi.org\/10.1186\/s13098-015-0038-z","journal-title":"Diabetol Metab Syndr"},{"key":"3028_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","volume":"5","author":"HD McIntyre","year":"2019","unstructured":"McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P (2019) Gestational diabetes mellitus. Nat Rev Dis Primers 5:47. https:\/\/doi.org\/10.1038\/s41572-019-0098-8","journal-title":"Nat Rev Dis Primers"},{"key":"3028_CR7","doi-asserted-by":"publisher","first-page":"1284160","DOI":"10.3389\/fendo.2023.1284160","volume":"14","author":"YP Xie","year":"2023","unstructured":"Xie YP, Lin S, Xie BY, Zhao HF (2023) Recent progress in metabolic reprogramming in gestational diabetes mellitus: a review. Front Endocrinol (Lausanne) 14:1284160. https:\/\/doi.org\/10.3389\/fendo.2023.1284160","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3028_CR8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bpobgyn.2014.04.025","volume":"29","author":"R Gabbay-Benziv","year":"2015","unstructured":"Gabbay-Benziv R, Baschat AA (2015) Gestational diabetes as one of the \u201cgreat obstetrical syndromes\u201d\u2013the maternal, placental, and fetal dialog. Best Pract Res Clin Obstet Gynaecol 29:150\u2013155. https:\/\/doi.org\/10.1016\/j.bpobgyn.2014.04.025","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"3028_CR9","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.3390\/ijms19113665","volume":"19","author":"NA Sallam","year":"2018","unstructured":"Sallam NA, Palmgren VAC, Singh RD, John CM, Thompson JA (2018) Programming of vascular dysfunction in the intrauterine milieu of diabetic pregnancies. Int J Mol Sci 19:3665. https:\/\/doi.org\/10.3390\/ijms19113665","journal-title":"Int J Mol Sci"},{"key":"3028_CR10","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.3390\/antiox12101894","volume":"12","author":"AS Jimenez-Osorio","year":"2023","unstructured":"Jimenez-Osorio AS, Carreon-Torres E, Correa-Solis E, Angel-Garcia J, Arias-Rico J, Jimenez-Garza O, Morales-Castillejos L, Diaz-Zuleta HA, Baltazar-Tellez RM, Sanchez-Padilla ML, Flores-Chavez OR, Estrada-Luna D (2023) Inflammation and oxidative stress induced by obesity, gestational diabetes, and preeclampsia in pregnancy: role of high-density lipoproteins as vectors for bioactive compounds. Antioxidants (Basel) 12:1894. https:\/\/doi.org\/10.3390\/antiox12101894","journal-title":"Antioxidants (Basel)"},{"key":"3028_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3390\/antiox12020281","volume":"12","author":"M Amponsah-Offeh","year":"2023","unstructured":"Amponsah-Offeh M, Diaba-Nuhoho P, Speier S, Morawietz H (2023) Oxidative stress, antioxidants and hypertension. Antioxidants (Basel) 12:281. https:\/\/doi.org\/10.3390\/antiox12020281","journal-title":"Antioxidants (Basel)"},{"key":"3028_CR12","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.3390\/antiox12081589","volume":"12","author":"H Morawietz","year":"2023","unstructured":"Morawietz H, Brendel H, Diaba-Nuhoho P, Catar R, Perakakis N, Wolfrum C, Bornstein SR (2023) Cross-talk of NADPH oxidases and inflammation in obesity. Antioxidants (Basel) 12:1589. https:\/\/doi.org\/10.3390\/antiox12081589","journal-title":"Antioxidants (Basel)"},{"key":"3028_CR13","doi-asserted-by":"publisher","first-page":"e13671","DOI":"10.1111\/apha.13671","volume":"232","author":"M Cornejo","year":"2021","unstructured":"Cornejo M, Fuentes G, Valero P, Vega S, Grismaldo A, Toledo F, Pardo F, Moore-Carrasco R, Subiabre M, Casanello P, Faas MM, van Goor H, Sobrevia L (2021) Gestational diabesity and foetoplacental vascular dysfunction. Acta Physiol (Oxf) 232:e13671. https:\/\/doi.org\/10.1111\/apha.13671","journal-title":"Acta Physiol (Oxf)"},{"key":"3028_CR14","doi-asserted-by":"publisher","first-page":"165414","DOI":"10.1016\/j.bbadis.2019.02.009","volume":"1866","author":"C Echeverria","year":"2020","unstructured":"Echeverria C, Eltit F, Santibanez JF, Gatica S, Cabello-Verrugio C, Simon F (2020) Endothelial dysfunction in pregnancy metabolic disorders. Biochim Biophys Acta Mol Basis Dis 1866:165414. https:\/\/doi.org\/10.1016\/j.bbadis.2019.02.009","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"3028_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-1-4020-9173-5_2","volume":"646","author":"B Koletzko","year":"2009","unstructured":"Koletzko B, von Kries R, Monasterolo RC, Subias JE, Scaglioni S, Giovannini M, Beyer J, Demmelmair H, Anton B, Gruszfeld D, Dobrzanska A, Sengier A, Langhendries JP, Cachera MF, Grote V, European Childhood Obesity Trial Study Group (2009) Infant feeding and later obesity risk. Adv Exp Med Biol 646:15\u201329. https:\/\/doi.org\/10.1007\/978-1-4020-9173-5_2","journal-title":"Adv Exp Med Biol"},{"key":"3028_CR16","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1373\/clinchem.2013.203331","volume":"59","author":"DR Coustan","year":"2013","unstructured":"Coustan DR (2013) Gestational diabetes mellitus. Clin Chem 59:1310\u20131321. https:\/\/doi.org\/10.1373\/clinchem.2013.203331","journal-title":"Clin Chem"},{"key":"3028_CR17","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.2337\/dc11-0268","volume":"34","author":"DK Tobias","year":"2011","unstructured":"Tobias DK, Hu FB, Forman JP, Chavarro J, Zhang C (2011) Increased risk of hypertension after gestational diabetes mellitus: findings from a large prospective cohort study. Diabetes Care 34:1582\u20131584. https:\/\/doi.org\/10.2337\/dc11-0268","journal-title":"Diabetes Care"},{"key":"3028_CR18","doi-asserted-by":"publisher","first-page":"CD012327","DOI":"10.1002\/14651858.CD012327.pub2","volume":"8","author":"R Martis","year":"2018","unstructured":"Martis R, Crowther CA, Shepherd E, Alsweiler J, Downie MR, Brown J (2018) Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 8:CD012327. https:\/\/doi.org\/10.1002\/14651858.CD012327.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"3028_CR19","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45","journal-title":"Nucleic Acids Res"},{"key":"3028_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/metabo12020175","volume":"12","author":"O Hartvigsson","year":"2022","unstructured":"Hartvigsson O, Barman M, Savolainen O, Ross AB, Sandin A, Jacobsson B, Wold AE, Sandberg AS, Brunius C (2022) Differences between arterial and venous umbilical cord plasma metabolome and association with parity. Metabolites 12:175. https:\/\/doi.org\/10.3390\/metabo12020175","journal-title":"Metabolites"},{"key":"3028_CR21","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3390\/ijms18061203","volume":"18","author":"M Ruiz-Palacios","year":"2017","unstructured":"Ruiz-Palacios M, Prieto-Sanchez MT, Ruiz-Alcaraz AJ, Blanco-Carnero JE, Sanchez-Campillo M, Parrilla JJ, Larque E (2017) Insulin treatment may alter fatty acid carriers in placentas from gestational diabetes subjects. Int J Mol Sci 18:1203. https:\/\/doi.org\/10.3390\/ijms18061203","journal-title":"Int J Mol Sci"},{"key":"3028_CR22","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1046\/j.1365-2125.1999.00017.x","volume":"48","author":"DE Newby","year":"1999","unstructured":"Newby DE, Sciberras DG, Ferro CJ, Gertz BJ, Sommerville D, Majumdar A, Lowry RC, Webb DJ (1999) Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man. Br J Clin Pharmacol 48:336\u2013344. https:\/\/doi.org\/10.1046\/j.1365-2125.1999.00017.x","journal-title":"Br J Clin Pharmacol"},{"key":"3028_CR23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41387-021-00173-0","volume":"11","author":"M Eleftheriades","year":"2021","unstructured":"Eleftheriades M, Chatzakis C, Papachatzopoulou E, Papadopoulos V, Lambrinoudaki I, Dinas K, Chrousos G, Sotiriadis A (2021) Prediction of insulin treatment in women with gestational diabetes mellitus. Nutr Diabetes 11:30. https:\/\/doi.org\/10.1038\/s41387-021-00173-0","journal-title":"Nutr Diabetes"},{"key":"3028_CR24","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/1753-0407.12422","volume":"8","author":"SH Koning","year":"2016","unstructured":"Koning SH, Hoogenberg K, Lutgers HL, van den Berg PP, Wolffenbuttel BH (2016) Gestational diabetes mellitus: current knowledge and unmet needs. J Diabetes 8:770\u2013781. https:\/\/doi.org\/10.1111\/1753-0407.12422","journal-title":"J Diabetes"},{"key":"3028_CR25","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.cnur.2021.07.008","volume":"56","author":"M Aras","year":"2021","unstructured":"Aras M, Tchang BG, Pape J (2021) Obesity and diabetes. Nurs Clin North Am 56:527\u2013541. https:\/\/doi.org\/10.1016\/j.cnur.2021.07.008","journal-title":"Nurs Clin North Am"},{"key":"3028_CR26","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41569-020-00465-5","volume":"18","author":"ACT Ng","year":"2021","unstructured":"Ng ACT, Delgado V, Borlaug BA, Bax JJ (2021) Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging. Nat Rev Cardiol 18:291\u2013304. https:\/\/doi.org\/10.1038\/s41569-020-00465-5","journal-title":"Nat Rev Cardiol"},{"key":"3028_CR27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.ogc.2020.04.003","volume":"47","author":"P Sawangkum","year":"2020","unstructured":"Sawangkum P, Louis JM (2020) Gestational weight gain: achieving a healthier weight between pregnancies. Obstet Gynecol Clin North Am 47:397\u2013407. https:\/\/doi.org\/10.1016\/j.ogc.2020.04.003","journal-title":"Obstet Gynecol Clin North Am"},{"key":"3028_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fendo.2013.00037","volume":"4","author":"ME Cerf","year":"2013","unstructured":"Cerf ME (2013) Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne) 4:37. https:\/\/doi.org\/10.3389\/fendo.2013.00037","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"Suppl 2","key":"3028_CR29","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.2337\/dc07-s201","volume":"30","author":"TA Buchanan","year":"2007","unstructured":"Buchanan TA, Xiang A, Kjos SL, Watanabe R (2007) What is gestational diabetes? Diabetes Care 30(Suppl 2):S105-111. https:\/\/doi.org\/10.2337\/dc07-s201","journal-title":"Diabetes Care"},{"key":"3028_CR30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/sp.2000.6360","volume":"24","author":"S Kalhan","year":"2000","unstructured":"Kalhan S, Parimi P (2000) Gluconeogenesis in the fetus and neonate. Semin Perinatol 24:94\u2013106. https:\/\/doi.org\/10.1053\/sp.2000.6360","journal-title":"Semin Perinatol"},{"key":"3028_CR31","unstructured":"Quintanilla Rodriguez BS, Mahdy H (2024) Gestational diabetes. In: StatPearls. StatPearls Publishing, Treasure Island"},{"key":"3028_CR32","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s001250100609","volume":"44","author":"DT Osmond","year":"2001","unstructured":"Osmond DT, King RG, Brennecke SP, Gude NM (2001) Placental glucose transport and utilisation is altered at term in insulin-treated, gestational-diabetic patients. Diabetologia 44:1133\u20131139. https:\/\/doi.org\/10.1007\/s001250100609","journal-title":"Diabetologia"},{"key":"3028_CR33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s40200-019-00388-0","volume":"18","author":"R Tabrizi","year":"2019","unstructured":"Tabrizi R, Asemi Z, Lankarani KB, Akbari M, Khatibi SR, Naghibzadeh-Tahami A, Sanjari M, Alizadeh H, Afshari M, Khodadost M, Moosazadeh M (2019) Gestational diabetes mellitus in association with macrosomia in Iran: a meta-analysis. J Diabetes Metab Disord 18:41\u201350. https:\/\/doi.org\/10.1007\/s40200-019-00388-0","journal-title":"J Diabetes Metab Disord"},{"key":"3028_CR34","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.2337\/dc12-1203","volume":"36","author":"O Pivovarova","year":"2013","unstructured":"Pivovarova O, Bernigau W, Bobbert T, Isken F, Mohlig M, Spranger J, Weickert MO, Osterhoff M, Pfeiffer AF, Rudovich N (2013) Hepatic insulin clearance is closely related to metabolic syndrome components. Diabetes Care 36:3779\u20133785. https:\/\/doi.org\/10.2337\/dc12-1203","journal-title":"Diabetes Care"},{"key":"3028_CR35","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.2337\/dc08-0045","volume":"31","author":"SH Kim","year":"2008","unstructured":"Kim SH, Reaven GM (2008) Insulin resistance and hyperinsulinemia: you can\u2019t have one without the other. Diabetes Care 31:1433\u20131438. https:\/\/doi.org\/10.2337\/dc08-0045","journal-title":"Diabetes Care"},{"key":"3028_CR36","doi-asserted-by":"publisher","first-page":"108203","DOI":"10.1016\/j.jdiacomp.2022.108203","volume":"36","author":"I Melena","year":"2022","unstructured":"Melena I, Piani F, Tommerdahl KL, Severn C, Chung LT, MacDonald A, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Cara-Fuentes G, Parikh CR, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P (2022) Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: results from the diabetic kidney alarm (DKA) study. J Diabetes Complications 36:108203. https:\/\/doi.org\/10.1016\/j.jdiacomp.2022.108203","journal-title":"J Diabetes Complications"},{"key":"3028_CR37","doi-asserted-by":"publisher","first-page":"e4322","DOI":"10.1210\/clinem\/dgac481","volume":"107","author":"AB Ademolu","year":"2022","unstructured":"Ademolu AB (2022) Branched chain amino acids and gestational diabetes mellitus. J Clin Endocrinol Metab 107:e4322\u2013e4323. https:\/\/doi.org\/10.1210\/clinem\/dgac481","journal-title":"J Clin Endocrinol Metab"},{"key":"3028_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41387-020-00131-2","volume":"10","author":"KC Lewandowski","year":"2020","unstructured":"Lewandowski KC, Biesiada L, Grzesiak M, Sakowicz A (2020) C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins-possible link to metabolic programming? Nutr Diabetes 10:29. https:\/\/doi.org\/10.1038\/s41387-020-00131-2","journal-title":"Nutr Diabetes"},{"key":"3028_CR39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5114\/pedm.2021.107165","volume":"27","author":"M Jamiolkowska-Sztabkowska","year":"2021","unstructured":"Jamiolkowska-Sztabkowska M, Glowinska-Olszewska B, Bossowski A (2021) C-peptide and residual beta-cell function in pediatric diabetes - state of the art. Pediatr Endocrinol Diabetes Metab 27:123\u2013133. https:\/\/doi.org\/10.5114\/pedm.2021.107165","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"key":"3028_CR40","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1210\/jc.2004-1512","volume":"90","author":"D Marzioni","year":"2005","unstructured":"Marzioni D, Fiore G, Giordano A, Nabissi M, Florio P, Verdenelli F, Petraglia F, Castellucci M (2005) Placental expression of substance P and vasoactive intestinal peptide: evidence for a local effect on hormone release. J Clin Endocrinol Metab 90:2378\u20132383. https:\/\/doi.org\/10.1210\/jc.2004-1512","journal-title":"J Clin Endocrinol Metab"},{"key":"3028_CR41","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1095\/biolreprod65.2.538","volume":"65","author":"ML Candenas","year":"2001","unstructured":"Candenas ML, Magraner J, Armesto CP, Anselmi E, Nieto PM, Martin JD, Advenier C, Pinto FM (2001) Changes in the expression of tachykinin receptors in the rat uterus during the course of pregnancy. Biol Reprod 65:538\u2013543. https:\/\/doi.org\/10.1095\/biolreprod65.2.538","journal-title":"Biol Reprod"},{"key":"3028_CR42","doi-asserted-by":"publisher","first-page":"196","DOI":"10.4239\/wjd.v2.i11.196","volume":"2","author":"A Vambergue","year":"2011","unstructured":"Vambergue A, Fajardy I (2011) Consequences of gestational and pregestational diabetes on placental function and birth weight. World J Diabetes 2:196\u2013203. https:\/\/doi.org\/10.4239\/wjd.v2.i11.196","journal-title":"World J Diabetes"},{"key":"3028_CR43","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1093\/oxfordjournals.humrep.a138580","volume":"9","author":"G Bodelsson","year":"1994","unstructured":"Bodelsson G, Stjernquist M (1994) Endothelium-dependent relaxation to substance P in human umbilical artery is mediated via prostanoid synthesis. Hum Reprod 9:733\u2013737. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a138580","journal-title":"Hum Reprod"},{"key":"3028_CR44","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3389\/fendo.2020.00655","volume":"11","author":"CJ McElwain","year":"2020","unstructured":"McElwain CJ, Tuboly E, McCarthy FP, McCarthy CM (2020) Mechanisms of endothelial dysfunction in pre-eclampsia and gestational diabetes mellitus: windows into future cardiometabolic health? Front Endocrinol (Lausanne) 11:655. https:\/\/doi.org\/10.3389\/fendo.2020.00655","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3028_CR45","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S2213-8587(15)00227-2","volume":"3","author":"L Poston","year":"2015","unstructured":"Poston L, Bell R, Croker H, Flynn AC, Godfrey KM, Goff L, Hayes L, Khazaezadeh N, Nelson SM, Oteng-Ntim E, Pasupathy D, Patel N, Robson SC, Sandall J, Sanders TA, Sattar N, Seed PT, Wardle J, Whitworth MK, Briley AL, UPBEAT Trial Consortium (2015) Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol 3:767\u2013777. https:\/\/doi.org\/10.1016\/S2213-8587(15)00227-2","journal-title":"Lancet Diabetes Endocrinol"},{"key":"3028_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12916-018-1248-7","volume":"17","author":"HL Mills","year":"2019","unstructured":"Mills HL, Patel N, White SL, Pasupathy D, Briley AL, Santos Ferreira DL, Seed PT, Nelson SM, Sattar N, Tilling K, Poston L, Lawlor DA, UPBEAT Consortium (2019) The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial. BMC Med 17:15. https:\/\/doi.org\/10.1186\/s12916-018-1248-7","journal-title":"BMC Med"},{"key":"3028_CR47","doi-asserted-by":"publisher","first-page":"e12725","DOI":"10.1111\/ijpo.12725","volume":"16","author":"KV Dalrymple","year":"2021","unstructured":"Dalrymple KV, Tydeman FAS, Taylor PD, Flynn AC, O\u2019Keeffe M, Briley AL, Santosh P, Hayes L, Robson SC, Nelson SM, Sattar N, Whitworth MK, Mills HL, Singh C, Seed CPT, White SL, Lawlor DA, Godfrey KM, Poston L, UPBEAT Consortium (2021) Adiposity and cardiovascular outcomes in three-year-old children of participants in UPBEAT, an RCT of a complex intervention in pregnant women with obesity. Pediatr Obes 16:e12725. https:\/\/doi.org\/10.1111\/ijpo.12725","journal-title":"Pediatr Obes"},{"key":"3028_CR48","doi-asserted-by":"publisher","first-page":"e1003229","DOI":"10.1371\/journal.pmed.1003229","volume":"17","author":"E Antoun","year":"2020","unstructured":"Antoun E, Kitaba NT, Titcombe P, Dalrymple KV, Garratt ES, Barton SJ, Murray R, Seed PT, Holbrook JD, Kobor MS, Lin DT, MacIsaac JL, Burdge GC, White SL, Poston L, Godfrey KM, Lillycrop KA, UPBEAT Consortium (2020) Maternal dysglycaemia, changes in the infant\u2019s epigenome modified with a diet and physical activity intervention in pregnancy: secondary analysis of a randomised control trial. PLoS Medicine 17:e1003229. https:\/\/doi.org\/10.1371\/journal.pmed.1003229","journal-title":"PLoS Medicine"},{"key":"3028_CR49","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1038\/s41366-022-01210-3","volume":"46","author":"PD Taylor","year":"2022","unstructured":"Taylor PD, Gu H, Saunders H, Fiori F, Dalrymple KV, Sethupathi P, Yamanouchi L, Miller F, Jones B, Vieira MC, Singh C, Briley A, Seed PT, Pasupathy D, Santosh PJ, Groves AM, Sinha MD, Chowienczyk PJ, Poston L, UPBEAT Consortium (2022) Lifestyle intervention in obese pregnancy and cardiac remodelling in 3-year olds: children of the UPBEAT RCT. Int J Obes (Lond) 46:2145\u20132155. https:\/\/doi.org\/10.1038\/s41366-022-01210-3","journal-title":"Int J Obes (Lond)"},{"key":"3028_CR50","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/S0140-6736(18)31930-5","volume":"392","author":"J Sandall","year":"2018","unstructured":"Sandall J, Tribe RM, Avery L, Mola G, Visser GH, Homer CS, Gibbons D, Kelly NM, Kennedy HP, Kidanto H, Taylor P, Temmerman M (2018) Short-term and long-term effects of caesarean section on the health of women and children. Lancet 392:1349\u20131357. https:\/\/doi.org\/10.1016\/S0140-6736(18)31930-5","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1007\/s00424-024-03052-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000}}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-024-03028-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-024-03028-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-024-03028-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T05:05:46Z","timestamp":1736312746000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-024-03028-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3028"],"URL":"https:\/\/doi.org\/10.1007\/s00424-024-03028-6","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00424-024-03052-6","asserted-by":"object"}]},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"22 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2024","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: In the original version of this manuscript, there are 9 authors listed in the author group, which are Philine S. Carstens, Heike Brendel, M. Leyre Villar\u2011Ballesteros, Jennifer Mittag, Clara Hengst, Cahit Birdir, Paul D. Taylor, Lucilla Poston, and Henning Morawietz, and the author requested to add one author in the author group, which is Coy Brunssen.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The corrected list in the author group is presented below.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Philine S. Carstens, Heike Brendel, M. Leyre Villar-Ballesteros, Jennifer Mittag, Clara Hengst, Coy Brunssen, Cahit Birdir, Paul D. Taylor, Lucilla Poston and Henning Morawietz","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2024","order":10,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":11,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00424-024-03052-6","URL":"https:\/\/doi.org\/10.1007\/s00424-024-03052-6","order":13,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional ethics committee of the participating center and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All patients received detailed verbal and written information about the study and gave written informed consent. The study was approved by the Ethics Committee of the TUD Dresden University of Technology (EK 277\u201307-2018 (BO), extension 2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}