{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:10:11Z","timestamp":1772089811149,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Secretar\u00eda de Ciencias, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","award":["FC2015-1-121"],"award-info":[{"award-number":["FC2015-1-121"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00424-025-03133-0","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:59:53Z","timestamp":1769061593000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The progression of triple-negative breast cancer is linked to a gradual decrease of the BK channel in the plasma membrane and an increase in intracellular structures"],"prefix":"10.1007","volume":"478","author":[{"given":"Rodrigo","family":"Zamora-C\u00e1rdenas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura","family":"L\u00f3pez-Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Alamilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo A.","family":"Rodr\u00edguez-Menchaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloy G.","family":"Moreno-Galindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-2009","authenticated-orcid":false,"given":"Ricardo A.","family":"Navarro-Polanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"3133_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1937-6448(10)79005-5","volume-title":"International review of cell and molecular biology","author":"A Becchetti","year":"2010","unstructured":"Becchetti A, Pillozzi S, Morini R, Nesti E, Arcangeli A (2010) New insights into the regulation of ion channels by integrins. In: Jeon K (ed) International review of cell and molecular biology, 1st edn. Academic, California, pp 135\u2013190. https:\/\/doi.org\/10.1016\/S1937-6448(10)79005-5","edition":"1"},{"key":"3133_CR2","doi-asserted-by":"publisher","first-page":"RP92511","DOI":"10.7554\/eLife.92511","volume":"12","author":"H Bischof","year":"2024","unstructured":"Bischof H, Maier S, Koprowski P, Kulawiak B, Burgstaller S, Jasi\u0144ska J, Serafimov K, Zochowska M, Gross D, Schroth W, Matt L, Juarez Lopez DA, Zhang Y, Bonzheim I, B\u00fcttner FA, Fend F, Schwab M, Birkenfeld AL, Malli R, L\u00e4mmerhofer M, Bednarczyk P, Szewczyk A, Lukowski R (2024) MitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming. eLife 12:RP92511. https:\/\/doi.org\/10.7554\/eLife.92511","journal-title":"eLife"},{"key":"3133_CR3","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/j.bbamcr.2018.05.015","volume":"1865","author":"AHL Bong","year":"2018","unstructured":"Bong AHL, Monteith GR (2018) Calcium signaling and the therapeutic targeting of cancer cells. Biochim Biophys Acta Mol Cell Res 1865:1786\u20131794. https:\/\/doi.org\/10.1016\/j.bbamcr.2018.05.015","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"3133_CR4","doi-asserted-by":"publisher","first-page":"595664","DOI":"10.3389\/fnins.2020.595664","volume":"14","author":"F Brandalise","year":"2020","unstructured":"Brandalise F, Ratto D, Leone R, Olivero F, Roda E, Locatelli CA, Grazia Bottone M, Rossi P (2020) Deeper and deeper on the role of BK and Kir4.1 channels in glioblastoma invasiveness: a novel summative mechanism? Front Neurosci 14:595664. https:\/\/doi.org\/10.3389\/fnins.2020.595664","journal-title":"Front Neurosci"},{"key":"3133_CR5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.4161\/chan.26242","volume":"7","author":"GF Contreras","year":"2013","unstructured":"Contreras GF, Castillo K, Enrique N, Carrasquel-Ursulaez W, Castillo JP, Milesi V, Neely A, Alvarez O, Ferreira G, Gonzalez C, Latorre R (2013) A BK (Slo1) channel journey from molecule to physiology. Channels (Austin) 7:442\u2013458. https:\/\/doi.org\/10.4161\/chan.26242","journal-title":"Channels (Austin)"},{"key":"3133_CR6","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2024.2396346","volume":"18","author":"RL Dinsdale","year":"2024","unstructured":"Dinsdale RL, Meredith AL (2024) Evaluation of four KCNMA1 channelopathy variants on BK channel current under Ca(V)1.2 activation. Channels 18:2396346. https:\/\/doi.org\/10.1080\/19336950.2024.2396346","journal-title":"Channels"},{"key":"3133_CR7","doi-asserted-by":"publisher","first-page":"20706","DOI":"10.3390\/ijms151120706","volume":"15","author":"C Du","year":"2014","unstructured":"Du C, Chen L, Zhang H, Wang Z, Liu W, Xie X, Xie M (2014) Caveolin-1 limits the contribution of BKCa channel to MCF-7 breast cancer cell proliferation and invasion. Int J Mol Sci 15:20706\u201320722. https:\/\/doi.org\/10.3390\/ijms151120706","journal-title":"Int J Mol Sci"},{"key":"3133_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1373507","volume":"15","author":"F Echeverria","year":"2024","unstructured":"Echeverria F, Gonzalez-Sanabria N, Alvarado-Sanchez R, Fernandez M, Castillo K, Latorre R (2024) Large conductance voltage-and calcium-activated K(+) (BK) channel in health and disease. Front Pharmacol 15:1373507. https:\/\/doi.org\/10.3389\/fphar.2024.1373507","journal-title":"Front Pharmacol"},{"key":"3133_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00210","volume":"11","author":"S Echeverry","year":"2020","unstructured":"Echeverry S, Grismaldo A, Sanchez C, Sierra C, Henao JC, Granados ST, Sutachan JJ, Torres YP (2020) Activation of BK channel contributes to PL-induced mesenchymal stem cell migration. Front Physiol 11:210. https:\/\/doi.org\/10.3389\/fphys.2020.00210","journal-title":"Front Physiol"},{"key":"3133_CR10","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.1158\/1078-0432.CCR-05-0327","volume":"11","author":"SP Fraser","year":"2005","unstructured":"Fraser SP, Diss JKJ, Chioni A-M, Mycielska ME, Pan H, Yamaci RF, Pani F, Siwy Z, Krasowska M, Grzywna Z, Brackenbury WJ, Theodorou D, Koyut\u00fcrk M, Kaya H, Battaloglu E, De Bella MT, Slade MJ, Tolhurst R, Palmieri C, Jiang J, Latchman DS, Coombes RC, Djamgoz MBA (2005) Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 11:5381\u20135389. https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-0327","journal-title":"Clin Cancer Res"},{"key":"3133_CR11","doi-asserted-by":"publisher","first-page":"10925","DOI":"10.1038\/s41598-021-90465-3","volume":"11","author":"S Ga\u0142ecka","year":"2021","unstructured":"Ga\u0142ecka S, Kulawiak B, Bednarczyk P, Singh H, Szewczyk A (2021) Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant. Sci Rep 11:10925. https:\/\/doi.org\/10.1038\/s41598-021-90465-3","journal-title":"Sci Rep"},{"key":"3133_CR12","doi-asserted-by":"publisher","first-page":"e0305222","DOI":"10.1371\/journal.pone.0305222","volume":"19","author":"C Godina","year":"2024","unstructured":"Godina C, Khazaei S, Belting M, Vallon-Christersson J, Nodin B, Jirstr\u00f6m K, Isaksson K, Bosch A, Jernstr\u00f6m H (2024) High caveolin-1 mRNA expression in triple-negative breast cancer is associated with an aggressive tumor microenvironment, chemoresistance, and poor clinical outcome. PLoS One 19:e0305222. https:\/\/doi.org\/10.1371\/journal.pone.0305222","journal-title":"PLoS One"},{"key":"3133_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1146\/annurev-physiol-022516-034038","volume":"81","author":"V Gonzalez-Perez","year":"2019","unstructured":"Gonzalez-Perez V, Lingle CJ (2019) Regulation of BK channels by beta and gamma subunits. Annu Rev Physiol 81:113\u2013137. https:\/\/doi.org\/10.1146\/annurev-physiol-022516-034038","journal-title":"Annu Rev Physiol"},{"key":"3133_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.761474","volume":"12","author":"N Gonzalez-Sanabria","year":"2021","unstructured":"Gonzalez-Sanabria N, Echeverria F, Segura I, Alvarado-Sanchez R, Latorre R (2021) BK in double-membrane organelles: a biophysical, pharmacological, and functional survey. Front Physiol 12:761474. https:\/\/doi.org\/10.3389\/fphys.2021.761474","journal-title":"Front Physiol"},{"key":"3133_CR15","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2147\/bctt.S516542","volume":"17","author":"H Jie","year":"2025","unstructured":"Jie H, Ma W, Huang C (2025) Diagnosis, prognosis, and treatment of triple-negative breast cancer: a review. Breast Cancer (Dove Med Press) 17:265\u2013274. https:\/\/doi.org\/10.2147\/bctt.S516542","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"3133_CR16","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/1471-2407-9-258","volume":"9","author":"D Khaitan","year":"2009","unstructured":"Khaitan D, Sankpal UT, Weksler B, Meister EA, Romero IA, Couraud P-O, Ningaraj NS (2009) Role of KCNMA1gene in breast cancer invasion and metastasis to brain. BMC Cancer 9:258. https:\/\/doi.org\/10.1186\/1471-2407-9-258","journal-title":"BMC Cancer"},{"key":"3133_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/bs.irn.2016.03.018","volume":"128","author":"B Li","year":"2016","unstructured":"Li B, Gao TM (2016) Functional role of mitochondrial and nuclear BK channels. Int Rev Neurobiol 128:163\u2013191. https:\/\/doi.org\/10.1016\/bs.irn.2016.03.018","journal-title":"Int Rev Neurobiol"},{"key":"3133_CR18","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1038\/onc.2011.355","volume":"31","author":"XF Liu","year":"2012","unstructured":"Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I (2012) CAPC negatively regulates NF-\u03baB activation and suppresses tumor growth and metastasis. Oncogene 31:1673\u20131682. https:\/\/doi.org\/10.1038\/onc.2011.355","journal-title":"Oncogene"},{"key":"3133_CR19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000217878","volume":"15","author":"AA Marino","year":"2009","unstructured":"Marino AA, Iliev IG, Schwalke MA, Gonzalez E, Marler KC, Flanagan CA (2009) Association between cell membrane potential and breast cancer. Tumor Biol 15:82\u201389. https:\/\/doi.org\/10.1159\/000217878","journal-title":"Tumor Biol"},{"key":"3133_CR20","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.3892\/ijo.2018.4301","volume":"52","author":"Y Miyagawa","year":"2018","unstructured":"Miyagawa Y, Matsushita Y, Suzuki H, Komatsu M, Yoshimaru T, Kimura R, Yanai A, Honda J, Tangoku A, Sasa M, Miyoshi Y, Katagiri T (2018) Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer. Int J Oncol 52:1539\u20131558. https:\/\/doi.org\/10.3892\/ijo.2018.4301","journal-title":"Int J Oncol"},{"key":"3133_CR21","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1111\/bph.15147","volume":"179","author":"CJ Mohr","year":"2022","unstructured":"Mohr CJ, Schroth W, Murdter TE, Gross D, Maier S, Stegen B, Dragoi A, Steudel FA, Stehling S, Hoppe R, Madden S, Ruth P, Huber SM, Brauch H, Lukowski R (2022) Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models. Br J Pharmacol 179:2906\u20132924. https:\/\/doi.org\/10.1111\/bph.15147","journal-title":"Br J Pharmacol"},{"key":"3133_CR22","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1016\/j.ejca.2013.07.013","volume":"49","author":"A Mound","year":"2013","unstructured":"Mound A, Rodat-Despoix L, Bougarn S, Ouadid-Ahidouch H, Matifat F (2013) Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation. Eur J Cancer 49:3738\u20133751. https:\/\/doi.org\/10.1016\/j.ejca.2013.07.013","journal-title":"Eur J Cancer"},{"key":"3133_CR23","doi-asserted-by":"publisher","first-page":"e41664","DOI":"10.1371\/journal.pone.0041664","volume":"7","author":"M Oeggerli","year":"2012","unstructured":"Oeggerli M, Tian Y, Ruiz C, Wijker B, Sauter G, Obermann E, G\u00fcth U, Zlobec I, Sausbier M, Kunzelmann K, Bubendorf L (2012) Role of KCNMA1 in breast cancer. PLoS One 7:e41664. https:\/\/doi.org\/10.1371\/journal.pone.0041664","journal-title":"PLoS One"},{"key":"3133_CR24","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.bbrc.2004.02.041","volume":"316","author":"H Ouadid-Ahidouch","year":"2004","unstructured":"Ouadid-Ahidouch H, Roudbaraki M, Ahidouch A, Delcourt P, Prevarskaya N (2004) Cell-cycle-dependent expression of the large Ca2+-activated K\u2009+\u2009channels in breast cancer cells. Biochem Biophys Res Commun 316:244\u2013251. https:\/\/doi.org\/10.1016\/j.bbrc.2004.02.041","journal-title":"Biochem Biophys Res Commun"},{"key":"3133_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.irn.2016.03.013","volume-title":"International review of neurobiology","author":"A Pantazis","year":"2016","unstructured":"Pantazis A, Olcese R (2016) Biophysics of BK channel gating. In: Contet C (ed) International review of neurobiology, 1st edn. Academic, California, pp 1\u201349. https:\/\/doi.org\/10.1016\/bs.irn.2016.03.013","edition":"1"},{"key":"3133_CR26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1478-811X-11-14","volume":"11","author":"RR Resende","year":"2013","unstructured":"Resende RR, Andrade LM, Oliveira AG, Guimar\u00e3es ES, Guatimosim S, Leite MF (2013) Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus. Cell Commun Signal 11:14. https:\/\/doi.org\/10.1186\/1478-811X-11-14","journal-title":"Cell Commun Signal"},{"key":"3133_CR27","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1359\/jbmr.2003.18.10.1863","volume":"18","author":"R Rezzonico","year":"2009","unstructured":"Rezzonico R, Cayatte C, Bourget-Ponzio I, Romey G, Belhacene N, Loubat A, Rocchi S, Van Obberghen E, Girault JA, Rossi B, Schmid\u2010Antomarchi H (2009) Focal Adhesion Kinase pp125FAK Interacts With the Large Conductance Calcium\u2010Activated hSlo Potassium Channel in Human Osteoblasts: Potential Role in Mechanotransduction. J Bone Miner Res 18:1863\u20131871. https:\/\/doi.org\/10.1359\/jbmr.2003.18.10.1863","journal-title":"J Bone Miner Res"},{"key":"3133_CR28","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s13238-012-2076-8","volume":"3","author":"BS Rothberg","year":"2012","unstructured":"Rothberg BS (2012) The BK channel: a vital link between cellular calcium and electrical signaling. Protein Cell 3:883\u2013892. https:\/\/doi.org\/10.1007\/s13238-012-2076-8","journal-title":"Protein Cell"},{"key":"3133_CR29","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s43440-021-00229-z","volume":"73","author":"A Selezneva","year":"2021","unstructured":"Selezneva A, Yoshida M, Gibb A, Willis D (2021) Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages. Pharmacol Rep 73:881\u2013890. https:\/\/doi.org\/10.1007\/s43440-021-00229-z","journal-title":"Pharmacol Rep"},{"key":"3133_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1006\/bbrc.1999.0496","volume":"257","author":"D Siemen","year":"1999","unstructured":"Siemen D, Loupatatzis C, Borecky J, Gulbins E, Lang F (1999) Ca2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line. Biochem Biophys Res Commun 257:549\u2013554. https:\/\/doi.org\/10.1006\/bbrc.1999.0496","journal-title":"Biochem Biophys Res Commun"},{"key":"3133_CR31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1186\/s12885-020-07071-1","volume":"20","author":"G Sizemore","year":"2020","unstructured":"Sizemore G, McLaughlin S, Newman M, Brundage K, Ammer A, Martin K, Pugacheva E, Coad J, Mattes MD, Yu H-G (2020) Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer. BMC Cancer 20:595. https:\/\/doi.org\/10.1186\/s12885-020-07071-1","journal-title":"BMC Cancer"},{"key":"3133_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212241","author":"I Teruel","year":"2024","unstructured":"Teruel I, Castell\u00e0 E, Recalde S, Vi\u00f1as G, Petit A, Trigueros M, Mart\u00ednez-Balibrea E, Felip E, Bergamino M, Bernat-Peguera A, Cirauqui B, Quiroga V, Ferrando-D\u00edez A, Pous A, L\u00f3pez A, Boronat L, Soler G, Recuero J, Romeo M, Guill\u00e9n P, Mes\u00eda R, Ballana E, Mart\u00ednez-Card\u00fas A, Margel\u00ed M (2024) Assessing the prognostic value of cytoplasmic and stromal Caveolin-1 in early triple-negative breast cancer undergoing neoadjuvant chemotherapy. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms252212241","journal-title":"Int J Mol Sci"},{"key":"3133_CR33","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s00424-013-1359-0","volume":"466","author":"L Toro","year":"2014","unstructured":"Toro L, Li M, Zhang Z, Singh H, Wu Y, Stefani E (2014) MaxiK channel and cell signalling. Pflugers Arch 466:875\u2013886. https:\/\/doi.org\/10.1007\/s00424-013-1359-0","journal-title":"Pflugers Arch"},{"key":"3133_CR34","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fphys.2013.00185","volume":"4","author":"M Yang","year":"2013","unstructured":"Yang M, Brackenbury WJ (2013) Membrane potential and cancer progression. Front Physiol 4:185","journal-title":"Front Physiol"},{"key":"3133_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fphys.2015.00029","volume":"6","author":"H Yang","year":"2015","unstructured":"Yang H, Zhang G, Cui J (2015) BK channels: multiple sensors, one activation gate. Front Physiol 6:29. https:\/\/doi.org\/10.3389\/fphys.2015.00029","journal-title":"Front Physiol"},{"key":"3133_CR36","doi-asserted-by":"publisher","first-page":"10072","DOI":"10.1073\/pnas.0302919101","volume":"101","author":"MM Zarei","year":"2004","unstructured":"Zarei MM, Eghbali M, Alioua A, Song M, Knaus H-G, Stefani E, Toro L (2004) An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca2+-activated K+ channel splice variant. PNAS 101:10072\u201310077. https:\/\/doi.org\/10.1073\/pnas.0302919101","journal-title":"PNAS"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-025-03133-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-025-03133-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-025-03133-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:23:14Z","timestamp":1772086994000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-025-03133-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["3133"],"URL":"https:\/\/doi.org\/10.1007\/s00424-025-03133-0","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"9 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}