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Body tissues, such as skin, can offer sites of short-term extrarenal Na\n                    <jats:sup>+<\/jats:sup>\n                    storage and previous research has shown that this can help guard against hypertension in small mammals (e.g., rodents). Large mammals have relatively greater Na\n                    <jats:sup>+<\/jats:sup>\n                    storage potential, but whether extrarenal Na\n                    <jats:sup>+<\/jats:sup>\n                    storage occurs for this group is unknown. Here, we report preliminary evidence of extrarenal Na\n                    <jats:sup>+<\/jats:sup>\n                    storage in cattle. We provided a large pulse-dose of NaCl to four cattle (body mass: ~720\u00a0kg) and measured excretion of Na\n                    <jats:sup>+<\/jats:sup>\n                    and potassium (K\n                    <jats:sup>+<\/jats:sup>\n                    ) in urine and faeces for a period of 7-days. Following NaCl administration, Na\n                    <jats:sup>+<\/jats:sup>\n                    excretion spiked in both urine and faeces for ~\u200948\u00a0h before returning to baseline measurements. After ~\u200996\u00a0h, however, Na\n                    <jats:sup>+<\/jats:sup>\n                    excretion increased again; a consistent physiological phenomenon across all individuals studied. We did not observe a pattern in urinary K\n                    <jats:sup>+<\/jats:sup>\n                    excretion, indicating that the mechanism of Na\n                    <jats:sup>+<\/jats:sup>\n                    storage does not appear to involve exchange for K\n                    <jats:sup>+<\/jats:sup>\n                    . However, faecal K\n                    <jats:sup>+<\/jats:sup>\n                    excretion was reciprocal to that of Na\n                    <jats:sup>+<\/jats:sup>\n                    , presumably reflecting exchange of Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    across the walls of the large intestine. We infer that during the initial period of Na\n                    <jats:sup>+<\/jats:sup>\n                    stress, short-term extrarenal Na\n                    <jats:sup>+<\/jats:sup>\n                    storage occurred and the stored Na\n                    <jats:sup>+<\/jats:sup>\n                    was later released only when the body had returned to Na\n                    <jats:sup>+<\/jats:sup>\n                    homeostasis. Additional experiments are required to understand how patterns of Na\n                    <jats:sup>+<\/jats:sup>\n                    regulation changes across body sizes and the specific body compartments involved. Cattle may be a useful model system for examining the impact of high Na\n                    <jats:sup>+<\/jats:sup>\n                    intake in mammals larger than humans.\n                  <\/jats:p>","DOI":"10.1007\/s00424-026-03155-2","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:41:42Z","timestamp":1772250102000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary evidence of extrarenal sodium storage in a large mammal: implications for comparative physiology and hypertension research"],"prefix":"10.1007","volume":"478","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-8851","authenticated-orcid":false,"given":"Andrew J.","family":"Abraham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan S.","family":"Duvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callum","family":"Leese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"le Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Riond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Ortmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Terranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Leese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Clauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"issue":"21","key":"3155_CR1","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1056\/NEJMra2030212","volume":"385","author":"DH Ellison","year":"2021","unstructured":"Ellison DH, Welling P (2021) Insights into salt handling and blood pressure. 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