{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:18:18Z","timestamp":1778861898465,"version":"3.51.4"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s00424-026-03169-w","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:56:03Z","timestamp":1776923763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective effects of vitamin E and quercetin against MDMA-induced cardiac and hematological dysfunction in male wistar rats"],"prefix":"10.1007","volume":"478","author":[{"given":"Ayodeji Folorunsho","family":"Ajayi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Tolulope","family":"Oluwole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses Agbomhere","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayomide Jonathan","family":"Jegede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence Bukola","family":"Adisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lateef Olabisi","family":"Okeleji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toluwalope Oluwafisayo","family":"Iyiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-3526","authenticated-orcid":false,"given":"Oyedayo Phillips","family":"Akano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"issue":"6","key":"3169_CR1","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41591-021-01336-3","volume":"27","author":"JM Mitchell","year":"2021","unstructured":"Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, Ot\u2019alora GM, Garas W, Paleos C, Gorman I, Nicholas C, Mithoefer M, Carlin S, Poulter B, Mithoefer A, Quevedo S, Wells G, Klaire SS, van der Kolk B, Tzarfaty K, Amiaz R, Worthy R, Shannon S, Woolley JD, Marta C, Gelfand Y, Hapke E, Amar S, Wallach Y, Brown R, Hamilton S, Wang JB, Coker A, Matthews R, de Boer A, Yazar-Klosinski B, Emerson A, Doblin R (2021) MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med 27(6):1025\u20131033","journal-title":"Nat Med"},{"key":"3169_CR2","doi-asserted-by":"publisher","first-page":"174156","DOI":"10.1016\/j.ejphar.2021.174156","volume":"903","author":"DA Fonseca","year":"2021","unstructured":"Fonseca DA, Ribeiro DM, Tapadas M, Cotrim MD (2021) Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms. Eur J Pharmacol 903:174156","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"3169_CR3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1080\/20009666.2019.1650593","volume":"9","author":"P Kafle","year":"2019","unstructured":"Kafle P, Shrestha B, Mandal A, Sharma D, Bhandari M, Amgai B, Khalid M, Sidhu JS, Solaimanzadeh I, Gayam V, Surana R, Dufresne A (2019) Ecstasy induced acute systolic heart failure and Non-Ischemic Cardiomyopathy in a young female: a rare case report and literature review. J Community Hosp Intern Med Perspect 9(4):336\u2013339","journal-title":"J Community Hosp Intern Med Perspect"},{"issue":"1","key":"3169_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12012-009-9034-6","volume":"9","author":"SK Shenouda","year":"2009","unstructured":"Shenouda SK, Varner KJ, Carvalho F, Lucchesi PA (2009) Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes. Cardiovasc Toxicol 9(1):30\u201338","journal-title":"Cardiovasc Toxicol"},{"issue":"18","key":"3169_CR5","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.1002\/pmic.200800215","volume":"8","author":"KH Moon","year":"2008","unstructured":"Moon KH, Upreti VV, Yu LR, Lee IJ, Ye X, Eddington ND, Veenstra TD, Song BJ (2008) Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver. Proteomics 8(18):3906\u20133918","journal-title":"Proteomics"},{"issue":"6","key":"3169_CR6","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.bcp.2003.10.020","volume":"67","author":"C Montiel-Duarte","year":"2004","unstructured":"Montiel-Duarte C, Ansorena E, L\u00f3pez-Zabalza MJ, Cenarruzabeitia E, Iraburu MJ (2004) Role of reactive oxygen species, glutathione and NF-kappaB in apoptosis induced by 3,4-methylenedioxymethamphetamine (Ecstasy) on hepatic stellate cells. Biochem Pharmacol 67(6):1025\u20131033","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"3169_CR7","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00414-008-0262-2","volume":"122","author":"D Cerretani","year":"2008","unstructured":"Cerretani D, Riezzo I, Fiaschi AI, Centini F, Giorgi G, D\u2019Errico S, Fiore C, Karch SB, Neri M, Pomara C, Turillazzi E, Fineschi V (2008) Cardiac oxidative stress determination and myocardial morphology after a single ecstasy (MDMA) administration in a rat model. Int J Legal Med 122(6):461\u2013469","journal-title":"Int J Legal Med"},{"issue":"1","key":"3169_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1582-4934.2007.00009.x","volume":"11","author":"M Neri","year":"2007","unstructured":"Neri M, Cerretani D, Fiaschi AI, Laghi PF, Lazzerini PE, Maffione AB, Micheli L, Bruni G, Nencini C, Giorgi G, D\u2019Errico S, Fiore C, Pomara C, Riezzo I, Turillazzi E, Fineschi V (2007) Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats. J Cell Mol Med 11(1):156\u2013170","journal-title":"J Cell Mol Med"},{"issue":"4","key":"3169_CR9","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1093\/cvr\/cvn129","volume":"79","author":"SK Shenouda","year":"2008","unstructured":"Shenouda SK, Lord KC, McIlwain E, Lucchesi PA, Varner KJ (2008) Ecstasy produces left ventricular dysfunction and oxidative stress in rats. Cardiovasc Res 79(4):662\u2013670","journal-title":"Cardiovasc Res"},{"key":"3169_CR10","doi-asserted-by":"publisher","first-page":"3423450","DOI":"10.1155\/2016\/3423450","volume":"2016","author":"M Neri","year":"2016","unstructured":"Neri M, Riezzo I, Pomara C, Schiavone S, Turillazzi E (2016) Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations. Mediators Inflamm 2016:3423450","journal-title":"Mediators Inflamm"},{"key":"3169_CR11","doi-asserted-by":"publisher","first-page":"100075","DOI":"10.1016\/j.crtox.2022.100075","volume":"3","author":"JP Capela","year":"2022","unstructured":"Capela JP, Carvalho FD (2022) A review on the mitochondrial toxicity of ecstasy (3,4-methylenedioxymethamphetamine, MDMA). Curr Res Toxicol 3:100075","journal-title":"Curr Res Toxicol"},{"issue":"2","key":"3169_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"AG Porter","year":"1999","unstructured":"Porter AG, J\u00e4nicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6(2):99\u2013104","journal-title":"Cell Death Differ"},{"issue":"4","key":"3169_CR13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1517\/17425255.1.4.715","volume":"1","author":"DC Gaze","year":"2005","unstructured":"Gaze DC, Collinson PO (2005) Cardiac troponins as biomarkers of drug- and toxin-induced cardiac toxicity and cardioprotection. Expert Opin Drug Metab Toxicol 1(4):715\u2013725","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"8816","key":"3169_CR14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/0140-6736(92)91469-O","volume":"340","author":"JA Henry","year":"1992","unstructured":"Henry JA, Jeffreys KJ, Dawling S (1992) Toxicity and deaths from 3,4-methylenedioxymethamphetamine (ecstasy). Lancet 340(8816):384\u2013387","journal-title":"Lancet"},{"issue":"1","key":"3169_CR15","first-page":"19","volume":"24","author":"N Khalaji","year":"2020","unstructured":"Khalaji N, Mohammadzadeh A, Naseri Goosheh Derag M, Naderi R, Asgari Hassanlouei E (2020) Combination effect of ecstasy and curcumin on hematological parameters and serum immunoglobulin levels in early and late phase in male rats. Physiol Pharmacol 24(1):19\u201327","journal-title":"Physiol Pharmacol"},{"issue":"20","key":"3169_CR16","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4103\/0973-7847.194044","volume":"10","author":"AV Anand David","year":"2016","unstructured":"Anand David AV, Arulmoli R, Parasuraman S (2016) Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev 10(20):84\u201389","journal-title":"Pharmacogn Rev"},{"issue":"1","key":"3169_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bcp.2011.08.010","volume":"83","author":"M Russo","year":"2012","unstructured":"Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL (2012) The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol 83(1):6\u201315","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"3169_CR18","doi-asserted-by":"publisher","first-page":"8168","DOI":"10.3390\/ijms16048168","volume":"16","author":"M Bartekov\u00e1","year":"2015","unstructured":"Bartekov\u00e1 M, \u0160imon\u010d\u00edkov\u00e1 P, Fogarassyov\u00e1 M, Ivanov\u00e1 M, Okruhlicov\u00e1 \u013d, Tribulov\u00e1 N, Dovinov\u00e1 I, Baran\u010d\u00edk M (2015) Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction. Int J Mol Sci 16(4):8168\u20138185","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3169_CR19","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1002\/eji.200425778","volume":"35","author":"M Comalada","year":"2005","unstructured":"Comalada M, Camuesco D, Sierra S, Ballester I, Xaus J, G\u00e1lvez J, Zarzuelo A (2005) In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway. Eur J Immunol 35(2):584\u2013592","journal-title":"Eur J Immunol"},{"issue":"2","key":"3169_CR20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/ptr.1374","volume":"18","author":"T Mahesh","year":"2004","unstructured":"Mahesh T, Menon VP (2004) Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats. Phytother Res PTR 18(2):123\u2013127","journal-title":"Phytother Res PTR"},{"issue":"1","key":"3169_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/15376516.2017.1351507","volume":"28","author":"S Kasmi","year":"2018","unstructured":"Kasmi S, Bkhairia I, Harrabi B, Mnif H, Marrakchi R, Ghozzi H, Kallel C, Nasri M, Zeghal K, Jamoussi K, Hakim A (2018) Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. Toxicol Mech Methods 28(1):12\u201322","journal-title":"Toxicol Mech Methods"},{"issue":"9","key":"3169_CR22","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.3390\/antiox13091135","volume":"13","author":"D Kilicarslan You","year":"2024","unstructured":"Kilicarslan You D, Fuwad A, Lee KH, Kim HK, Kang L, Kim SM, Jeon TJ (2024) Evaluation of the Protective Role of Vitamin E against ROS-Driven Lipid Oxidation in Model Cell Membranes. Antioxid Basel Switz 13(9):1135","journal-title":"Antioxid Basel Switz"},{"issue":"2","key":"3169_CR23","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.18295\/2075-0528.1566","volume":"14","author":"S Rizvi","year":"2014","unstructured":"Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F (2014) The role of vitamin e in human health and some diseases. Sultan Qaboos Univ Med J 14(2):e157\u2013165","journal-title":"Sultan Qaboos Univ Med J"},{"issue":"2","key":"3169_CR24","doi-asserted-by":"publisher","first-page":"369S","DOI":"10.1093\/jn\/131.2.369S","volume":"131","author":"L Packer","year":"2001","unstructured":"Packer L, Weber SU, Rimbach G (2001) Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr 131(2):369S\u201373S","journal-title":"J Nutr"},{"issue":"6","key":"3169_CR25","first-page":"898","volume":"13","author":"Q Wu","year":"2024","unstructured":"Wu Q, Luo Y, Lu H, Xie T, Hu Z, Chu Z, Luo F (2024) The Potential Role of Vitamin E and the Mechanism in the Prevention and Treatment of Inflammatory Bowel Disease. Foods Basel Switz 13(6):898","journal-title":"Foods Basel Switz"},{"issue":"5","key":"3169_CR26","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.nutres.2012.03.012","volume":"32","author":"Y Sun","year":"2012","unstructured":"Sun Y, Ma A, Li Y, Han X, Wang Q, Liang H (2012) Vitamin E supplementation protects erythrocyte membranes from oxidative stress in healthy Chinese middle-aged and elderly people. Nutr Res N Y N 32(5):328\u2013334","journal-title":"Nutr Res N Y N"},{"issue":"1","key":"3169_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12263-011-0227-9","volume":"7","author":"HR Vasanthi","year":"2012","unstructured":"Vasanthi HR, Parameswari RP, Das DK (2012) Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation. Genes Nutr 7(1):19\u201328","journal-title":"Genes Nutr"},{"key":"3169_CR28","unstructured":"Figurasin R, Lee VR, Maguire NJ 3,4-Methylenedioxymethamphetamine (MDMA) Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2025 Aug 28]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538482\/"},{"key":"3169_CR29","doi-asserted-by":"publisher","unstructured":"Ajayi AF, Oluwole DT, Akhigbe RE, Hamed MA, Ajayi LO Proton Pump Dysfunction and Upregulation of Caspase-3 Activity via Oxidative\u2010Sensitive Signaling Mediate Rohypnol\u2010Induced Testicular Toxicity. 2023 [cited 2026 Jan 31]; Available from: https:\/\/onlinelibrary.wiley.com\/doi\/https:\/\/doi.org\/10.1155\/2023\/7215328","DOI":"10.1155\/2023\/7215328"},{"key":"3169_CR30","doi-asserted-by":"crossref","unstructured":"F C, L Z, Z Z JSCCYZ M C, H W, W T, Y L, Y X, H L, M Z, J Y, Q W, K W. Quercetin Mitigates Methamphetamine-Induced Anxiety-Like Behavior Through Ameliorating Mitochondrial Dysfunction and Neuroinflammation. Front Mol Neurosci [Internet]. 2022 Feb 28 [cited 2026 Feb 18];15. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35295707\/","DOI":"10.3389\/fnmol.2022.829886"},{"key":"3169_CR31","first-page":"239784732110055","volume":"5","author":"M Malmir","year":"2021","unstructured":"Malmir M, Mehranjani MS, Faraji T, Noreini SN (2021) Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A. Toxicol Res Appl 5:23978473211005562","journal-title":"Toxicol Res Appl"},{"issue":"1","key":"3169_CR32","first-page":"33","volume":"25","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Akhigbe RE (2020) Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis. Redox Rep Commun Free Radic Res 25(1):33\u201340","journal-title":"Redox Rep Commun Free Radic Res"},{"issue":"6","key":"3169_CR33","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18(6):499\u2013502","journal-title":"Clin Chem"},{"key":"3169_CR34","unstructured":"Etah EN, E G (2024) L S, N M. Evaluation of Electrocardiographic Activity (ECG) and Blood Pressure Changes in Experimental Animal Models Treated with Doxorubicin and Hesperidin Co-Administration. Biomed J Sci Tech Res. ;59(4)"},{"key":"3169_CR35","doi-asserted-by":"publisher","first-page":"109664","DOI":"10.1016\/j.steroids.2025.109664","volume":"222","author":"LO Okeleji","year":"2025","unstructured":"Okeleji LO, Hamed MA, Jegede AI, Oyovwi MO, Ajayi AF (2025) Protective effects of coenzyme Q10 against trihexyphenidyl-induced testicular oxidative damage: modulation of antioxidant enzymes, inflammatory markers, hormonal and steroidogenic pathways in rats. Steroids 222:109664","journal-title":"Steroids"},{"issue":"4","key":"3169_CR36","first-page":"620","volume":"16","author":"OP Akano","year":"2025","unstructured":"Akano OP, Akinsomisoye OS (2025) Irvingia gabonensis seed extracts protect against lead-induced testicular damage in Wistar rats. Indian J Nat Prod Resour IJNPR Former Nat Prod Radiance NPR 16(4):620\u2013628","journal-title":"Indian J Nat Prod Resour IJNPR Former Nat Prod Radiance NPR"},{"issue":"2","key":"3169_CR37","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0003-2697(83)90019-2","volume":"132","author":"K Suzuki","year":"1983","unstructured":"Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T (1983) Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 132(2):345\u2013352","journal-title":"Anal Biochem"},{"key":"3169_CR38","unstructured":"Weissman BA, Gross SS (2001) Measurement of NO and NO synthase. Curr Protoc Neurosci. ;Chap. 7:Unit7.13."},{"issue":"1","key":"3169_CR39","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/jfmk1010069","volume":"1","author":"P Castrogiovanni","year":"2016","unstructured":"Castrogiovanni P, Trovato FM, Szychlinska MA, Loreto C, Giunta S, Scuderi S, Passanisi R, Fidone F, Fagone P, Imbesi R, Nicoletti F, Castorina S (2016) Effects of Synthetic Anti-Inflammatory Sterol in CB3V-Induced Myocarditis: A Morphological Study on Heart Muscle Tissue. J Funct Morphol Kinesiol 1(1):69\u201389","journal-title":"J Funct Morphol Kinesiol"},{"issue":"8","key":"3169_CR40","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00204-012-0815-5","volume":"86","author":"M Carvalho","year":"2012","unstructured":"Carvalho M, Carmo H, Costa VM, Capela JP, Pontes H, Remi\u00e3o F, Carvalho F (2012) Bastos M de L. Toxicity of amphetamines: an update. Arch Toxicol 86(8):1167\u20131231","journal-title":"Arch Toxicol"},{"issue":"8","key":"3169_CR41","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.neubiorev.2013.04.016","volume":"37","author":"AC Parrott","year":"2013","unstructured":"Parrott AC (2013) MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational Ecstasy users. Neurosci Biobehav Rev 37(8):1466\u20131484","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"3169_CR42","first-page":"917","volume":"165","author":"H Kalant","year":"2001","unstructured":"Kalant H (2001) The pharmacology and toxicology of ecstasy (MDMA) and related drugs. CMAJ Can Med Assoc J J Assoc Medicale Can 165(7):917\u2013928","journal-title":"CMAJ Can Med Assoc J J Assoc Medicale Can"},{"issue":"3","key":"3169_CR43","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1124\/pr.55.3.3","volume":"55","author":"AR Green","year":"2003","unstructured":"Green AR, Mechan AO, Elliott JM, O\u2019Shea E, Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Pharmacol Rev 55(3):463\u2013508","journal-title":"Pharmacol Rev"},{"key":"3169_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neubiorev.2018.11.004","volume":"96","author":"F M\u00fcller","year":"2019","unstructured":"M\u00fcller F, Br\u00e4ndle R, Liechti ME, Borgwardt S (2019) Neuroimaging of chronic MDMA (ecstasy) effects: A meta-analysis. Neurosci Biobehav Rev 96:10\u201320","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"3169_CR45","first-page":"167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y, Quercetin (2016) Inflamm Immun Nutrients 8(3):167","journal-title":"Inflamm Immun Nutrients"},{"issue":"1","key":"3169_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","volume":"14","author":"C Moussa","year":"2017","unstructured":"Moussa C, Hebron M, Huang X, Ahn J, Rissman RA, Aisen PS, Turner RS (2017) Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer\u2019s disease. J Neuroinflammation 14(1):1","journal-title":"J Neuroinflammation"},{"key":"3169_CR47","doi-asserted-by":"crossref","unstructured":"Akinmoladun AC, Olaniyan OO, Famusiwa CD, Josiah SS, Olaleye MT (2020) Ameliorative effect of quercetin, catechin, and taxifolin on rotenone-induced testicular and splenic weight gain and oxidative stress in rats. J Basic Clin Physiol Pharmacol. ;31(3):\/j\/jbcpp.2020.31.issue-3\/jbcpp-2018-0230\/jbcpp-2018-0230.xml","DOI":"10.1515\/jbcpp-2018-0230"},{"issue":"2\u20133","key":"3169_CR48","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","volume":"585","author":"AW Boots","year":"2008","unstructured":"Boots AW, Haenen GRMM, Bast A (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585(2\u20133):325\u2013337","journal-title":"Eur J Pharmacol"},{"key":"3169_CR49","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1038\/srep01940","volume":"3","author":"J Dalli","year":"2013","unstructured":"Dalli J, Colas RA, Serhan CN (2013) Novel n-3 immunoresolvents: structures and actions. Sci Rep 3:1940","journal-title":"Sci Rep"},{"issue":"1","key":"3169_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40360-016-0070-0","volume":"17","author":"A Teixeira-Gomes","year":"2016","unstructured":"Teixeira-Gomes A, Costa VM, Feio-Azevedo R, Duarte JA, Duarte-Ara\u00fajo M, Fernandes E, Bastos M, de Carvalho L, Capela F (2016) Ecstasy toxicity to adolescent rats following an acute low binge dose. BMC Pharmacol Toxicol 17(1):1\u201314","journal-title":"BMC Pharmacol Toxicol"},{"key":"3169_CR51","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1749-6632.2002.tb04183.x","volume":"965","author":"R Pacifici","year":"2002","unstructured":"Pacifici R, Zuccaro P, Farr\u00e9 M, Pichini S, Di Carlo S, Roset PN, Palmi I, Ortu\u00f1o J, Menoyo E, Segura J, de la Torre R (2002) Cell-mediated immune response in MDMA users after repeated dose administration: studies in controlled versus noncontrolled settings. Ann N Y Acad Sci 965:421\u2013433","journal-title":"Ann N Y Acad Sci"},{"key":"3169_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fphar.2012.00121","volume":"3","author":"SM Kousik","year":"2012","unstructured":"Kousik SM, Napier TC, Carvey PM (2012) The Effects of Psychostimulant Drugs on Blood Brain Barrier Function and Neuroinflammation. Front Pharmacol 3:121","journal-title":"Front Pharmacol"},{"key":"3169_CR53","doi-asserted-by":"publisher","first-page":"960","DOI":"10.12688\/f1000research.123245.1","volume":"11","author":"M Biswas","year":"2022","unstructured":"Biswas M, Suvarna R, Krishnan SV, Devasia T, Shenoy Belle V, Prabhu K (2022) The mechanistic role of neutrophil lymphocyte ratio perturbations in the leading non communicable lifestyle diseases. F1000Research 11:960","journal-title":"F1000Research"},{"key":"3169_CR54","doi-asserted-by":"publisher","first-page":"107256","DOI":"10.1016\/j.phrs.2024.107256","volume":"205","author":"K Jiang","year":"2024","unstructured":"Jiang K, Hwa J, Xiang Y (2024) Novel strategies for targeting neutrophil against myocardial infarction. Pharmacol Res 205:107256","journal-title":"Pharmacol Res"},{"issue":"4","key":"3169_CR55","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1006\/brbi.1995.1026","volume":"9","author":"AV Turnbull","year":"1995","unstructured":"Turnbull AV, Rivier C (1995) Regulation of the HPA axis by cytokines. Brain Behav Immun 9(4):253\u2013275","journal-title":"Brain Behav Immun"},{"key":"3169_CR56","doi-asserted-by":"publisher","first-page":"162750","DOI":"10.1155\/2013\/162750","volume":"2013","author":"S Kumar","year":"2013","unstructured":"Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal 2013:162750","journal-title":"ScientificWorldJournal"},{"issue":"6","key":"3169_CR57","first-page":"1123","volume":"24","author":"D Xu","year":"2019","unstructured":"Xu D, Hu MJ, Wang YQ, Cui YL (2019) Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Mol Basel Switz 24(6):1123","journal-title":"Mol Basel Switz"},{"key":"3169_CR58","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.nutr.24.012003.132446","volume":"25","author":"U Singh","year":"2005","unstructured":"Singh U, Devaraj S, Jialal I, Vitamin E (2005) oxidative stress, and inflammation. Annu Rev Nutr 25:151\u2013174","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"3169_CR59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2007.03.024","volume":"43","author":"MG Traber","year":"2007","unstructured":"Traber MG, Atkinson J, Vitamin E (2007) antioxidant and nothing more. Free Radic Biol Med 43(1):4\u201315","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"3169_CR60","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2174\/1871530314666140922143950","volume":"14","author":"D Wu","year":"2014","unstructured":"Wu D, Meydani SN (2014) Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocr Metab Immune Disord Drug Targets 14(4):283\u2013289","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"4","key":"3169_CR61","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/iub.1976","volume":"71","author":"ED Lewis","year":"2019","unstructured":"Lewis ED, Meydani SN, Wu D (2019) Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life 71(4):487\u2013494","journal-title":"IUBMB Life"},{"issue":"4","key":"3169_CR62","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00213-005-0174-5","volume":"189","author":"CD Verrico","year":"2007","unstructured":"Verrico CD, Miller GM, Madras BK (2007) MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology 189(4):489\u2013503","journal-title":"Psychopharmacology"},{"key":"3169_CR63","unstructured":"Ashraf MA, Nookala V Biochemistry of Platelet Activating Factor. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2025 Aug 27]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557392\/"},{"issue":"2","key":"3169_CR64","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/00001721-199603000-00011","volume":"7","author":"PM Bath","year":"1996","unstructured":"Bath PM, Butterworth RJ (1996) Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis Int J Haemost Thromb 7(2):157\u2013161","journal-title":"Blood Coagul Fibrinolysis Int J Haemost Thromb"},{"issue":"1","key":"3169_CR65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/138161211795049804","volume":"17","author":"AY Gasparyan","year":"2011","unstructured":"Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17(1):47\u201358","journal-title":"Curr Pharm Des"},{"key":"3169_CR66","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2013.03.022","volume":"66","author":"E Niki","year":"2014","unstructured":"Niki E (2014) Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radic Biol Med 66:3\u201312","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"3169_CR67","first-page":"123","volume":"118","author":"L Khorsandi","year":"2017","unstructured":"Khorsandi L, Orazizadeh M, Niazvand F, Abbaspour MR, Mansouri E, Khodadadi A (2017) Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells. Bratisl Lek Listy 118(2):123\u2013128","journal-title":"Bratisl Lek Listy"},{"key":"3169_CR68","doi-asserted-by":"crossref","unstructured":"Piccione G, Casella S, Lutri L, Vazzana I, Ferrantelli V, Caola G Reference values for some haematological, haematochemical, and electrophoretic parameters in the Girgentana goat. Turk J Vet Anim Sci [Internet]. 2010 Jan 1 [cited 2025 Aug 27]; Available from: https:\/\/journals.tubitak.gov.tr\/veterinary\/vol34\/iss2\/12","DOI":"10.3906\/vet-0902-1"},{"issue":"12","key":"3169_CR69","doi-asserted-by":"publisher","first-page":"292","DOI":"10.4330\/wjc.v11.i12.292","volume":"11","author":"G Lippi","year":"2019","unstructured":"Lippi G, Cervellin G, Sanchis-Gomar F (2019) Red blood cell distribution width: A marker of anisocytosis potentially associated with atrial fibrillation. World J Cardiol 11(12):292\u2013304","journal-title":"World J Cardiol"},{"issue":"1","key":"3169_CR70","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/dmrr.694","volume":"23","author":"M Rizzo","year":"2007","unstructured":"Rizzo M, Berneis K (2007) Small, dense low-density-lipoproteins and the metabolic syndrome. Diabetes Metab Res Rev 23(1):14\u201320","journal-title":"Diabetes Metab Res Rev"},{"issue":"10B Supplementa","key":"3169_CR71","first-page":"3347","volume":"28","author":"AI Ajayi","year":"2024","unstructured":"Ajayi AI, Okoro IO (2024) Effects of Methamphetamine Exposure on Lipid Profile and Cardiovascular Risk in Wistar Rats. J Appl Sci Environ Manag 28(10B Supplementary):3347\u20133351","journal-title":"J Appl Sci Environ Manag"},{"issue":"13","key":"3169_CR72","first-page":"1775","volume":"17","author":"JL Cadet","year":"2003","unstructured":"Cadet JL, Jayanthi S, Deng X (2003) Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis. FASEB J Off Publ Fed Am Soc Exp Biol 17(13):1775\u20131788","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"10","key":"3169_CR73","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","volume":"124","author":"M Ouimet","year":"2019","unstructured":"Ouimet M, Barrett TJ, Fisher EA (2019) HDL and Reverse Cholesterol Transport: Basic Mechanisms and their Roles in Vascular Health and Disease. Circ Res 124(10):1505\u20131518","journal-title":"Circ Res"},{"issue":"1","key":"3169_CR74","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1161\/01.CIR.79.1.8","volume":"79","author":"DJ Gordon","year":"1989","unstructured":"Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR, Bangdiwala S, Tyroler HA (1989) High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 79(1):8\u201315","journal-title":"Circulation"},{"issue":"3","key":"3169_CR75","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000343106","volume":"61","author":"E Niki","year":"2012","unstructured":"Niki E, Traber MG (2012) A history of vitamin E. Ann Nutr Metab 61(3):207\u2013212","journal-title":"Ann Nutr Metab"},{"issue":"6","key":"3169_CR76","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.3945\/jn.111.157263","volume":"142","author":"SK Panchal","year":"2012","unstructured":"Panchal SK, Poudyal H, Brown L (2012) Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. J Nutr 142(6):1026\u20131032","journal-title":"J Nutr"},{"key":"3169_CR77","doi-asserted-by":"publisher","first-page":"8686248","DOI":"10.1155\/2020\/8686248","volume":"2020","author":"M Wang","year":"2020","unstructured":"Wang M, Mao Y, Wang B, Wang S, Lu H, Ying L, Li Y (2020) Quercetin Improving Lipid Metabolism by Regulating Lipid Metabolism Pathway of Ileum Mucosa in Broilers. Oxid Med Cell Longev 2020:8686248","journal-title":"Oxid Med Cell Longev"},{"issue":"3\u20134","key":"3169_CR78","first-page":"457","volume":"383","author":"R Ricciarelli","year":"2002","unstructured":"Ricciarelli R, Zingg JM, Azzi A (2002) The 80th anniversary of vitamin E: beyond its antioxidant properties. Biol Chem 383(3\u20134):457\u2013465","journal-title":"Biol Chem"},{"issue":"10","key":"3169_CR79","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3390\/ijms17101745","volume":"17","author":"F Shahidi","year":"2016","unstructured":"Shahidi F, de Camargo AC (2016) Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. Int J Mol Sci 17(10):1745","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3169_CR80","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.atherosclerosis.2014.05.914","volume":"235","author":"PP Toth","year":"2014","unstructured":"Toth PP, Grabner M, Punekar RS, Quimbo RA, Cziraky MJ, Jacobson TA (2014) Cardiovascular risk in patients achieving low-density lipoprotein cholesterol and particle targets. Atherosclerosis 235(2):585\u2013591","journal-title":"Atherosclerosis"},{"issue":"9","key":"3169_CR81","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1038\/oby.2008.315","volume":"16","author":"L Rivera","year":"2008","unstructured":"Rivera L, Mor\u00f3n R, S\u00e1nchez M, Zarzuelo A, Galisteo M (2008) Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obes Silver Spring Md 16(9):2081\u20132087","journal-title":"Obes Silver Spring Md"},{"key":"3169_CR82","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.fct.2013.05.006","volume":"58","author":"J Moon","year":"2013","unstructured":"Moon J, Do HJ, Kim OY, Shin MJ (2013) Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc 58:347\u2013354","journal-title":"Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc"},{"issue":"4","key":"3169_CR83","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1161\/01.CIR.67.4.730","volume":"67","author":"WP Castelli","year":"1983","unstructured":"Castelli WP, Abbott RD, McNamara PM (1983) Summary estimates of cholesterol used to predict coronary heart disease. Circulation 67(4):730\u2013734","journal-title":"Circulation"},{"issue":"7","key":"3169_CR84","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1373\/clinchem.2004.033175","volume":"50","author":"M Dobi\u00e1sov\u00e1","year":"2004","unstructured":"Dobi\u00e1sov\u00e1 M (2004) Atherogenic index of plasma [log(triglycerides\/HDL-cholesterol)]: theoretical and practical implications. Clin Chem 50(7):1113\u20131115","journal-title":"Clin Chem"},{"issue":"25 Suppl 2","key":"3169_CR85","first-page":"S49","volume":"129","author":"DC Goff","year":"2014","unstructured":"Goff DC, Lloyd-Jones DM, Bennett G, Coady S, D\u2019Agostino RB, Gibbons R, Greenland P, Lackland DT, Levy D, O\u2019Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC, Sorlie P, Stone NJ, Wilson PWF, Jordan HS, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC, Tomaselli GF, American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (2014) 2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation 129(25 Suppl 2):S49\u201373","journal-title":"Circulation"},{"issue":"4","key":"3169_CR86","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1124\/pr.110.003723","volume":"62","author":"P Kannankeril","year":"2010","unstructured":"Kannankeril P, Roden DM, Darbar D (2010) Drug-induced long QT syndrome. Pharmacol Rev 62(4):760\u2013781","journal-title":"Pharmacol Rev"},{"issue":"3","key":"3169_CR87","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1152\/physrev.00036.2011","volume":"92","author":"JI Vandenberg","year":"2012","unstructured":"Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP (2012) hERG K(+) channels: structure, function, and clinical significance. Physiol Rev 92(3):1393\u20131478","journal-title":"Physiol Rev"},{"issue":"5","key":"3169_CR88","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/tx049960f","volume":"17","author":"M Carvalho","year":"2004","unstructured":"Carvalho M, Remi\u00e3o F, Milhazes N, Borges F, Fernandes E, Monteiro M do, Gon\u00e7alves C, Seabra MJ, Amado V, Carvalho F, Bastos F (2004) Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro. Chem Res Toxicol 17(5):623\u2013632","journal-title":"Chem Res Toxicol"},{"issue":"3","key":"3169_CR89","first-page":"427","volume":"19","author":"JE Sprague","year":"1998","unstructured":"Sprague JE, Everman SL, Nichols DE (1998) An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology 19(3):427\u2013441","journal-title":"Neurotoxicology"},{"issue":"20","key":"3169_CR90","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4103\/0973-7847.194044","volume":"10","author":"AV Anand David","year":"2016","unstructured":"Anand David AV, Arulmoli R, Parasuraman S (2016) Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev 10(20):84\u201389","journal-title":"Pharmacogn Rev"},{"key":"3169_CR91","doi-asserted-by":"publisher","first-page":"110700","DOI":"10.1016\/j.cbi.2023.110700","volume":"384","author":"DA Esp\u00edrito-Santo","year":"2023","unstructured":"Esp\u00edrito-Santo DA, Cordeiro GS, Santos LS, Silva RT, Pereira MU, Matos RJB, Boaventura GT, Barreto-Medeiros JM (2023) Cardioprotective effect of the quercetin on cardiovascular remodeling and atherosclerosis in rodents fed a high-fat diet: A systematic review. Chem Biol Interact 384:110700","journal-title":"Chem Biol Interact"},{"issue":"9","key":"3169_CR92","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1096\/fasebj.13.9.977","volume":"13","author":"JM Upston","year":"1999","unstructured":"Upston JM, Terentis AC, Stocker R (1999) Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement. FASEB J 13(9):977\u2013994","journal-title":"FASEB J"},{"issue":"17","key":"3169_CR93","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1001\/jama.1997.03540410058031","volume":"277","author":"SN Meydani","year":"1997","unstructured":"Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, Loszewski R, Thompson C, Pedrosa MC, Diamond RD, Stollar BD (1997) Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA 277(17):1380\u20131386","journal-title":"JAMA"},{"issue":"6","key":"3169_CR94","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1093\/ajcn\/73.6.1052","volume":"73","author":"D Manzella","year":"2001","unstructured":"Manzella D, Barbieri M, Ragno E, Paolisso G (2001) Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes. Am J Clin Nutr 73(6):1052\u20131057","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"3169_CR95","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0022-3565(24)37769-9","volume":"287","author":"BK Yamamoto","year":"1998","unstructured":"Yamamoto BK, Zhu W (1998) The effects of methamphetamine on the production of free radicals and oxidative stress. J Pharmacol Exp Ther 287(1):107\u2013114","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"3169_CR96","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3390\/antiox12020517","volume":"12","author":"EO Olufunmilayo","year":"2023","unstructured":"Olufunmilayo EO, Gerke-Duncan MB, Holsinger RMD (2023) Oxidative Stress and Antioxidants in Neurodegenerative Disorders. Antioxidants 12(2):517","journal-title":"Antioxidants"},{"issue":"10","key":"3169_CR97","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97(10):2499\u20132574","journal-title":"Arch Toxicol"},{"issue":"12","key":"3169_CR98","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/j.freeradbiomed.2006.04.033","volume":"41","author":"SB Lotito","year":"2006","unstructured":"Lotito SB, Frei B (2006) Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 41(12):1727\u20131746","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"3169_CR99","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00204-012-0815-5","volume":"86","author":"M Carvalho","year":"2012","unstructured":"Carvalho M, Carmo H, Costa VM, Capela JP, Pontes H, Remi\u00e3o F, Carvalho F (2012) Bastos M de L. Toxicity of amphetamines: an update. Arch Toxicol 86(8):1167\u20131231","journal-title":"Arch Toxicol"},{"issue":"1","key":"3169_CR100","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopsych.2013.09.034","volume":"76","author":"S Jayanthi","year":"2014","unstructured":"Jayanthi S, McCoy MT, Chen B, Britt JP, Kourrich S, Yau HJ, Ladenheim B, Krasnova IN, Bonci A, Cadet JL (2014) Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms. Biol Psychiatry 76(1):47\u201356","journal-title":"Biol Psychiatry"},{"issue":"37","key":"3169_CR101","doi-asserted-by":"publisher","first-page":"26464","DOI":"10.1074\/jbc.R113.472936","volume":"288","author":"R Radi","year":"2013","unstructured":"Radi R (2013) Peroxynitrite, a stealthy biological oxidant. J Biol Chem 288(37):26464\u201326472","journal-title":"J Biol Chem"},{"issue":"10","key":"3169_CR102","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1089\/ars.2019.7928","volume":"33","author":"M El Kazzi","year":"2020","unstructured":"El Kazzi M, Rayner BS, Chami B, Dennis JM, Thomas SR, Witting PK (2020) Neutrophil-Mediated Cardiac Damage After Acute Myocardial Infarction: Significance of Defining a New Target Cell Type for Developing Cardioprotective Drugs. Antioxid Redox Signal 33(10):689\u2013712","journal-title":"Antioxid Redox Signal"},{"issue":"16","key":"3169_CR103","doi-asserted-by":"publisher","first-page":"e6631","DOI":"10.1097\/MD.0000000000006631","volume":"96","author":"M Zhang","year":"2017","unstructured":"Zhang M, Lv D, Zhou W, Ji L, Zhou B, Chen H, Gu Y, Zhao J, He J (2017) The levels of triglyceride and total cholesterol in methamphetamine dependence. Med (Baltim) 96(16):e6631","journal-title":"Med (Baltim)"},{"issue":"3","key":"3169_CR104","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/clinchem\/47.3.377","volume":"47","author":"FS Apple","year":"2001","unstructured":"Apple FS, Wu AH (2001) Myocardial infarction redefined: role of cardiac troponin testing. Clin Chem 47(3):377\u2013379","journal-title":"Clin Chem"},{"issue":"10","key":"3169_CR105","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1503\/cmaj\/051291","volume":"173","author":"L Babuin","year":"2005","unstructured":"Babuin L, Jaffe AS (2005) Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ Can Med Assoc J 173(10):1191\u20131202","journal-title":"CMAJ Can Med Assoc J"},{"issue":"9","key":"3169_CR106","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1021\/tx400130v","volume":"26","author":"VM Costa","year":"2013","unstructured":"Costa VM, Carvalho F, Duarte JA, Bastos M, de Remi\u00e3o L (2013) The heart as a target for xenobiotic toxicity: the cardiac susceptibility to oxidative stress. Chem Res Toxicol 26(9):1285\u20131311","journal-title":"Chem Res Toxicol"},{"issue":"12","key":"3169_CR107","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1016\/j.bbabio.2011.09.022","volume":"1807","author":"R Lagoa","year":"2011","unstructured":"Lagoa R, Graziani I, Lopez-Sanchez C, Garcia-Martinez V, Gutierrez-Merino C (2011) Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. Biochim Biophys Acta 1807(12):1562\u20131572","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"3169_CR108","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","volume":"79","author":"MP Blaustein","year":"1999","unstructured":"Blaustein MP, Lederer WJ (1999) Sodium\/calcium exchange: its physiological implications. Physiol Rev 79(3):763\u2013854","journal-title":"Physiol Rev"},{"key":"3169_CR109","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1146\/annurev.biochem.71.102201.141218","volume":"71","author":"JH Kaplan","year":"2002","unstructured":"Kaplan JH (2002) Biochemistry of Na,K-ATPase. Annu Rev Biochem 71:511\u2013535","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"3169_CR110","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1124\/mi.3.3.157","volume":"3","author":"Z Xie","year":"2003","unstructured":"Xie Z, Cai T (2003) Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function. Mol Interv 3(3):157\u2013168","journal-title":"Mol Interv"},{"issue":"4","key":"3169_CR111","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/mus.20745","volume":"35","author":"M Periasamy","year":"2007","unstructured":"Periasamy M, Kalyanasundaram A (2007) SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve 35(4):430\u2013442","journal-title":"Muscle Nerve"},{"key":"3169_CR112","doi-asserted-by":"publisher","unstructured":"Varga ZV, Ferdinandy P, Liaudet L, Pacher P Drug-induced mitochondrial dysfunction and cardiotoxicity. Am J Physiol-Heart Circ Physiol [Internet]. 2015 Nov 1 [cited 2025 Aug 27]; Available from: https:\/\/journals.physiology.org\/doi\/https:\/\/doi.org\/10.1152\/ajpheart.00554.2015","DOI":"10.1152\/ajpheart.00554.2015"},{"issue":"2\u20133","key":"3169_CR113","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cbi.2005.02.004","volume":"152","author":"DJ Dorta","year":"2005","unstructured":"Dorta DJ, Pigoso AA, Mingatto FE, Rodrigues T, Prado IMR, Helena AFC, Uyemura SA, Santos AC, Curti C (2005) The interaction of flavonoids with mitochondria: effects on energetic processes. Chem Biol Interact 152(2\u20133):67\u201378","journal-title":"Chem Biol Interact"},{"issue":"2","key":"3169_CR114","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"AG Porter","year":"1999","unstructured":"Porter AG, J\u00e4nicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6(2):99\u2013104","journal-title":"Cell Death Differ"},{"issue":"4","key":"3169_CR115","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S, Apoptosis (2007) A Review of Programmed Cell Death. Toxicol Pathol 35(4):495\u2013516","journal-title":"Toxicol Pathol"},{"issue":"2","key":"3169_CR116","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1520\/JFS14464J","volume":"44","author":"SB Karch","year":"1999","unstructured":"Karch SB, Stephens BG, Ho CH (1999) Methamphetamine-related deaths in San Francisco: demographic, pathologic, and toxicologic profiles. J Forensic Sci 44(2):359\u2013368","journal-title":"J Forensic Sci"},{"issue":"14","key":"3169_CR117","doi-asserted-by":"publisher","first-page":"8144","DOI":"10.1073\/pnas.96.14.8144","volume":"96","author":"J Narula","year":"1999","unstructured":"Narula J, Pandey P, Arbustini E, Haider N, Narula N, Kolodgie FD, Dal Bello B, Semigran MJ, Bielsa-Masdeu A, Dec GW, Israels S, Ballester M, Virmani R, Saxena S, Kharbanda S (1999) Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proc Natl Acad Sci U S A 96(14):8144\u20138149","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"3169_CR118","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/S0090-4295(99)00358-1","volume":"54","author":"DA Shoskes","year":"1999","unstructured":"Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54(6):960\u2013963","journal-title":"Urology"},{"issue":"3","key":"3169_CR119","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.etap.2010.07.002","volume":"30","author":"CM Liu","year":"2010","unstructured":"Liu CM, Ma JQ, Sun YZ (2010) Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environ Toxicol Pharmacol 30(3):264\u2013271","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"3169_CR120","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cbi.2011.12.005","volume":"195","author":"AB Granado-Serrano","year":"2012","unstructured":"Granado-Serrano AB, Mart\u00edn MA, Bravo L, Goya L, Ramos S (2012) Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact 195(2):154\u2013164","journal-title":"Chem Biol Interact"},{"issue":"8","key":"3169_CR121","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1111\/j.1360-0443.2007.01874.x","volume":"102","author":"S Kaye","year":"2007","unstructured":"Kaye S, McKetin R, Duflou J, Darke S (2007) Methamphetamine and cardiovascular pathology: a review of the evidence. Addict Abingdon Engl 102(8):1204\u20131211","journal-title":"Addict Abingdon Engl"},{"issue":"1","key":"3169_CR122","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/add.14713","volume":"115","author":"J Duflou","year":"2020","unstructured":"Duflou J (2020) Psychostimulant use disorder and the heart. Addict Abingdon Engl 115(1):175\u2013183","journal-title":"Addict Abingdon Engl"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-026-03169-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-026-03169-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-026-03169-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:03:42Z","timestamp":1778861022000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-026-03169-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":122,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3169"],"URL":"https:\/\/doi.org\/10.1007\/s00424-026-03169-w","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"13 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were approved by the Oyo State Ministry of Health Research Ethics Committee (reference no. 13\/479\/44221B) and were conducted in compliance with international guidelines for the care and use of laboratory animals (EU Directive 2010\/63\/EU).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable. This study does not contain any individual person\u2019s data in any form (including individual images, videos, or identifiable information).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable. No human participants were involved in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Patients or members of the public were not involved in the design, conduct, reporting plans of this research.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient and Public Involvement"}},{"value":"Not applicable. This was an experimental animal study and not a clinical trial involving human participants.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Trial Registration"}}],"article-number":"41"}}