{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:44:18Z","timestamp":1788986658628,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21222280"],"award-info":[{"award-number":["21222280"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21221870"],"award-info":[{"award-number":["21221870"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21221950"],"award-info":[{"award-number":["21221950"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21251843"],"award-info":[{"award-number":["21251843"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009610","name":"Pontificia Universidad Cat\u00f3lica de Chile","doi-asserted-by":"publisher","award":["220723001"],"award-info":[{"award-number":["220723001"]}],"id":[{"id":"10.13039\/501100009610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009610","name":"Pontificia Universidad Cat\u00f3lica de Chile","doi-asserted-by":"publisher","award":["220723001"],"award-info":[{"award-number":["220723001"]}],"id":[{"id":"10.13039\/501100009610","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 S.A.","award":["SOW2 RDCL00220001\/COF3709"],"award-info":[{"award-number":["SOW2 RDCL00220001\/COF3709"]}]},{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 S.A.","award":["SOW2 RDCL00220001\/COF3709"],"award-info":[{"award-number":["SOW2 RDCL00220001\/COF3709"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["16\/01743-5"],"award-info":[{"award-number":["16\/01743-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00424-026-03193-w","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:17:29Z","timestamp":1783657049000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A conceptual review of intracellular pH as a regulator of the adenosine\u2013L-arginine\u2013nitric oxide (ALANO) axis in human fetoplacental endothelial dysfunction in gestational diabetes mellitus"],"prefix":"10.1007","volume":"478","author":[{"given":"Gonzalo","family":"Fuentes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Cornejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherin","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Sobrevia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"3193_CR1","unstructured":"American college of obstetricians and gynecologists (ACOG) (2023) Obesity and pregnancy. ACOG FAQ182. Washington, DC: ACOG Last updated January 2023. Last reviewed May 2024"},{"key":"3193_CR2","doi-asserted-by":"publisher","unstructured":"American diabetes association professional practice committee (2025) ; 48: S27\u2013S49. https:\/\/doi.org\/10.2337\/dc25-S002","DOI":"10.2337\/dc25-S002"},{"key":"3193_CR3","doi-asserted-by":"publisher","unstructured":"American diabetes association professional practice committee for diabetes (2026) ; 49: S321\u2013S338. https:\/\/doi.org\/10.2337\/dc26-S015","DOI":"10.2337\/dc26-S015"},{"key":"3193_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.placenta.2016.05.003","volume":"43","author":"J Araos","year":"2016","unstructured":"Araos J, Silva L, Salsoso R, S\u00e1ez T, Barros E, Toledo F, Guti\u00e9rrez J, Pardo F, Leiva A, Sanhueza C, Sobrevia L (2016) Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus. Placenta 43:47\u201353. https:\/\/doi.org\/10.1016\/j.placenta.2016.05.003","journal-title":"Placenta"},{"key":"3193_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/15257770.2016.1210805","volume":"36","author":"RC Boswell-Casteel","year":"2017","unstructured":"Boswell-Casteel RC, Hays FA (2017) Equilibrative nucleoside transporters-A review. Nucleosides nucleotides nucleic acids 36:7\u201330. https:\/\/doi.org\/10.1080\/15257770.2016.1210805","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"3193_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mam.2019.01.001","volume":"66","author":"C Cabal\u00edn","year":"2019","unstructured":"Cabal\u00edn C, Villalobos-Labra R, Toledo F, Aguayo C, Gonz\u00e1lez M, Salom\u00f3n C, Sobrevia L (2019) Involvement of A2B adenosine receptors as anti-inflammatory in gestational diabesity. Mol Aspects Med 66:31\u201339. https:\/\/doi.org\/10.1016\/j.mam.2019.01.001","journal-title":"Mol Aspects Med"},{"key":"3193_CR7","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3945\/ajcn.2008.27416","volume":"90","author":"PM Catalano","year":"2009","unstructured":"Catalano PM, Farrell K, Thomas A, Huston-Presley L, Mencin P, de Mouzon SH et al (2009) Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr 90:1303\u20131313. https:\/\/doi.org\/10.3945\/ajcn.2008.27416","journal-title":"Am J Clin Nutr"},{"key":"3193_CR8","unstructured":"Centers for disease control and prevention. Weight gain during pregnancy (2024) https:\/\/www.cdc.gov\/maternal-infant-health\/pregnancy-weight\/index.html. Last accessed March 4, 2026"},{"key":"3193_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.placenta.2017.01.120","volume":"51","author":"N Celis","year":"2017","unstructured":"Celis N, Araos J, Sanhueza C, Cornejo V, Ram\u00edrez MA, Salom\u00f3n C, Sobrevia L (2017) Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells. Placenta 51:10\u201317. https:\/\/doi.org\/10.1016\/j.placenta.2017.01.120","journal-title":"Placenta"},{"key":"3193_CR10","doi-asserted-by":"publisher","first-page":"e13671","DOI":"10.1111\/apha.13671","volume":"232","author":"M Cornejo","year":"2021","unstructured":"Cornejo M, Fuentes G, Valero P, Ram\u00edrez MA, Sanhueza C, Toledo F, Sobrevia L (2021) Gestational diabesity and foetoplacental vascular dysfunction. Acta Physiol (Oxf) 232:e13671. https:\/\/doi.org\/10.1111\/apha.13671","journal-title":"Acta Physiol (Oxf)"},{"key":"3193_CR11","doi-asserted-by":"publisher","first-page":"166834","DOI":"10.1016\/j.bbadis.2023.166834","volume":"1869","author":"MS Diniz","year":"2023","unstructured":"Diniz MS, Hiden U, Falc\u00e3o-Pires I, Medina-Cleghorn D, Sobrevia L, Desoye G (2023) Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: a potential threat for programming cardiovascular disease. Biochim Biophys Acta Mol Basis Dis 1869:166834. https:\/\/doi.org\/10.1016\/j.bbadis.2023.166834","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"3193_CR12","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.freeradbiomed.2025.06.007","volume":"237","author":"K Etchegaray-Armijo","year":"2025","unstructured":"Etchegaray-Armijo K, Bustos-Arriagada E, Navarro-Rosenblatt D, Vera C, Garmendia ML, Sobrevia L, L\u00f3pez-Alarc\u00f3n C, Casanello P (2025) Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis. Free Radic Biol Med 237:650\u2013665. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.06.007","journal-title":"Free Radic Biol Med"},{"key":"3193_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/cvr\/cvp410","volume":"86","author":"M Far\u00edas","year":"2010","unstructured":"Far\u00edas M, Puebla C, Westermeier F, V\u00e1squez B, Salom\u00f3n C, Sobrevia L (2010) Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C\/EBP\u03b1 in human umbilical vein endothelial cells from gestational diabetes. Cardiovasc Res 86:45\u201354. https:\/\/doi.org\/10.1093\/cvr\/cvp410","journal-title":"Cardiovasc Res"},{"key":"3193_CR14","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1161\/01.res.74.6.1220","volume":"74","author":"I Fleming","year":"1994","unstructured":"Fleming I, Hecker M, Busse R (1994) Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells. Circ Res 74:1220\u20131226. https:\/\/doi.org\/10.1161\/01.res.74.6.1220","journal-title":"Circ Res"},{"key":"3193_CR15","doi-asserted-by":"publisher","first-page":"E101","DOI":"10.1016\/j.placenta.2019.06.320","volume":"83","author":"G Fuentes","year":"2019","unstructured":"Fuentes G, Valero P, Cornejo M, Paublo M, Andrea Lopez M, Antonio Ramirez M, Sobrevia L (2019) The intracellular pH in human umbilical vein endothelial cells from gestational diabesity is unaltered by insulin. Placenta 83:E101\u2013E101. https:\/\/doi.org\/10.1016\/j.placenta.2019.06.320","journal-title":"Placenta"},{"key":"3193_CR16","doi-asserted-by":"publisher","unstructured":"Fuentes G (2026) Gestational diabetes mellitus: intracellular pH and hydrogen sulfide as determinants of endothelial function and nitric oxide synthase regulation. [Groningen]: Univ Groningen 360. https:\/\/doi.org\/10.33612\/diss.1481563707","DOI":"10.33612\/diss.1481563707"},{"key":"3193_CR17","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1007\/s00125-026-06679-5","volume":"69","author":"G Fuentes","year":"2026","unstructured":"Fuentes G, Valero P, Cornejo M, Silva K, Ram\u00edrez MA, Gonz\u00e1lez DR, Hillebrands J-L, van Goor H, Sobrevia L (2026) Maternal pre-pregnancy body mass index differentially regulates intracellular pH in human umbilical vein endothelium from gestational diabetes mellitus, with alkalinisation-associated reduction of adenosine transport in normal-weight pregnancies. Diabetologia 69:1618\u20131642. https:\/\/doi.org\/10.1007\/s00125-026-06679-5","journal-title":"Diabetologia"},{"key":"3193_CR18","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.3390\/diagnostics13122034","volume":"13","author":"C Giacometti","year":"2023","unstructured":"Giacometti C, Ludwig K, Guidi M, Colantuono E, Coracina A, Rigano M, Cassaro M, Ambrosi A (2023) Gestational diabetes-placental expression of human equilibrative nucleoside transporter 1 (hENT1): is delayed villous maturation an adaptive pattern? Diagnostics (Basel) 13:2034. https:\/\/doi.org\/10.3390\/diagnostics13122034","journal-title":"Diagnostics (Basel)"},{"key":"3193_CR19","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1002\/jcp.22635","volume":"226","author":"M Gonz\u00e1lez","year":"2011","unstructured":"Gonz\u00e1lez M, Gallardo V, Rodr\u00edguez N, Salom\u00f3n C, Westermeier F, Guzm\u00e1n-Guti\u00e9rrez E, Abarz\u00faa F, Leiva A, Casanello P, Sobrevia L (2011) Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation. J Cell Physiol 226:2916\u20132924. https:\/\/doi.org\/10.1002\/jcp.22635","journal-title":"J Cell Physiol"},{"key":"3193_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s11302-015-9491-2","volume":"12","author":"E Guzm\u00e1n-Guti\u00e9rrez","year":"2016","unstructured":"Guzm\u00e1n-Guti\u00e9rrez E, Armella A, Toledo F, Pardo F, Leiva A, Sobrevia L (2016) Insulin requires A1 adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium. Purinergic Signal 12:175\u2013190. https:\/\/doi.org\/10.1007\/s11302-015-9491-2","journal-title":"Purinergic Signal"},{"key":"3193_CR21","doi-asserted-by":"publisher","first-page":"e41705","DOI":"10.1371\/journal.pone.0041705","volume":"7","author":"E Guzm\u00e1n-Guti\u00e9rrez","year":"2012","unstructured":"Guzm\u00e1n-Guti\u00e9rrez E, Westermeier F, Salom\u00f3n C, Gonz\u00e1lez M, Pardo F, Leiva A, Sobrevia L (2012) Insulin-increased L-arginine transport requires A2A adenosine receptors activation in human umbilical vein endothelium. PLoS ONE 7:e41705. https:\/\/doi.org\/10.1371\/journal.pone.0041705","journal-title":"PLoS ONE"},{"key":"3193_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1078\/0171-9335-00306","volume":"82","author":"I Lang","year":"2003","unstructured":"Lang I, Pabst MA, Hiden U, Blaschitz A, Dohr G, Hahn T, Desoye G (2003) Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells. Eur J Cell Biol 82:163\u2013173. https:\/\/doi.org\/10.1078\/0171-9335-00306","journal-title":"Eur J Cell Biol"},{"key":"3193_CR23","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1161\/CIRCRESAHA.125.325386","volume":"136","author":"A Orlowski","year":"2025","unstructured":"Orlowski A, Di Mattia RA, Aiello EA (2025) Intracellular pH regulation in ventricular myocytes: implications for cardiac health and disease. Circ Res 136:1636\u20131656. https:\/\/doi.org\/10.1161\/CIRCRESAHA.125.325386","journal-title":"Circ Res"},{"key":"3193_CR24","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/333664a0","volume":"333","author":"RM Palmer","year":"1988","unstructured":"Palmer RM, Ashton DS, Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333:664\u2013666. https:\/\/doi.org\/10.1038\/333664a0","journal-title":"Nature"},{"key":"3193_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/cvr\/cvq055","volume":"86","author":"A Pandolfi","year":"2010","unstructured":"Pandolfi A, Di Pietro N (2010) High glucose, nitric oxide, and adenosine: a vicious circle in chronic hyperglycaemia? Cardiovasc Res 86:9\u201311. https:\/\/doi.org\/10.1093\/cvr\/cvq055","journal-title":"Cardiovasc Res"},{"key":"3193_CR26","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1186\/s12885-017-3532-x","volume":"17","author":"AK Pedersen","year":"2017","unstructured":"Pedersen AK, Mendes Lopes de Melo J, M\u00f8rup N, Tritsaris K, Pedersen SF (2017) Tumor microenvironment conditions alter Akt and Na+\/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer. BMC Cancer 17:542. https:\/\/doi.org\/10.1186\/s12885-017-3532-x","journal-title":"BMC Cancer"},{"key":"3193_CR27","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.bbadis.2018.01.032","volume":"1864","author":"MA Ram\u00edrez","year":"2018","unstructured":"Ram\u00edrez MA, Morales J, Cornejo M, Salom\u00f3n C, Sobrevia L (2018) Intracellular acidification reduces L-arginine transport via system y\u2009+\u2009L but not via system y+\/CATs and nitric oxide synthase activity in human umbilical vein endothelial cells. Biochim Biophys Acta Mol Basis Dis 1864:1192\u20131202. https:\/\/doi.org\/10.1016\/j.bbadis.2018.01.032","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"3193_CR28","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1476-5381.1993.tb13832.x","volume":"110","author":"MA Read","year":"1993","unstructured":"Read MA, Boura AL, Walters WA (1993) Vascular actions of purines in the foetal circulation of the human placenta. Br J Pharmacol 110:454\u2013460. https:\/\/doi.org\/10.1111\/j.1476-5381.1993.tb13832.x","journal-title":"Br J Pharmacol"},{"key":"3193_CR29","doi-asserted-by":"publisher","unstructured":"Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, Stanford FC, Batterham RL, Farooqi IS, Farpour-Lambert NJ, le Roux CW, Sattar N, Baur LA, Morrison KM, Misra A, Kadowaki T, Tham KW, Sumithran P, Garvey WT, Kirwan JP, Fern\u00e1ndez-Real JM, Corkey BE, Toplak H, Kokkinos A, Kushner RF, Branca F, Valabhji J, Bl\u00fcher M, Bornstein SR, Grill HJ, Ravussin E, Gregg E, Al Busaidi NB, Alfaris NF, Al Ozairi E, Carlsson LMS, Cl\u00e9ment K, Despr\u00e9s JP, Dixon JB, Galea G, Kaplan LM, Laferr\u00e8re B, Laville M, Lim S, Luna Fuentes JR, Mooney VM, Nadglowski J Jr, Urudinachi A, Olszanecka-Glinianowicz M, Pan A, Pattou F, Schauer PR, Tsch\u00f6p MH, van der Merwe MT, Vettor R, Mingrone G (2025) Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. ; 13: 221\u2013262. https:\/\/doi.org\/10.1016\/S2213-8587(24)00316-4. Erratum in: Lancet Diabetes Endocrinol. 2025; 13:e6. https:\/\/doi.org\/10.1016\/S2213-8587(25)00006-3","DOI":"10.1016\/S2213-8587(24)00316-4"},{"key":"3193_CR30","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1113\/JP290546","volume":"604","author":"MVC Rudge","year":"2026","unstructured":"Rudge MVC, Magalh\u00e3es CG, Fran\u00e7a DCH, Costa RA, Silva K, Calderon IMP, Sobrevia L (2026) Reframing gestational diabetes mellitus through two new paradigms: Early detection and lifelong intergenerational follow-up. J Physiol 604:3253\u20133264. https:\/\/doi.org\/10.1113\/JP290546","journal-title":"J Physiol"},{"key":"3193_CR31","doi-asserted-by":"publisher","first-page":"e40578","DOI":"10.1371\/journal.pone.0040578","volume":"7","author":"C Salom\u00f3n","year":"2012","unstructured":"Salom\u00f3n C, Westermeier F, Puebla C, Guzm\u00e1n-Guti\u00e9rrez E, Far\u00edas M, Villalobos-Labra R, Sobrevia L (2012) Gestational diabetes reduces adenosine transport in human placental microvascular endothelium, an effect reversed by insulin. PLoS ONE 7:e40578. https:\/\/doi.org\/10.1371\/journal.pone.0040578","journal-title":"PLoS ONE"},{"key":"3193_CR32","doi-asserted-by":"publisher","first-page":"165993","DOI":"10.1016\/j.bbadis.2020.165993","volume":"1867","author":"R Salsoso","year":"2021","unstructured":"Salsoso R, Mate A, Toledo F, V\u00e1zquez CM, Sobrevia L (2021) Insulin requires A2B adenosine receptors to modulate the L-arginine\/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia. Biochim Biophys Acta \u2013 Mol Basis Dis 1867:165993. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165993","journal-title":"Biochim Biophys Acta \u2013 Mol Basis Dis"},{"key":"3193_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2005.01.011","volume":"27","author":"R San Mart\u00edn","year":"2006","unstructured":"San Mart\u00edn R, Sobrevia L (2006) Gestational diabetes and the adenosine\/L-arginine\/nitric oxide (ALANO) pathway in human umbilical vein endothelium. Placenta 27:1\u201310. https:\/\/doi.org\/10.1016\/j.placenta.2005.01.011","journal-title":"Placenta"},{"key":"3193_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/164_2026_803","author":"K Silva","year":"2026","unstructured":"Silva K, Valero P, Espinoza F, Rivas JC, Sauceda-Acosta D, Sobrevia L (2026) Are there common mechanisms and consequences of placental endothelial dysfunction in women with gestational diabetes mellitus and preeclampsia? Handb Exp Pharmacol. (In press) https:\/\/doi.org\/10.1007\/164_2026_803","journal-title":"Handb Exp Pharmacol"},{"key":"3193_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mam.2016.11.002","volume":"55","author":"L Silva","year":"2017","unstructured":"Silva L, Subiabre M, Araos J, S\u00e1ez T, Salsoso R, Pardo F, Leiva A, San Mart\u00edn R, Toledo F, Sobrevia L (2017) Insulin\/adenosine axis linked signalling. Mol Aspects Med 55:45\u201361. https:\/\/doi.org\/10.1016\/j.mam.2016.11.002","journal-title":"Mol Aspects Med"},{"key":"3193_CR36","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1113\/JP290342","volume":"604","author":"L Sobrevia","year":"2026","unstructured":"Sobrevia L (2026) Endothelial physiology in metabolic diseases: from cells to patients. J Physiol 604:4085\u20134091. https:\/\/doi.org\/10.1113\/JP290342","journal-title":"J Physiol"},{"key":"3193_CR37","doi-asserted-by":"publisher","first-page":"S159","DOI":"10.1016\/j.placenta.2010.12.011","volume":"32","author":"L Sobrevia","year":"2011","unstructured":"Sobrevia L, Abarz\u00faa F, Nien JK, Salom\u00f3n C, Toledo F, S\u00e1ez T, Pardo F (2011) Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes. Placenta 32:S159\u2013S164. https:\/\/doi.org\/10.1016\/j.placenta.2010.12.011","journal-title":"Placenta"},{"key":"3193_CR38","volume-title":"Fetal Programming in Obesity and Diabetes (Chap. 2). The International Union of Physiological Sciences (IUPS)","author":"L Sobrevia","year":"2026","unstructured":"Sobrevia L, Silva K, Valero P, Catalano P, Casanello P (2026) Obesity in pregnancy and risk and consequences of metabolic diseases. In: Sobrevia L (ed) Fetal Programming in Obesity and Diabetes (Chap. 2). The International Union of Physiological Sciences (IUPS). Elsevier, Amsterdam, The Netherlands. (In press)."},{"key":"3193_CR39","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.3390\/diagnostics12112881","volume":"12","author":"L Spanou","year":"2022","unstructured":"Spanou L, Dimou A, Kostara CE, Bairaktari E, Anastasiou E, Tsimihodimos V (2022) A study of the metabolic pathways affected by gestational diabetes mellitus: comparison with type 2 diabetes. Diagnostics (Basel) 12:2881. https:\/\/doi.org\/10.3390\/diagnostics12112881","journal-title":"Diagnostics (Basel)"},{"key":"3193_CR40","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1007\/s40200-020-00659-1","volume":"19","author":"S \u00dcn\u00fcvar","year":"2020","unstructured":"\u00dcn\u00fcvar S, Meleko\u011flu R, \u015ealva E, Acar C, Ya\u015far \u015e (2020) Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus. J Diabetes Metab Disord 19:1391\u20131396. https:\/\/doi.org\/10.1007\/s40200-020-00659-1","journal-title":"J Diabetes Metab Disord"},{"key":"3193_CR41","doi-asserted-by":"publisher","first-page":"101019","DOI":"10.1016\/j.mam.2021.101019","volume":"87","author":"P Valero","year":"2022","unstructured":"Valero P, Fuentes G, Cornejo M, Vega S, Grismaldo A, Pardo F, Garc\u00eda-Rivas G, Hillebrands JL, Faas MM, Casanello P, van der Beek EM, van Goor H, Sobrevia L (2022) Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus. Mol Aspects Med 87:101019. https:\/\/doi.org\/10.1016\/j.mam.2021.101019","journal-title":"Mol Aspects Med"},{"key":"3193_CR42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1113\/jphysiol.2004.068288","volume":"560","author":"G V\u00e1squez","year":"2004","unstructured":"V\u00e1squez G, Sanhueza F, V\u00e1squez R, Gonz\u00e1lez M, Salom\u00f3n C, Sobrevia L (2004) Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 560:111\u2013122. https:\/\/doi.org\/10.1113\/jphysiol.2004.068288","journal-title":"J Physiol"},{"key":"3193_CR43","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1016\/j.bbadis.2018.07.007","volume":"1864","author":"R Villalobos-Labra","year":"2018","unstructured":"Villalobos-Labra R, S\u00e1ez P, Subiabre M, Toledo F, Silva L, Sobrevia L (2018) Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium. Biochim Biophys Acta Mol Basis Dis 1864:3195\u20133210. https:\/\/doi.org\/10.1016\/j.bbadis.2018.07.007","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"3193_CR44","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.2337\/db11-0155","volume":"60","author":"F Westermeier","year":"2011","unstructured":"Westermeier F, Salom\u00f3n C, Gonz\u00e1lez M, Puebla C, Guzm\u00e1n-Guti\u00e9rrez E, Far\u00edas M, Sobrevia L (2011) Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium. Diabetes 60:1677\u20131687. https:\/\/doi.org\/10.2337\/db11-0155","journal-title":"Diabetes"},{"key":"3193_CR45","unstructured":"World Health Organization, Diabetes FS (2024) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes. Last accessed March 4, 2026"},{"key":"3193_CR46","unstructured":"World Health Organization. Obesity and overweight, Fact Sheet (2025) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes. Last accessed March 4, 2026"},{"key":"3193_CR47","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.envint.2018.10.044","volume":"121","author":"Y Wu","year":"2018","unstructured":"Wu Y, Zhang J, Peng S, Wang X, Luo L, Liu L, Huang Q, Tian M, Zhang X, Shen H (2018) Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium. Environ Int 121:1227\u20131234. https:\/\/doi.org\/10.1016\/j.envint.2018.10.044","journal-title":"Environ Int"},{"key":"3193_CR48","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1096\/fj.01-0125com","volume":"16","author":"AW Wyatt","year":"2002","unstructured":"Wyatt AW, Steinert JR, Wheeler-Jones CP, Morgan AJ, Sugden D, Pearson JD, Sobrevia L, Mann GE (2002) Early activation of the p42\/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism. FASEB J 16:1584\u20131594. https:\/\/doi.org\/10.1096\/fj.01-0125com","journal-title":"FASEB J"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-026-03193-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-026-03193-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-026-03193-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:06:50Z","timestamp":1784171210000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-026-03193-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3193"],"URL":"https:\/\/doi.org\/10.1007\/s00424-026-03193-w","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"4 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"62"}}