{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:27:43Z","timestamp":1786692463082,"version":"build-2736575974"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade De S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pflugers Arch - Eur J Physiol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00424-026-03195-8","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:42:07Z","timestamp":1785206527000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-dependent and compartment-specific macrophage accumulation associates with glomerular injury in BTBR ob\/ob mice"],"prefix":"10.1007","volume":"478","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-3238","authenticated-orcid":false,"given":"Mariana Charleaux","family":"de Ponte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9191-4382","authenticated-orcid":false,"given":"Victoria Mel Dussan","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2397-3485","authenticated-orcid":false,"given":"Leticia Barreto","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-4445","authenticated-orcid":false,"given":"Karina","family":"Thieme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"1","key":"3195_CR1","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.2337\/dc11-S062","volume":"34","author":"American Diabetes Association","year":"2011","unstructured":"American Diabetes Association (2011) Diagnosis and classification of diabetes mellitus. Diabetes Care 34(1):S62\u2013S69. https:\/\/doi.org\/10.2337\/dc11-S062. PMID: 21193628; PMCID: PMC3006051","journal-title":"Diabetes Care"},{"issue":"10397","key":"3195_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","volume":"402","author":"GBD 2021 Diabetes Collaborators","year":"2023","unstructured":"GBD 2021 Diabetes Collaborators (2023) Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 402(10397):203\u2013234. https:\/\/doi.org\/10.1016\/S0140-6736(23)01301-6","journal-title":"Lancet"},{"issue":"1","key":"3195_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4093\/dmj.2021.0280","volume":"46","author":"SH Lee","year":"2022","unstructured":"Lee SH, Park SY, Choi CS (2022) Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J 46(1):15\u201337. https:\/\/doi.org\/10.4093\/dmj.2021.0280","journal-title":"Diabetes Metab J"},{"issue":"6","key":"3195_CR4","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1007\/s12325-025-03185-9","volume":"42","author":"K Islam","year":"2025","unstructured":"Islam K, Islam R, Nguyen I, Malik H, Pirzadah H, Shrestha B, Lentz IB, Shekoohi S, Kaye AD (2025) Diabetes mellitus and associated vascular disease: pathogenesis, complications, and evolving treatments. Adv Ther 42(6):2659\u20132678. https:\/\/doi.org\/10.1007\/s12325-025-03185-9","journal-title":"Adv Ther"},{"issue":"5","key":"3195_CR5","doi-asserted-by":"publisher","first-page":"C1061","DOI":"10.1152\/ajpcell.00188.2022","volume":"324","author":"G Kaur","year":"2023","unstructured":"Kaur G, Harris NR (2023) Endothelial glycocalyx in retina, hyperglycemia, and diabetic retinopathy. Am J Physiol Cell Physiol 324(5):C1061\u2013C1077. https:\/\/doi.org\/10.1152\/ajpcell.00188.2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"3195_CR6","doi-asserted-by":"publisher","first-page":"904001","DOI":"10.3389\/fendo.2022.904001","volume":"13","author":"L Lin","year":"2022","unstructured":"Lin L, Tan W, Pan X, Tian E, Wu Z, Yang J (2022) Metabolic Syndrome-Related Kidney Injury: A Review and Update. Front Endocrinol (Lausanne) 13:904001. https:\/\/doi.org\/10.3389\/fendo.2022.904001. PMID: 35813613; PMCID: PMC9261267","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"3195_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4103\/jpbs.jpbs_1059_25","volume":"17","author":"A Uma","year":"2025","unstructured":"Uma A, Sivaraman S, Manoharan R, Periasamy P (2025) Diabetic kidney disease in type 2 diabetes: a comprehensive review of epidemiology, pathophysiology, and therapeutic advances. J Pharm Bioallied Sci 17(2):33\u201335. https:\/\/doi.org\/10.4103\/jpbs.jpbs_1059_25","journal-title":"J Pharm Bioallied Sci"},{"key":"3195_CR8","doi-asserted-by":"publisher","unstructured":"Selby NM, Taal MW (2020) An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. ;22 Suppl 1:3\u201315. https:\/\/doi.org\/10.1111\/dom.14007. PMID: 32267079","DOI":"10.1111\/dom.14007"},{"issue":"2","key":"3195_CR9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","volume":"102","author":"KR Tuttle","year":"2022","unstructured":"Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J (2022) Molecular mechanisms and therapeutic targets for diabetic kidney disease. Kidney Int 102(2):248\u2013260. https:\/\/doi.org\/10.1016\/j.kint.2022.05.012","journal-title":"Kidney Int"},{"issue":"2","key":"3195_CR10","doi-asserted-by":"publisher","first-page":"F456","DOI":"10.1152\/ajprenal.00249.2019","volume":"317","author":"BD Shepard","year":"2019","unstructured":"Shepard BD (2019) Sex differences in diabetes and kidney disease: mechanisms and consequences. Am J Physiol Renal Physiol 317(2):F456\u2013F462. https:\/\/doi.org\/10.1152\/ajprenal.00249.2019","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"3195_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/0004563216646397","volume":"54","author":"A Aregbesola","year":"2017","unstructured":"Aregbesola A, Voutilainen S, Virtanen JK, Mursu J, Tuomainen TP (2017) Gender difference in type 2 diabetes and the role of body iron stores. Ann Clin Biochem 54(1):113\u2013120. https:\/\/doi.org\/10.1177\/0004563216646397","journal-title":"Ann Clin Biochem"},{"issue":"3","key":"3195_CR12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/1753-0407.13367","volume":"15","author":"M Oshima","year":"2023","unstructured":"Oshima M, Iwata Y, Toyama T, Kitajima S, Hara A, Sakai N, Shimizu M, Furuichi K, Haneda M, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Makino H, Wada T (2023) Sex differences in risk factors for end-stage kidney disease and death in type 2 diabetes: a retrospective cohort study. J Diabetes 15(3):246\u2013254. https:\/\/doi.org\/10.1111\/1753-0407.13367","journal-title":"J Diabetes"},{"key":"3195_CR13","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2147\/DMSO.S451628","volume":"17","author":"F Zhang","year":"2024","unstructured":"Zhang F, Han Y, Zheng G, Li W (2024) Gender Differences in the Incidence of Nephropathy and Changes in Renal Function in Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study. Diabetes Metab Syndr Obes 17:943\u2013957 PMID: 38435634; PMCID: PMC10906732","journal-title":"Diabetes Metab Syndr Obes"},{"key":"3195_CR14","doi-asserted-by":"publisher","first-page":"4626382","DOI":"10.1155\/2016\/4626382","volume":"2016","author":"A Kajiwara","year":"2016","unstructured":"Kajiwara A, Kita A, Saruwatari J, Miyazaki H, Kawata Y, Morita K, Oniki K, Yoshida A, Jinnouchi H, Nakagawa K (2016) Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes. J Diabetes Res 2016:4626382. https:\/\/doi.org\/10.1155\/2016\/4626382. Epub 2016 May 9. PMID: 27247948; PMCID: PMC4876234","journal-title":"J Diabetes Res"},{"issue":"8","key":"3195_CR15","doi-asserted-by":"publisher","first-page":"F996","DOI":"10.1152\/ajprenal.00282.2013","volume":"305","author":"C Maric-Bilkan","year":"2013","unstructured":"Maric-Bilkan C (2013) Gender-associated features in diabetic kidney disease. Am J Physiol Ren Physiol 305(8):F996\u2013F1004. https:\/\/doi.org\/10.1152\/ajprenal.00282.2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"3195_CR16","doi-asserted-by":"publisher","unstructured":"Alicic RZ, Johnson EJ, Tuttle KR (2018) Inflammatory Mechanisms as New Biomarkers and Therapeutic Targets for Diabetic Kidney Disease. Adv Chronic Kidney Dis. ;25(2):181\u2013191. https:\/\/doi.org\/10.1053\/j.ackd.2017.12.002. PMID: 29580582","DOI":"10.1053\/j.ackd.2017.12.002"},{"issue":"11","key":"3195_CR17","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/13543784.2018.1538352","volume":"27","author":"JA Moreno","year":"2018","unstructured":"Moreno JA, Gomez-Guerrero C, Mas S, Sanz AB, Lorenzo O, Ruiz-Ortega M, Opazo L, Mezzano S, Egido J (2018) Targeting inflammation in diabetic nephropathy: a tale of hope. Expert Opin Investig Drugs 27(11):917\u2013930. https:\/\/doi.org\/10.1080\/13543784.2018.1538352","journal-title":"Expert Opin Investig Drugs"},{"key":"3195_CR18","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cytogfr.2025.05.007","volume":"84","author":"Z Ansari","year":"2025","unstructured":"Ansari Z, Chaurasia A, Neha, Sharma N, Bachheti RK, Gupta PC (2025) Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression. Cytokine Growth Factor Rev 84:120\u2013134. https:\/\/doi.org\/10.1016\/j.cytogfr.2025.05.007. Epub 2025 May 29. PMID: 40467395","journal-title":"Cytokine Growth Factor Rev"},{"issue":"5","key":"3195_CR19","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s41591-019-0415-5","volume":"25","author":"MA Niewczas","year":"2019","unstructured":"Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS (2019) A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat Med 25(5):805\u2013813. https:\/\/doi.org\/10.1038\/s41591-019-0415-5","journal-title":"Nat Med"},{"issue":"1","key":"3195_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jnma.2023.12.001","volume":"116","author":"SM Swaminathan","year":"2024","unstructured":"Swaminathan SM, Rao IR, Bhojaraja MV, Attur RP, Nagri SK, Rangaswamy D, Shenoy SV, Nagaraju SP (2024) Role of novel biomarker monocyte chemo-attractant protein-1 in early diagnosis & predicting progression of diabetic kidney disease: a comprehensive review. J Natl Med Assoc 116(1):33\u201344. https:\/\/doi.org\/10.1016\/j.jnma.2023.12.001","journal-title":"J Natl Med Assoc"},{"issue":"1","key":"3195_CR21","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2563671","volume":"47","author":"SM Swaminathan","year":"2025","unstructured":"Swaminathan SM, Bhojaraja MV, Rao IR, Prabhu AR, Kaniyoor Nagri S, Rangaswamy D, Shenoy SV, Shetty S, Maradi R, Gupta A, Ballala K, Nagaraju SP (2025) Role of novel biomarkers urinary NGAL and MCP-1 in predicting progression of diabetic kidney disease in type 2 DM. Ren Fail 47(1):2563671. https:\/\/doi.org\/10.1080\/0886022X.2025.2563671","journal-title":"Ren Fail"},{"issue":"5","key":"3195_CR22","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1681\/ASN.2020081112","volume":"32","author":"LC Veiras","year":"2021","unstructured":"Veiras LC, Shen JZY, Bernstein EA, Regis GC, Cao D, Okwan-Duodu D, Khan Z, Gibb DR, Dominici FP, Bernstein KE, Giani JF (2021) Renal inflammation induces salt sensitivity in male db\/db mice through dysregulation of ENaC. J Am Soc Nephrol 32(5):1131\u20131149. https:\/\/doi.org\/10.1681\/ASN.2020081112","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"3195_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.31436\/imjm.v20i4.1827","volume":"20","author":"A Ahmad","year":"2021","unstructured":"Ahmad A, Ajeel M, Aldabbagh K (2021) Measurement of inflammation-related biomarkers in different chronic kidney diseases in humans: role of aging and gender? Int Med J Malaysia 20(4):113\u2013120. https:\/\/doi.org\/10.31436\/imjm.v20i4.1827","journal-title":"Int Med J Malaysia"},{"key":"3195_CR24","doi-asserted-by":"publisher","unstructured":"Lima FA, Mon\u00e7\u00e3o JS, Honorio MS, Fujimori M, Fran\u00e7a DCH, Cotrim ACM, Fran\u00e7a ECH, Fran\u00e7a-Botelho AC, Fagundes-Triches DLG, Marchi PGF, Honorio-Fran\u00e7a AC, Fran\u00e7a EL (2023) Chronobiological changes in biochemical hemorheological parameters and cytokine levels in the blood of diabetic patients on hemodialysis: a cross-sectional study. Int J Mol Sci 24(3):. https:\/\/doi.org\/10.3390\/ijms24032735","DOI":"10.3390\/ijms24032735"},{"issue":"5","key":"3195_CR25","doi-asserted-by":"publisher","first-page":"F1217","DOI":"10.1152\/ajprenal.00293.2019","volume":"317","author":"H Wang","year":"2019","unstructured":"Wang H, Sheng J, He H, Chen X, Li J, Tan R, Wang L, Lan HY (2019) A simple and highly purified method for isolation of glomeruli from the mouse kidney. Am J Physiol Renal Physiol 317(5):F1217\u2013F1223. https:\/\/doi.org\/10.1152\/ajprenal.00293.2019","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1 Suppl 1","key":"3195_CR26","doi-asserted-by":"publisher","first-page":"A6","DOI":"10.1053\/j.ajkd.2019.09.003","volume":"75","author":"R Saran","year":"2020","unstructured":"Saran R, Robinson B, Abbott KC, Bragg-Gresham J, Chen X, Gipson D, Gu H, Hirth RA, Hutton D, Jin Y, Kapke A, Kurtz V, Li Y, McCullough K, Modi Z, Morgenstern H, Mukhopadhyay P, Pearson J, Pisoni R, Repeck K, Schaubel DE, Shamraj R, Steffick D, Turf M, Woodside KJ, Xiang J, Yin M, Zhang X, Shahinian V (2020) US Renal Data System 2019 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis 75(1 Suppl 1):A6\u2013A7. https:\/\/doi.org\/10.1053\/j.ajkd.2019.09.003","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"3195_CR27","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.kint.2022.10.030","volume":"103","author":"S Rayego-Mateos","year":"2023","unstructured":"Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fern\u00e1ndez C, Marchant V, Donate-Correa J, Navarro-Gonz\u00e1lez JF, Ortiz A, Ruiz-Ortega M (2023) Targeting inflammation to treat diabetic kidney disease: the road to 2030. Kidney Int 103(2):282\u2013296. https:\/\/doi.org\/10.1016\/j.kint.2022.10.030","journal-title":"Kidney Int"},{"key":"3195_CR28","doi-asserted-by":"publisher","unstructured":"Gado M, Tsaousidou E, Bornstein SR, Perakakis N (2024) Sex-based differences in insulin resistance. J Endocrinol. ;261(1):e230245. https:\/\/doi.org\/10.1530\/JOE-23-0245. PMID: 38265844","DOI":"10.1530\/JOE-23-0245"},{"issue":"3","key":"3195_CR29","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","volume":"63","author":"B Tramunt","year":"2020","unstructured":"Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal JF, Montagner A, Gourdy P (2020) Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia 63(3):453\u2013461. https:\/\/doi.org\/10.1007\/s00125-019-05040-3","journal-title":"Diabetologia"},{"key":"3195_CR30","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.molmet.2018.11.006","volume":"20","author":"M Keuper","year":"2019","unstructured":"Keuper M, Berti L, Raedle B, Sachs S, B\u00f6hm A, Fritsche L, Fritsche A, H\u00e4ring HU, Hrab\u011b de Angelis M, Jastroch M, Hofmann SM, Staiger H (2019) Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin. Mol Metab 20:28\u201337. https:\/\/doi.org\/10.1016\/j.molmet.2018.11.006","journal-title":"Mol Metab"},{"issue":"15","key":"3195_CR31","doi-asserted-by":"publisher","first-page":"e23845","DOI":"10.1096\/fj.202302377R","volume":"38","author":"TS Nicolaisen","year":"2024","unstructured":"Nicolaisen TS, Sj\u00f8berg KA, Carl CS, Richter EA, Kiens B, Fritzen AM, Lundsgaard AM (2024) Greater molecular potential for glucose metabolism in adipose tissue and skeletal muscle of women compared with men. FASEB J 38(15):e23845. https:\/\/doi.org\/10.1096\/fj.202302377R. PMID: 39082199; PMCID: PMC11607633","journal-title":"FASEB J"},{"key":"3195_CR32","doi-asserted-by":"publisher","unstructured":"Mather A, Pollock C (2011) Glucose handling by the kidney. Kidney Int Suppl. ;(120):S1-6. https:\/\/doi.org\/10.1038\/ki.2010.509. PMID: 21358696","DOI":"10.1038\/ki.2010.509"},{"issue":"9","key":"3195_CR33","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1681\/ASN.2009121290","volume":"21","author":"KL Hudkins","year":"2010","unstructured":"Hudkins KL, Pichaiwong W, Wietecha T, Kowalewska J, Banas MC, Spencer MW, M\u00fchlfeld A, Koelling M, Pippin JW, Shankland SJ, Askari B, Rabaglia ME, Keller MP, Attie AD, Alpers CE (2010) BTBR ob\/ob mutant mice model progressive diabetic nephropathy. J Am Soc Nephrol 21(9):1533\u201342. https:\/\/doi.org\/10.1681\/ASN.2009121290","journal-title":"J Am Soc Nephrol"},{"key":"3195_CR34","doi-asserted-by":"publisher","first-page":"1167546","DOI":"10.3389\/fendo.2023.1167546","volume":"14","author":"BM Veloso Pereira","year":"2023","unstructured":"Veloso Pereira BM, Charleaux de Ponte M, Malavolta Luz AP, Thieme K (2023) DNA methylation enzymes in the kidneys of male and female BTBR ob\/ob mice. Front Endocrinol (Lausanne) 14:1167546. https:\/\/doi.org\/10.3389\/fendo.2023.1167546. PMID: 37091852; PMCID: PMC10113614","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"3195_CR35","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/s41573-021-00242-0","volume":"20","author":"IS Daehn","year":"2021","unstructured":"Daehn IS, Duffield JS (2021) The glomerular filtration barrier: a structural target for novel kidney therapies. Nat Rev Drug Discov 20(10):770\u2013788. https:\/\/doi.org\/10.1038\/s41573-021-00242-0. Epub 2021 Jul 14. PMID: 34262140; PMCID: PMC8278373","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"3195_CR36","doi-asserted-by":"publisher","first-page":"e70081","DOI":"10.1111\/apha.70081","volume":"241","author":"D Loreth","year":"2025","unstructured":"Loreth D, Sachs W, Meyer-Schwesinger C (2025) The Life of a Kidney Podocyte. Acta Physiol (Oxf) 241(8):e70081. https:\/\/doi.org\/10.1111\/apha.70081. PMID: 40698593; PMCID: PMC12284917","journal-title":"Acta Physiol (Oxf)"},{"issue":"5","key":"3195_CR37","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s42255-020-0204-y","volume":"2","author":"L Butt","year":"2020","unstructured":"Butt L, Unnersj\u00f6-Jess D, H\u00f6hne M, Edwards A, Binz-Lotter J, Reilly D, Hahnfeldt R, Ziegler V, Fremter K, Rinschen MM, Helmst\u00e4dter M, Ebert LK, Castrop H, Hackl MJ, Walz G, Brinkkoetter PT, Liebau MC, Tory K, Hoyer PF, Beck BB, Brismar H, Blom H, Schermer B, Benzing T (2020) A molecular mechanism explaining albuminuria in kidney disease. Nat Metab 2(5):461\u2013474. https:\/\/doi.org\/10.1038\/s42255-020-0204-y","journal-title":"Nat Metab"},{"key":"3195_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acc.2021.08.001","volume":"108","author":"I Kostovska","year":"2022","unstructured":"Kostovska I, Trajkovska KT, Topuzovska S, Cekovska S, Labudovic D, Kostovski O, Spasovski G (2022) Nephrinuria and podocytopathies. Adv Clin Chem 108:1\u201336. https:\/\/doi.org\/10.1016\/bs.acc.2021.08.001. Epub 2021 Sep 10. PMID: 35659057","journal-title":"Adv Clin Chem"},{"issue":"1","key":"3195_CR39","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40348-023-00164-4","volume":"10","author":"C Menendez-Castro","year":"2023","unstructured":"Menendez-Castro C, Cordasic N, Fahlbusch FB, Woelfle J, Hilgers KF, Hartner A (2023) Sex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis. Mol Cell Pediatr 10(1):8. https:\/\/doi.org\/10.1186\/s40348-023-00164-4. PMID: 37624430; PMCID: PMC10457250","journal-title":"Mol Cell Pediatr"},{"issue":"7","key":"3195_CR40","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.3390\/cells9071700","volume":"9","author":"J Blaine","year":"2020","unstructured":"Blaine J, Dylewski J (2020) Regulation of the Actin Cytoskeleton in Podocytes. Cells 9(7):1700. https:\/\/doi.org\/10.3390\/cells9071700. PMID: 32708597; PMCID: PMC7408282","journal-title":"Cells"},{"issue":"6","key":"3195_CR41","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrneph.2013.78","volume":"9","author":"PT Brinkkoetter","year":"2013","unstructured":"Brinkkoetter PT, Ising C, Benzing T (2013) The role of the podocyte in albumin filtration. Nat Rev Nephrol 9(6):328\u201336. https:\/\/doi.org\/10.1038\/nrneph.2013.78","journal-title":"Nat Rev Nephrol"},{"key":"3195_CR42","doi-asserted-by":"publisher","unstructured":"Klessens CQF, Zandbergen M, Wolterbeek R, Bruijn JA, Rabelink TJ, Bajema IM, IJpelaar DHT (2017) Macrophages in diabetic nephropathy in patients with type 2 diabetes. Nephrol Dial Transplant. ;32(8):1322\u20131329. https:\/\/doi.org\/10.1093\/ndt\/gfw260. PMID: 27416772","DOI":"10.1093\/ndt\/gfw260"},{"key":"3195_CR43","doi-asserted-by":"publisher","unstructured":"Chow FY, Nikolic-Paterson DJ, Atkins RC, Tesch GH (2004) Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis. Nephrol Dial Transplant. ;19(12):2987-96. https:\/\/doi.org\/10.1093\/ndt\/gfh441. PMID: 15574996","DOI":"10.1093\/ndt\/gfh441"},{"key":"3195_CR44","doi-asserted-by":"publisher","unstructured":"Chow F, Ozols E, Nikolic-Paterson DJ, Atkins RC, Tesch GH (2004) Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int. ;65(1):116\u2009\u2013\u200928. https:\/\/doi.org\/10.1111\/j.1523-1755.2004.00367.x. PMID: 14675042","DOI":"10.1111\/j.1523-1755.2004.00367.x"},{"key":"3195_CR45","doi-asserted-by":"publisher","unstructured":"Kato S, Luyckx VA, Ots M, Lee KW, Ziai F, Troy JL, Brenner BM, MacKenzie HS (1999) Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int. ;56(3):1037-48. https:\/\/doi.org\/10.1046\/j.1523-1755.1999.00643.x. PMID: 10469372","DOI":"10.1046\/j.1523-1755.1999.00643.x"},{"issue":"9","key":"3195_CR46","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2337\/db08-0895","volume":"58","author":"E Tarabra","year":"2009","unstructured":"Tarabra E, Giunti S, Barutta F, Salvidio G, Burt D, Deferrari G, Gambino R, Vergola D, Pinach S, Perin PC, Camussi G, Gruden G (2009) Effect of the monocyte chemoattractant protein-1\/CC chemokine receptor 2 system on nephrin expression in streptozotocin-treated mice and human cultured podocytes. Diabetes 58(9):2109\u201318. https:\/\/doi.org\/10.2337\/db08-0895","journal-title":"Diabetes"},{"issue":"2","key":"3195_CR47","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00125-006-0497-8","volume":"50","author":"FY Chow","year":"2007","unstructured":"Chow FY, Nikolic-Paterson DJ, Ma FY, Ozols E, Rollins BJ, Tesch GH (2007) Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db\/db mice. Diabetologia 50(2):471\u201380. https:\/\/doi.org\/10.1007\/s00125-006-0497-8","journal-title":"Diabetologia"},{"key":"3195_CR48","doi-asserted-by":"publisher","first-page":"1303076","DOI":"10.3389\/fimmu.2023.1303076","volume":"14","author":"Y Liu","year":"2024","unstructured":"Liu Y, Xu K, Xiang Y, Ma B, Li H, Li Y, Shi Y, Li S, Bai Y (2024) Role of MCP-1 as an inflammatory biomarker in nephropathy. Front Immunol 14:1303076. https:\/\/doi.org\/10.3389\/fimmu.2023.1303076. PMID: 38239353; PMCID: PMC10794684","journal-title":"Front Immunol"},{"issue":"42","key":"3195_CR49","doi-asserted-by":"publisher","first-page":"e35613","DOI":"10.1097\/MD.0000000000035613","volume":"102","author":"S He","year":"2023","unstructured":"He S, Yao L, Li J (2023) Role of MCP-1\/CCR2 axis in renal fibrosis: Mechanisms and therapeutic targeting. Med (Baltim) 102(42):e35613. https:\/\/doi.org\/10.1097\/MD.0000000000035613. PMID: 37861543; PMCID: PMC10589562","journal-title":"Med (Baltim)"},{"issue":"1","key":"3195_CR50","doi-asserted-by":"publisher","first-page":"11954","DOI":"10.1038\/s41598-020-68769-7","volume":"10","author":"F Luciano-Mateo","year":"2020","unstructured":"Luciano-Mateo F, Cabr\u00e9 N, Fern\u00e1ndez-Arroyo S, Baiges-Gaya G, Hern\u00e1ndez-Aguilera A, Rodr\u00edguez-Tom\u00e0s E, Mu\u00f1oz-Pinedo C, Men\u00e9ndez JA, Camps J, Joven J (2020) Chemokine C-C motif ligand 2 overexpression drives tissue-specific metabolic responses in the liver and muscle of mice. Sci Rep 10(1):11954. https:\/\/doi.org\/10.1038\/s41598-020-68769-7. PMID: 32686726; PMCID: PMC7371894","journal-title":"Sci Rep"},{"key":"3195_CR51","doi-asserted-by":"publisher","first-page":"1053457","DOI":"10.3389\/fimmu.2022.1053457","volume":"13","author":"Z Lin","year":"2023","unstructured":"Lin Z, Shi JL, Chen M, Zheng ZM, Li MQ, Shao J (2023) CCL2: An important cytokine in normal and pathological pregnancies: A review. Front Immunol 13:1053457. https:\/\/doi.org\/10.3389\/fimmu.2022.1053457. PMID: 36685497; PMCID: PMC9852914","journal-title":"Front Immunol"},{"issue":"10","key":"3195_CR52","doi-asserted-by":"publisher","first-page":"7211","DOI":"10.1002\/jcp.30375","volume":"236","author":"S Zhu","year":"2021","unstructured":"Zhu S, Liu M, Bennett S, Wang Z, Pfleger KDG, Xu J (2021) The molecular structure and role of CCL2 (MCP-1) and C-C chemokine receptor CCR2 in skeletal biology and diseases. J Cell Physiol 236(10):7211\u20137222. https:\/\/doi.org\/10.1002\/jcp.30375","journal-title":"J Cell Physiol"},{"issue":"9","key":"3195_CR53","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1159\/000536522","volume":"148","author":"S Kanoo","year":"2024","unstructured":"Kanoo S, Goodluck H, Kim YC, Garrido AN, Crespo-Masip M, Lopez N, Zhang H, Gonzalez-Villalobos RA, Ma LJ, Vallon V (2024) Deletion, but not heterozygosity, of eNOS raises blood pressure and aggravates nephropathy in BTBR ob\/ob mice. Nephron 148(9):631\u2013642. https:\/\/doi.org\/10.1159\/000536522","journal-title":"Nephron"}],"container-title":["Pfl\u00fcgers Archiv - European Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-026-03195-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00424-026-03195-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00424-026-03195-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:43:45Z","timestamp":1786689825000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00424-026-03195-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3195"],"URL":"https:\/\/doi.org\/10.1007\/s00424-026-03195-8","relation":{},"ISSN":["0031-6768","1432-2013"],"issn-type":[{"value":"0031-6768","type":"print"},{"value":"1432-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"20 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Institutional Animal Care and Use Committee of the Institute of Biomedical Sciences of University of Sao Paulo (CEUA-ICB\/USP, protocol numbers 5348280918 and 7358100320) approved all mice procedures.","order":1,"name":"Ethics","label":"Statement of Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"69"}}