{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:00:26Z","timestamp":1792818026335,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"crossref","award":["VIDI 11281"],"award-info":[{"award-number":["VIDI 11281"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VENI 13682"],"award-info":[{"award-number":["VENI 13682"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Research Council","award":["Grant 269072"],"award-info":[{"award-number":["Grant 269072"]}]},{"name":"CAPES Foundation, Ministry of Education of Brazil"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Planta"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Main conclusion<\/jats:title>\n                    <jats:p>\n                      Overexpression of pathogen-induced cysteine-rich transmembrane proteins (PCMs) in\n                      <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                      enhances resistance against biotrophic pathogens and stimulates hypocotyl growth, suggesting a potential role for PCMs in connecting both biological processes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Plants possess a sophisticated immune system to protect themselves against pathogen attack. The defense hormone salicylic acid (SA) is an important player in the plant immune gene regulatory network. Using RNA-seq time series data of\n                      <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                      leaves treated with SA, we identified a largely uncharacterized SA-responsive gene family of eight members that are all activated in response to various pathogens or their immune elicitors and encode small proteins with cysteine-rich transmembrane domains. Based on their nucleotide similarity and chromosomal position, the designated Pathogen-induced Cysteine-rich transMembrane protein (PCM) genes were subdivided into three subgroups consisting of\n                      <jats:italic>PCM1-3<\/jats:italic>\n                      (subgroup I),\n                      <jats:italic>PCM4-6<\/jats:italic>\n                      (subgroup II), and\n                      <jats:italic>PCM7-<\/jats:italic>\n                      <jats:italic>8<\/jats:italic>\n                      (subgroup III). Of the PCM genes, only\n                      <jats:italic>PCM4<\/jats:italic>\n                      (also known as\n                      <jats:italic>PCC1<\/jats:italic>\n                      ) has previously been implicated in plant immunity. Transient expression assays in\n                      <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                      indicated that most PCM proteins localize to the plasma membrane. Ectopic overexpression of the PCMs in\n                      <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                      resulted in all eight cases in enhanced resistance against the biotrophic oomycete pathogen\n                      <jats:italic>Hyaloperonospora arabidopsidis<\/jats:italic>\n                      Noco2. Additionally, overexpression of PCM subgroup I genes conferred enhanced resistance to the hemi-biotrophic bacterial pathogen\n                      <jats:italic>Pseudomonas syringae<\/jats:italic>\n                      pv.\n                      <jats:italic>tomato<\/jats:italic>\n                      DC3000. The PCM-overexpression lines were found to be also affected in the expression of genes related to light signaling and development, and accordingly, PCM-overexpressing seedlings displayed elongated hypocotyl growth. These results point to a function of PCMs in both disease resistance and photomorphogenesis, connecting both biological processes, possibly via effects on membrane structure or activity of interacting proteins at the plasma membrane.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00425-021-03606-3","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T11:20:11Z","timestamp":1618485611000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A family of pathogen-induced cysteine-rich transmembrane proteins is involved in plant disease resistance"],"prefix":"10.1007","volume":"253","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-9202","authenticated-orcid":false,"given":"Marciel","family":"Pereira Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-7740","authenticated-orcid":false,"given":"Richard","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-8822","authenticated-orcid":false,"given":"Marcel C.","family":"Van Verk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2404-5946","authenticated-orcid":false,"given":"Nicole M.","family":"Nieuwendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Reinst\u00e4dler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-8957","authenticated-orcid":false,"given":"Ralph","family":"Panstruga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-4646","authenticated-orcid":false,"given":"Corn\u00e9 M. J.","family":"Pieterse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2295-7271","authenticated-orcid":false,"given":"Saskia C. M.","family":"Van Wees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"3606_CR1","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders S, Huber W (2010) Differential expression analysis for sequence count data. Genome Biol 11:R106","journal-title":"Genome Biol"},{"key":"3606_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W (2015) HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics 31:166\u2013169","journal-title":"Bioinformatics"},{"key":"3606_CR3","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/35048692","volume":"408","author":"Arabidopsis Genome Initiative","year":"2000","unstructured":"Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796\u2013815","journal-title":"Nature"},{"key":"3606_CR4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev-arplant-050213-040145","volume":"65","author":"CL Ballar\u00e9","year":"2014","unstructured":"Ballar\u00e9 CL (2014) Light regulation of plant defense. Annu Rev Plant Biol 65:335\u2013363","journal-title":"Annu Rev Plant Biol"},{"key":"3606_CR5","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nrg3244","volume":"13","author":"Z Bar-Joseph","year":"2012","unstructured":"Bar-Joseph Z, Gitter A, Simon I (2012) Studying and modelling dynamic biological processes using time-series gene expression data. Nat Rev Genet 13:552\u2013564","journal-title":"Nat Rev Genet"},{"key":"3606_CR6","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1105\/tpc.105.039982","volume":"18","author":"M Bartsch","year":"2006","unstructured":"Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze JL, Bautor J, Parker JE (2006) Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell 18:1038\u20131051","journal-title":"Plant Cell"},{"key":"3606_CR7","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1146\/annurev.arplant.57.032905.105346","volume":"60","author":"T Boller","year":"2009","unstructured":"Boller T, Felix G (2009) A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors. Annu Rev Plant Biol 60:379\u2013406","journal-title":"Annu Rev Plant Biol"},{"key":"3606_CR8","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1093\/bioinformatics\/bth456","volume":"20","author":"EI Boyle","year":"2004","unstructured":"Boyle EI, Weng SA, Gollub J, Jin H, Botstein D, Cherry JM, Sherlock G (2004) GO::TermFinder\u2014open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics 20:3710\u20133715","journal-title":"Bioinformatics"},{"key":"3606_CR9","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1105\/tpc.111.083345","volume":"23","author":"E Breeze","year":"2011","unstructured":"Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang CJ, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston V (2011) High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 23:873\u2013894","journal-title":"Plant Cell"},{"key":"3606_CR10","first-page":"266","volume":"58","author":"L Caarls","year":"2017","unstructured":"Caarls L, Van der Does D, Hickman R, Jansen W, Van Verk MC, Proietti S, Lorenzo O, Solano R, Pieterse CMJ, Van Wees SCM (2017) Assessing the role of ETHYLENE RESPONSE FACTOR transcriptional repressors in salicylic acid-mediated suppression of jasmonic acid-responsive genes. Plant Cell Physiol 58:266\u2013278","journal-title":"Plant Cell Physiol"},{"key":"3606_CR11","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","volume":"16","author":"SJ Clough","year":"1998","unstructured":"Clough SJ, Bent AF (1998) Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J 16:735\u2013743","journal-title":"Plant J"},{"key":"3606_CR12","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/ng1806","volume":"38","author":"C Consonni","year":"2006","unstructured":"Consonni C, Humphry ME, Hartmann HA, Livaja M, Durner J, Westphal L, Vogel J, Lipka V, Kemmerling B, Schulze-Lefert P, Somerville SC, Panstruga R (2006) Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Nature Genet 38:716\u2013720","journal-title":"Nature Genet"},{"key":"3606_CR13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/tpj.13167","volume":"86","author":"S Coolen","year":"2016","unstructured":"Coolen S, Proietti S, Hickman R, Davila Olivas NH, Huang PP, Van Verk MC, Van Pelt JA, Wittenberg AH, De Vos M, Prins M, Van Loon JJ, Aarts MG, Dicke M, Pieterse CMJ, Van Wees SCM (2016) Transcriptome dynamics of Arabidopsis during sequential biotic and abiotic stresses. Plant J 86:249\u2013267","journal-title":"Plant J"},{"key":"3606_CR14","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1016\/j.cub.2016.10.031","volume":"26","author":"M De Wit","year":"2016","unstructured":"De Wit M, Keuskamp DH, Bongers FJ, Hornitschek P, Gommers CMM, Reinen E, Martinez-Ceron C, Fankhauser C, Pierik R (2016) Integration of phytochrome and cryptochrome signals determines plant growth during competition for light. Curr Biol 26:3320\u20133326","journal-title":"Curr Biol"},{"key":"3606_CR15","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nrg2812","volume":"11","author":"PN Dodds","year":"2010","unstructured":"Dodds PN, Rathjen JP (2010) Plant immunity: towards an integrated view of plant-pathogen interactions. Nat Rev Genet 11:539\u2013548","journal-title":"Nat Rev Genet"},{"key":"3606_CR16","doi-asserted-by":"publisher","first-page":"W30","DOI":"10.1093\/nar\/gkv397","volume":"43","author":"RD Finn","year":"2015","unstructured":"Finn RD, Clements J, Arndt W, Miller BL, Wheeler TJ, Schreiber F, Bateman A, Eddy SR (2015) HMMER web server: 2015 update. Nucleic Acids Res 43:W30-38","journal-title":"Nucleic Acids Res"},{"key":"3606_CR17","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1534\/genetics.104.028662","volume":"168","author":"JA Fischer","year":"2004","unstructured":"Fischer JA, Acosta S, Kenny A, Cater C, Robinson C, Hook J (2004) Drosophila klarsicht has distinct subcellular localization domains for nuclear envelope and microtubule localization in the eye. Genetics 168:1385\u20131393","journal-title":"Genetics"},{"key":"3606_CR18","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1146\/annurev-arplant-042811-105606","volume":"64","author":"ZQ Fu","year":"2013","unstructured":"Fu ZQ, Dong X (2013) Systemic acquired resistance: turning local infection into global defense. Annu Rev Plant Biol 64:839\u2013863","journal-title":"Annu Rev Plant Biol"},{"key":"3606_CR19","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/tpj.13398","volume":"89","author":"J Gamir","year":"2017","unstructured":"Gamir J, Darwiche R, Van\u2019t Hof P, Choudhary V, Stumpe M, Schneiter R, Mauch F (2017) The sterol-binding activity of PATHOGENESIS-RELATED PROTEIN 1 reveals the mode of action of an antimicrobial protein. Plant J 89:502\u2013509","journal-title":"Plant J"},{"key":"3606_CR20","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.envexpbot.2009.08.005","volume":"68","author":"Q Hayat","year":"2010","unstructured":"Hayat Q, Hayat S, Irfan M, Ahmad A (2010) Effect of exogenous salicylic acid under changing environment: a review. Environ Exp Bot 68:14\u201325","journal-title":"Environ Exp Bot"},{"key":"3606_CR21","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1105\/tpc.16.00958","volume":"29","author":"R Hickman","year":"2017","unstructured":"Hickman R, Van Verk MC, Van Dijken AJH, Pereira Mendes M, Vroegop-Vos IA, Caarls L, Steenbergen M, Van der Nagel I, Wesselink GJ, Jironkin A, Talbot A, Rhodes J, De Vries M, Schuurink RC, Denby K, Pieterse CMJ, Van Wees SCM (2017) Architecture and dynamics of the jasmonic acid gene regulatory network. Plant Cell 29:2086\u20132105","journal-title":"Plant Cell"},{"key":"3606_CR22","doi-asserted-by":"publisher","DOI":"10.1101\/742742","author":"R Hickman","year":"2019","unstructured":"Hickman R, Pereira Mendes M, Van Verk MC, Van Dijken AJH, Di Sora J, Denby K, Pieterse CMJ, Van Wees SCM (2019) Transcriptional dynamics of the salicylic acid response and its interplay with the jasmonic acid pathway. BioRxiv. https:\/\/doi.org\/10.1101\/742742","journal-title":"BioRxiv"},{"key":"3606_CR23","doi-asserted-by":"publisher","first-page":"420747","DOI":"10.1155\/2008\/420747","volume":"2008","author":"T Hruz","year":"2008","unstructured":"Hruz T, Laule O, Szabo G, Wessendorp F, Bleuler S, Oertle L, Widmayer P, Gruissem W, Zimmermann P (2008) Genevestigator V3: a reference expression database for the meta-analysis of transcriptomes. Adv Bioinformatics 2008:420747","journal-title":"Adv Bioinformatics"},{"key":"3606_CR24","doi-asserted-by":"publisher","first-page":"R123","DOI":"10.1186\/gb-2010-11-12-r123","volume":"11","author":"G Krouk","year":"2010","unstructured":"Krouk G, Mirowski P, LeCun Y, Shasha DE, Coruzzi GM (2010) Predictive network modeling of the high-resolution dynamic plant transcriptome in response to nitrate. Genome Biol 11:R123","journal-title":"Genome Biol"},{"key":"3606_CR25","doi-asserted-by":"publisher","first-page":"e0184","DOI":"10.1199\/tab.0184","volume":"14","author":"H Kuhn","year":"2016","unstructured":"Kuhn H, Kwaaitaal M, Kusch S, Acevedo-Garcia J, Wu H, Panstruga R (2016) Biotrophy at its best: novel findings and unsolved mysteries of the Arabidopsis-powdery mildew pathosystem. Arabidopsis Book 14:e0184","journal-title":"Arabidopsis Book"},{"key":"3606_CR26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/pcp\/pcn175","volume":"50","author":"M Kuramata","year":"2009","unstructured":"Kuramata M, Masuya S, Takahashi Y, Kitagawa E, Inoue C, Ishikawa S, Youssefian S, Kusano T (2009) Novel cysteine-rich peptides from Digitaria ciliaris and Oryza sativa enhance tolerance to cadmium by limiting its cellular accumulation. Plant Cell Physiol 50:106\u2013117","journal-title":"Plant Cell Physiol"},{"key":"3606_CR27","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1007\/s00425-010-1265-z","volume":"232","author":"A Leon-Reyes","year":"2010","unstructured":"Leon-Reyes A, Van der Does D, De Lange ES, Delker C, Wasternack C, Van Wees SCM, Ritsema T, Pieterse CMJ (2010) Salicylate-mediated suppression of jasmonate-responsive gene expression in Arabidopsis is targeted downstream of the jasmonate biosynthesis pathway. Planta 232:1423\u20131432","journal-title":"Planta"},{"key":"3606_CR28","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1105\/tpc.15.00471","volume":"27","author":"LA Lewis","year":"2015","unstructured":"Lewis LA, Polanski K, De Torres-Zabala M, Jayaraman S, Bowden L, Moore J, Penfold CA, Jenkins DJ, Hill C, Baxter L, Kulasekaran S, Truman W, Littlejohn G, Prusinska J, Mead A, Steinbrenner J, Hickman R, Rand D, Wild DL, Ott S, Buchanan-Wollaston V, Smirnoff N, Beynon J, Denby K, Grant M (2015) Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv tomato DC3000. Plant Cell 27:3038\u20133064","journal-title":"Plant Cell"},{"key":"3606_CR29","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1101\/gr.1224503","volume":"13","author":"L Li","year":"2003","unstructured":"Li L, Stoeckert CJ Jr, Roos DS (2003) OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res 13:2178\u20132189","journal-title":"Genome Res"},{"key":"3606_CR30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550","journal-title":"Genome Biol"},{"key":"3606_CR31","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/ppl.12013","volume":"148","author":"S Luhua","year":"2013","unstructured":"Luhua S, Hegie A, Suzuki N, Shulaev E, Luo X, Cenariu D, Ma V, Kao S, Lim J, Gunay MB, Oosumi T, Lee SC, Harper J, Cushman J, Gollery M, Girke T, Bailey-Serres J, Stevenson RA, Zhu JK, Mittler R (2013) Linking genes of unknown function with abiotic stress responses by high-throughput phenotype screening. Physiol Plant 148:322\u2013333","journal-title":"Physiol Plant"},{"key":"3606_CR32","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1094\/MPMI-07-10-0149","volume":"24","author":"E Luna","year":"2011","unstructured":"Luna E, Pastor V, Robert J, Flors V, Mauch-Mani B, Ton J (2011) Callose deposition: a multifaceted plant defense response. Mol Plant-Microbe Interact 24:183\u2013193","journal-title":"Mol Plant-Microbe Interact"},{"key":"3606_CR33","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1242\/dev.103424","volume":"141","author":"C Luschnig","year":"2014","unstructured":"Luschnig C, Vert G (2014) The dynamics of plant plasma membrane proteins: PINs and beyond. Development 141:2924\u20132938","journal-title":"Development"},{"key":"3606_CR34","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1046\/j.1365-313X.2003.01954.x","volume":"37","author":"C Mart\u00ednez","year":"2004","unstructured":"Mart\u00ednez C, Pons E, Prats G, Le\u00f3n J (2004) Salicylic acid regulates flowering time and links defence responses and reproductive development. Plant J 37:209\u2013217","journal-title":"Plant J"},{"key":"3606_CR35","doi-asserted-by":"publisher","first-page":"e87216","DOI":"10.1371\/journal.pone.0087216","volume":"9","author":"R Mir","year":"2014","unstructured":"Mir R, Le\u00f3n J (2014) Pathogen and circadian controlled 1 (PCC1) protein is anchored to the plasma membrane and interacts with subunit 5 of COP9 signalosome in Arabidopsis. PLoS ONE 9:e87216","journal-title":"PLoS ONE"},{"key":"3606_CR36","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1093\/jxb\/ert177","volume":"64","author":"R Mir","year":"2013","unstructured":"Mir R, Hern\u00e1ndez ML, Abou-Mansour E, Mart\u00ednez-Rivas JM, Mauch F, M\u00e9traux JP, Le\u00f3n J (2013) Pathogen and Circadian Controlled 1 (PCC1) regulates polar lipid content, ABA-related responses, and pathogen defence in Arabidopsis thaliana. J Exp Bot 64:3385\u20133395","journal-title":"J Exp Bot"},{"key":"3606_CR37","first-page":"1436","volume":"169","author":"TD Niehaus","year":"2015","unstructured":"Niehaus TD, Thamm AM, De Crecy-Lagard V, Hanson AD (2015) Proteins of unknown biochemical function: a persistent problem and a roadmap to help overcome it. Plant Physiol 169:1436\u20131442","journal-title":"Plant Physiol"},{"key":"3606_CR38","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1104\/pp.18.00920","volume":"178","author":"K Nozue","year":"2018","unstructured":"Nozue K, Devisetty UK, Lekkala S, Mueller-Moule P, Bak A, Casteel CL, Maloof JN (2018) Network analysis reveals a role for salicylic acid pathway components in shade avoidance. Plant Physiol 178:1720\u20131732","journal-title":"Plant Physiol"},{"key":"3606_CR39","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1093\/pcp\/pcx191","volume":"59","author":"T Obayashi","year":"2017","unstructured":"Obayashi T, Aoki Y, Tadaka S, Kagaya Y, Kinoshita K (2017) ATTED-II in 2018: a plant coexpression database based on investigation of the statistical property of the mutual rank index. Plant Cell Physiol 59:e3","journal-title":"Plant Cell Physiol"},{"key":"3606_CR40","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.cell.2016.04.038","volume":"165","author":"RC O'Malley","year":"2016","unstructured":"O\u2019Malley RC, Huang SC, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR (2016) Cistrome and epicistrome features shape the regulatory DNA landscape. Cell 165:1280\u20131292","journal-title":"Cell"},{"key":"3606_CR41","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cub.2011.12.015","volume":"22","author":"KM Pajerowska-Mukhtar","year":"2012","unstructured":"Pajerowska-Mukhtar KM, Wang W, Tada Y, Oka N, Tucker CL, Fonseca JP, Dong X (2012) The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Curr Biol 22:103\u2013112","journal-title":"Curr Biol"},{"key":"3606_CR42","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1093\/jxb\/err031","volume":"62","author":"M Rivas-San Vicente","year":"2011","unstructured":"Rivas-San Vicente M, Plasencia J (2011) Salicylic acid beyond defence: its role in plant growth and development. J Exp Bot 62:3321\u20133338","journal-title":"J Exp Bot"},{"key":"3606_CR43","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s00425-003-1143-z","volume":"218","author":"N Sauerbrunn","year":"2004","unstructured":"Sauerbrunn N, Schlaich NL (2004) PCC1: a merging point for pathogen defence and circadian signalling in Arabidopsis. Planta 218:552\u2013561","journal-title":"Planta"},{"key":"3606_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-3040.2009.02045.x","volume":"33","author":"S Segarra","year":"2010","unstructured":"Segarra S, Mir R, Martinez C, Le\u00f3n J (2010) Genome-wide analyses of the transcriptomes of salicylic acid-deficient versus wild-type plants uncover Pathogen and Circadian Controlled 1 (PCC1) as a regulator of flowering time in Arabidopsis. Plant Cell Environ 33:11\u201322","journal-title":"Plant Cell Environ"},{"key":"3606_CR45","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.plaphy.2008.06.011","volume":"46","author":"J Sels","year":"2008","unstructured":"Sels J, Mathys J, De Coninck BM, Cammue BP, De Bolle MF (2008) Plant pathogenesis-related (PR) proteins: a focus on PR peptides. Plant Physiol Biochem 46:941\u2013950","journal-title":"Plant Physiol Biochem"},{"key":"3606_CR46","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498\u20132504","journal-title":"Genome Res"},{"key":"3606_CR47","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cell.2010.05.037","volume":"142","author":"HJ Sharpe","year":"2010","unstructured":"Sharpe HJ, Stevens TJ, Munro S (2010) A comprehensive comparison of transmembrane domains reveals organelle-specific properties. Cell 142:158\u2013169","journal-title":"Cell"},{"key":"3606_CR48","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1365-313X.2009.04060.x","volume":"61","author":"TL Shimada","year":"2010","unstructured":"Shimada TL, Shimada T, Hara-Nishimura I (2010) A rapid and non-destructive screenable marker, FAST, for identifying transformed seeds of Arabidopsis thaliana. Plant J 61:519\u2013528","journal-title":"Plant J"},{"key":"3606_CR49","doi-asserted-by":"publisher","first-page":"18842","DOI":"10.1073\/pnas.0708139104","volume":"104","author":"SH Spoel","year":"2007","unstructured":"Spoel SH, Johnson JS, Dong X (2007) Regulation of tradeoffs between plant defenses against pathogens with different lifestyles. Proc Natl Acad Sci USA 104:18842\u201318847","journal-title":"Proc Natl Acad Sci USA"},{"key":"3606_CR50","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL (2009) TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25:1105\u20131111","journal-title":"Bioinformatics"},{"key":"3606_CR51","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1111\/nph.13286","volume":"206","author":"K Tsuda","year":"2015","unstructured":"Tsuda K, Somssich IE (2015) Transcriptional networks in plant immunity. New Phytol 206:932\u2013947","journal-title":"New Phytol"},{"key":"3606_CR52","doi-asserted-by":"publisher","first-page":"D1190","DOI":"10.1093\/nar\/gkx1002","volume":"46","author":"M Van Bel","year":"2018","unstructured":"Van Bel M, Diels T, Vancaester E, Kreft L, Botzki A, Van de Peer Y, Coppens F, Vandepoele K (2018) PLAZA 4.0: an integrative resource for functional, evolutionary and comparative plant genomics. Nucleic Acids Res 46:D1190\u2013D1196","journal-title":"Nucleic Acids Res"},{"key":"3606_CR53","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1105\/tpc.17.00771","volume":"30","author":"K Van Gelderen","year":"2018","unstructured":"Van Gelderen K, Kang C, Paalman R, Keuskamp D, Hayes S, Pierik R (2018) Far-red light detection in the shoot regulates lateral root development through the HY5 transcription factor. Plant Cell 30:101\u2013116","journal-title":"Plant Cell"},{"key":"3606_CR54","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev.phyto.44.070505.143425","volume":"44","author":"LC Van Loon","year":"2006","unstructured":"Van Loon LC, Rep M, Pieterse CMJ (2006) Significance of inducible defense-related proteins in infected plants. Annu Rev Phytopathol 44:135\u2013162","journal-title":"Annu Rev Phytopathol"},{"key":"3606_CR55","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1104\/pp.109.136028","volume":"150","author":"K Vandepoele","year":"2009","unstructured":"Vandepoele K, Quimbaya M, Casneuf T, De Veylder L, Van de Peer Y (2009) Unraveling transcriptional control in Arabidopsis using cis-regulatory elements and coexpression networks. Plant Physiol 150:535\u2013546","journal-title":"Plant Physiol"},{"key":"3606_CR56","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/bioinformatics\/btp647","volume":"26","author":"TM Venancio","year":"2010","unstructured":"Venancio TM, Aravind L (2010) CYSTM, a novel cysteine-rich transmembrane module with a role in stress tolerance across eukaryotes. Bioinformatics 26:149\u2013152","journal-title":"Bioinformatics"},{"key":"3606_CR57","doi-asserted-by":"publisher","first-page":"e123","DOI":"10.1371\/journal.ppat.0020123","volume":"2","author":"D Wang","year":"2006","unstructured":"Wang D, Amornsiripanitch N, Dong X (2006) A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants. PLoS Pathog 2:e123","journal-title":"PLoS Pathog"},{"key":"3606_CR58","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1105\/tpc.112.102046","volume":"24","author":"O Windram","year":"2012","unstructured":"Windram O, Madhou P, McHattie S, Hill C, Hickman R, Cooke E, Jenkins DJ, Penfold CA, Baxter L, Breeze E, Kiddle SJ, Rhodes J, Atwell S, Kliebenstein DJ, Kim YS, Stegle O, Borgwardt K, Zhang CJ, Tabrett A, Legaie R, Moore J, Finkenstadt B, Wild DL, Mead A, Rand D, Beynon J, Ott S, Buchanan-Wollaston V, Denby KJ (2012) Arabidopsis defense against Botrytis cinerea: Chronology and regulation deciphered by high-resolution temporal transcriptomic analysis. Plant Cell 24:3530\u20133557","journal-title":"Plant Cell"},{"key":"3606_CR59","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/pcp\/pcx202","volume":"59","author":"Y Xu","year":"2018","unstructured":"Xu Y, Yu Z, Zhang D, Huang J, Wu C, Yang G, Yan K, Zhang S, Zheng C (2018) CYSTM, a novel non-secreted cysteine-rich peptide family, involved in environmental stresses in Arabidopsis thaliana. Plant Cell Physiol 59:423\u2013438","journal-title":"Plant Cell Physiol"},{"key":"3606_CR60","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s11103-019-00825-x","volume":"99","author":"Y Xu","year":"2019","unstructured":"Xu Y, Yu Z, Zhang S, Wu C, Yang G, Yan K, Zheng C, Huang J (2019) CYSTM3 negatively regulates salt stress tolerance in Arabidopsis. Plant Mol Biol 99:395\u2013406","journal-title":"Plant Mol Biol"}],"container-title":["Planta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00425-021-03606-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00425-021-03606-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00425-021-03606-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T07:27:43Z","timestamp":1620718063000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00425-021-03606-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["3606"],"URL":"https:\/\/doi.org\/10.1007\/s00425-021-03606-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.25.220970","asserted-by":"object"}]},"ISSN":["0032-0935","1432-2048"],"issn-type":[{"value":"0032-0935","type":"print"},{"value":"1432-2048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"14 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"102"}}