{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:36:31Z","timestamp":1792524991970,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872949"],"award-info":[{"award-number":["81872949"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019HM081"],"award-info":[{"award-number":["ZR2019HM081"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Planta"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00425-022-03921-3","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T03:29:27Z","timestamp":1655782167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Loss of anthocyanidin synthase gene is associated with white flowers of Salvia miltiorrhiza Bge. f. alba, a natural variant of S. miltiorrhiza"],"prefix":"10.1007","volume":"256","author":[{"given":"Caicai","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-7075","authenticated-orcid":false,"given":"Zhenqiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"3921_CR1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bse.2019.05.003","volume":"85","author":"LCB Aizza","year":"2019","unstructured":"Aizza LCB, Sawaya CHFSA, Dornelas MC (2019) Identification of anthocyanins in the corona of two species of Passiflora and their hybrid by ultra-high performance chromatography with electrospray ionization tandem mass spectrometry (UHPLC\u2013ESI\u2013MS\/MS). Biochem Syst Ecol 85:60\u201367. https:\/\/doi.org\/10.1016\/j.bse.2019.05.003","journal-title":"Biochem Syst Ecol"},{"key":"3921_CR2","doi-asserted-by":"crossref","unstructured":"Anders S, Huber W (2010) Differential expression analysis for sequence count data. Genome Biol. 11: 106. http:\/\/genomebiology.com\/2010\/11\/10\/R106.","DOI":"10.1186\/gb-2010-11-10-r106"},{"issue":"11","key":"3921_CR3","doi-asserted-by":"publisher","first-page":"e0142777","DOI":"10.1371\/journal.pone.0142777","volume":"10","author":"Z Ben-Simhon","year":"2015","unstructured":"Ben-Simhon Z, Judeinstein S, Trainin T, Harel-Beja R, Bar-Ya\u2019akov I, Borochov-Neori H, Holland D (2015) A \u201cwhite\u201d anthocyanin-less pomegranate (Punica granatum L.) caused by an insertion in the coding region of the leucoanthocyanidin dioxygenase (LDOX; ANS) gene. PLoS ONE 10(11):e0142777. https:\/\/doi.org\/10.1371\/journal.pone.0142777","journal-title":"PLoS ONE"},{"issue":"8","key":"3921_CR4","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.1073\/pnas.0330964100","volume":"100","author":"RJ Britten","year":"2003","unstructured":"Britten RJ, Rowen L, Williams J, Cameron A (2003) Majority of divergence between closely related DNA samples is due to Indels. Proc Natl Acad Sci USA 100(8):4661\u20134665. https:\/\/doi.org\/10.1073\/pnas.0330964100","journal-title":"Proc Natl Acad Sci USA"},{"key":"3921_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/978-1-4939-3167-5_18","volume":"1374","author":"S Ghosh","year":"2016","unstructured":"Ghosh S, Chan CK (2016) Analysis of RNA-seq data using Tophat and Cufflinks. Methods Mol Biol 1374:339\u2013361. https:\/\/doi.org\/10.1007\/978-1-4939-3167-5_18","journal-title":"Methods Mol Biol"},{"key":"3921_CR6","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1105\/tpc.7.7.1071","volume":"7","author":"TA Holton","year":"1995","unstructured":"Holton TA, Cornish EC (1995) Genetics and biochemistry of anthocyanin biosynthesis. Plant Cell 7:1071\u20131083. https:\/\/doi.org\/10.1105\/tpc.7.7.1071","journal-title":"Plant Cell"},{"issue":"5","key":"3921_CR7","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1111\/tpj.14557","volume":"101","author":"Y Jia","year":"2020","unstructured":"Jia Y, Selva C, Zhang YJ, Li B, McFawn LA, Broughton S, Zhang XQ, Westcott S, Wang PH, Tan C, Angessa T, Xu YH, Whitford R, Li CD (2020) Uncovering the evolutionary origin of blue anthocyanins in cereal grains. Plant J 101(5):1057\u20131074. https:\/\/doi.org\/10.1111\/tpj.14557","journal-title":"Plant J"},{"key":"3921_CR8","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1186\/s12870-020-02553-7","volume":"20","author":"T Jiang","year":"2020","unstructured":"Jiang T, Zhang M, Wen C, Xie X, Tian W, Wen S, Liu L (2020) Integrated metabolomics and transcriptomic analysis of the anthocyanin regulatory networks in Salvia miltiorrhiza Bge flowers. BMC Plant Biol 20:349","journal-title":"BMC Plant Biol"},{"key":"3921_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.tplants.2005.03.002","volume":"10","author":"R Koes","year":"2005","unstructured":"Koes R, Verweij W, Quattrocchio F (2005) Flavonoids: a colorful model for the regulation and evolution of biochemical pathways. Trends Plant Sci 10:236\u2013242. https:\/\/doi.org\/10.1016\/j.tplants.2005.03.002","journal-title":"Trends Plant Sci"},{"key":"3921_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1071\/FP10164","volume":"38","author":"P Kotepong","year":"2011","unstructured":"Kotepong P, Ketsa S, Van Doorn WG (2011) A white mutant of Malay apple fruit (Syzygium malaccense) lacks transcript expression and activity for the last enzyme of anthocyanin synthesis, and the normal expression of a MYB transcription factor. Func Plant Biol 38:75\u201386. https:\/\/doi.org\/10.1071\/FP10164","journal-title":"Func Plant Biol"},{"key":"3921_CR11","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s10265-006-0067-7","volume":"120","author":"H Kubo","year":"2007","unstructured":"Kubo H, Nawa N, Lupsea SA (2007) Anthocyaninless1 gene of Arabidopsis thaliana encodes a UDP-glucose: flavonoid-3-O-glucosyltransferase. J Plant Res 120:445\u2013449. https:\/\/doi.org\/10.1007\/s10265-006-0067-7","journal-title":"J Plant Res"},{"key":"3921_CR12","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1007\/s00299-002-0545-x","volume":"21","author":"ES Larsen","year":"2003","unstructured":"Larsen ES, Alfenito MR, Briggs WR, Walbot V (2003) A carnation anthocyanin mutant is complemented by the glutathione S-transferases encoded by maize Bz2 and petunia An9. Plant Cell Rep 21:900\u2013904. https:\/\/doi.org\/10.1007\/s00299-002-0545-x","journal-title":"Plant Cell Rep"},{"key":"3921_CR13","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler Transform. Bioinformatics 25:1754\u20131760. https:\/\/doi.org\/10.1093\/bioinformatics\/btp324","journal-title":"Bioinformatics"},{"key":"3921_CR14","first-page":"44","volume":"41","author":"JT Li","year":"2008","unstructured":"Li JT, Dong JE, Liang ZS, Shu ZM, Yuan GW (2008) Distributional differences of fat-soluble compounds in the roots, stems and leaves of four Salvia plants. J Mol Cell Biol 41:44\u201352","journal-title":"J Mol Cell Biol"},{"key":"3921_CR150","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13007-021-00776-9","volume":"17","author":"N Li","year":"2021","unstructured":"Li N, Song Y, Li J, Hao R, Feng X, Li L (2021) Resequencing and transcriptomic analysis reveal differences in nitrite reductase in jujube fruit (Ziziphus jujube Mill.). Plant Methods 17:75. https:\/\/doi.org\/10.1186\/s13007-021-00776-9","journal-title":"Plant Methods"},{"issue":"3","key":"3921_CR140","first-page":"190","volume":"19","author":"J Li","year":"1995","unstructured":"Li J, Sun X, Zhou F, Li J, Wang S (1995) New resources of Salvia miltiorrhiza in Shandong Province. J Shandong Coll Tradit Chin Med 19(3):190\u2013191","journal-title":"J Shandong Coll Tradit Chin Med"},{"issue":"16","key":"3921_CR15","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R (2009) 1000 Genome project data processing subgroup the sequence alignment\/map format and SAMtools. Bioinformatics 25(16):2078\u20132079. https:\/\/doi.org\/10.1093\/bioinformatics\/btp352","journal-title":"Bioinformatics"},{"key":"3921_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40529-015-0086-6","volume":"56","author":"YL Li","year":"2015","unstructured":"Li YL, Xin XM, Chang ZM, Shi RJ, Miao ZM, Ding J, Hao GP (2015) The endophytic fungi of Salvia miltiorrhiza Bge.f. alba are a potential source of natural antioxidants. Bot Stud 56:5. https:\/\/doi.org\/10.1186\/s40529-015-0086-6","journal-title":"Bot Stud"},{"key":"3921_CR17","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.3390\/ijms20092225","volume":"20","author":"H Li","year":"2019","unstructured":"Li H, Liu J, Pei T, Bai Z, Han R, Liang Z (2019) Overexpression of SmANS enhances anthocyanin accumulation and alters phenolic acids content in Salvia miltiorrhiza and Salvia miltiorrhiza Bge f. alba plantlets. Int J Mol Sci 20:2225. https:\/\/doi.org\/10.3390\/ijms20092225","journal-title":"Int J Mol Sci"},{"key":"3921_CR120","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s12161-015-0318-0","volume":"9","author":"F Lao","year":"2016","unstructured":"Lao F, Giusti MM (2016) Quantification of Purple Corn (Zea mays L.) Anthocyanins using spectrophotometric and HPLC approaches: method comparison and correlation. Food Anal. Methods 9:1367\u2013138. https:\/\/doi.org\/10.1007\/s12161-015-0318-0","journal-title":"Food Anal. Methods"},{"key":"3921_CR18","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.2307\/1592215","volume":"21","author":"X Mao","year":"2005","unstructured":"Mao X, Cai T, Olyarchuk JG, Wei L (2005) Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics 21:3787\u20133793. https:\/\/doi.org\/10.2307\/1592215","journal-title":"Bioinformatics"},{"key":"3921_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1365-313X.1991.00037.x","volume":"1","author":"C Martin","year":"1991","unstructured":"Martin C, Prescott A, Mackay S, Bartlett J, Vrijlandt E (1991) Control of anthocyanin biosynthesis in flowers of Antirrhinum majus. Plant J 1:37\u201349. https:\/\/doi.org\/10.1111\/j.1365-313X.1991.00037.x","journal-title":"Plant J"},{"issue":"3","key":"3921_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10681-011-0534-7","volume":"184","author":"T Nakatsuka","year":"2012","unstructured":"Nakatsuka T, Saito M, Sato-Ushiku Y, Yamada E, Nakasato T, Hoshi N, Fujiwara K (2012) Hikage Development of DNA markers that discriminate between white-and blue-flowers in Japanese gentian plants. EUPHYTICA 184(3):335\u2013344","journal-title":"EUPHYTICA"},{"issue":"5","key":"3921_CR21","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1093\/bioinformatics\/btx699","volume":"34","author":"BS Pedersen","year":"2018","unstructured":"Pedersen BS, Quinlan AR (2018) Mosdepth: quick coverage calculation for genomes and exomes. Bioinformatics 34(5):867\u2013868. https:\/\/doi.org\/10.1093\/bioinformatics\/btx699","journal-title":"Bioinformatics"},{"key":"3921_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41438-018-0076-4","volume":"6","author":"YY Peng","year":"2019","unstructured":"Peng YY, Wang KL, Cooney JM, Wang TC, Espley RV, Allan AC (2019) Differential regulation of the anthocyanin profile in purple kiwifruit (Actinidia species). Hortic Res 6:3. https:\/\/doi.org\/10.1038\/s41438-018-0076-4","journal-title":"Hortic Res"},{"issue":"7","key":"3921_CR23","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.3389\/fpls.2016.01892","volume":"19","author":"MZ Rafique","year":"2016","unstructured":"Rafique MZ, Elisabete C, Ralf S, Luisa P, Lorena H, Antje F, Malnoy M, Martens S (2016) Nonsense mutation inside anthocyanidin synthase gene controls pigmentation in yellow raspberry (Rubus idaeus L.). Front Plant Sci 19(7):1892. https:\/\/doi.org\/10.3389\/fpls.2016.01892","journal-title":"Front Plant Sci"},{"issue":"3","key":"3921_CR24","first-page":"331","volume":"31","author":"R Ran","year":"2008","unstructured":"Ran R, Zhou FQ, Wang T, Kong QY (2008) Comparison of tanshinone IIA in radix Salvia miltiorrhiza from Shandong. J Chin Med Mater 31(3):331\u2013333","journal-title":"J Chin Med Mater"},{"key":"3921_CR25","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s12864-017-3623-8","volume":"18","author":"WR Roberts","year":"2017","unstructured":"Roberts WR, Roalson EH (2017) Comparative transcriptome analyses of flower development in four species of Achimenes (Gesneriaceae). BMC Genomics 18:240. https:\/\/doi.org\/10.1186\/s12864-017-3623-8","journal-title":"BMC Genomics"},{"key":"3921_CR130","first-page":"14","volume":"2","author":"D Shang","year":"1986","unstructured":"Shang D, Zhao X (1986) Treatment of thromboangiitis obliterans by activating blood circulation and removing blood stasis - Clinical study of 144 cases. Shandong J Tradit Chin Med 2:14\u201315","journal-title":"Shandong J Tradit Chin Med"},{"issue":"4","key":"3921_CR26","doi-asserted-by":"publisher","first-page":"434","DOI":"10.2503\/jjshs1.80.434","volume":"80","author":"K Shimizu","year":"2011","unstructured":"Shimizu K, Ohnishi N, Morikawa N, Ishigami A, Otake S, Rabah IO, Sakata Y, Hashimoto F (2011) A 94-bp deletion of anthocyanidin synthase gene in acyanic flower lines of lisianthus [Eustoma grandiflorum (Raf.) Shinn.]. J Jpn Soc Hortic Sci 80(4):434\u2013442. https:\/\/doi.org\/10.2503\/jjshs1.80.434","journal-title":"J Jpn Soc Hortic Sci"},{"key":"3921_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s13258-015-0373-3","volume":"38","author":"DH Shin","year":"2016","unstructured":"Shin DH, Choi MG, Kang CS, Park CS, Choi SB, Park YI (2016) Overexpressing the wheat dihydroflavonol 4-reductase gene TaDFR increases anthocyanin accumulation in an Arabidopsis dfr mutant. Genes Genom 38:333\u2013340. https:\/\/doi.org\/10.1007\/s13258-015-0373-3","journal-title":"Genes Genom"},{"key":"3921_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.indcrop.2015.03.081","volume":"71","author":"Z Song","year":"2015","unstructured":"Song Z, Li X (2015) Expression profiles of rosmarinic acid biosynthesis genes in two Salvia miltiorrhiza lines with differing water-soluble phenolic contents. Ind Crops Prod 71:24\u201330. https:\/\/doi.org\/10.1016\/j.indcrop.2015.03.081","journal-title":"Ind Crops Prod"},{"key":"3921_CR29","first-page":"1099","volume":"48","author":"JY Song","year":"2013","unstructured":"Song JY, Luo HM, Li CF, Sun C, Xu J, Chen SL (2013) Salvia miltiorrhiza as medicinal model plant. Acta Pharm Sin 48:1099\u20131106","journal-title":"Acta Pharm Sin"},{"key":"3921_CR30","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s12041-016-0621-6","volume":"95","author":"Z Song","year":"2016","unstructured":"Song Z, Wang J, Li X (2016) Expression profiles of genes involved in tanshinone biosynthesis of two Salvia miltiorrhiza genotypes with different tanshinone contents. J Genet 95:433\u2013439. https:\/\/doi.org\/10.1007\/s12041-016-0621-6","journal-title":"J Genet"},{"key":"3921_CR31","doi-asserted-by":"publisher","first-page":"e20041","DOI":"10.1002\/tpg2.20041","volume":"13","author":"Z Song","year":"2020","unstructured":"Song Z, Lin C, Xing P, Fen Y, Jin H, Zhou C, Gu YQ, Wang J, Li X (2020) A high-quality reference genome sequence of Salvia miltiorrhiza provides insights into tanshinone synthesis in its red rhizomes. Plant Genome 13:e20041. https:\/\/doi.org\/10.1002\/tpg2.20041","journal-title":"Plant Genome"},{"key":"3921_CR32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3100\/1043-4534-13.2.301","volume-title":"Flora of China","author":"ZY Wu","year":"1977","unstructured":"Wu ZY, Li XW (1977) Flora of China, vol 66. Science Press, Beijing, pp 145\u2013150. https:\/\/doi.org\/10.3100\/1043-4534-13.2.301"},{"key":"3921_CR33","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s11033-009-9703-3","volume":"37","author":"YF Yang","year":"2010","unstructured":"Yang YF, Hou S, Cui GH, Chen SL, Wei JH, Huang LQ (2010) Characterization of reference genes for quantitative real-time PCR analysis in various tissues of Salvia miltiorrhiza. Mol Biol Rep 37:507\u2013513. https:\/\/doi.org\/10.1007\/s11033-009-9703-3","journal-title":"Mol Biol Rep"},{"key":"3921_CR34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/gb-2010-11-2-r14","volume":"11","author":"MD Young","year":"2010","unstructured":"Young MD, Wakefield MJ, Smyth GK, Oshlack A (2010) Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol 11:14. https:\/\/doi.org\/10.1186\/gb-2010-11-2-r14","journal-title":"Genome Biol"},{"key":"3921_CR35","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3389\/fpls.2017.01545","volume":"8","author":"XW Zhou","year":"2017","unstructured":"Zhou XW, Li JY, Zhu YL, Ni S, Chen LJ, Feng XJ, Zhang YF, Li SQ, Zhu HG, Wen YG (2017) De novo assembly of the Camellia nitidissima transcriptome reveals key genes of flower pigment biosynthesis. Front Plant Sci 8:1545. https:\/\/doi.org\/10.3389\/fpls.2017.01545","journal-title":"Front Plant Sci"}],"container-title":["Planta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00425-022-03921-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00425-022-03921-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00425-022-03921-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T13:11:03Z","timestamp":1656681063000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00425-022-03921-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["3921"],"URL":"https:\/\/doi.org\/10.1007\/s00425-022-03921-3","relation":{},"ISSN":["0032-0935","1432-2048"],"issn-type":[{"value":"0032-0935","type":"print"},{"value":"1432-2048","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"22 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflicts of interest in this work and have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"15"}}