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The terminal region of this\n                      <jats:italic>AtAPC7<\/jats:italic>\n                      gene has been shown in\n                      <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                      to accumulate more transcripts than the full-length gene. The\n                      <jats:italic>AtAPC7-CT<\/jats:italic>\n                      gene (terminal region of the\n                      <jats:italic>AtAPC7<\/jats:italic>\n                      ) encodes a protein with significant homology to a tobacco viral replication inhibitor (IVR). Its stable overexpression in transgenic\n                      <jats:italic>A. thaliana<\/jats:italic>\n                      lines resulted in notable improvements in biomass, seed yield, earliness of vegetative-reproductive transitions, and reduced susceptibility to viruses. In this study, we generated stable transgenic soybean lines overexpressing the\n                      <jats:italic>GmAPC7-CT<\/jats:italic>\n                      gene (terminal region or 3\u2019 portion of Glyma.15G096000, corresponding to the\n                      <jats:italic>AtAPC7-CT<\/jats:italic>\n                      ) and evaluated seed yield and susceptibility of these lines to soybean mosaic virus and\n                      <jats:italic>Meloidogyne incognita<\/jats:italic>\n                      . The\n                      <jats:italic>GmAPC7-CT<\/jats:italic>\n                      gene is 624 nucleotides long and encodes a 207-amino acid protein with two tetratricopeptide repeat (TPR) domains. GmAPC7-CT showed 100% amino acid identity with full-length GmAPC7, 81.16% identity with AtAPC7-CT, and 87.94% identity with tobacco IVR. Stable transgenic lines demonstrated significant advancements in plant development and seed yield, with the top three lines producing up to 43% more pods, 44% more seeds, and a 16% increase in seed weight. Furthermore, these soybean lines showed up to a 70% reduction in susceptibility to soybean mosaic virus and\n                      <jats:italic>M. incognita<\/jats:italic>\n                      , reflected by decreased viral RNA load and nematode reproduction factor. Collectively, these results support a conserved role of GmAPC7-CT in soybean and AtAPC7-CT in\n                      <jats:italic>A. thaliana<\/jats:italic>\n                      , acting similarly to the tobacco IVR. Thus, our findings underscore the strong biotechnological potential of the\n                      <jats:italic>GmAPC7-CT<\/jats:italic>\n                      gene to improve key agronomic traits in soybean through genetic engineering approaches, including conventional breeding,\u00a0transgenesis, and genome editing.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00425-026-05097-6","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:55:41Z","timestamp":1788792941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transgenic overexpression of GmAPC7-CT improves seed yield and reduces susceptibility to soybean mosaic virus and Meloidogyne incognita in soybean"],"prefix":"10.1007","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-8959","authenticated-orcid":false,"given":"Marcos Fernando","family":"Basso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9fanie Menezes","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Helo\u00edsa","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuanne Pires","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Sabrina","family":"Freitas-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Nascimento Silva","family":"Fragoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Rocha","family":"Fragoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Gino","family":"de Ara\u00fajo-Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Silva","family":"Hemerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"de Almeida-Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fatima","family":"Grossi-de-Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"8042","key":"5097_CR1","doi-asserted-by":"publisher","first-page":"E4","DOI":"10.1038\/s41586-024-08416-7","volume":"636","author":"J Abramson","year":"2024","unstructured":"Abramson J, Adler J, Dunger J et al (2024) Accurate structure prediction of biomolecular interactions with AlphaFold 3. 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