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Recent work demonstrated that the forkhead domain encoding gene<jats:italic>FoxB<\/jats:italic>is involved in dorsal-ventral axis formation in spider limbs. Here, Dpp likely acts as a dorsal morphogen, and FoxB is likely in control of ventral tissues as RNAi-mediated knockdown of<jats:italic>FoxB<\/jats:italic>causes dorsalization of the limbs. In this study, we present phenotypes of<jats:italic>FoxB<\/jats:italic>knockdown that demonstrate a function in the establishment of the DV body axis. Knockdown of FoxB function leads to embryos with partially duplicated median germ bands (<jats:italic>Duplicitas media<\/jats:italic>) that are possibly the result of ectopic activation of Dpp signalling. Another class of phenotypes is characterized by unnaturally slim (dorsal-ventrally compressed) germ bands in which ventral tissue is either not formed, or is specified incorrectly, likely a result of Dpp over-activity. These results suggest that FoxB functions as an antagonist of Dpp signalling during body axis patterning, similarly as it is the case in limb development. FoxB thus represents a general player in the establishment of dorsal-ventral structures during spider ontogeny.<\/jats:p>","DOI":"10.1007\/s00427-020-00650-z","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T22:02:32Z","timestamp":1581112952000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The forkhead box containing transcription factor FoxB is a potential component of dorsal-ventral body axis formation in the spider Parasteatoda tepidariorum"],"prefix":"10.1007","volume":"230","author":[{"given":"Miriam","family":"Heing\u00e5rd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-4129","authenticated-orcid":false,"given":"Ralf","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"650_CR1","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1242\/dev.00390","volume":"130","author":"Y Akiyama-Oda","year":"2003","unstructured":"Akiyama-Oda Y, Oda H (2003) Early patterning of the spider embryo: a cluster of mesenchymal cells at the cumulus produces Dpp signals received by germ disc epithelial cells. 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