{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:20:52Z","timestamp":1780446052719,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T00:00:00Z","timestamp":1111622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1007\/s00428-005-1205-7","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T09:10:12Z","timestamp":1111569012000},"page":"402-410","source":"Crossref","is-referenced-by-count":24,"title":["TASK-3 immunoreactivity shows differential distribution in the human gastrointestinal tract"],"prefix":"10.1007","volume":"446","author":[{"given":"Ilona","family":"Kov\u00e1cs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Pocsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Czifra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Sarkadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9za","family":"Szucs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Ruszn\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,3,24]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s004240100620","volume":"442","author":"I Ashmole","year":"2001","unstructured":"Ashmole I, Goodwin PA, Stanfield PR (2001) TASK-5, a novel member of the tandem pore K+ channel family. Pflugers Arch 442:828\u2013833","journal-title":"Pflugers Arch"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1177\/35.12.2445810","volume":"35","author":"PB Bell Jr","year":"1987","unstructured":"Bell PB Jr, Rundquist I, Svensson I, Collins VP (1987) Formaldehyde sensitivity of a GFAP epitope, removed by extraction of the cytoskeleton with high salt. J Histochem Cytochem 35:1375\u20131380","journal-title":"J Histochem Cytochem"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7793.2000.00135.x","volume":"525","author":"KJ Buckler","year":"2000","unstructured":"Buckler KJ, Williams BA, Honore E (2000) An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J Physiol 525:135\u2013142","journal-title":"J Physiol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0169-328X(00)00183-2","volume":"82","author":"CG Chapman","year":"2000","unstructured":"Chapman CG, Meadows HJ, Godden RJ, Campbell DA, Duckworth M, Kelsell RE, Murdock PR, Randall AD, Rennie GI, Gloger IS (2000) Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. Brain Res Mol Brain Res 82:74\u201383","journal-title":"Brain Res Mol Brain Res"},{"key":"CR5","first-page":"863","volume":"14","author":"G Czirj\u00e1k","year":"2000","unstructured":"Czirj\u00e1k G, Fischer T, Sp\u00e4t A, Lesage F, Enyedi P (2000) TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II. Mol Endocrinol 14:863\u2013874","journal-title":"Mol Endocrinol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/mend.16.3.0788","volume":"16","author":"G Czirj\u00e1k","year":"2003","unstructured":"Czirj\u00e1k G, Enyedi P (2003a) TASK-3 dominates the background potassium conductance in rat adrenal glomerulosa cells. Mol Endocrinol 16:621\u2013629","journal-title":"Mol Endocrinol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1124\/mol.63.3.646","volume":"63","author":"G Czirj\u00e1k","year":"2003","unstructured":"Czirj\u00e1k G, Enyedi P (2003b) Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits. Mol Pharmacol 63:646\u2013652","journal-title":"Mol Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0014-5793(01)02222-0","volume":"492","author":"N Decher","year":"2001","unstructured":"Decher N, Maier M, Dittrich W, Gassenhuber J, Bruggemann A, Busch AE, Steinmeyer K (2001) Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family. FEBS Lett 492:84\u201389","journal-title":"FEBS Lett"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1093\/emboj\/16.17.5464","volume":"16","author":"F Duprat","year":"1997","unstructured":"Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M (1997) TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J 16:5464\u20135471","journal-title":"EMBO J"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0021-9258(17)35095-0","volume":"168","author":"H Fraenkel-Conrat","year":"1947","unstructured":"Fraenkel-Conrat H, Brandon BA, Olcott HS (1947) The reaction of formaldehyde with proteins. IV. Participation of indole groups. Gramicidine. J Biol Chem 168:99\u2013118","journal-title":"J Biol Chem"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1021\/ja01188a018","volume":"70","author":"H Fraenkel-Conrat","year":"1948","unstructured":"Fraenkel-Conrat H, Olcott HS (1948a) The reaction of formaldehyde with proteins. V. Cross-linking between amino and primary amide or guanidyl groups. J Am Chem Soc 70:2673\u20132684","journal-title":"J Am Chem Soc"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0021-9258(18)57292-6","volume":"174","author":"H Fraenkel-Conrat","year":"1948","unstructured":"Fraenkel-Conrat H, Olcott HS (1948b) The reaction of formaldehyde with proteins. VI. Cross-linking of amino groups with phenol, imidazole and indole groups. J Biol Chem 174:827\u2013843","journal-title":"J Biol Chem"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0021-9258(18)57104-0","volume":"177","author":"H Fraenkel-Conrat","year":"1949","unstructured":"Fraenkel-Conrat H, Mecham DK (1949) The reaction of formaldehyde with proteins. VII. Demonstration of intermolecular cross-linking by means of osmotic pressure measurements. J Biol Chem 177:477\u2013486","journal-title":"J Biol Chem"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0065-3233(08)60627-0","volume":"II","author":"D French","year":"1945","unstructured":"French D, Edsall JT (1945) Reactions of formaldehyde with amino acids and proteins. Adv Protein Chem II:277\u2013335","journal-title":"Adv Protein Chem"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/bbrc.2001.4562","volume":"282","author":"C Girard","year":"2001","unstructured":"Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K+ channels. Biochem Biophys Res Commun 282:249\u2013256","journal-title":"Biochem Biophys Res Commun"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"26499","DOI":"10.1074\/jbc.M010357200","volume":"276","author":"ME Hartness","year":"2001","unstructured":"Hartness ME, Lewis A, Searle GJ, O\u2019Kelly I, Peers C, Kemp PJ (2001) Combined antisense and pharmacological approaches implicate hTASK as an airway O2 sensing K+ channel. J Biol Chem 276:26499\u201326508","journal-title":"J Biol Chem"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1055\/s-2007-996274","volume":"12","author":"JC Hutton","year":"1980","unstructured":"Hutton JC, Sener A, Herchuelz A, Valverde I, Boschero AC, Malaisse WJ (1980) The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration. Horm Metab Res 12:294\u2013299","journal-title":"Horm Metab Res"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1006\/bbrc.2001.5064","volume":"284","author":"D Kim","year":"2001","unstructured":"Kim D, Gnatenco C (2001) TASK-5, a new member of the tandem-pore K+ channel family. Biochem Biophys Res Commun 284:923\u2013930","journal-title":"Biochem Biophys Res Commun"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s004249900071","volume":"438","author":"SJ Kim","year":"1999","unstructured":"Kim SJ, Greger R (1999) Voltage-dependent, slowly activating K+ current (IKs) and its augmentation by carbachol in rat pancreatic acini. Pflugers Arch 438:604\u2013611","journal-title":"Pflugers Arch"},{"key":"CR20","first-page":"H1669","volume":"277","author":"Y Kim","year":"1999","unstructured":"Kim Y, Bang H, Kim D (1999) TBAK-1 and TASK-1, two-pore K+ channel subunits: kinetic properties and expression in rat heart. Am J Physiol 277:H1669\u2013H1678","journal-title":"Am J Physiol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"9340","DOI":"10.1074\/jbc.275.13.9340","volume":"275","author":"Y Kim","year":"2000","unstructured":"Kim Y, Bang H, Kim D (2000) TASK-3, a new member of the tandem pore K+ channel family. J Biol Chem 275:9340\u20139347","journal-title":"J Biol Chem"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s004249900070","volume":"438","author":"M K\u00f6ttgen","year":"1999","unstructured":"K\u00f6ttgen M, Hoefer A, Kim SJ, Beschorner U, Schreiber R, Hug MJ, Greger R (1999) Carbachol activates a K+ channel of very small conductance in the basolateral membrane of rat pancreatic acinar cells. Pflugers Arch 438:597\u2013603","journal-title":"Pflugers Arch"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","volume":"82","author":"K Kunzelmann","year":"2002","unstructured":"Kunzelmann K, Mall M (2002) Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 82:245\u2013289","journal-title":"Physiol Rev"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"32068","DOI":"10.1074\/jbc.M302631200","volume":"278","author":"I Lauritzen","year":"2003","unstructured":"Lauritzen I, Zanzouri M, Honor\u00e9 E, Duprat F, Ehrengruber MU, Lazdunski M, Patel AJ (2003) K+-dependent cerebellar granule neuron apoptosis. J Biol Chem 278:32068\u201332076","journal-title":"J Biol Chem"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1523\/JNEUROSCI.18-03-00868.1998","volume":"18","author":"D Leonoudakis","year":"1998","unstructured":"Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS (1998) An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci 18:868\u2013877","journal-title":"J Neurosci"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"24449","DOI":"10.1074\/jbc.C100184200","volume":"276","author":"CM Lopes","year":"2001","unstructured":"Lopes CM, Zilberberg N, Goldstein SA (2001) Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers. J Biol Chem 276:24449\u201324452","journal-title":"J Biol Chem"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0028-3908(00)00189-1","volume":"40","author":"HJ Meadows","year":"2001","unstructured":"Meadows HJ, Randall AD (2001) Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel. Neuropharmacology 40:551\u2013559","journal-title":"Neuropharmacology"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0169-328X(00)00263-1","volume":"86","author":"AD Medhurst","year":"2001","unstructured":"Medhurst AD, Rennie G, Chapman CG, Meadows H, Duckworth MD, Kelsell RE, Gloger II, Pangalos MN (2001) Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 86:101\u2013114","journal-title":"Brain Res Mol Brain Res"},{"key":"CR29","first-page":"1","volume":"208","author":"KH Meyer","year":"1929","unstructured":"Meyer KH (1929) Die Chemie der Micelle und ihrer Anwendung auf biochemische und biologische Probleme. Biochem Z 208:1\u201331","journal-title":"Biochem Z"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/002215540305100101","volume":"51","author":"C Montero","year":"2003","unstructured":"Montero C (2003) The antigen\u2013antibody reaction in immunohistochemistry. J Histochem Cytochem 51:1\u20134","journal-title":"J Histochem Cytochem"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1535-6108(03)00054-0","volume":"3","author":"D Mu","year":"2003","unstructured":"Mu D, Chen L, Zhang X, See L-H, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KCQ, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S (2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell 3:297\u2013302","journal-title":"Cancer Cell"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hlca.19440270135","volume":"27","author":"HS Nitschmann von","year":"1944","unstructured":"Nitschmann von HS, Hadorn H (1944) Die Umsetzung des Caseins mit Formaldehyd. V. \u00dcber des Verhalten der e-Aminogruppen des Lysins und der Peptidogruppen. Helv Chim Acta 27:299\u2013312","journal-title":"Helv Chim Acta"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/8084","volume":"2","author":"AJ Patel","year":"1999","unstructured":"Patel AJ, Honore E, Lesage F, Fink M, Romey G, Lazdunski M (1999) Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci 2:422\u2013426","journal-title":"Nat Neurosci"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1073\/pnas.1232448100","volume":"100","author":"L Pei","year":"2003","unstructured":"Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T (2003) Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proc Natl Acad Sci U S A 100:7803\u20137807","journal-title":"Proc Natl Acad Sci U S A"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"16650","DOI":"10.1074\/jbc.M000030200","volume":"275","author":"S Rajan","year":"2000","unstructured":"Rajan S, Wischmeyer E, Xin Liu G, Preisig-M\u00fcller R, Daut J, Karschin A, Derst C (2000) TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histidine as pH sensor. J Biol Chem 275:16650\u201316657","journal-title":"J Biol Chem"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"30863","DOI":"10.1074\/jbc.273.47.30863","volume":"273","author":"R Reyes","year":"1998","unstructured":"Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (1998) Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem 273:30863\u201330869","journal-title":"J Biol Chem"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1007\/s00018-004-4082-3","volume":"61","author":"Z Ruszn\u00e1k","year":"2004","unstructured":"Ruszn\u00e1k Z, Pocsai K, Kov\u00e1cs I, P\u00f3r \u00c1, P\u00e1l B, B\u00edr\u00f3 T, Szucs G (2004) Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum. Cell Mol Life Sci 61:1532\u20131542","journal-title":"Cell Mol Life Sci"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/39.6.1709656","volume":"39","author":"S-R Shi","year":"1991","unstructured":"Shi S-R, Key ME, Kalra KL (1991) Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39:741\u2013748","journal-title":"J Histochem Cytochem"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3109\/10520299609117158","volume":"71","author":"S-R Shi","year":"1996","unstructured":"Shi S-R, Cote RJ, Young I, Imam SA, Taylor CR (1996) Use of pH 9.5 Tris HCl buffer containing 5% urea for antigen retrieval immunohistochemistry. Biotech Histochem 71:190\u2013196","journal-title":"Biotech Histochem"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-005-1205-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-005-1205-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-005-1205-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T03:20:11Z","timestamp":1625628011000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-005-1205-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,24]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["1205"],"URL":"https:\/\/doi.org\/10.1007\/s00428-005-1205-7","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,24]]}}}