{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:45Z","timestamp":1791268845482,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T00:00:00Z","timestamp":1179964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2007,6,20]]},"DOI":"10.1007\/s00428-007-0430-7","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T19:41:39Z","timestamp":1179949299000},"page":"653-657","source":"Crossref","is-referenced-by-count":66,"title":["Bone formation in cardiac valves: a histopathological study of 128 cases"],"prefix":"10.1007","volume":"450","author":[{"given":"Ivo","family":"Steiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Ka\u0161parov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Kohout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Dominik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,24]]},"reference":[{"key":"430_CR1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0735-1097(01)01422-X","volume":"38","author":"Y Agmon","year":"2001","unstructured":"Agmon Y, Khandheria BK, Meissner I, Sicks JRD, O\u2019Fallon WM, Wiebers DO, Whisnant JP, Seward JB, Tajik AJ (2001) Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? J Am Coll Cardiol 38:827\u2013834","journal-title":"J Am Coll Cardiol"},{"key":"430_CR2","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.athoracsur.2005.07.039","volume":"81","author":"NA Charokopos","year":"2006","unstructured":"Charokopos NA, Antonitsis P, Rouska E, Kostopoulos I, Charaf A, Spanos PK (2006) Cartilaginous and osseous metaplasia with bone marrow formation in the aortic valve of a patient with giant cell aortitis. Ann Thorac Surg 81:1877\u20131879","journal-title":"Ann Thorac Surg"},{"key":"430_CR3","doi-asserted-by":"crossref","first-page":"11201","DOI":"10.1073\/pnas.1932554100","volume":"10","author":"TM Doherty","year":"2003","unstructured":"Doherty TM, Asotra K, Fitzpatrick LA, Qiao JH, Wilkin DJ, Detrano RC, Dunstan CR, Shah PK, Rajavashisth TB (2003) Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci USA 10:11201\u201311206","journal-title":"Proc Natl Acad Sci USA"},{"key":"430_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ccd.1810290102","volume":"29","author":"T Feldman","year":"1993","unstructured":"Feldman T, Glagov S, Carroll JD (1993) Restenosis following successful balloon valvuloplasty: bone formation in aortic valve leaflets. Catheter Cardiovasc Diagn 29:1\u20137","journal-title":"Catheter Cardiovasc Diagn"},{"key":"430_CR5","first-page":"232","volume":"24","author":"AL Fern\u00e1ndez Gonz\u00e1les","year":"1997","unstructured":"Fern\u00e1ndez Gonz\u00e1les AL, Montero JA, Martinez Monzon\u00eds A, Gil O, Alemany P (1997) Osseous metaplasia and hematopoietic bone marrow in a calcified aortic valve. Texas Heart Inst J 24:232","journal-title":"Texas Heart Inst J"},{"key":"430_CR6","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","volume":"111","author":"RV Freeman","year":"2005","unstructured":"Freeman RV, Otto CM (2005) Spectrum of calcific aortic valve disease. Pathogenesis, disease progression, and treatment strategies. Circulation 111:3316\u20133326","journal-title":"Circulation"},{"key":"430_CR7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/ajcp\/93.6.809","volume":"93","author":"DA Groom","year":"1990","unstructured":"Groom DA, Starke WR (1990) Cartilaginous metaplasia in calcific aortic valve disease. Am J Clin Pathol 93:809\u2013812","journal-title":"Am J Clin Pathol"},{"key":"430_CR8","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/01.STR.0000013741.41309.67","volume":"33","author":"JL Hunt","year":"2002","unstructured":"Hunt JL, Fairman R, Mitchell ME, Carpenter JP, Golden M, Khalapyan T, Wolfe M, Neschis D, Milner R, Scoll B, Cusack A, Mohler ER (2002) Bone formation in carotid plaques: a clinicopathological study. Stroke 33:1214\u20131219","journal-title":"Stroke"},{"key":"430_CR9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s004280050289","volume":"433","author":"M Jeziorska","year":"1998","unstructured":"Jeziorska M, McCollum C, Woolley DE (1998) Observations on bone formation and remodelling in advanced atherosclerotic lesions of human carotid arteries. Virchows Arch 433:559\u2013565","journal-title":"Virchows Arch"},{"key":"430_CR10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1309\/W75NTE5QBC9DXE03","volume":"126","author":"A Mazzone","year":"2006","unstructured":"Mazzone A, Epistolato MC, Gianetti J, Castagnini M, Sassi C, Ceravolo R, Bevilacqua S, Gevilacqua S, Glauber M, Biagini A, Tanganelli P (2006) Biologic features (inflammation and neoangiogenesis) and atherosclerotic risk factors in carotid plaques and calcified aortic valve stenosis. Two different sites of the same disease? Am J Clin Pathol 126:494\u2013502","journal-title":"Am J Clin Pathol"},{"key":"430_CR11","first-page":"163","volume":"9","author":"M Mirzaie","year":"2003","unstructured":"Mirzaie M, Schultz M, Schwartz P, Coulibaly M, Sch\u00f6ndube F (2003) Evidence of woven bone formation in heart valve disease. Ann Thorac Cardiovasc Surg 9:163\u2013169","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"430_CR12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","volume":"103","author":"ER Mohler","year":"2001","unstructured":"Mohler ER, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS (2001) Bone formation and inflammation in cardiac valves. Circulation 103:1522\u20131528","journal-title":"Circulation"},{"key":"430_CR13","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.amjcard.2004.08.013","volume":"94","author":"ER Mohler","year":"2004","unstructured":"Mohler ER (2004) Mechanisms of aortic valve calcification. Am J Cardiol 94:1396\u20131402","journal-title":"Am J Cardiol"},{"key":"430_CR14","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/01.CIR.92.8.2163","volume":"92","author":"KD O\u2019Brien","year":"1995","unstructured":"O\u2019Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM (1995) Osteopontin is expressed in human aortic valvular lesions. Circulation 92:2163\u20132168","journal-title":"Circulation"},{"key":"430_CR15","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","volume":"107","author":"NM Rajamannan","year":"2003","unstructured":"Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, Bonow RO, Spelsberg T (2003) Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 107:2181\u20132184","journal-title":"Circulation"},{"key":"430_CR16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross R (1999) Atherosclerosis\u2014an inflammatory disease. N Engl J Med 340:115\u2013126","journal-title":"N Engl J Med"},{"key":"430_CR17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.carpath.2005.03.005","volume":"14","author":"FJ Schoen","year":"2005","unstructured":"Schoen FJ (2005) Cardiac valves and valvular pathology. Update on function, disease, repair, and replacement. Cardiovasc Pathol 14:189\u2013194","journal-title":"Cardiovasc Pathol"},{"key":"430_CR18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.carpath.2006.05.001","volume":"15","author":"FJ Schoen","year":"2006","unstructured":"Schoen FJ (2006) New frontiers in the pathology and therapy of heart valve disease: 2006 Society for Cardiovascular Pathology, Distinguished Achievement Award Lecture, United States\u2013Canadian Academy of Pathology, Atlanta, GA, February 12, 2006. Cardiovasc Pathol 15:271\u2013279","journal-title":"Cardiovasc Pathol"},{"key":"430_CR19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0046-8177(03)00245-4","volume":"34","author":"Y Soini","year":"2003","unstructured":"Soini Y, Salo T, Satta J (2003) Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum Pathol 34:756\u2013763","journal-title":"Hum Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-007-0430-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-007-0430-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-007-0430-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:34:01Z","timestamp":1559079241000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-007-0430-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,24]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6,20]]}},"alternative-id":["430"],"URL":"https:\/\/doi.org\/10.1007\/s00428-007-0430-7","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,24]]}}}