{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:39:40Z","timestamp":1773427180503,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T00:00:00Z","timestamp":1187136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2007,11,5]]},"DOI":"10.1007\/s00428-007-0482-8","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T12:19:37Z","timestamp":1187093977000},"page":"937-942","source":"Crossref","is-referenced-by-count":23,"title":["Epithelial\u2013mesenchymal transition (EMT) of renal tubular cells in canine glomerulonephritis"],"prefix":"10.1007","volume":"451","author":[{"given":"Luca","family":"Aresu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pia","family":"Rastaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Scanziani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Baily","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Radaelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Pregel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Valenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,8,15]]},"reference":[{"key":"482_CR1","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1083\/jcb.99.4.1424","volume":"99","author":"A Ben-Ze\u2019ev","year":"1984","unstructured":"Ben-Ze\u2019ev A (1984) Differential control of cytokeratins and vimentin synthesis by cell-cell contact and cell spreading in cultured epithelial cells. J Cell Biol 99:1424\u20131433","journal-title":"J Cell Biol"},{"key":"482_CR2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-4827(86)90033-9","volume":"164","author":"A Ben-Ze\u2019ev","year":"1986","unstructured":"Ben-Ze\u2019ev A (1986) Tumor promoter-induced disruption of junctional complexes in cultured epithelial cells is followed by the inhibition of cytokeratin and desmoplakin synthesis. Exp Cell Res 164:335\u2013352","journal-title":"Exp Cell Res"},{"key":"482_CR3","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1053\/hupa.2000.20373","volume":"31","author":"YJ Choi","year":"2000","unstructured":"Choi YJ, Chakraborty S, Nguyen V et al (2000) Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor. Hum Pathol 31:1491\u20131497","journal-title":"Hum Pathol"},{"key":"482_CR4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1523-1755.2005.00422.x","volume":"68","author":"KS Eardley","year":"2005","unstructured":"Eardley KS, Cockwell P (2005) Macrophages and progressive tubulointerstitial disease. Kidney Int 68:437\u2013455","journal-title":"Kidney Int"},{"key":"482_CR5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000070698","volume":"21","author":"KU Eckardt","year":"2003","unstructured":"Eckardt KU, Rosenberger C, Jurgensen JS, Wiesener MS (2003) Role of hypoxia in the pathogenesis of renal disease. Blood Purif 21:253\u2013257","journal-title":"Blood Purif"},{"key":"482_CR6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","volume":"110","author":"M Iwano","year":"2002","unstructured":"Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG (2002) Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110:341\u2013350","journal-title":"J Clin Invest"},{"key":"482_CR7","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","volume":"112","author":"R Kalluri","year":"2003","unstructured":"Kalluri R, Neilson EG (2003) Epithelial\u2013mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776\u20131784","journal-title":"J Clin Invest"},{"key":"482_CR8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1523-1755.2005.67097.x","volume":"67","author":"W Kriz","year":"2005","unstructured":"Kriz W, LeHir M (2005) Pathways to nephron loss starting from glomerular diseases-insights from animal models. Kidney Int 67:404\u2013419","journal-title":"Kidney Int"},{"key":"482_CR9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1523-1755.2005.00386.x","volume":"68","author":"AM Kuusniemi","year":"2005","unstructured":"Kuusniemi AM, Lapatto R, Holmberg C, Karikoski R, Rapola J, Jalanko H (2005) Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change. Kidney Int 68:121\u2013132","journal-title":"Kidney Int"},{"key":"482_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","volume":"15","author":"Y Liu","year":"2004","unstructured":"Liu Y (2004) Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15:1\u201312","journal-title":"J Am Soc Nephrol"},{"key":"482_CR11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1681\/ASN.2005070757","volume":"17","author":"M Nangaku","year":"2006","unstructured":"Nangaku M (2006) Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 17:17\u201325","journal-title":"J Am Soc Nephrol"},{"key":"482_CR12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2169\/internalmedicine.43.9","volume":"43","author":"M Nangaku","year":"2004","unstructured":"Nangaku M (2004) Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure. Intern Med 43:9\u201317","journal-title":"Intern Med"},{"key":"482_CR13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1523-1755.2002.00430.x","volume":"62","author":"MP Rastaldi","year":"2002","unstructured":"Rastaldi MP, Ferrario F, Giardino L et al (2002) Epithelial\u2013mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 62:137\u2013146","journal-title":"Kidney Int"},{"key":"482_CR14","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199811123392007","volume":"339","author":"G Remuzzi","year":"1998","unstructured":"Remuzzi G, Bertani T (1998) Pathophysiology of progressive nephropathies. N Engl J Med 339:1448\u20131456","journal-title":"N Engl J Med"},{"key":"482_CR15","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1111\/j.1523-1755.2005.09915.x","volume":"99","author":"B Rodriguez-Iturbe","year":"2005","unstructured":"Rodriguez-Iturbe B, Johnson RJ, Herrera-Acosta J (2005) Tubulointerstitial damage and progression of renal failure. Kidney Int Suppl 99:S82\u2013S86","journal-title":"Kidney Int Suppl"},{"key":"482_CR16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/030098589303000312","volume":"30","author":"E Scanziani","year":"1993","unstructured":"Scanziani E, Grieco V, Salvi S (1993) Expression of vimentin in the tubular epithelium of bovine kidneys with interstitial nephritis. Vet Pathol 30:298\u2013293","journal-title":"Vet Pathol"},{"key":"482_CR17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/019131299281329","volume":"23","author":"R Sinniah","year":"1999","unstructured":"Sinniah R, Khan TN (1999) Renal tubular basement membrane changes in tubulointerstitial damage in patients with glomerular diseases. Ultrastruct Pathol 23:359\u2013368","journal-title":"Ultrastruct Pathol"},{"key":"482_CR18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0002-9440(10)63946-6","volume":"158","author":"T Suzuki","year":"2001","unstructured":"Suzuki T, Kimura M, Asano M, Fujigaki Y, Hishida A (2001) Role of atrophic tubules in development of interstitial fibrosis in microembolism-induced renal failure in rat. Am J Pathol 158:75\u201385","journal-title":"Am J Pathol"},{"key":"482_CR19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0034-5288(95)90043-8","volume":"59","author":"M Vilafranca","year":"1995","unstructured":"Vilafranca M, Wohlsein P, Trautwein G (1995) Expression of class II major histocompatibility complex molecules in renal tubular epithelial cells of canine kidneys affected with tubulointerstitial nephritis. Res Vet Sci 59:114\u2013117","journal-title":"Res Vet Sci"},{"key":"482_CR20","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1600-6143.2005.00843.x","volume":"5","author":"A Vongwiwatana","year":"2005","unstructured":"Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF (2005) Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 5:1367\u20131374","journal-title":"Am J Transplant"},{"key":"482_CR21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1513\/pats.200601-004TK","volume":"3","author":"BC Willis","year":"2006","unstructured":"Willis BC, duBois RM, Borok Z (2006) Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc 3:377\u2013382","journal-title":"Proc Am Thorac Soc"},{"key":"482_CR22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.etp.2005.07.001","volume":"57","author":"J Yamate","year":"2005","unstructured":"Yamate J, Kuribayashi M, Kuwamura M, Kotani T, Ogihara K (2005) Differential immunoexpressions of cytoskeletons in renal epithelial and interstitial cells in rat and canine fibrotic kidneys, and in kidney-related cell lines under fibrogenic stimuli. Exp Toxicol Pathol 57:135\u2013147","journal-title":"Exp Toxicol Pathol"},{"key":"482_CR23","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1093\/ndt\/13.8.1967","volume":"13","author":"B Yang","year":"1998","unstructured":"Yang B, Wagner BE, Savill J, El Nahas AM (1998) Cellular apoptosis and proliferation in experimental renal fibrosis. Nephrol Dial Transplant 13:2216\u20132226","journal-title":"Nephrol Dial Transplant"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-007-0482-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-007-0482-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-007-0482-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:34:03Z","timestamp":1559064843000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-007-0482-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,15]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11,5]]}},"alternative-id":["482"],"URL":"https:\/\/doi.org\/10.1007\/s00428-007-0482-8","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,15]]}}}