{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:12:57Z","timestamp":1761559977899},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T00:00:00Z","timestamp":1213833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1007\/s00428-008-0627-4","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T06:58:07Z","timestamp":1213772287000},"page":"177-188","source":"Crossref","is-referenced-by-count":8,"title":["Ultrastructure of myoepithelial cells as a target cell in sialoadenitis of submandibular glands of lupus-prone female NZBxNZWF1 mice"],"prefix":"10.1007","volume":"453","author":[{"given":"Toshiharu","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,6,19]]},"reference":[{"key":"627_CR1","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/1529-0131(200111)44:11<2633::AID-ART443>3.0.CO;2-9","volume":"44","author":"N Amft","year":"2001","unstructured":"Amft N, Curnow SJ, Scheel-Toellner D, Devadas A, Oates J, Crocker J, Hamburger J, Ainsworth J, Mathews J, Salmon M, Bowman Sj, Buckley CD (2001) Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structure in Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 44:2633\u20132641","journal-title":"Arthritis Rheum"},{"key":"627_CR2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-0714.1995.tb01168.x","volume":"24","author":"JC Atkinson","year":"1995","unstructured":"Atkinson JC, Royce LS, Wellner R, Pillemer SR, Bermudez D, Fox PC (1995) Anti-salivary antibodies in primary Sj\u00f6gren\u2019s syndrome. J Oral Pathol Med 24:206\u2013212","journal-title":"J Oral Pathol Med"},{"key":"627_CR3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3109\/00016487809111939","volume":"85","author":"B Carls\u00f6\u00f6","year":"1978","unstructured":"Carls\u00f6\u00f6 B, Ostberg Y (1978) Ultrastructural observations on the parotitis autoimmunica in the NZB\/NZW hybrid mice. Acta Otalaryngol 85:298\u2013306","journal-title":"Acta Otalaryngol"},{"key":"627_CR4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1006\/clin.1995.1128","volume":"76","author":"B Chandrasekar","year":"1995","unstructured":"Chandrasekar B, McGuff S, Aufdermorte TB, Troyer DA, Talal N, Dernande G (1995) Effects of calorie restriction on transforming growth factor \u03b21 and proinflammatory cytokines in murine Sj\u00f6gren\u2019s syndrome. Clin Immunol Immunopathol 76:291\u2013296","journal-title":"Clin Immunol Immunopathol"},{"key":"627_CR5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.it.2005.09.001","volume":"26","author":"JA Croker","year":"2005","unstructured":"Croker JA, Kimberly RP (2005) Challenge and candidates in human disease. Trends Immunol 26:580\u2013586","journal-title":"Trends Immunol"},{"key":"627_CR6","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1016\/S0021-9258(19)36960-1","volume":"267","author":"P Defilippi","year":"1992","unstructured":"Defilippi P, Silengo L, Tarone G (1992) \u03b16\/\u03b21 integrin (laminin receptor) is down-regulated by tumor necrosis factor \u03b1 and interleukin-1b in human endothelial cells. J Biol Chem 267:18303\u201318307","journal-title":"J Biol Chem"},{"key":"627_CR7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0722.2004.00183.x","volume":"113","author":"N Delaleu","year":"2005","unstructured":"Delaleu N, Jonsson R, K\u00f6ller MM (2005) Sj\u00f6gren\u2019s syndrome. Eur J Oral Sci 113:101\u2013113","journal-title":"Eur J Oral Sci"},{"key":"627_CR8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/08916930008994077","volume":"32","author":"I Gal","year":"2000","unstructured":"Gal I, Lakos G, Zeher M (2000) Comparison of the anti-Ro\/SSA autoantibody profile between patients with primary and secondary Sj\u00f6gren\u2019s syndrome. Autoimmunity 32:89\u201392","journal-title":"Autoimmunity"},{"key":"627_CR9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0030-4220(74)90417-4","volume":"37","author":"JS Greenspan","year":"1974","unstructured":"Greenspan JS, Daniels TE, Talal N, Sylvester RA (1974) The histology of Sj\u00f6gren\u2019s syndrome in labial salivary gland biopsies. Oral Surg 37:217\u2013229","journal-title":"Oral Surg"},{"key":"627_CR10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.276.5312.604","volume":"276","author":"N Haneji","year":"1997","unstructured":"Haneji N, Nakamura T, Takio K, Yanagi K, Higashiyama H, Saito I, Noji S, Sugino H, Hayashi Y (1997) Identification of alpha-fodrin as a candidate autoantigen in primary Sjogren\u2019s syndrome. Science 276:604\u2013607","journal-title":"Science"},{"key":"627_CR11","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1191\/0961203303lu483oa","volume":"12","author":"K Hasegawa","year":"2003","unstructured":"Hasegawa K, Hayashi T (2003) Synthetic CpG olygodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB\/NZWF1 mice. Lupus 12:838\u2013845","journal-title":"Lupus"},{"key":"627_CR12","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.1780380809","volume":"38","author":"Y Hayashi","year":"1995","unstructured":"Hayashi Y, Hamano H, Haneji N, Ishimaru N, Yanagi K (1995) Biased T cell receptor V beta gene usage during specific stages of the development of autoimmune sialadenitis in the MRL\/lpr mouse model of Sj\u00f6gren\u2019s syndrome. Arthirtis Rheum 38:1077\u20131084","journal-title":"Arthirtis Rheum"},{"key":"627_CR13","first-page":"45","volume":"20","author":"T Hayashi","year":"2005","unstructured":"Hayashi T, Hasegawa K, Ichinohe N (2005) ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic lekocytoclastic vasculitis in NZB\/NZWF1 mice. Histol Histopathol 20:45\u201352","journal-title":"Histol Histopathol"},{"key":"627_CR14","doi-asserted-by":"crossref","unstructured":"Hayashi T, Hasegawa K, Sasaki Y, Mori T, Adachi C, Maeda K (2007) Systemic administration of interleukin-4 expressing DNA delays the development of glomerulonephritis and prolongs survivals in lupus-prone female NZB\/NZWF1 mice. Nephrol Dial Transplant 22:3131\u20133138","DOI":"10.1093\/ndt\/gfm465"},{"key":"627_CR15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1053\/jcpa.2001.0493","volume":"125","author":"T Hayashi","year":"2001","unstructured":"Hayashi T, Shirachi T, Hasegawa K (2001) Relationship between sialoadenitis and periductal laminin expression in the submandibular salivary gland of NZB\/NZW F1 Mice. J Comp Pathol 125:110\u2013116","journal-title":"J Comp Pathol"},{"key":"627_CR16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/vim.1997.10.137","volume":"10","author":"T Hishikawa","year":"1997","unstructured":"Hishikawa T, Ogasawara H, Kaneko H, Shirasawa T, Matsuura Y, Sekigawa I, Takasaki Y, Hashimoto H, Hirose S, Handa S, Nagasawa R, Maruyama N (1997) Detection of antibodies to a recombinant gag protein derived from human endogenous retrovirus clone 4-1 in autoimmune disease. Viral Immunol 10:137\u2013147","journal-title":"Viral Immunol"},{"key":"627_CR17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00428-003-0964-2","volume":"444","author":"S Ihrler","year":"2004","unstructured":"Ihrler S, Blasenbreu-Vogt S, Sendelfofert A, R\u00f6ssle M, Harrison JD, L\u00f6hrs U (2004) Regeneration in chronic sialadenitis: an analysis of proliferation and apoptosis based on double immunohistochemical labeling. Virchows Arch 444:356\u2013361","journal-title":"Virchows Arch"},{"key":"627_CR18","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0002-9440(10)65027-4","volume":"156","author":"N Ishimaru","year":"2000","unstructured":"Ishimaru N, Yoneda T, Saegusa T, Yanagi K, Haneji N, Moriyama K, Saito I, Hayashi Y (2000) Severe destruction of autoimmune lesions with aging in murine Sj\u00f6gren\u2019s syndrome through Fas-mediated apoptosis. Am J Pathol 156:1557\u201364","journal-title":"Am J Pathol"},{"key":"627_CR19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1084\/jem.153.5.1151","volume":"153","author":"S Izui","year":"1981","unstructured":"Izui S, Elder JH, McConahey PJ, Dixon FJ (1981) Identification of retroviral gp70 and anti-gp70 antibodies involved in circulating immune complexes in NZBNZW mice. J Exp Med 153:1151\u20131160","journal-title":"J Exp Med"},{"key":"627_CR20","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1073\/pnas.84.5.1361","volume":"84","author":"L Jacob","year":"1987","unstructured":"Jacob L, Lety M-A, Monterio RC, Jacob F, Bach J-F, Louvard D (1987) Altered cell-surface proteins, crossreactive with DNA, on spleen cells of autoimmune lupic mice. Proc Natl Acad Sci USA 84:1361\u20131363","journal-title":"Proc Natl Acad Sci USA"},{"key":"627_CR21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1365-2249.2001.01500.x","volume":"124","author":"EK Kapsogeorgou","year":"2001","unstructured":"Kapsogeorgou EK, Dimitriou ID, Abu-Helu RF, Moutsopoulos HM, Manoussakis MN (2001) Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sj\u00f6gren\u2019s syndrome: high expression of intercellular adhesion molecule-(ICAM-1) in biopsy specimens and cultured cells. Clin Exp Immunol 124:126\u2013133","journal-title":"Clin Exp Immunol"},{"key":"627_CR22","first-page":"561","volume":"16","author":"R Matsumura","year":"1998","unstructured":"Matsumura R, Umemiya K, Kagami M, Tomioka H, Tanabe E, Sugiyama T, Sueishi M, Nakajima A, Azuma M, Okumuea K, Sumida T (1998) Glandular and extraglandular expression of the Fas\u2013Fas ligand and apoptosis in patients with Sj\u00f6gren\u2019s syndrome. Clin Exp Rheumatol 16:561\u2013568","journal-title":"Clin Exp Rheumatol"},{"key":"627_CR23","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1006\/jaut.1993.1053","volume":"6","author":"CP McArhtur","year":"1993","unstructured":"McArhtur CP, Fix NW, Kragel P (1993) Monoclonal antibody detection of laminin in minor salivary glands of patients with Sj\u00f6gren\u2019s syndrome. J Autoimmun 6:649\u2013661","journal-title":"J Autoimmun"},{"key":"627_CR24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1601-0825.2006.01292.x","volume":"12","author":"DI Mitsias","year":"2006","unstructured":"Mitsias DI, Kapsogeorgou EK, Moutsopoulos HM (2006) Sj\u00f6gren\u2019s syndrome: why autoimmune epithelitis? Oral Dis 12:523\u2013532","journal-title":"Oral Dis"},{"key":"627_CR25","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/eji.1830240910","volume":"24","author":"S Miyake","year":"1994","unstructured":"Miyake S, Sakurai T, Okumura k, Yagita H (1994) Identification of collagen and laminin receptor integrins on murine T lymphocytes. Eur J Immunol 24:2000\u20132005","journal-title":"Eur J Immunol"},{"key":"627_CR26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jcp.56.7.481","volume":"56","author":"CC Mok","year":"2003","unstructured":"Mok CC, Lau CS (2003) Pathogenesis of systemic lupus erythematosus. J Clin Pathol 56:481\u201390","journal-title":"J Clin Pathol"},{"key":"627_CR27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/ard.2004.033837","volume":"65","author":"C Molina","year":"2006","unstructured":"Molina C, Alliende C, Aguilera S, Kwon YJ, Leyton L, Martinez B, Leyton C, Perez P, Gonzalez MJ (2006) Basal lamina disorganization of the acini and ducts of labial salivary gland from patients with Sj\u00f6gren\u2019s syndrome: association with mononuclear cell infiltration. Ann Rheum Dis 65:178\u2013183","journal-title":"Ann Rheum Dis"},{"key":"627_CR28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/B:BGEN.0000038023.36727.50","volume":"5","author":"RM Nagler","year":"2004","unstructured":"Nagler RM (2004) Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring. Biogerontology 5:223\u2013233","journal-title":"Biogerontology"},{"key":"627_CR29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.trsl.2006.07.003","volume":"148","author":"H Nakamura","year":"2006","unstructured":"Nakamura H, Kawakami A, Eguchi K (2006) Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sj\u00f6gren\u2019s syndrome. Transl Res 148:281\u2013288","journal-title":"Transl Res"},{"key":"627_CR30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-065X.1996.tb00917.x","volume":"152","author":"K Nakagawa","year":"1996","unstructured":"Nakagawa K, Leonard CH (1996) The potential roles of endogenous retoroviruses in autoimmunity. Immunol Rev 152:193\u2013236","journal-title":"Immunol Rev"},{"key":"627_CR31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s005340170002","volume":"8","author":"Y Nakanuma","year":"2001","unstructured":"Nakanuma Y, Tsuneyama K, Harada K (2001) Pathology and pathogenesis of intrahepatic bile duct loss. J Hepatobiliary Pancreat Surg 8:303\u2013315","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"627_CR32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1191\/096120398678920046","volume":"7","author":"JC Nossent","year":"1998","unstructured":"Nossent JC, Swaak AJ (1998) Systemic lupus erythematosus VII: frequency and impact of secondary Sj\u00f6gren\u2019s syndrome. Lupus 7:231\u2013234","journal-title":"Lupus"},{"key":"627_CR33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/labinvest.3780215","volume":"81","author":"M Ohlsson","year":"2001","unstructured":"Ohlsson M, Skatstein K, Bolstad AI, Johannessen AC, Jonsson R (2001) Fas-induced apoptosis is a rare event in Sj\u00f6gren\u2019s syndrome. Lab Invest 81:95\u2013105","journal-title":"Lab Invest"},{"key":"627_CR34","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1601-0825.2005.01219.x","volume":"13","author":"K Ohno","year":"2007","unstructured":"Ohno K, Hattori T, Kagami H, Ueda M (2007) Effects of preceding sialoadenitis on the development of autoimmunity against salivary gland. Oral Dis 13:158\u2013162","journal-title":"Oral Dis"},{"key":"627_CR35","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/art.20789","volume":"52","author":"L Ping","year":"2005","unstructured":"Ping L, Ogawa N, Sugai S (2005) Novel role of CD40 in Fas-dependent apoptosis of cultured salivary epithelial cells from patients with Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 52:573\u2013581","journal-title":"Arthritis Rheum"},{"key":"627_CR36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/10408368709105881","volume":"25","author":"EJ Raubenheimer","year":"1987","unstructured":"Raubenheimer EJ (1987) The myoepithelial cell: embryology, function, and proliferative aspects. Crit Rev Clin Lab Sci 25:161\u2013193","journal-title":"Crit Rev Clin Lab Sci"},{"key":"627_CR37","first-page":"34","volume":"149","author":"M Reichlin","year":"1998","unstructured":"Reichlin M (1998) Antibodies to Ro and La. Ann Med Intern 149:34\u201341","journal-title":"Ann Med Intern"},{"key":"627_CR38","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1365-3083.2002.01058.x","volume":"55","author":"S Salmonson","year":"2002","unstructured":"Salmonson S, Larsson P, Tengner P, Mellquist E, Hjelmstrom P, Wahren-Herlenius M (2002) Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sj\u00f6gren\u2019s syndrome. Scand J Immunol 55:336\u2013342","journal-title":"Scand J Immunol"},{"key":"627_CR39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1749-0774.2002.tb00099.x","volume":"15","author":"Y Shibata","year":"2002","unstructured":"Shibata Y, Hishikawa Y, Izumi S, Fujita S, Yamaguchi A, Koji T (2002) Involvement of Fas\/Fas ligand in the induction of apoptosis in chronic sialoadenitis of minor salivary glands including Sj\u00f6gren\u2019s syndrome. Hum Cell 15:52\u201360","journal-title":"Hum Cell"},{"key":"627_CR40","first-page":"35","volume":"21","author":"Y Shimizu","year":"1990","unstructured":"Shimizu Y, Van Seventer GA, Horgan KJ, Shaw S (1990) Costimulation of proliferative response of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol 21:35\u201342","journal-title":"J Immunol"},{"key":"627_CR41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/clim.2002.5189","volume":"103","author":"SCA Blokland Van","year":"2002","unstructured":"Van Blokland SCA, Versnel MA (2002) Pathogenesis of Sj\u00f6gren\u2019s syndrome: characteristics of different mouse models for autoimmune exocrinopathy. Clin Immunol 103:111\u2013124","journal-title":"Clin Immunol"},{"key":"627_CR42","first-page":"2617","volume":"27","author":"T Witte","year":"2000","unstructured":"Witte T, Matthias T, Arnett FC, Peter HH, Hartung K, Sachse C, Wigand R, Braner A, Kaldon JR, Lakomok HJ, Schmidt RE (2000) IgA and IgG autoantibodies against alpha-fodrin as markers for Sj\u00f6gren\u2019s syndrome. J Rheumatol 27:2617\u20132620","journal-title":"J Rheumatol"},{"key":"627_CR43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<93::AID-PATH507>3.0.CO;2-A","volume":"190","author":"M Yasoshima","year":"2000","unstructured":"Yasoshima M, Tsuneyama K, Harada K, Sasaki M, Gershwin ME, Nakanuma Y (2000) Immunohistochemical analysis of cell\u2013matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrosis. J Pathol 190:93\u201399","journal-title":"J Pathol"},{"key":"627_CR44","first-page":"S67","volume":"44","author":"T Zelles","year":"1999","unstructured":"Zelles T, Boros I, Varga G (1999) Membrane stretch and salivary glands\u2014facts and theories. Arch Oral Biol 44:S67\u2013S571","journal-title":"Arch Oral Biol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-008-0627-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-008-0627-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-008-0627-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T06:28:25Z","timestamp":1631428105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-008-0627-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,19]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["627"],"URL":"https:\/\/doi.org\/10.1007\/s00428-008-0627-4","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,19]]}}}