{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:29:54Z","timestamp":1761708594779},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T00:00:00Z","timestamp":1286928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s00428-010-0990-9","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T17:52:38Z","timestamp":1286992358000},"page":"635-642","source":"Crossref","is-referenced-by-count":13,"title":["Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta"],"prefix":"10.1007","volume":"457","author":[{"given":"Mikhail","family":"Lisovsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Dresser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Woda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y.","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,13]]},"reference":[{"key":"990_CR1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.gtc.2007.08.008","volume":"36","author":"GY Lauwers","year":"2007","unstructured":"Lauwers GY, Srivastava A (2007) Gastric preneoplastic lesions and epithelial dysplasia. Gastroenterol Clin North Am 36:813\u2013829","journal-title":"Gastroenterol Clin North Am"},{"key":"990_CR2","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/0046-8177(94)90058-2","volume":"25","author":"DA Antonioli","year":"1994","unstructured":"Antonioli DA (1994) Precursors of gastric carcinoma: a critical review with a brief description of early (curable) gastric cancer. Hum Pathol 25:994\u20131005","journal-title":"Hum Pathol"},{"key":"990_CR3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/PAS.0b013e31815b890e","volume":"32","author":"DY Park","year":"2008","unstructured":"Park DY, Srivastava A, Kim GH et al (2008) Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia. Am J Surg Pathol 32:524\u2013533","journal-title":"Am J Surg Pathol"},{"key":"990_CR4","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/gut.45.5.784","volume":"45","author":"GY Lauwers","year":"1999","unstructured":"Lauwers GY, Riddell RH (1999) Gastric epithelial dysplasia. Gut 45:784\u2013790","journal-title":"Gut"},{"key":"990_CR5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00000478-200002000-00001","volume":"24","author":"M Rugge","year":"2000","unstructured":"Rugge M, Correa P, Dixon MF et al (2000) Gastric dysplasia: the Padova international classification. Am J Surg Pathol 24:167\u2013176","journal-title":"Am J Surg Pathol"},{"key":"990_CR6","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1101\/gad.1211604","volume":"18","author":"D Bilder","year":"2004","unstructured":"Bilder D (2004) Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 18:1909\u20131925","journal-title":"Genes Dev"},{"key":"990_CR7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2008.09.045","volume":"135","author":"L Zhan","year":"2008","unstructured":"Zhan L, Rosenberg A, Bergami KC et al (2008) Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135:865\u2013878","journal-title":"Cell"},{"key":"990_CR8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ncb922","volume":"5","author":"R Albertson","year":"2003","unstructured":"Albertson R, Doe CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 5:166\u2013170","journal-title":"Nat Cell Biol"},{"key":"990_CR9","doi-asserted-by":"crossref","first-page":"R674","DOI":"10.1016\/j.cub.2004.08.017","volume":"14","author":"J Betschinger","year":"2004","unstructured":"Betschinger J, Knoblich JA (2004) Dare to be different: asymmetric cell division in Drosophila. C. elegans and vertebrates. Curr Biol 14:R674\u2013R685","journal-title":"Curr Biol"},{"key":"990_CR10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ncb948","volume":"5","author":"PJ Plant","year":"2003","unstructured":"Plant PJ, Fawcett JP, Lin DC et al (2003) A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol 5:301\u2013308","journal-title":"Nat Cell Biol"},{"key":"990_CR11","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0960-9822(03)00244-6","volume":"13","author":"T Yamanaka","year":"2003","unstructured":"Yamanaka T, Horikoshi Y, Sugiyama Y et al (2003) Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol 13:734\u2013743","journal-title":"Curr Biol"},{"key":"990_CR12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1242\/dev.01645","volume":"132","author":"AD Chalmers","year":"2005","unstructured":"Chalmers AD, Pambos M, Mason J et al (2005) aPKC, Crumbs3 and Lgl2 control apicobasal polarity in early vertebrate development. Development 132:977\u2013986","journal-title":"Development"},{"key":"990_CR13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.devcel.2004.05.003","volume":"6","author":"A Hutterer","year":"2004","unstructured":"Hutterer A, Betschinger J, Petronczki M et al (2004) Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell 6:845\u2013854","journal-title":"Dev Cell"},{"key":"990_CR14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1083\/jcb.200502055","volume":"170","author":"X Zhang","year":"2005","unstructured":"Zhang X, Wang P, Gangar A et al (2005) Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. J Cell Biol 170:273\u2013283","journal-title":"J Cell Biol"},{"key":"990_CR15","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.96525","volume":"200","author":"E Gateff","year":"1978","unstructured":"Gateff E (1978) Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 200:1448\u20131459","journal-title":"Science"},{"key":"990_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.289.5476.113","volume":"289","author":"D Bilder","year":"2000","unstructured":"Bilder D, Li M, Perrimon N (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289:113\u2013116","journal-title":"Science"},{"key":"990_CR17","doi-asserted-by":"crossref","first-page":"8688","DOI":"10.1038\/sj.onc.1208023","volume":"23","author":"D Grifoni","year":"2004","unstructured":"Grifoni D, Garoia F, Schimanski CC et al (2004) The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Oncogene 23:8688\u20138694","journal-title":"Oncogene"},{"key":"990_CR18","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/sj.onc.1208520","volume":"24","author":"CC Schimanski","year":"2005","unstructured":"Schimanski CC, Schmitz G, Kashyap A et al (2005) Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene 24:3100\u20133109","journal-title":"Oncogene"},{"key":"990_CR19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/modpathol.2009.68","volume":"22","author":"M Lisovsky","year":"2009","unstructured":"Lisovsky M, Dresser K, Baker S et al (2009) Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol 22:977\u2013984","journal-title":"Mod Pathol"},{"key":"990_CR20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/jcp.43.4.303","volume":"43","author":"GM Sobala","year":"1990","unstructured":"Sobala GM, King RF, Axon AT, Dixon MF (1990) Reflux gastritis in the intact stomach. J Clin Pathol 43:303\u2013306","journal-title":"J Clin Pathol"},{"key":"990_CR21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2559.1993.tb01217.x","volume":"23","author":"CM Quinn","year":"1993","unstructured":"Quinn CM, Bjarnason I, Price AB (1993) Gastritis in patients on non-steroidal anti-inflammatory drugs. Histopathology 23:341\u2013348","journal-title":"Histopathology"},{"key":"990_CR22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.dld.2008.02.039","volume":"40","author":"A Srivastava","year":"2008","unstructured":"Srivastava A, Lauwers GY (2008) Gastric epithelial dysplasia: the Western perspective. Dig Liver Dis 40:641\u2013649","journal-title":"Dig Liver Dis"},{"key":"990_CR23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31\u201349","journal-title":"Acta Pathol Microbiol Scand"},{"key":"990_CR24","first-page":"37","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of the digestive system","author":"C Fenoglio-Preser","year":"2000","unstructured":"Fenoglio-Preser C, Carneiro F, Correa P et al (2000) Tumors of the stomach. In: Hamilton SR, Aaltonen LA (eds) World Health Organization classification of tumours: pathology and genetics of tumours of the digestive system. IARC Press, Lyon, pp 37\u201352"},{"key":"990_CR25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ijc.1460","volume":"94","author":"S Tsukashita","year":"2001","unstructured":"Tsukashita S, Kushima R, Bamba M (2001) MUC gene expression and histogenesis of adenocarcinoma of the stomach. Int J Cancer 94:166\u2013170","journal-title":"Int J Cancer"},{"key":"990_CR26","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1158\/1078-0432.CCR-06-1339","volume":"12","author":"Y Tajima","year":"2006","unstructured":"Tajima Y, Yamazaki K, Makino R (2006) Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background. Clin Cancer Res 12:6469\u20136479","journal-title":"Clin Cancer Res"},{"key":"990_CR27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/modpathol.2009.135","volume":"23","author":"DY Park","year":"2010","unstructured":"Park DY, Srivastava A, Kim GH (2010) CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. Mod Pathol 23:54\u201361","journal-title":"Mod Pathol"},{"key":"990_CR28","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/PAS.0b013e318198a1d4","volume":"33","author":"RL Rucker-Schmidt","year":"2009","unstructured":"Rucker-Schmidt RL, Sanchez CA, Blount PL (2009) Nonadenomatous dysplasia in Barrett esophagus: a clinical, pathologic, and DNA content flow cytometric study. Am J Surg Pathol 33:886\u2013893","journal-title":"Am J Surg Pathol"},{"key":"990_CR29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/modpathol.2010.59","volume":"23","author":"IS Brown","year":"2010","unstructured":"Brown IS, Whiteman DC, Lauwers GY (2010) Foveolar type dysplasia in Barrett esophagus. Mod Pathol 23:834\u2013843","journal-title":"Mod Pathol"},{"key":"990_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/modpathol.2009.147","volume":"23","author":"D Mahajan","year":"2010","unstructured":"Mahajan D, Bennett AE, Liu X (2010) Grading of gastric foveolar-type dysplasia in Barrett\u2019s esophagus. Mod Pathol 23:1\u201311","journal-title":"Mod Pathol"},{"key":"990_CR31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0046-8177(97)90095-2","volume":"28","author":"NS Goldstein","year":"1997","unstructured":"Goldstein NS, Lewin KJ (1997) Gastric epithelial dysplasia and adenoma: historical review andhistological criteria for grading. Hum Pathol 28:127\u2013133","journal-title":"Hum Pathol"},{"key":"990_CR32","first-page":"3503","volume":"62","author":"WM Clements","year":"2002","unstructured":"Clements WM, Wang J, Sarnaik A et al (2002) beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 62:3503\u20133506","journal-title":"Cancer Res"},{"key":"990_CR33","first-page":"3231","volume":"52","author":"A Horii","year":"1992","unstructured":"Horii A, Nakatsuru S, Miyoshi Y et al (1992) The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer. Cancer Res 52:3231\u20133233","journal-title":"Cancer Res"},{"key":"990_CR34","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1038\/sj.onc.1210259","volume":"26","author":"M Nojima","year":"2007","unstructured":"Nojima M, Suzuki H, Toyota M et al (2007) Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 26:4699\u20134713","journal-title":"Oncogene"},{"key":"990_CR35","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/nature04116","volume":"437","author":"GL Dollar","year":"2005","unstructured":"Dollar GL, Weber U, Mlodzik M et al (2005) Regulation of Lethal giant larvae by Dishevelled. Nature 437:1376\u20131380","journal-title":"Nature"},{"key":"990_CR36","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/01.MP.0000080349.37658.5E","volume":"16","author":"SC Abraham","year":"2003","unstructured":"Abraham SC, Park SJ, Lee JH et al (2003) Genetic alterations in gastric adenomas of intestinal and foveolar phenotypes. Mod Pathol 16:786\u2013795","journal-title":"Mod Pathol"},{"key":"990_CR37","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1097\/00000478-200210000-00004","volume":"26","author":"SC Abraham","year":"2002","unstructured":"Abraham SC, Montgomery EA, Singh VK et al (2002) Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology. Am J Surg Pathol 26:1276\u20131285","journal-title":"Am J Surg Pathol"},{"key":"990_CR38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/PAS.0b013e31817d7ff4","volume":"33","author":"ZM Chen","year":"2009","unstructured":"Chen ZM, Scudiere JR, Abraham SC et al (2009) Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am J Surg Pathol 33:186\u2013193","journal-title":"Am J Surg Pathol"},{"key":"990_CR39","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbamem.2007.08.029","volume":"1778","author":"E Ass\u00e9mat","year":"2008","unstructured":"Ass\u00e9mat E, Bazelli\u00e8res E, Pallesi-Pocachard E et al (2008) Polarity complex proteins. Biochim Biophys Acta 1778:614\u2013630","journal-title":"Biochim Biophys Acta"},{"key":"990_CR40","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.1158\/0008-5472.CAN-05-2372","volume":"65","author":"RP Regala","year":"2005","unstructured":"Regala RP, Weems C, Jamieson L et al (2005) Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res 65:8905\u20138911","journal-title":"Cancer Res"},{"key":"990_CR41","doi-asserted-by":"crossref","first-page":"12519","DOI":"10.1073\/pnas.0505641102","volume":"102","author":"AM Eder","year":"2005","unstructured":"Eder AM, Sui X, Rosen DG et al (2005) Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA 102:12519\u201312524","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-010-0990-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-010-0990-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-010-0990-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:35:58Z","timestamp":1559079358000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-010-0990-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,13]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["990"],"URL":"https:\/\/doi.org\/10.1007\/s00428-010-0990-9","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,13]]}}}