{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:32:07Z","timestamp":1760783527153},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T00:00:00Z","timestamp":1333584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00428-012-1224-0","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T08:05:13Z","timestamp":1333526713000},"page":"473-480","source":"Crossref","is-referenced-by-count":17,"title":["Intraepithelially entrapped blood vessels in oral carcinoma in-situ"],"prefix":"10.1007","volume":"460","author":[{"given":"Akinori","family":"Funayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Al-Eryani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Shingaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Saku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1368-8375(99)00070-6","volume":"36","author":"S Franceschi","year":"2000","unstructured":"Franceschi S, Bodoli E, Herrero R, Munoz N (2000) Comparison of cancers of the oral cavity and pharynx worldwide: etiological clues. Oral Oncol 36:106\u2013115","journal-title":"Oral Oncol"},{"key":"1224_CR2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1440-1827.2009.02499.x","volume":"60","author":"T Kobayashi","year":"2010","unstructured":"Kobayashi T, Maruyama S, Cheng J, Ida-Yonemochi H, Yagi M, Takagi R, Saku T (2010) Histopathological varieties of oral carcinoma in situ: diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia. Pathol Int 60:156\u2013166","journal-title":"Pathol Int"},{"key":"1224_CR3","first-page":"15","volume-title":"Histological typing of oral and oropharyngeal tumours. World Health Organization International Histological Classification of Tumors","author":"PN Wahi","year":"1971","unstructured":"Wahi PN, Cohen B, Luthra UK, Torloni H (1971) Histological typing of oral and oropharyngeal tumours. World Health Organization International Histological Classification of Tumors. World Health Organization, Geneva, pp 15\u201323"},{"key":"1224_CR4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-642-60592-5","volume-title":"Histological typing of cancer and precancer of the oral mucosa. World Health Organization International Histological Classification of Tumors","author":"JJ Pindborg","year":"1997","unstructured":"Pindborg JJ, Reichart PA, Smith CJ, van der Waal I (1997) Histological typing of cancer and precancer of the oral mucosa. World Health Organization International Histological Classification of Tumors, 2nd edn. Springer, Berlin, pp 21\u201329","edition":"2"},{"key":"1224_CR5","first-page":"177","volume-title":"Pathology and genetics of head and neck tumours. World Health Organization Classification of Tumours","author":"N Gale","year":"2005","unstructured":"Gale N, Piclch BZ, Sidransky D et al (2005) Epithelial precursor lesions. In: Barnes L, Evson JW, Reichart P, Sidransky D (eds) Pathology and genetics of head and neck tumours. World Health Organization Classification of Tumours. IARC Press, Lyon, pp 177\u2013179"},{"key":"1224_CR6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.oraloncology.2011.03.015","volume":"47","author":"T Mikami","year":"2011","unstructured":"Mikami T, Cheng J, Maruyama S, Kobayashi T, Funayama A, Yamazaki M, Adeola HA, Wu L, Shingaki S, Saito C, Saku T (2011) Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ. Oral Oncol 47:497\u2013503","journal-title":"Oral Oncol"},{"key":"1224_CR7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000324926","volume":"78","author":"A Funayama","year":"2011","unstructured":"Funayama A, Cheng J, Maruyama S, Yamazaki M, Kobayashi T, Syafriadi M, Kundu S, Shingaki S, Saito C, Saku T (2011) Enhanced expressions of podoplanin in oral carcinomas in-situ and squamous cell carcinomas. Pathobiology 78:171\u2013180","journal-title":"Pathobiology"},{"key":"1224_CR8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0714.2004.00283.x","volume":"34","author":"M Syafriadi","year":"2005","unstructured":"Syafriadi M, Cheng J, Jen KY, Ida-Yonemochi H, Suzuki M, Saku T (2005) Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells. J Oral Pathol Med 34:140\u2013149","journal-title":"J Oral Pathol Med"},{"key":"1224_CR9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1600-0714.2006.00444.x","volume":"35","author":"T Takeda","year":"2006","unstructured":"Takeda T, Sugihara K, Hirayama Y et al (2006) Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias. J Oral Pathol Med 35:369\u2013375","journal-title":"J Oral Pathol Med"},{"key":"1224_CR10","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1158\/1078-0432.CCR-07-1609","volume":"14","author":"I Pavlova","year":"2008","unstructured":"Pavlova I, Williams M, El-Naggar A et al (2008) Understanding the biological basis of autofluorescence imaging for oral cancer detection: high-resolution fluorescence microscopy in viable tissue. Clin Cancer Res 14:2396\u20132404","journal-title":"Clin Cancer Res"},{"key":"1224_CR11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2559.2011.03929.x","volume":"59","author":"CG Alvarado","year":"2011","unstructured":"Alvarado CG, Maruyama S, Cheng J, Ida-Yonemochi H, Kobayashi T, Yamazaki M, Takagi R, Saku T (2011) Nuclear translocation of \u03b2-catenin synchronized with loss of E-cadherin in oral epithelial dysplasia with a characteristic two-phase appearance. Histopathology 59:283\u2013291","journal-title":"Histopathology"},{"key":"1224_CR12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0714.2004.00026.x","volume":"33","author":"T Ikarashi","year":"2004","unstructured":"Ikarashi T, Ida-Yonemochi H, Ohshiro K, Cheng J, Saku T (2004) Intraepithelial expression of perlecan, a basement membrane-type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium. J Oral Pathol Med 33:87\u201395","journal-title":"J Oral Pathol Med"},{"key":"1224_CR13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1600-0714.2009.00750.x","volume":"38","author":"WM Tilakaratne","year":"2009","unstructured":"Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Shahidul AM, Maruyama S, Cheng J, Saku T (2009) Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers. J Oral Pathol Med 38:348\u2013355","journal-title":"J Oral Pathol Med"},{"key":"1224_CR14","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.joms.2008.06.081","volume":"67","author":"D Kademani","year":"2009","unstructured":"Kademani D, Lewis JT, Lamb DH, Rallis DJ, Harrington JR (2009) Angiogenesis and CD34 expression as a predictor of recurrence in oral squamous cell carcinoma. J Oral Maxillofac Surg 67:1800\u20131805","journal-title":"J Oral Maxillofac Surg"},{"key":"1224_CR15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1054\/ijom.2003.0433","volume":"33","author":"EJ Hannen","year":"2004","unstructured":"Hannen EJ, Riediger D (2004) The quantification of angiogenesis in relation to metastasis in oral cancer: a review. Int J Oral Maxillafac Surg 33:2\u20137","journal-title":"Int J Oral Maxillafac Surg"},{"key":"1224_CR16","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/bjc.1997.571","volume":"76","author":"SP Dobbs","year":"1997","unstructured":"Dobbs SP, Hewett PW, Johnson IR, Carmichael J, Murray JC (1997) Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer 76:1410\u20131415","journal-title":"Br J Cancer"},{"key":"1224_CR17","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.humpath.2010.03.010","volume":"42","author":"N Che","year":"2011","unstructured":"Che N, Zhao XL, Sun T et al (2011) The role of Twist 1 in hepatocellular carcinoma angiogenesis: a clinical study. Hum Pathol 42:840\u2013847","journal-title":"Hum Pathol"},{"key":"1224_CR18","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/cncr.20482","volume":"101","author":"M Muto","year":"2004","unstructured":"Muto M, Nakane M, Katada C et al (2004) Squamous cell carcinoma in situ at oropharyngeal and hypopharygeal mucosal site. Cancer 101:1375\u20131381","journal-title":"Cancer"},{"key":"1224_CR19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/lary.21553","volume":"121","author":"H Matsuba","year":"2011","unstructured":"Matsuba H, Katada C, Masaki T et al (2011) Diagnosis of extent of advanced oropharyngeal cancers by narrow band imaging with magnifying endoscopy. Laryngoscope 121:753\u2013759","journal-title":"Laryngoscope"},{"key":"1224_CR20","doi-asserted-by":"crossref","unstructured":"Takano JH, Yakushiji T, Kamiyama I, et al (2010) Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature. Int J Oral Maxillofac Surg 39:208\u2013213","DOI":"10.1016\/j.ijom.2010.01.007"},{"key":"1224_CR21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00441-008-0707-4","volume":"335","author":"LL Nikitenko","year":"2008","unstructured":"Nikitenko LL (2008) Vascular endothelium in cancer. Cell Tissue Res 335:223\u2013240","journal-title":"Cell Tissue Res"},{"key":"1224_CR22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrc2444","volume":"8","author":"C Murdoch","year":"2008","unstructured":"Murdoch C, Muthana M, Coffelt SB, Lewis CE (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 8:618\u2013631","journal-title":"Nat Rev Cancer"},{"key":"1224_CR23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0714.2004.00282.x","volume":"34","author":"W Swelam","year":"2005","unstructured":"Swelam W, Ida-Yonemochi H, Saku T (2005) Angiogenesis in mucous retention cyst: a human in-vivo-like model of endothelial cell differentiation in mucous substrate. J Oral Pathol Med 34:30\u201338","journal-title":"J Oral Pathol Med"},{"key":"1224_CR24","first-page":"9","volume":"147","author":"N Weidner","year":"1995","unstructured":"Weidner N (1995) Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147:9\u201319","journal-title":"Am J Pathol"},{"key":"1224_CR25","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/S0959-8049(96)00379-6","volume":"32","author":"PB Vermeulen","year":"1996","unstructured":"Vermeulen PB, Gasparini G, Fox SB et al (1996) Quantification of angiogenesis in solid human tumors: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 32:2474\u20132484","journal-title":"Eur J Cancer"},{"key":"1224_CR26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.oraloncology.2004.08.001","volume":"41","author":"T Martonea","year":"2005","unstructured":"Martonea T, Rossoa P, Alberaa R et al (2005) Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome. Oral Oncol 41:147\u2013155","journal-title":"Oral Oncol"},{"key":"1224_CR27","doi-asserted-by":"crossref","unstructured":"Meert A-P, Paesmans M, Martin1 B et al (2002) The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Brit J Cancer 87:694-701","DOI":"10.1038\/sj.bjc.6600551"},{"key":"1224_CR28","first-page":"2821","volume":"6","author":"K Tae","year":"2000","unstructured":"Tae K, El-Naggar AK, Yoo E et al (2000) Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis. Clin Cancer Res 6:2821\u20132828","journal-title":"Clin Cancer Res"},{"key":"1224_CR29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ijom.2004.10.016","volume":"34","author":"C Li","year":"2005","unstructured":"Li C, Shintani S, Terakado N et al (2005) Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas. Int J Oral Maxillofac Surg 34:559\u2013565","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1224_CR30","first-page":"1616","volume":"6","author":"RL Keith","year":"2000","unstructured":"Keith RL, Miller YE, Gemmill RM et al (2000) Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res 6:1616\u20131625","journal-title":"Clin Cancer Res"},{"key":"1224_CR31","first-page":"113","volume":"4","author":"DJ Krutchkoff","year":"1991","unstructured":"Krutchkoff DJ, Eisengerg E, Anderson C (1991) Dysplasia of oral mucosa: a unified approach to proper evaluation. Mod Pathol 4:113\u2013119","journal-title":"Mod Pathol"},{"key":"1224_CR32","doi-asserted-by":"crossref","unstructured":"Abu Eid R, Sawair F, Landini G, Saku T (2012) Age and the architecture of oral mucosa. Age (Dordr). doi: 10.1007\/s11357-011-9261-1","DOI":"10.1007\/s11357-011-9261-1"},{"key":"1224_CR33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1055\/s-2006-925385","volume":"38","author":"MA Kara","year":"2006","unstructured":"Kara MA, Bergman JJ (2006) Autofluorescence imaging and narrow-band imaging for the detection of early neoplasia in patients with Barrett's esophagus. Endoscopy 38:627\u2013631","journal-title":"Endoscopy"},{"key":"1224_CR34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00042737-200608000-00006","volume":"18","author":"K Yasuda","year":"2006","unstructured":"Yasuda K (2006) Early gastric cancer: diagnosis, treatment techniques and outcomes. Eur J Gastroenterol Hepatol 18:839\u2013845","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1224_CR35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000321807","volume":"83","author":"S Oba","year":"2011","unstructured":"Oba S, Tanaka S, Sano Y, Oka S, Chayama K (2011) Current status of narrow-band imaging magnifying colonoscopy for colorectal neoplasia in Japan. Digestion 83:167\u2013172","journal-title":"Digestion"},{"key":"1224_CR36","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/S1542-3565(05)00262-4","volume":"3","author":"M Muto","year":"2005","unstructured":"Muto M, Katada C, Sano Y, Yoshida S (2005) Narrow band imaging: a new diagnostic approach to visualize angiogenesis in superficial neoplasia. Clin Gastroenterol Hepatol 3:S16\u201320","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-012-1224-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-012-1224-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-012-1224-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T18:23:56Z","timestamp":1561573436000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-012-1224-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1007\/s00428-012-1224-0","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,5]]}}}