{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:10:13Z","timestamp":1791382213767,"version":"4.3.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s00428-012-1236-9","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T03:56:13Z","timestamp":1336017373000},"page":"629-636","source":"Crossref","is-referenced-by-count":69,"title":["Intratumoral hemorrhage, vessel density, and the inflammatory reaction contribute to volume increase of sporadic vestibular schwannomas"],"prefix":"10.1007","volume":"460","author":[{"given":"Maurits","family":"de Vries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pancras C. W.","family":"Hogendoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Briaire-de Bruyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn J. A.","family":"Malessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andel G. L.","family":"van der Mey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,4]]},"reference":[{"issue":"5","key":"1236_CR1","first-page":"616","volume":"16","author":"W Szeremeta","year":"1995","unstructured":"Szeremeta W, Monsell EM, Rock JP, Caccamo DV (1995) Proliferation indices of vestibular schwannomas by Ki-67 and proliferating cell nuclear antigen. Am J Otol 16(5):616\u2013619","journal-title":"Am J Otol"},{"issue":"6","key":"1236_CR2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1067\/mhn.2000.111356","volume":"123","author":"K Niemczyk","year":"2000","unstructured":"Niemczyk K, Vaneecloo FM, Lecomte MH, Lejeune JP, Lemaitre L, Skarzynski H et al (2000) Correlation between Ki-67 index and some clinical aspects of acoustic neuromas (vestibular schwannomas). Otolaryngol Head Neck Surg 123(6):779\u2013783","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"1236_CR3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.bjc.6600729","volume":"88","author":"EJ Davidson","year":"2003","unstructured":"Davidson EJ, Morris LS, Scott IS, Rushbrook SM, Bird K, Laskey RA et al (2003) Minichromosome maintenance (Mcm) proteins, cyclin B1 and D1, phosphohistone H3 and in situ DNA replication for functional analysis of vulval intraepithelial neoplasia. Br J Cancer 88(2):257\u2013262","journal-title":"Br J Cancer"},{"issue":"6","key":"1236_CR4","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/humrep\/deg255","volume":"18","author":"RM Brenner","year":"2003","unstructured":"Brenner RM, Slayden OD, Rodgers WH, Critchley HO, Carroll R, Nie XJ et al (2003) Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium. Hum Reprod 18(6):1185\u20131193","journal-title":"Hum Reprod"},{"issue":"3","key":"1236_CR5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00129039-200609000-00007","volume":"14","author":"H Takahashi","year":"2006","unstructured":"Takahashi H, Murai Y, Tsuneyama K, Nomoto K, Okada E, Fujita H et al (2006) Overexpression of phosphorylated histone H3 is an indicator of poor prognosis in gastric adenocarcinoma patients. Appl Immunohistochem Mol Morphol 14(3):296\u2013302","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"1236_CR6","doi-asserted-by":"crossref","unstructured":"(1995) Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma). American Academy of Otolaryngology-Head and Neck Surgery Foundation, INC. Otolaryngol Head Neck Surg 113(3):179\u2013180.","DOI":"10.1016\/S0194-5998(95)70101-X"},{"issue":"1","key":"1236_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1096-9896(199801)184:1<24::AID-PATH952>3.0.CO;2-W","volume":"184","author":"JV Bovee","year":"1998","unstructured":"Bovee JV, van den Broek LJ, de Boer WI, Hogendoorn PC (1998) Expression of growth factors and their receptors in adamantinoma of long bones and the implication for its histogenesis. J Pathol 184(1):24\u201330","journal-title":"J Pathol"},{"issue":"12","key":"1236_CR8","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/S0959-8049(02)00094-1","volume":"38","author":"PB Vermeulen","year":"2002","unstructured":"Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M et al (2002) Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer 38(12):1564\u20131579","journal-title":"Eur J Cancer"},{"issue":"3","key":"1236_CR9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/path.1711770310","volume":"177","author":"SB Fox","year":"1995","unstructured":"Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC, Harris AL (1995) Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 177(3):275\u2013283","journal-title":"J Pathol"},{"issue":"1","key":"1236_CR10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00428-011-1168-9","volume":"460","author":"CE Andrea de","year":"2011","unstructured":"de Andrea CE, Wiweger MI, Bovee JV, Romeo S, Hogendoorn PC (2011) Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation. Virchows Arch 460(1):95\u2013102","journal-title":"Virchows Arch"},{"issue":"8","key":"1236_CR11","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/MAO.0b013e31814b2787","volume":"28","author":"D Koutsimpelas","year":"2007","unstructured":"Koutsimpelas D, Stripf T, Heinrich UR, Mann WJ, Brieger J (2007) Expression of vascular endothelial growth factor and basic fibroblast growth factor in sporadic vestibular schwannomas correlates to growth characteristics. Otol Neurotol 28(8):1094\u20131099","journal-title":"Otol Neurotol"},{"issue":"4","key":"1236_CR12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3171\/jns.2003.98.4.0807","volume":"98","author":"A Bedavanija","year":"2003","unstructured":"Bedavanija A, Brieger J, Lehr HA, Maurer J, Mann WJ (2003) Association of proliferative activity and size in acoustic neuroma: implications for timing of surgery. J Neurosurg 98(4):807\u2013811","journal-title":"J Neurosurg"},{"issue":"1","key":"1236_CR13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00129492-200101000-00016","volume":"22","author":"A Gomez-Brouchet","year":"2001","unstructured":"Gomez-Brouchet A, Delisle MB, Cognard C, Bonafe A, Charlet JP, Deguine O et al (2001) Vestibular schwannomas: correlations between magnetic resonance imaging and histopathologic appearance. Otol Neurotol 22(1):79\u201386","journal-title":"Otol Neurotol"},{"issue":"8","key":"1236_CR14","first-page":"487","volume":"194","author":"CM Jeng","year":"1995","unstructured":"Jeng CM, Huang JS, Lee WY, Wang YC, Kung CH, Lau MK (1995) Magnetic resonance imaging of acoustic schwannomas. J Formos Med Assoc 194(8):487\u2013493","journal-title":"J Formos Med Assoc"},{"issue":"12","key":"1236_CR15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1258\/0022215001904653","volume":"114","author":"P Fundova","year":"2000","unstructured":"Fundova P, Charabi S, Tos M, Thomsen J (2000) Cystic vestibular schwannoma: surgical outcome. J Laryngol Otol 114(12):935\u2013939","journal-title":"J Laryngol Otol"},{"issue":"5","key":"1236_CR16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-2007-986436","volume":"17","author":"SE Jones","year":"2007","unstructured":"Jones SE, Baguley DM, Moffat DA (2007) Are facial nerve outcomes worse following surgery for cystic vestibular schwannoma? Skull Base 17(5):281\u2013284","journal-title":"Skull Base"},{"issue":"5","key":"1236_CR17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jocn.2007.01.007","volume":"15","author":"S Sinha","year":"2008","unstructured":"Sinha S, Sharma BS (2008) Cystic acoustic neuromas: surgical outcome in a series of 58 patients. J Clin Neurosci 15(5):511\u2013515","journal-title":"J Clin Neurosci"},{"issue":"5","key":"1236_CR18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1017\/S0022215100126854","volume":"108","author":"S Charabi","year":"1994","unstructured":"Charabi S, Mantoni M, Tos M, Thomsen J (1994) Cystic vestibular schwannomas: neuroimaging and growth rate. J Laryngol Otol 108(5):375\u2013379","journal-title":"J Laryngol Otol"},{"issue":"4","key":"1236_CR19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3171\/jns.2006.105.4.576","volume":"105","author":"CK Park","year":"2006","unstructured":"Park CK, Kim DC, Park SH, Kim JE, Paek SH, Kim DG et al (2006) Microhemorrhage, a possible mechanism for cyst formation in vestibular schwannomas. J Neurosurg 105(4):576\u2013580","journal-title":"J Neurosurg"},{"issue":"2","key":"1236_CR20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3171\/JNS\/2008\/109\/8\/0306","volume":"109","author":"A Stadlbauer","year":"2008","unstructured":"Stadlbauer A, Buchfelder M, Nimsky C, Saeger W, Salomonowitz E, Pinker K et al (2008) Proton magnetic resonance spectroscopy in pituitary macroadenomas: preliminary results. J Neurosurg 109(2):306\u2013312","journal-title":"J Neurosurg"},{"issue":"21","key":"1236_CR21","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","volume":"285","author":"J Folkman","year":"1971","unstructured":"Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285(21):1182\u20131186","journal-title":"N Engl J Med"},{"issue":"1","key":"1236_CR22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/00016489609137713","volume":"116","author":"S Charabi","year":"1996","unstructured":"Charabi S, Simonsen K, Charabi B, Jacobsen GK, Moos T, Rygaard J et al (1996) Nerve growth factor receptor expression in heterotransplanted vestibular schwannoma in athymic nude mice. Acta Otolaryngol 116(1):59\u201363","journal-title":"Acta Otolaryngol"},{"key":"1236_CR23","first-page":"1","volume":"530","author":"S Charabi","year":"1997","unstructured":"Charabi S (1997) Acoustic neuroma\/vestibular schwannoma in vivo and in vitro growth models. A clinical and experimental study. Acta Otolaryngol Suppl 530:1\u201327","journal-title":"Acta Otolaryngol Suppl"},{"issue":"3","key":"1236_CR24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/jmri.10061","volume":"15","author":"CS Rijswijk van","year":"2002","unstructured":"van Rijswijk CS, Kunz P, Hogendoorn PC, Taminiau AH, Doornbos J, Bloem JL (2002) Diffusion-weighted MRI in the characterization of soft-tissue tumors. J Magn Reson Imaging 15(3):302\u2013307","journal-title":"J Magn Reson Imaging"},{"issue":"11","key":"1236_CR25","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1007\/s00330-007-0680-4","volume":"17","author":"F Bonneville","year":"2007","unstructured":"Bonneville F, Savatovsky J, Chiras J (2007) Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions. Eur Radiol 17(11):2908\u20132920","journal-title":"Eur Radiol"},{"issue":"10 Suppl","key":"1236_CR26","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/cncr.24237","volume":"115","author":"I Pedrosa","year":"2009","unstructured":"Pedrosa I, Alsop DC, Rofsky NM (2009) Magnetic resonance imaging as a biomarker in renal cell carcinoma. Cancer 115(10 Suppl):2334\u20132345","journal-title":"Cancer"},{"issue":"9","key":"1236_CR27","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1080\/00016480310005101","volume":"123","author":"J Brieger","year":"2003","unstructured":"Brieger J, Bedavanija A, Lehr HA, Maurer J, Mann WJ (2003) Expression of angiogenic growth factors in acoustic neurinoma. Acta Otolaryngol 123(9):1040\u20131045","journal-title":"Acta Otolaryngol"},{"issue":"8","key":"1236_CR28","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1080\/00016480050218681","volume":"120","author":"C Labit-Bouvier","year":"2000","unstructured":"Labit-Bouvier C, Crebassa B, Bouvier C, Andrac-Meyer L, Magnan J, Charpin C (2000) Clinicopathologic growth factors in vestibular schwannomas: a morphological and immunohistochemical study of 69 tumours. Acta Otolaryngol 120(8):950\u2013954","journal-title":"Acta Otolaryngol"},{"issue":"8","key":"1236_CR29","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1158\/1078-0432.CCR-10-2047","volume":"17","author":"EP Buddingh","year":"2011","unstructured":"Buddingh EP, Kuijjer ML, Duim RA, Burger H, Agelopoulos K, Myklebost O et al (2011) Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage activating agents. Clin Cancer Res 17(8):2110\u20132119","journal-title":"Clin Cancer Res"},{"issue":"7","key":"1236_CR30","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/carcin\/bgp127","volume":"30","author":"F Colotta","year":"2009","unstructured":"Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30(7):1073\u20131081","journal-title":"Carcinogenesis"},{"issue":"2","key":"1236_CR31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4161\/cbt.10.2.12160","volume":"10","author":"HP Hsu","year":"2010","unstructured":"Hsu HP, Shan YS, Lai MD, Lin PW (2010) Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival. Cancer Biol Ther 10(2):144\u2013154","journal-title":"Cancer Biol Ther"},{"issue":"6","key":"1236_CR32","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.193.6.727","volume":"193","author":"EY Lin","year":"2001","unstructured":"Lin EY, Nguyen AV, Russell RG, Pollard JW (2001) Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193(6):727\u2013740","journal-title":"J Exp Med"},{"issue":"9614","key":"1236_CR33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0140-6736(08)60241-X","volume":"371","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Romero P, Palucka AK, Marincola FM (2008) Tumour immunity: effector response to tumour and role of the microenvironment. Lancet 371(9614):771\u2013783","journal-title":"Lancet"},{"issue":"2","key":"1236_CR34","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4049\/jimmunol.0902360","volume":"184","author":"LS Ojalvo","year":"2010","unstructured":"Ojalvo LS, Whittaker CA, Condeelis JS, Pollard JW (2010) Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol 184(2):702\u2013712","journal-title":"J Immunol"},{"issue":"8","key":"1236_CR35","doi-asserted-by":"crossref","first-page":"e6562","DOI":"10.1371\/journal.pone.0006562","volume":"4","author":"B Qian","year":"2009","unstructured":"Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J et al (2009) A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4(8):e6562","journal-title":"PLoS One"},{"issue":"5","key":"1236_CR36","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1189\/jlb.0609385","volume":"86","author":"G Solinas","year":"2009","unstructured":"Solinas G, Germano G, Mantovani A, Allavena P (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86(5):1065\u20131073","journal-title":"J Leukoc Biol"},{"issue":"7","key":"1236_CR37","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1158\/0008-5472.CAN-04-4037","volume":"65","author":"P Allavena","year":"2005","unstructured":"Allavena P, Signorelli M, Chieppa M, Erba E, Bianchi G, Marchesi F et al (2005) Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res 65(7):2964\u20132971","journal-title":"Cancer Res"},{"issue":"1","key":"1236_CR38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1586\/erm.10.97","volume":"11","author":"RA Mukhtar","year":"2011","unstructured":"Mukhtar RA, Nseyo O, Campbell MJ, Esserman LJ (2011) Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics. Expert Rev Mol Diagn 11(1):91\u2013100","journal-title":"Expert Rev Mol Diagn"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-012-1236-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T14:17:06Z","timestamp":1497968226000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-012-1236-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,4]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["1236"],"URL":"https:\/\/doi.org\/10.1007\/s00428-012-1236-9","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,4]]}}}