{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:14:48Z","timestamp":1783185288930,"version":"3.54.6"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,8,11]],"date-time":"2012-08-11T00:00:00Z","timestamp":1344643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1007\/s00428-012-1291-2","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T05:00:12Z","timestamp":1344574812000},"page":"393-398","source":"Crossref","is-referenced-by-count":21,"title":["Hepatic stellate cells are involved in the pathogenesis of acute-on-chronic liver failure (ACLF)"],"prefix":"10.1007","volume":"461","author":[{"given":"Archana","family":"Rastogi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,11]]},"reference":[{"issue":"2","key":"1291_CR1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00428-011-1115-9","volume":"459","author":"A Rastogi","year":"2011","unstructured":"Rastogi A, Kumar A, Sakhuja P et al (2011) Liver histology as predictor of outcome in patients with acute-on-chronic liver failure (ACLF). Virchows Arch 459(2):121\u2013127","journal-title":"Virchows Arch"},{"issue":"4","key":"1291_CR2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1586\/egh.11.47","volume":"5","author":"W Laleman","year":"2011","unstructured":"Laleman W, Verbeke L, Meersseman P et al (2011) Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. Expert Rev Gastroenterol Hepatol 5(4):523\u2013537","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"1291_CR3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/gut.2008.171116","volume":"58","author":"P Sancho-Bru","year":"2009","unstructured":"Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M (2009) Stem and progenitor cells for liver repopulation: can we standardize the process from bench to bedside? Gut 58:594\u2013603","journal-title":"Gut"},{"key":"1291_CR4","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/labinvest.3700349","volume":"85","author":"JK Sicklick","year":"2005","unstructured":"Sicklick JK, Li Y-X, Choi SS, Qi Y et al (2005) Role for hedgehog signaling in hepatic stellate cell activation and viability. Lab Investig 85:1368\u20131380","journal-title":"Lab Investig"},{"key":"1291_CR5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2007.12.085","volume":"367","author":"C Kordes","year":"2008","unstructured":"Kordes C, Sawitza I, H\u00e4ussinger D (2008) Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun 367:116\u2013123","journal-title":"Biochem Biophys Res Commun"},{"key":"1291_CR6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12072-008-9106-x","volume":"3","author":"SK Sarin","year":"2009","unstructured":"Sarin SK, Kumar A, Almeida J et al (2009) Acute on chronic liver failure (ACLF): consensus recommendations of the Asia Pacific Association for the Study of the Liver (APASL). Hepatol Int 3:269\u2013282","journal-title":"Hepatol Int"},{"key":"1291_CR7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak K, Baptista A, Bianchi L et al (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22:696\u2013699","journal-title":"J Hepatol"},{"key":"1291_CR8","unstructured":"Fauci AS, Brauwald E, Kasper DL(2005) Harrison\u2019s principle of internal medicine, 17th ed. Amazon"},{"key":"1291_CR9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/archderm.1973.01620240073033","volume":"108","author":"E Horwath","year":"1973","unstructured":"Horwath E, Kovacs K, Ross RC (1973) Liver ultrastructure in methotrexate treatment of psoriasis. Arch Dermatol 108:427\u2013428","journal-title":"Arch Dermatol"},{"key":"1291_CR10","first-page":"1233","volume":"138","author":"A Schmitt-Graff","year":"1991","unstructured":"Schmitt-Graff A, Kruger S, Bochard F et al (1991) Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 138:1233\u20131242","journal-title":"Am J Pathol"},{"key":"1291_CR11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2001-17550","volume":"21","author":"PD Geerts","year":"2001","unstructured":"Geerts PD (2001) History, heterogeneity, developmental, biology, and functions of quiescent hepatic stellate cells. Sem Liver Dis 21:311\u2013335","journal-title":"Sem Liver Dis"},{"key":"1291_CR12","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.5858\/2007-131-1728-HSCALF","volume":"131","author":"KM Roger","year":"2007","unstructured":"Roger KM (2007) Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 131:1728\u20131734","journal-title":"Arch Pathol Lab Med"},{"key":"1291_CR13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"SL Friedman","year":"2008","unstructured":"Friedman SL (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88:125\u2013172","journal-title":"Physiol Rev"},{"key":"1291_CR14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s005350050264","volume":"34","author":"AD Burt","year":"1999","unstructured":"Burt AD (1999) Pathobiology of hepatic stellate cells. J Gastroenterol 34:299\u2013304","journal-title":"J Gastroenterol"},{"issue":"1 Suppl","key":"1291_CR15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0168-8278(00)80413-4","volume":"32","author":"DA Brenner","year":"2000","unstructured":"Brenner DA, Waterboer T, Choi SK et al (2000) New aspects of hepatic fibrosis. J Hepatol 32(1 Suppl):32\u201338","journal-title":"J Hepatol"},{"key":"1291_CR16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","volume":"36","author":"D Cassiman","year":"2002","unstructured":"Cassiman D, Libbrecht L, Desmet V et al (2002) Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36:200\u2013209","journal-title":"J Hepatol"},{"issue":"5","key":"1291_CR17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0168-8278(96)80238-8","volume":"25","author":"S Tsukada","year":"1996","unstructured":"Tsukada S, Parsons CJ, Rippe RA (1996) Mechanisms of liver fibrosis. J Hepatol 25(5):677\u2013683","journal-title":"J Hepatol"},{"key":"1291_CR18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0002-9440(10)64082-5","volume":"158","author":"S Paku","year":"2001","unstructured":"Paku S, Schnur J, Nagy P et al (2001) Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol 158:1313\u20131323","journal-title":"Am J Pathol"},{"issue":"3","key":"1291_CR19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/jb\/mvr001","volume":"149","author":"M Tanaka","year":"2011","unstructured":"Tanaka M, Itoh T, Tanimizu N et al (2011) Liver stem\/progenitor cells: their characteristics and regulatory mechanisms. J Biochem 149(3):231\u2013239","journal-title":"J Biochem"},{"key":"1291_CR20","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1634\/stemcells.2008-0115","volume":"26","author":"L Yang","year":"2008","unstructured":"Yang L, Jung Y, Omenetti A et al (2008) Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells 26:2104\u20132113","journal-title":"Stem Cells"},{"issue":"5","key":"1291_CR21","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/hep.23184","volume":"50","author":"I Sawitza","year":"2009","unstructured":"Sawitza I, Kordes C, Reister S et al (2009) The niche of stellate cells within rat liver. Hepatology 50(5):1617\u20131624","journal-title":"Hepatology"},{"issue":"3","key":"1291_CR22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/hep.23754","volume":"52","author":"A Dech\u00eane","year":"2010","unstructured":"Dech\u00eane A, Sowa JP, Robert K et al (2010) Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology 52(3):1008\u20131016","journal-title":"Hepatology"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-012-1291-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-012-1291-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-012-1291-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T03:42:41Z","timestamp":1643168561000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-012-1291-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,11]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["1291"],"URL":"https:\/\/doi.org\/10.1007\/s00428-012-1291-2","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,11]]}}}