{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T12:13:29Z","timestamp":1768047209002,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,9,21]],"date-time":"2014-09-21T00:00:00Z","timestamp":1411257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s00428-014-1651-1","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T05:50:09Z","timestamp":1411192209000},"page":"521-530","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Are alterations of tight junctions at molecular and ultrastructural level different in duodenal biopsies of patients with celiac disease and Crohn's disease?"],"prefix":"10.1007","volume":"465","author":[{"given":"Pooja","family":"Goswami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasenjit","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Nag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhartha Datta","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govind K.","family":"Makharia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,21]]},"reference":[{"issue":"3","key":"1651_CR1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0169-409X(00)00046-6","volume":"41","author":"JR Turner","year":"2000","unstructured":"Turner JR (2000) Show me the pathway! Regulation of paracellular permeability by Na (+)-glucose cotransport. Adv Drug Deliv Rev 41(3):265\u2013281","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"1651_CR2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s11894-008-0101-0","volume":"10","author":"A Zhu","year":"2008","unstructured":"Zhu A, Kaunitz J (2008) Gastroduodenal mucosal defense. Curr Gastroenterol Rep 10(6):548\u2013554","journal-title":"Curr Gastroenterol Rep"},{"issue":"6","key":"1651_CR3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.coph.2009.06.022","volume":"9","author":"KL Edelblum","year":"2009","unstructured":"Edelblum KL, Turner JR (2009) The tight junction in inflammatory disease: communication breakdown. Curr Opin Pharmacol 9(6):715\u2013720","journal-title":"Curr Opin Pharmacol"},{"issue":"5","key":"1651_CR4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11894-999-0023-5","volume":"1","author":"D Hollander","year":"1999","unstructured":"Hollander D (1999) Intestinal permeability, leaky gut, and intestinal disorders. Curr Gastroenterol Rep 1(5):410\u2013416","journal-title":"Curr Gastroenterol Rep"},{"issue":"6","key":"1651_CR5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1681\/ASN.V1061337","volume":"10","author":"AS Fanning","year":"1999","unstructured":"Fanning AS, Mitic LL, Anderson JM (1999) Transmembrane proteins in the tight junction barrier. J Am Soc Nephrol 10(6):1337\u20131345","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"1651_CR6","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1016\/S0002-9270(99)00500-6","volume":"94","author":"R D\u2019Inc\u00e0","year":"1999","unstructured":"D\u2019Inc\u00e0 R, Di Leo V, Corrao G, Martines D et al (1999) Intestinal permeability test as a predictor of clinical course in Crohn\u2019s disease. Am J Gastroenterol 94(10):2956\u20132960","journal-title":"Am J Gastroenterol"},{"key":"1651_CR7","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1242\/jcs.060665","volume":"123","author":"R Rosenthal","year":"2010","unstructured":"Rosenthal R, Milatz S, Krug SM, Oelrich B et al (2010) Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci 123:1913\u20131921","journal-title":"J Cell Sci"},{"key":"1651_CR8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-6632.2009.04052.x","volume":"1165","author":"CM Itallie Van","year":"2009","unstructured":"Van Itallie CM, Holmes J, Bridges A, Anderson JM (2009) Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold. Ann N Y Acad Sci 1165:82\u201387","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"1651_CR9","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.bbamem.2010.07.014","volume":"1798","author":"S Milatz","year":"2010","unstructured":"Milatz S, Krug SM, Rosenthal R, G\u00fcnzel D et al (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim Biophys Acta 1798(11):2048\u20132057","journal-title":"Biochim Biophys Acta"},{"issue":"28","key":"1651_CR10","doi-asserted-by":"crossref","first-page":"26233","DOI":"10.1074\/jbc.M502003200","volume":"280","author":"T D\u2019Souza","year":"2005","unstructured":"D\u2019Souza T, Agarwal R, Morin PJ (2005) Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem 280(28):26233\u201326240","journal-title":"J Biol Chem"},{"issue":"4","key":"1651_CR11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1593\/neo.07118","volume":"9","author":"B Litkouhi","year":"2007","unstructured":"Litkouhi B, Kwong J, Lo C-M, Smedley JG 3rd et al (2007) Claudin-4 over expression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin. Neoplasia 9(4):304\u2013314","journal-title":"Neoplasia"},{"issue":"10","key":"1651_CR12","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1172\/JCI12464","volume":"107","author":"C Itallie Van","year":"2001","unstructured":"Van Itallie C, Rahner C, Anderson JM (2001) Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 107(10):1319\u20131327","journal-title":"J Clin Invest"},{"issue":"1","key":"1651_CR13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.devcel.2009.12.008","volume":"18","author":"D Du","year":"2010","unstructured":"Du D, Xu F, Yu L, Zhang C et al (2010) The tight junction protein, occludin, regulates the directional migration of epithelial cells. Dev Cell 18(1):52\u201363","journal-title":"Dev Cell"},{"issue":"6","key":"1651_CR14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.addr.2005.01.005","volume":"57","author":"KJ Mandell","year":"2005","unstructured":"Mandell KJ, Parkos CA (2005) The JAM family of proteins. Adv Drug Deliv Rev 57(6):857\u2013867","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"1651_CR15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0955-0674(03)00104-2","volume":"15","author":"G Bazzoni","year":"2003","unstructured":"Bazzoni G (2003) The JAM, family of junctional adhesion molecules. Curr Opin Cell Biol 15(5):525\u2013530","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"1651_CR16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"S Husby","year":"2012","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 IR, Mearin ML et al (2012) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 54(1):136\u2013160","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"Suppl I","key":"1651_CR17","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/gut.2005.081950a","volume":"55","author":"EF Stange","year":"2006","unstructured":"Stange EF, Travis SPL, Vermeire S, Beglinger C et al (2006) European evidence based consensus on the diagnosis and management of Crohn\u2019s disease: definitions and diagnosis. Gut 55(Suppl I):i1\u2013i15","journal-title":"Gut"},{"key":"1651_CR18","doi-asserted-by":"crossref","unstructured":"Sostegni R, Daperno M, Scaglione N, Lavagna A, Rocca R, Pera A (2003) Review article: Crohn\u2019s disease: monitoring disease activity. Aliment PharmacolTher 17 (Suppl. 2): 11\u201317","DOI":"10.1046\/j.1365-2036.17.s2.17.x"},{"key":"1651_CR19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","volume":"102","author":"MN Marsh","year":"1992","unstructured":"Marsh MN (1992) Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 102:330\u2013354","journal-title":"Gastroenterology"},{"issue":"12","key":"1651_CR20","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1590\/S0100-879X2008001200010","volume":"41","author":"EG Vilela","year":"2008","unstructured":"Vilela EG, Torres HOG, Ferrari MLA, Lima AS, Cunha AS (2008) Gut permeability to lactulose and mannitol differs in treated Crohn\u2019s disease and celiac disease patients and healthy subjects. Braz J Med Biol Res 41(12):1105\u20131109","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"1651_CR21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/gut.2003.025494corr1","volume":"54","author":"NA Wright","year":"2005","unstructured":"Wright NA (2005) Morson and Dawson\u2019s Gastrointestinal Pathology, 4th edn. Gut 54(4):568\u2013568","journal-title":"Gut"},{"issue":"5","key":"1651_CR22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00041552-200009000-00009","volume":"9","author":"AS Yu","year":"2000","unstructured":"Yu AS (2000) Paracellular solute transport: more than just a leak? Curr Opin Nephrol Hypertens 9(5):513\u2013515","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"1651_CR23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00428-009-0879-7","volume":"456","author":"DN Szak\u00e1l","year":"2010","unstructured":"Szak\u00e1l DN, Gyorffy H, Arat\u00f3 A, Cseh A et al (2010) Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch 456(3):245\u2013250","journal-title":"Virchows Arch"},{"issue":"2","key":"1651_CR24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/gutjnl-2011-300123","volume":"61","author":"M Schumann","year":"2012","unstructured":"Schumann M, Gunzel D, Buergel N, Richter JF et al (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut 61(2):220\u2013228","journal-title":"Gut"},{"key":"1651_CR25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1749-6632.2012.06565.x","volume":"1258","author":"M Schumann","year":"2012","unstructured":"Schumann M, Kamel S, Pahlitzsch ML, Lebenheim L et al (2012) Defective tight junctions in refractory celiac disease. Ann N Y Acad Sci 1258:43\u201351","journal-title":"Ann N Y Acad Sci"},{"key":"1651_CR26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-2007-982747","volume":"45","author":"G Veres","year":"2007","unstructured":"Veres G, Gyorffy H, Szakall DN, Szabo E et al (2007) Claudins expression in the proximal and distal parts of duodenum in patients with celiac disease. Z Gastroenterol 45:45\u2013A117","journal-title":"Z Gastroenterol"},{"key":"1651_CR27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1741-7015-9-23","volume":"9","author":"A Sapone","year":"2011","unstructured":"Sapone A, Lammers KM, Casolaro V, Cammarota M et al (2011) Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 9:23","journal-title":"BMC Med"},{"issue":"1","key":"1651_CR28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/gut.2006.094375","volume":"56","author":"S Zeissig","year":"2007","unstructured":"Zeissig S, B\u00fcrgel N, G\u00fcnzel D, Richter J et al (2007) Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn\u2019s disease. Gut 56(1):61\u201372","journal-title":"Gut"},{"issue":"10","key":"1651_CR29","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/labinvest.2008.78","volume":"88","author":"CR Weber","year":"2008","unstructured":"Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR (2008) Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Investig 88(10):1110\u20131120","journal-title":"Lab Investig"},{"key":"1651_CR30","doi-asserted-by":"crossref","first-page":"31263","DOI":"10.1074\/jbc.M111.238147","volume":"286","author":"T Suzuki","year":"2011","unstructured":"Suzuki T, Yoshinaga N, Tanabe S (2011) Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 286:31263\u201331271","journal-title":"J Biol Chem"},{"issue":"6","key":"1651_CR31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000016886","volume":"16","author":"H Vogelsang","year":"1998","unstructured":"Vogelsang H, Schwarzenhofer M, Oberhuber G (1998) Changes in gastrointestinal permeability in celiac disease. Dig Dis 16(6):333\u2013336","journal-title":"Dig Dis"},{"issue":"3","key":"1651_CR32","doi-asserted-by":"crossref","first-page":"G422","DOI":"10.1152\/ajpgi.00412.2004","volume":"288","author":"TY Ma","year":"2005","unstructured":"Ma TY, Boivin MA, Ye D, Pedram A, Said HM (2005) Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 288(3):G422\u2013G430","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"1651_CR33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000063817","volume":"65","author":"M Montalto","year":"2002","unstructured":"Montalto M, Cuoco L, Ricci R, Maggiano N, Vecchio FM, Gasbarrini G (2002) Immunohistochemical analysis of ZO-1 in the duodenal mucosa of patients with untreated and treated celiac disease. Digestion 65(4):227\u2013233","journal-title":"Digestion"},{"issue":"5","key":"1651_CR34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.dld.2004.01.013","volume":"36","author":"D Pizzuti","year":"2004","unstructured":"Pizzuti D, Bortolami M, Mazzon E, Buda A et al (2004) Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet. Dig Liver Dis 36(5):337\u2013341","journal-title":"Dig Liver Dis"},{"issue":"4","key":"1651_CR35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/00365520500235334","volume":"41","author":"S Drago","year":"2006","unstructured":"Drago S, El Asmar R, Di Pierro M, Grazia Clemente M et al (2006) Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol 41(4):408\u2013419","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"1651_CR36","doi-asserted-by":"crossref","first-page":"G1054","DOI":"10.1152\/ajpgi.00055.2011","volume":"300","author":"RA Sadi","year":"2011","unstructured":"Sadi RA, Khatib K, Guo S, Ye D, Youssef M, Ma T (2011) Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Physiol 300(6):G1054\u2013G1064","journal-title":"Am J Physiol Gastrointest Physiol"},{"issue":"1","key":"1651_CR37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.gastro.2008.04.002","volume":"135","author":"S Vetrano","year":"2008","unstructured":"Vetrano S, Resciqno M, Cera MR, Correale C et al (2008) Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135(1):173\u2013184","journal-title":"Gastroenterology"},{"issue":"3","key":"1651_CR38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/gut.50.3.307","volume":"50","author":"JD S\u00f6derholm","year":"2002","unstructured":"S\u00f6derholm JD, Olaison G, Peterson KH, Franz\u00e9n LE et al (2002) Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn\u2019s disease. Gut 50(3):307\u2013313","journal-title":"Gut"},{"issue":"9","key":"1651_CR39","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3748\/wjg.14.1399","volume":"14","author":"J Benjamin","year":"2008","unstructured":"Benjamin J, Makharia GK, Ahuja V, Kalaivani M, Joshi YK (2008) Intestinal permeability and its association with the patient and disease characteristics in Crohn\u2019s disease. World J Gastroenterol 14(9):1399\u20131405","journal-title":"World J Gastroenterol"},{"issue":"8336","key":"1651_CR40","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0140-6736(83)92742-3","volume":"1","author":"I Bjarnason","year":"1983","unstructured":"Bjarnason I, Peters TJ, Veall N (1983) Intestinal permeability defect in coeliac disease. Lancet 1(8336):1284\u20131285","journal-title":"Lancet"},{"key":"1651_CR41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/00365521.2012.741616","volume":"68","author":"AL Lameris","year":"2013","unstructured":"Lameris AL, Huybers S, Kaukinen K, M\u00e4kel\u00e4 TH et al (2013) Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease. Scandinavian J Gastroenterol 68:58\u201359. doi: 10.3109\/00365521.2012.741616","journal-title":"Scandinavian J Gastroenterol"},{"issue":"3","key":"1651_CR42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00428-012-1195-1","volume":"460","author":"P Das","year":"2012","unstructured":"Das P, Goswami P, Das TK, Nag T et al (2012) Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis and tuberculosis: a new perspective. Virchows Arch 460(3):261\u2013270","journal-title":"Virchows Arch"},{"key":"1651_CR43","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1053\/gast.1997.v112.pm9041245","volume":"112","author":"A Fasano","year":"1997","unstructured":"Fasano A, Uzzau S, Fiore C, Margaretten K (1997) The enterotoxic effect on zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology 112:839\u2013846","journal-title":"Gastroenterology"},{"key":"1651_CR44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","volume":"135","author":"KM Lammers","year":"2008","unstructured":"Lammers KM, Lu R, Brownley J, Thomas K et al (2008) Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 135:194\u2013204","journal-title":"Gastroenterology"},{"key":"1651_CR45","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2036.2007.03413.x","volume":"26","author":"BM Paterson","year":"2007","unstructured":"Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB (2007) The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther 26:757\u2013766","journal-title":"Aliment Pharmacol Ther"},{"key":"1651_CR46","doi-asserted-by":"crossref","first-page":"M2048","DOI":"10.1053\/j.gastro.2009.04.016","volume":"136","author":"CP Kelly","year":"2009","unstructured":"Kelly CP, Green PHR, Murray JA, Di Marino A et al (2009) Effect of larazotide acetate on the prevention of signs and symptoms of coeliac disease in patients undergoing a gluten challenge: a randomised placebo-controlled study. Gastroenterology 136:M2048","journal-title":"Gastroenterology"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-014-1651-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-014-1651-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-014-1651-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T13:15:27Z","timestamp":1650201327000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-014-1651-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,21]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["1651"],"URL":"https:\/\/doi.org\/10.1007\/s00428-014-1651-1","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,21]]}}}