{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:31:09Z","timestamp":1791268269393,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00428-015-1793-9","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T08:01:32Z","timestamp":1434096092000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Olfactomedin-related proteins 4 (OLFM4) expression is involved in early gastric carcinogenesis and of prognostic significance in advanced gastric cancer"],"prefix":"10.1007","volume":"467","author":[{"given":"Bo Gun","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Lan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,13]]},"reference":[{"key":"1793_CR1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-1119(01)00763-6","volume":"283","author":"J Zhang","year":"2002","unstructured":"Zhang J, Liu W-L, Tang DC, Chen L, Wang M, et al. (2002) Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Gene 283:83\u201393","journal-title":"Gene"},{"key":"1793_CR2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2141.2008.07368.x","volume":"143","author":"KL Chin","year":"2008","unstructured":"Chin KL, Aerbajinai W, Zhu J, Drew L, Chen L, et al. (2008) The regulation of OLFM4 expression in myeloid precursor cells relies on NF\u2010\u03baB transcription factor. Br J Haematol 143:421\u2013432","journal-title":"Br J Haematol"},{"key":"1793_CR3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/mc.20596","volume":"49","author":"KK Kim","year":"2010","unstructured":"Kim KK, Park KS, Song SB, Kim KE (2010) Up regulation of GW112 gene by NF\u03baB promotes an antiapoptotic property in gastric cancer cells. Mol Carcinog 49:259\u2013270","journal-title":"Mol Carcinog"},{"key":"1793_CR4","doi-asserted-by":"crossref","first-page":"11056","DOI":"10.1073\/pnas.1001269107","volume":"107","author":"W Liu","year":"2010","unstructured":"Liu W, Yan M, Liu Y, Wang R, Li C, et al. (2010) Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. Proc Natl Acad Sci 107:11056\u201311061","journal-title":"Proc Natl Acad Sci"},{"key":"1793_CR5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1053\/j.gastro.2010.04.008","volume":"139","author":"HJ Lee","year":"2010","unstructured":"Lee HJ, Nam KT, Park HS, Kim MA, LaFleur BJ, et al. (2010) Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology 139:213\u2013225 e213","journal-title":"Gastroenterology"},{"key":"1793_CR6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/j.gastro.2009.05.035","volume":"137","author":"LG Flier Van der","year":"2009","unstructured":"Van der Flier LG, Haegebarth A, Stange DE, Van de Wetering M, Clevers H (2009) OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology 137:15\u201317","journal-title":"Gastroenterology"},{"key":"1793_CR7","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1158\/1078-0432.CCR-07-4125","volume":"14","author":"W Liu","year":"2008","unstructured":"Liu W, Liu Y, Zhu J, Wright E, Ding I, et al. (2008) Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma. Clin Cancer Res 14:1041\u20131049","journal-title":"Clin Cancer Res"},{"key":"1793_CR8","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.yexcr.2006.02.011","volume":"312","author":"W Liu","year":"2006","unstructured":"Liu W, Chen L, Zhu J, Rodgers GP (2006) The glycoprotein hGC-1 binds to cadherin and lectins. Exp Cell Res 312:1785\u20131797","journal-title":"Exp Cell Res"},{"key":"1793_CR9","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1158\/0008-5472.CAN-03-3443","volume":"64","author":"X Zhang","year":"2004","unstructured":"Zhang X, Huang Q, Yang Z, Li Y, Li C-Y (2004) GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res 64:2474\u20132481","journal-title":"Cancer Res"},{"key":"1793_CR10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1349-7006.2007.00397.x","volume":"98","author":"D Kobayashi","year":"2007","unstructured":"Kobayashi D, Koshida S, Moriai R, Tsuji N, Watanabe N (2007) Olfactomedin 4 promotes S\u2010phase transition in proliferation of pancreatic cancer cells. Cancer Sci 98:334\u2013340","journal-title":"Cancer Sci"},{"key":"1793_CR11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/gut.48.5.623","volume":"48","author":"S Shinozaki","year":"2001","unstructured":"Shinozaki S, Nakamura T, Iimura M, Kato Y, Iizuka B, et al. (2001) Upregulation of Reg 1\u03b1 and GW112 in the epithelium of inflamed colonic mucosa. Gut 48:623\u2013629","journal-title":"Gut"},{"key":"1793_CR12","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1080\/00365520410003588","volume":"39","author":"E Mannick","year":"2004","unstructured":"Mannick E, Schurr J, Zapata A, Lentz J, Gastanaduy M, et al. (2004) Gene expression in gastric biopsies from patients infected with Helicobacter pylori. Scand J Gastroenterol 39:1192\u20131200","journal-title":"Scand J Gastroenterol"},{"key":"1793_CR13","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/ijc.24624","volume":"125","author":"N Oue","year":"2009","unstructured":"Oue N, Sentani K, Noguchi T, Ohara S, Sakamoto N, et al. (2009) Serum olfactomedin 4 (GW112, hGC\u20101) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer 125:2383\u20132392","journal-title":"Int J Cancer"},{"key":"1793_CR14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2559.2007.02763.x","volume":"51","author":"W Liu","year":"2007","unstructured":"Liu W, Zhu J, Cao L, Rodgers G (2007) Expression of hGC\u20101 is correlated with differentiation of gastric carcinoma. Histopathology 51:157\u2013165","journal-title":"Histopathology"},{"key":"1793_CR15","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1038\/sj.onc.1209279","volume":"25","author":"P Aung","year":"2005","unstructured":"Aung P, Oue N, Mitani Y, Nakayama H, Yoshida K, et al. (2005) Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. Oncogene 25:2546\u20132557","journal-title":"Oncogene"},{"key":"1793_CR16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000086627","volume":"69","author":"N Oue","year":"2005","unstructured":"Oue N, Aung PP, Mitani Y, Kuniyasu H, Nakayama H, et al. (2005) Genes involved in invasion and metastasis of gastric cancer identified by array-based hybridization and serial analysis of gene expression. Oncology 69:17\u201322","journal-title":"Oncology"},{"key":"1793_CR17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10120-005-0320-0","volume":"8","author":"W Yasui","year":"2005","unstructured":"Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, et al. (2005) Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer 8:86\u201394","journal-title":"Gastric Cancer"},{"key":"1793_CR18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/IGC.0b013e31820866fe","volume":"21","author":"L Yu","year":"2011","unstructured":"Yu L, He M, Yang Z, Chen G, Li M, et al. (2011) Olfactomedin 4 is a marker for progression of cervical neoplasia. Int J Gynecol Cancer 21:367\u2013372","journal-title":"Int J Gynecol Cancer"},{"key":"1793_CR19","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/carcin\/bgr065","volume":"32","author":"L Chen","year":"2011","unstructured":"Chen L, Li H, Liu W, Zhu J, Zhao X, et al. (2011) Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1. Carcinogenesis 32:986\u2013994","journal-title":"Carcinogenesis"},{"key":"1793_CR20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1349-7006.2006.00383.x","volume":"98","author":"S Koshida","year":"2007","unstructured":"Koshida S, Kobayashi D, Moriai R, Tsuji N, Watanabe N (2007) Specific overexpression of OLFM4GW112\/hGC\u22121 mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci 98:315\u2013320","journal-title":"Cancer Sci"},{"key":"1793_CR21","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471\u20131474","journal-title":"Ann Surg Oncol"},{"key":"1793_CR22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/1097-0142(20010915)92:6<1427::AID-CNCR1466>3.0.CO;2-L","volume":"92","author":"HS Lee","year":"2001","unstructured":"Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, et al. (2001) MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 92:1427\u20131434","journal-title":"Cancer"},{"key":"1793_CR23","doi-asserted-by":"crossref","unstructured":"Jang BG, Lee BL, Kim WH (2013) Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. PLoS One 8: e82390.","DOI":"10.1371\/journal.pone.0082390"},{"key":"1793_CR24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s10555-010-9262-z","volume":"29","author":"PK Grover","year":"2010","unstructured":"Grover PK, Hardingham JE, Cummins AG (2010) Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis. Cancer Metastasis Rev 29:761\u2013775","journal-title":"Cancer Metastasis Rev"},{"key":"1793_CR25","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1158\/1078-0432.CCR-10-3152","volume":"17","author":"H-K Oh","year":"2011","unstructured":"Oh H-K, Tan AL-K, Das K, Ooi C-H, Deng N-T, et al. (2011) Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. Clin Cancer Res 17:2657\u20132667","journal-title":"Clin Cancer Res"},{"key":"1793_CR26","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1245\/s10434-011-2125-1","volume":"19","author":"Y-S Suh","year":"2012","unstructured":"Suh Y-S, Lee H-J, Jung E-J, Kim M-A, Nam KT, et al. (2012) The combined expression of metaplasia biomarkers predicts the prognosis of gastric cancer. Ann Surg Oncol 19:1240\u20131249","journal-title":"Ann Surg Oncol"},{"key":"1793_CR27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.stem.2011.02.020","volume":"8","author":"A Merlos-Su\u00e1rez","year":"2011","unstructured":"Merlos-Su\u00e1rez A, Barriga FM, Jung P, Iglesias M, C\u00e9spedes MV, et al. (2011) The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 8:511\u2013524","journal-title":"Cell Stem Cell"},{"key":"1793_CR28","first-page":"987","volume":"24","author":"N Wentzensen","year":"2004","unstructured":"Wentzensen N, Wilz B, Findeisen P, Wagner R, Dippold W, et al. (2004) Identification of differentially expressed genes in colorectal adenoma compared to normal tissue by suppression subtractive hybridization. Int J Oncol 24:987\u2013994","journal-title":"Int J Oncol"},{"key":"1793_CR29","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.ajpath.2013.06.028","volume":"183","author":"H Li","year":"2013","unstructured":"Li H, Rodriguez-Canales J, Liu W, Zhu J, Hanson JC, et al. (2013) Deletion of the olfactomedin 4 gene is associated with progression of human prostate cancer. Am J Pathol 183:1329\u20131338","journal-title":"Am J Pathol"},{"key":"1793_CR30","doi-asserted-by":"crossref","first-page":"M111","DOI":"10.1074\/mcp.M111.009712","volume":"10","author":"D Besson","year":"2011","unstructured":"Besson D, Pavageau A-H, Valo I, Bourreau A, B\u00e9langer A, et al. (2011) A quantitative proteomic approach of the different stages of colorectal cancer establishes OLFM4 as a new nonmetastatic tumor marker. Mol Cell Proteomics 10:M111 009712","journal-title":"Mol Cell Proteomics"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-015-1793-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-015-1793-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-015-1793-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:22:28Z","timestamp":1559078548000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-015-1793-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,13]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["1793"],"URL":"https:\/\/doi.org\/10.1007\/s00428-015-1793-9","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,13]]}}}