{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T02:54:12Z","timestamp":1783824852775,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00428-017-2074-6","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T06:45:27Z","timestamp":1485153927000},"page":"411-420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["In hepatic venous outflow obstruction, alcoholic liver disease, and nonalcoholic fatty liver disease, centrilobular scars, CD34+ vessels, and keratin 7+ hepatocytes are in close proximity"],"prefix":"10.1007","volume":"470","author":[{"given":"Susumu","family":"Matsukuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Utsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"2074_CR1","volume-title":"Sleisenger & Fordtran\u2019s gastrointestinal and liver disease","author":"M Feldman","year":"2006","unstructured":"Feldman M, Friedman LS, Brandt LJ (2006) Sleisenger & Fordtran\u2019s gastrointestinal and liver disease, 8th edn. Saunders\/Elsevier, Philadelphia","edition":"8"},{"key":"2074_CR2","volume-title":"MacSween\u2019s pathology of the liver","author":"AD Burt","year":"2012","unstructured":"Burt AD, Portmann BC, Ferrell L (2012) MacSween\u2019s pathology of the liver, 6th edn. Churchill Livingstone\/Elsevier, London","edition":"6"},{"key":"2074_CR3","first-page":"733","volume-title":"Histology for pathologist","author":"AA Suriawinata","year":"2012","unstructured":"Suriawinata AA, Thung SN (2012) Liver. In: Mills SE (ed) Histology for pathologist, 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 733\u2013758","edition":"4th"},{"key":"2074_CR4","volume-title":"Diagnostic immunohistochemistry","author":"DJ Dabbs","year":"2006","unstructured":"Dabbs DJ (2006) Diagnostic immunohistochemistry, 2nd edn. Churchill Livingston\/Elsevier, Philadelphia","edition":"2"},{"key":"2074_CR5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1369\/jhc.4A6514.2005","volume":"54","author":"MP Pusztaszeri","year":"2006","unstructured":"Pusztaszeri MP, Seelentag W, Bosman FT (2006) Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 54:385\u2013395","journal-title":"J Histochem Cytochem"},{"key":"2074_CR6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s004280000364","volume":"438","author":"I Theuerkauf","year":"2001","unstructured":"Theuerkauf I, Zhou H, Fischer H-P (2001) Immunohistochemical patterns of human live sinusoids under different conditions of pathologic perfusion. Virchows Arch 438:498\u2013504","journal-title":"Virchows Arch"},{"key":"2074_CR7","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1053\/hupa.2001.29678","volume":"32","author":"S Ohmori","year":"2001","unstructured":"Ohmori S, Shiraki K, Sugimoto K et al (2001) High expression of CD34-positive sinusoidal endothelial cells is a risk factor for hepatocellular carcinoma in patients with HCV-associated chronic liver diseases. Hum Pathol 32:1363\u20131370","journal-title":"Hum Pathol"},{"key":"2074_CR8","first-page":"179","volume":"14","author":"S Ohmori","year":"2004","unstructured":"Ohmori S, Shiraki K, Sugimoto K et al (2004) Expression of CD34-positive sinusoidal endothelial cells in patients with HBV-associated chronic liver diseases. Int J Mol Med 14:179\u2013184","journal-title":"Int J Mol Med"},{"key":"2074_CR9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1665-2681(19)31924-6","volume":"6","author":"AD Amarapurkar","year":"2007","unstructured":"Amarapurkar AD, Amarapurkar DN, Vibhav PND (2007) Angiogenesis in chronic liver disease. Ann Hepatol 6:170\u2013173","journal-title":"Ann Hepatol"},{"key":"2074_CR10","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.5858\/2004-128-1230-TIOFIA","volume":"128","author":"A Chedid","year":"2004","unstructured":"Chedid A, Arain S, Snyder A et al (2004) The immunology of fibrogenesis in alcoholic liver disease. Arch Pathol Lab Med 128:1230\u20131238","journal-title":"Arch Pathol Lab Med"},{"key":"2074_CR11","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1097\/PAS.0b013e3182254283","volume":"35","author":"RM Gill","year":"2011","unstructured":"Gill RM, Belt P, Wilson L, Bass NM, Ferrell LD (2011) Centrizonal arteries and microvessels in nonalcoholic steatohepatitis. Am J Surg Pathol 35:1400\u20131404","journal-title":"Am J Surg Pathol"},{"key":"2074_CR12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/PAS.0000000000000099","volume":"38","author":"G Krings","year":"2014","unstructured":"Krings G, Can B, Ferrell L (2014) Aberrant centrizonal features in chronic hepatic venous outflow obstruction. Centrilobular mimicry of portal-based disease. Am J Surg Pathol 38:205\u2013214","journal-title":"Am J Surg Pathol"},{"key":"2074_CR13","first-page":"11738","volume":"18","author":"I Delladetsima","year":"2016","unstructured":"Delladetsima I, Sakellariou S, Kokkori A, Tiniakos D (2016) Atrophic hepatocytes express keratin 7 in ischemia-associated liver lesions. Histol Histopathol Feb 18:11738","journal-title":"Histol Histopathol Feb"},{"key":"2074_CR14","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.prp.2009.06.007","volume":"205","author":"A Gabriel","year":"2009","unstructured":"Gabriel A, Kukla M, Wilk M, Liszka \u0141, Petelenz M, Musialik J (2009) Angiogenesis in chronic hepatitis C is associated with inflammatory activity grade and fibrosis stage. Pathol Res Pract 205:758\u2013764","journal-title":"Pathol Res Pract"},{"key":"2074_CR15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1159\/000355246","volume":"31","author":"N Tsuji","year":"2013","unstructured":"Tsuji N, Ishiguro S, Sasaki Y, Kudo M (2013) CD34 expression in noncancerous liver tissue predicts multicentric recurrence of hepatocellular carcinoma. Dig Dis 31:467\u2013471","journal-title":"Dig Dis"},{"key":"2074_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/329297","author":"H Lee","year":"2014","unstructured":"Lee H, Ainechi S, Dresser K, Kurian EM (2014) Central portalization correlates with fibrosis but not with risk factors for nonalcoholic steatohepatitis in steatotic chronic hepatitis C. Int J Hepatol. doi: 10.1155\/2014\/329297","journal-title":"Int J Hepatol"},{"key":"2074_CR17","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jhep.2004.08.017","volume":"41","author":"JA Eleazar","year":"2004","unstructured":"Eleazar JA, Memeo L, Jhang JS et al (2004) Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis. J Hepatol 41:983\u2013991","journal-title":"J Hepatol"},{"key":"2074_CR18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00428-010-0957-x","volume":"457","author":"J Delladetsima","year":"2010","unstructured":"Delladetsima J, Alexandrou P, Giaslakiotis K et al (2010) Hepatic progenitor cells in chronic hepatitis C: a phenomenon of older age and advanced liver disease. Virchows Arch 457:457\u2013466","journal-title":"Virchows Arch"},{"key":"2074_CR19","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/modpathol.2010.175","volume":"23","author":"RK Pai","year":"2010","unstructured":"Pai RK, Hart JA (2010) Aberrant expression of cytokeratin 7 in perivenular hepatocytes correlated with a cholestatic chemistry profile in patients with heart failure. Mod Pathol 23:1650\u20131656","journal-title":"Mod Pathol"},{"key":"2074_CR20","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1365-2559.2012.04278.x","volume":"61","author":"S Matsukuma","year":"2012","unstructured":"Matsukuma S, Takeo H, Kono T, Nagata Y, Sato K (2012) Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study. Histopathol 61:857\u2013862","journal-title":"Histopathol"},{"key":"2074_CR21","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1245\/s10434-011-2112-6","volume":"19","author":"M Narita","year":"2012","unstructured":"Narita M, Oussoultzoglou E, Chenard MP et al (2012) Liver injury due to chemotherapy-induced sinusoidal obstruction syndrome is associated with sinusoidal capillarization. Ann Surg Oncol 19:2230\u20132237","journal-title":"Ann Surg Oncol"},{"key":"2074_CR22","first-page":"182","volume-title":"Advanced laboratory methods in histology and pathology","author":"CE Gregory","year":"1994","unstructured":"Gregory CE, Griffin JL (1994) Enzyme histochemistry of skeletal muscle. In: Mikel UV (ed) Advanced laboratory methods in histology and pathology. Armed Forces Institute of Pathology, American Registry of Pathology, Washington, pp 182\u2013183"},{"key":"2074_CR23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(91)90084-O","volume":"13","author":"PJ Scheuer","year":"1991","unstructured":"Scheuer PJ (1991) Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13:372\u2013374","journal-title":"J Hepatol"},{"key":"2074_CR24","first-page":"1","volume":"26","author":"T Matsumoto","year":"1979","unstructured":"Matsumoto T, Komori R, Magara T et al (1979) A study on the normal structure of the human liver, with special reference to its angioarchitecture. Jikeikai Med J 26:1\u201340","journal-title":"Jikeikai Med J"},{"key":"2074_CR25","first-page":"285","volume":"32","author":"T Matsumoto","year":"1982","unstructured":"Matsumoto T, Kawakami M (1982) The unit-concept of hepatic parenchyma\u2014a re-examination based on angioarchitectural studies. Acta Pathol Jpn 32:285\u2013314","journal-title":"Acta Pathol Jpn"},{"key":"2074_CR26","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleiner","year":"2005","unstructured":"Kleiner DE, Brunt EM, Van Natta M et al (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313\u20131321","journal-title":"Hepatology"},{"key":"2074_CR27","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.5858\/2000-124-1599-ROHC","volume":"124","author":"IR Wanless","year":"2000","unstructured":"Wanless IR, Nakashima E, Sherman M (2000) Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med 124:1599\u20131607","journal-title":"Arch Pathol Lab Med"},{"key":"2074_CR28","first-page":"1","volume-title":"Progress in liver diseases","author":"W Ekataksin","year":"1997","unstructured":"Ekataksin W, Wake K (1997) New concepts in biliary and vascular anatomy of the liver. In: Boyer JL, Ockner RK (eds) Progress in liver diseases, vol VX. WB Saunders, Philadelphia, pp 1\u201330"},{"key":"2074_CR29","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.510300607","volume":"30","author":"R Saxena","year":"1999","unstructured":"Saxena R, Theise ND, Crawford JM (1999) Microanatomy of the human liver-exploring the hidden interfaces. Hepatology 30:1339\u20131346","journal-title":"Hepatology"},{"key":"2074_CR30","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/hep.22218","volume":"47","author":"R Kuwabara","year":"2008","unstructured":"Kuwabara R, Kofman AV, Landis CS, Swenson ES, Barendswaad E, Theise ND (2008) The hepatic stem cell niche: identification by label-retaining cell assay. Hepatology 47:1994\u20132002","journal-title":"Hepatology"},{"key":"2074_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhep.2006.05.002","volume":"45","author":"T Roskams","year":"2006","unstructured":"Roskams T (2006) Different types of liver progenitor cells and their niches. J Hepatol 45:1\u20134","journal-title":"J Hepatol"},{"key":"2074_CR32","volume-title":"Liver biopsy interpretation","author":"PJ Scheuer","year":"2006","unstructured":"Scheuer PJ, Lefkowitch JH (2006) Liver biopsy interpretation, 7th edn. Saunders\/Elsevier, Philadelphia","edition":"7"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2074-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-017-2074-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2074-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T13:29:10Z","timestamp":1658496550000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-017-2074-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["2074"],"URL":"https:\/\/doi.org\/10.1007\/s00428-017-2074-6","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}