{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:42:07Z","timestamp":1790106127075,"version":"4.0.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014738","name":"Vision Group on Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FIST, Department of Science and Technology (DST), Government of India"},{"name":"BTFS Program, Government of Karnataka"},{"DOI":"10.13039\/501100004843","name":"Manipal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00428-017-2094-2","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T18:45:19Z","timestamp":1488480319000},"page":"445-454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue"],"prefix":"10.1007","volume":"470","author":[{"given":"Samatha","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama Prasada","family":"Kabekkodu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinchu","family":"Jayaprakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satadru","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapaettu","family":"Satyamoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"issue":"9","key":"2094_CR1","first-page":"577","volume":"69","author":"T Daley","year":"2003","unstructured":"Daley T, Darling M (2003) Nonsquamous cell malignant tumours of the oral cavity: an overview. J Can Dent Assoc 69(9):577\u2013582","journal-title":"J Can Dent Assoc"},{"issue":"6","key":"2094_CR2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P","volume":"80","author":"DM Parkin","year":"1999","unstructured":"Parkin DM, Pisani P, Ferlay J (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80(6):827\u2013841","journal-title":"Int J Cancer"},{"issue":"2","key":"2094_CR3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4103\/0975-5950.154816","volume":"5","author":"S Gupta","year":"2014","unstructured":"Gupta S, Singh R, Gupta OP, Tripathi A (2014) Prevalence of oral cancer and pre-cancerous lesions and the association with numerous risk factors in North India: a hospital based study. Natl J Maxillofac Surg 5(2):142\u2013148. doi: 10.4103\/0975-5950.154816","journal-title":"Natl J Maxillofac Surg"},{"issue":"2","key":"2094_CR4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.7314\/APJCP.2014.15.2.537","volume":"15","author":"A Mishra","year":"2014","unstructured":"Mishra A, Meherotra R (2014) Head and neck cancer: global burden and regional trends in India. Asian Pacific Journal of Cancer Prevention : APJCP 15(2):537\u2013550","journal-title":"Asian Pacific Journal of Cancer Prevention : APJCP"},{"issue":"2","key":"2094_CR5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0964-1955(92)90038-3","volume":"28B","author":"M Kuriakose","year":"1992","unstructured":"Kuriakose M, Sankaranarayanan M, Nair MK, Cherian T, Sugar AW, Scully C, Prime SS (1992) Comparison of oral squamous cell carcinoma in younger and older patients in India. Eur J Cancer B Oral Oncol 28B(2):113\u2013120","journal-title":"Eur J Cancer B Oral Oncol"},{"issue":"5","key":"2094_CR6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1368-8375(00)00135-4","volume":"37","author":"CD Llewellyn","year":"2001","unstructured":"Llewellyn CD, Johnson NW, Warnakulasuriya KA (2001) Risk factors for squamous cell carcinoma of the oral cavity in young people\u2014a comprehensive literature review. Oral Oncol 37(5):401\u2013418","journal-title":"Oral Oncol"},{"issue":"8","key":"2094_CR7","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.oraloncology.2005.12.002","volume":"42","author":"KA Pathak","year":"2006","unstructured":"Pathak KA, Das AK, Agarwal R, Talole S, Deshpande MS, Chaturvedi P, Pai PS, Chaukar DA, D\u2019Cruz AK (2006) Selective neck dissection (I\u2013III) for node negative and node positive necks. Oral Oncol 42(8):837\u2013841. doi: 10.1016\/j.oraloncology.2005.12.002","journal-title":"Oral Oncol"},{"issue":"2","key":"2094_CR8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12663-011-0195-z","volume":"10","author":"H Ram","year":"2011","unstructured":"Ram H, Sarkar J, Kumar H, Konwar R, Bhatt ML, Mohammad S (2011) Oral cancer: risk factors and molecular pathogenesis. J Maxillofac Oral Surg 10(2):132\u2013137. doi: 10.1007\/s12663-011-0195-z","journal-title":"J Maxillofac Oral Surg"},{"key":"2094_CR9","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-15-0395","author":"NM Krishnan","year":"2016","unstructured":"Krishnan NM, Dhas K, Nair J, Palve V, Bagwan J, Siddappa G, Suresh A, Kekatpure VD, Kuriakose MA, Panda B (2016) A minimal DNA methylation signature in oral tongue squamous cell carcinoma links altered methylation with tumor attributes. Mol Cancer Res. doi: 10.1158\/1541-7786.MCR-15-0395","journal-title":"Mol Cancer Res"},{"issue":"6046","key":"2094_CR10","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1126\/science.1206923","volume":"333","author":"N Agrawal","year":"2011","unstructured":"Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Trevino L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN (2011) Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333(6046):1154\u20131157. doi: 10.1126\/science.1206923","journal-title":"Science"},{"issue":"9","key":"2094_CR11","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1600-0714.2011.01055.x","volume":"40","author":"R Radhakrishnan","year":"2011","unstructured":"Radhakrishnan R, Kabekkodu S, Satyamoorthy K (2011) DNA hypermethylation as an epigenetic mark for oral cancer diagnosis. J Oral Pathol Med 40(9):665\u2013676. doi: 10.1111\/j.1600-0714.2011.01055.x","journal-title":"J Oral Pathol Med"},{"key":"2094_CR12","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5437","author":"Z Hu","year":"2016","unstructured":"Hu Z, Zhong Z, Huang S, Wen H, Chen X, Chu H, Li Q, Sun C (2016) Decreased expression of Beclin1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma. Mol Med Rep. doi: 10.3892\/mmr.2016.5437","journal-title":"Mol Med Rep"},{"issue":"8","key":"2094_CR13","doi-asserted-by":"publisher","first-page":"e23452","DOI":"10.1371\/journal.pone.0023452","volume":"6","author":"CH Peng","year":"2011","unstructured":"Peng CH, Liao CT, Peng SC, Chen YJ, Cheng AJ, Juang JL, Tsai CY, Chen TC, Chuang YJ, Tang CY, Hsieh WP, Yen TC (2011) A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma. PLoS One 6(8):e23452. doi: 10.1371\/journal.pone.0023452","journal-title":"PLoS One"},{"issue":"8","key":"2094_CR14","doi-asserted-by":"publisher","first-page":"e0135078","DOI":"10.1371\/journal.pone.0135078","volume":"10","author":"A Agodi","year":"2015","unstructured":"Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Vinciguerra M (2015) DAPK1 promoter methylation and cervical cancer risk: a systematic review and a meta-analysis. PLoS One 10(8):e0135078. doi: 10.1371\/journal.pone.0135078","journal-title":"PLoS One"},{"issue":"6","key":"2094_CR15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/jop.12381","volume":"45","author":"HC Chen","year":"2016","unstructured":"Chen HC, Yang CM, Cheng JT, Tsai KW, Fu TY, Liou HH, Tseng HH, Lee JH, Li GC, Wang JS, Hou YY, Weng TJ, Ger LP (2016) Global DNA hypomethylation is associated with the development and poor prognosis of tongue squamous cell carcinoma. J Oral Pathol Med 45(6):409\u2013417. doi: 10.1111\/jop.12381","journal-title":"J Oral Pathol Med"},{"issue":"17","key":"2094_CR16","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1002\/cncr.27417","volume":"118","author":"S Nagata","year":"2012","unstructured":"Nagata S, Hamada T, Yamada N, Yokoyama S, Kitamoto S, Kanmura Y, Nomura M, Kamikawa Y, Yonezawa S, Sugihara K (2012) Aberrant DNA methylation of tumor-related genes in oral rinse: a noninvasive method for detection of oral squamous cell carcinoma. Cancer 118(17):4298\u20134308. doi: 10.1002\/cncr.27417","journal-title":"Cancer"},{"issue":"5","key":"2094_CR17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1593\/tlo.12232","volume":"5","author":"DA Ovchinnikov","year":"2012","unstructured":"Ovchinnikov DA, Cooper MA, Pandit P, Coman WB, Cooper-White JJ, Keith P, Wolvetang EJ, Slowey PD, Punyadeera C (2012) Tumor-suppressor gene promoter hypermethylation in saliva of head and neck cancer patients. Transl Oncol 5(5):321\u2013326","journal-title":"Transl Oncol"},{"issue":"1","key":"2094_CR18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/carcin\/bgs311","volume":"34","author":"MM Rettori","year":"2013","unstructured":"Rettori MM, de Carvalho AC, Bomfim Longo AL, de Oliveira CZ, Kowalski LP, Carvalho AL, Vettore AL (2013) Prognostic significance of TIMP3 hypermethylation in post-treatment salivary rinse from head and neck squamous cell carcinoma patients. Carcinogenesis 34(1):20\u201327. doi: 10.1093\/carcin\/bgs311","journal-title":"Carcinogenesis"},{"issue":"5","key":"2094_CR19","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.3892\/or.2013.2309","volume":"29","author":"S Zhang","year":"2013","unstructured":"Zhang S, Feng XL, Shi L, Gong CJ, He ZJ, Wu HJ, Ling TY (2013) Genome-wide analysis of DNA methylation in tongue squamous cell carcinoma. Oncol Rep 29(5):1819\u20131826. doi: 10.3892\/or.2013.2309","journal-title":"Oncol Rep"},{"issue":"2","key":"2094_CR20","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/bjc.2012.568","volume":"108","author":"PV Jithesh","year":"2013","unstructured":"Jithesh PV, Risk JM, Schache AG, Dhanda J, Lane B, Liloglou T, Shaw RJ (2013) The epigenetic landscape of oral squamous cell carcinoma. Br J Cancer 108(2):370\u2013379. doi: 10.1038\/bjc.2012.568","journal-title":"Br J Cancer"},{"issue":"3","key":"2094_CR21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/hmg\/8.3.459","volume":"8","author":"TH Huang","year":"1999","unstructured":"Huang TH, Perry MR, Laux DE (1999) Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet 8(3):459\u2013470","journal-title":"Hum Mol Genet"},{"issue":"15","key":"2094_CR22","doi-asserted-by":"publisher","first-page":"10637","DOI":"10.1074\/jbc.M113.491506","volume":"289","author":"SP Kabekkodu","year":"2014","unstructured":"Kabekkodu SP, Bhat S, Radhakrishnan R, Aithal A, Mascarenhas R, Pandey D, Rai L, Kushtagi P, Mundyat GP, Satyamoorthy K (2014) DNA promoter methylation-dependent transcription of the double C2-like domain beta (DOC2B) gene regulates tumor growth in human cervical cancer. J Biol Chem 289(15):10637\u201310649. doi: 10.1074\/jbc.M113.491506","journal-title":"J Biol Chem"},{"key":"2094_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12967-015-0506-0","volume":"13","author":"H Rotti","year":"2015","unstructured":"Rotti H, Mallya S, Kabekkodu SP, Chakrabarty S, Bhale S, Bharadwaj R, Bhat BK, Dedge AP, Dhumal VR, Gangadharan GG, Gopinath PM, Govindaraj P, Joshi KS, Kondaiah P, Nair S, Nair SN, Nayak J, Prasanna BV, Shintre P, Sule M, Thangaraj K, Patwardhan B, Valiathan MV, Satyamoorthy K (2015) DNA methylation analysis of phenotype specific stratified Indian population. J Transl Med 13:151. doi: 10.1186\/s12967-015-0506-0","journal-title":"J Transl Med"},{"issue":"1","key":"2094_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jviromet.2004.08.007","volume":"122","author":"AL Fuessel Haws","year":"2004","unstructured":"Fuessel Haws AL, He Q, Rady PL, Zhang L, Grady J, Hughes TK, Stisser K, Konig R, Tyring SK (2004) Nested PCR with the PGMY09\/11 and GP5(+)\/6(+) primer sets improves detection of HPV DNA in cervical samples. J Virol Methods 122(1):87\u201393. doi: 10.1016\/j.jviromet.2004.08.007","journal-title":"J Virol Methods"},{"issue":"5","key":"2094_CR25","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.7314\/APJCP.2015.16.5.2073","volume":"16","author":"SP Kabekkodu","year":"2015","unstructured":"Kabekkodu SP, Bhat S, Pandey D, Varghese VK, Shukla V, Ghosh S, Kushtagi P, Bhat P, Gopinath PM, Satyamoorthy K (2015) Prevalence of human papillomavirus types and phylogenetic analysis of HPV-16 L1 variants from southern India. Asian Pacific journal of cancer prevention : APJCP 16(5):2073\u20132080","journal-title":"Asian Pacific journal of cancer prevention : APJCP"},{"issue":"1","key":"2094_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cancergencyto.2006.09.008","volume":"173","author":"MF Calmon","year":"2007","unstructured":"Calmon MF, Colombo J, Carvalho F, Souza FP, Filho JF, Fukuyama EE, Camargo AA, Caballero OL, Tajara EH, Cordeiro JA, Rahal P (2007) Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer. Cancer Genet Cytogenet 173(1):31\u201337. doi: 10.1016\/j.cancergencyto.2006.09.008","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"2094_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.prp.2010.11.001","volume":"207","author":"N Missaoui","year":"2011","unstructured":"Missaoui N, Hmissa S, Trabelsi A, Traore C, Mokni M, Dante R, Frappart L (2011) Promoter hypermethylation of CDH13, DAPK1 and TWIST1 genes in precancerous and cancerous lesions of the uterine cervix. Pathol Res Pract 207(1):37\u201342. doi: 10.1016\/j.prp.2010.11.001","journal-title":"Pathol Res Pract"},{"issue":"2","key":"2094_CR28","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1007\/s12032-013-0818-y","volume":"31","author":"X Li","year":"2014","unstructured":"Li X, Lv L, Zheng J, Zhou J, Liu B, Chen H, Liang C, Wang R, Su L, Li X, Fan D (2014) The significance of LRPPRC overexpression in gastric cancer. Med Oncol 31(2):818. doi: 10.1007\/s12032-013-0818-y","journal-title":"Med Oncol"},{"issue":"4","key":"2094_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/gcc.20747","volume":"49","author":"N Sato","year":"2010","unstructured":"Sato N, Koinuma J, Ito T, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y (2010) Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis. Genes Chromosomes Cancer 49(4):353\u2013367. doi: 10.1002\/gcc.20747","journal-title":"Genes Chromosomes Cancer"},{"issue":"27","key":"2094_CR30","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1038\/onc.2011.24","volume":"30","author":"F Takahashi","year":"2011","unstructured":"Takahashi F, Chiba N, Tajima K, Hayashida T, Shimada T, Takahashi M, Moriyama H, Brachtel E, Edelman EJ, Ramaswamy S, Maheswaran S (2011) Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB\/HER inhibitor lapatinib. Oncogene 30(27):3084\u20133095. doi: 10.1038\/onc.2011.24","journal-title":"Oncogene"},{"issue":"1","key":"2094_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00428-014-1678-3","volume":"466","author":"I Serenaite","year":"2014","unstructured":"Serenaite I, Daniunaite K, Jankevicius F, Laurinavicius A, Petroska D, Lazutka JR, Jarmalaite S (2014) Heterogeneity of DNA methylation in multifocal prostate cancer. Virchows Arch 466(1):53\u201359. doi: 10.1007\/s00428-014-1678-3","journal-title":"Virchows Arch"},{"issue":"5","key":"2094_CR32","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00428-014-1622-6","volume":"465","author":"L Toffolatti","year":"2014","unstructured":"Toffolatti L, Scquizzato E, Cavallin S, Canal F, Scarpa M, Stefani PM, Gherlinzoni F, Dei Tos AP (2014) MGMT promoter methylation and correlation with protein expression in primary central nervous system lymphoma. Virchows Arch 465(5):579\u2013586. doi: 10.1007\/s00428-014-1622-6","journal-title":"Virchows Arch"},{"issue":"6","key":"2094_CR33","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00428-015-1749-0","volume":"466","author":"YY Rhee","year":"2015","unstructured":"Rhee YY, Lee TH, Song YS, Wen X, Kim H, Jheon S, Lee CT, Kim J, Cho NY, Chung JH, Kang GH (2015) Prognostic significance of promoter CpG island hypermethylation and repetitive DNA hypomethylation in stage I lung adenocarcinoma. Virchows Arch 466(6):675\u2013683. doi: 10.1007\/s00428-015-1749-0","journal-title":"Virchows Arch"},{"issue":"2","key":"2094_CR34","first-page":"123","volume":"54","author":"V Martinez-Glez","year":"2007","unstructured":"Martinez-Glez V, Franco-Hernandez C, Gonzalez-Gomez P, Isla A, De Campos JM, Vaquero J, Gutierrez M, Casartelli C, Rey JA (2007) DAPK1 promoter hypermethylation in brain metastases and peripheral blood. Neoplasma 54(2):123\u2013126","journal-title":"Neoplasma"},{"issue":"8","key":"2094_CR35","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.oraloncology.2011.05.014","volume":"47","author":"G Supic","year":"2011","unstructured":"Supic G, Kozomara R, Jovic N, Zeljic K, Magic Z (2011) Prognostic significance of tumor-related genes hypermethylation detected in cancer-free surgical margins of oral squamous cell carcinomas. Oral Oncol 47(8):702\u2013708. doi: 10.1016\/j.oraloncology.2011.05.014","journal-title":"Oral Oncol"},{"key":"2094_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12864-015-1381-z","volume":"16","author":"S Marttila","year":"2015","unstructured":"Marttila S, Kananen L, Hayrynen S, Jylhava J, Nevalainen T, Hervonen A, Jylha M, Nykter M, Hurme M (2015) Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics 16:179. doi: 10.1186\/s12864-015-1381-z","journal-title":"BMC Genomics"},{"key":"2094_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1471-2407-14-54","volume":"14","author":"SM Mitchell","year":"2014","unstructured":"Mitchell SM, Ross JP, Drew HR, Ho T, Brown GS, Saunders NF, Duesing KR, Buckley MJ, Dunne R, Beetson I, Rand KN, McEvoy A, Thomas ML, Baker RT, Wattchow DA, Young GP, Lockett TJ, Pedersen SK, Lapointe LC, Molloy PL (2014) A panel of genes methylated with high frequency in colorectal cancer. BMC Cancer 14:54. doi: 10.1186\/1471-2407-14-54","journal-title":"BMC Cancer"},{"issue":"Pt 1","key":"2094_CR38","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1042\/BJ20040469","volume":"382","author":"F Xu","year":"2004","unstructured":"Xu F, Morin C, Mitchell G, Ackerley C, Robinson BH (2004) The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome C oxidase) I and COX III mRNA. Biochem J 382(Pt 1):331\u2013336. doi: 10.1042\/BJ20040469","journal-title":"Biochem J"},{"issue":"21","key":"2094_CR39","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1101\/gad.1483906","volume":"20","author":"MP Cooper","year":"2006","unstructured":"Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM (2006) Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha\/LRP130 complex. Genes Dev 20(21):2996\u20133009. doi: 10.1101\/gad.1483906","journal-title":"Genes Dev"},{"issue":"46","key":"2094_CR40","doi-asserted-by":"publisher","first-page":"31960","DOI":"10.1074\/jbc.M805431200","volume":"283","author":"MP Cooper","year":"2008","unstructured":"Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM (2008) Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem 283(46):31960\u201331967. doi: 10.1074\/jbc.M805431200","journal-title":"J Biol Chem"},{"issue":"3","key":"2094_CR41","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.bbrc.2004.03.103","volume":"317","author":"N Tsuchiya","year":"2004","unstructured":"Tsuchiya N, Fukuda H, Nakashima K, Nagao M, Sugimura T, Nakagama H (2004) LRP130, a single-stranded DNA\/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo. Biochem Biophys Res Commun 317(3):736\u2013743. doi: 10.1016\/j.bbrc.2004.03.103","journal-title":"Biochem Biophys Res Commun"},{"issue":"15","key":"2094_CR42","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1016\/j.ejca.2012.01.018","volume":"48","author":"T Tian","year":"2012","unstructured":"Tian T, Ikeda J, Wang Y, Mamat S, Luo W, Aozasa K, Morii E (2012) Role of leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) for anti-apoptosis and tumourigenesis in cancers. Eur J Cancer 48(15):2462\u20132473. doi: 10.1016\/j.ejca.2012.01.018","journal-title":"Eur J Cancer"},{"issue":"17","key":"2094_CR43","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1242\/jcs.166074","volume":"128","author":"Y Zhen","year":"2015","unstructured":"Zhen Y, Stenmark H (2015) Cellular functions of Rab GTPases at a glance. J Cell Sci 128(17):3171\u20133176. doi: 10.1242\/jcs.166074","journal-title":"J Cell Sci"},{"issue":"2","key":"2094_CR44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0167-4889(02)00164-7","volume":"1589","author":"J Shan","year":"2002","unstructured":"Shan J, Yuan L, Budman DR, Xu HP (2002) WTH3, a new member of the Rab6 gene family, and multidrug resistance. Biochim Biophys Acta 1589(2):112\u2013123","journal-title":"Biochim Biophys Acta"},{"issue":"16","key":"2094_CR45","doi-asserted-by":"publisher","first-page":"7421","DOI":"10.1158\/0008-5472.CAN-05-0658","volume":"65","author":"K Tian","year":"2005","unstructured":"Tian K, Jurukovski V, Yuan L, Shan J, Xu H (2005) WTH3, which encodes a small G protein, is differentially regulated in multidrug-resistant and sensitive MCF7 cells. Cancer Res 65(16):7421\u20137428. doi: 10.1158\/0008-5472.CAN-05-0658","journal-title":"Cancer Res"},{"key":"2094_CR46","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1186\/1471-2407-14-968","volume":"14","author":"S Abogunrin","year":"2014","unstructured":"Abogunrin S, Di Tanna GL, Keeping S, Carroll S, Iheanacho I (2014) Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis. BMC Cancer 14:968. doi: 10.1186\/1471-2407-14-968","journal-title":"BMC Cancer"},{"issue":"2","key":"2094_CR47","doi-asserted-by":"publisher","first-page":"969","DOI":"10.4103\/0973-1482.179098","volume":"12","author":"NC Chaitanya","year":"2016","unstructured":"Chaitanya NC, Allam NS, Gandhi Babu DB, Waghray S, Badam RK, Lavanya R (2016) Systematic meta-analysis on association of human papilloma virus and oral cancer. J Cancer Res Ther 12(2):969\u2013974. doi: 10.4103\/0973-1482.179098","journal-title":"J Cancer Res Ther"},{"issue":"4","key":"2094_CR48","doi-asserted-by":"publisher","first-page":"249","DOI":"10.14639\/0392-100X-853","volume":"36","author":"P Morbini","year":"2016","unstructured":"Morbini P, Benazzo M (2016) Human papillomavirus and head and neck carcinomas: focus on evidence in the babel of published data. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 36(4):249\u2013258. doi: 10.14639\/0392-100X-853","journal-title":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2094-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-017-2094-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2094-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T17:05:21Z","timestamp":1589735121000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-017-2094-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["2094"],"URL":"https:\/\/doi.org\/10.1007\/s00428-017-2094-2","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}