{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:38:38Z","timestamp":1781275118262,"version":"3.54.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00428-017-2242-8","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T06:15:31Z","timestamp":1507184131000},"page":"361-368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Reduced H3K27me3 expression in radiation-associated angiosarcoma of the breast"],"prefix":"10.1007","volume":"472","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-2578","authenticated-orcid":false,"given":"Thomas","family":"Mentzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"2242_CR1","first-page":"517","volume":"132A","author":"K Kiss","year":"2017","unstructured":"Kiss K, Andreasen S, Moller Talman ML, Daugaard S, Mentzel T (2017) The incidence of radiotherapy-induced angiosarcoma of the skin after treatment for breast cancer in Denmark: a population-based study. Mod Pathol 132A:517","journal-title":"Mod Pathol"},{"issue":"8","key":"2242_CR2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/01.pas.0000156664.04955.83","volume":"29","author":"T Brenn","year":"2005","unstructured":"Brenn T, Fletcher CDM (2005) Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol 29(8):983\u2013996","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2242_CR3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/PAS.0b013e31815bf8fe","volume":"32","author":"KT Patton","year":"2008","unstructured":"Patton KT, Deyrup AT, Weiss SW (2008) Atypical vascular lesions after surgery and radiation of the breast. Am J Surg Pathol 32(6):943\u2013950","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2242_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/gcc.20827","volume":"50","author":"T Guo","year":"2011","unstructured":"Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR (2011) Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer 50(1):25\u201333","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"2242_CR5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/modpathol.2011.134","volume":"25","author":"T Mentzel","year":"2012","unstructured":"Mentzel T, Schildhaus HU, Palmedo G, B\u00fcttner R, Kutzner H (2012) Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical, and molecular analysis of 66 cases. Mod Pathol 25(1):75\u201385","journal-title":"Mod Pathol"},{"issue":"2","key":"2242_CR6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0560.2011.01843.x","volume":"39","author":"AP Fernandez","year":"2012","unstructured":"Fernandez AP, Sun Y, Tubbs RR, Goldblum JR, Billings SD (2012) FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations. J Cutan Pathol 39(2):234\u2013242","journal-title":"J Cutan Pathol"},{"issue":"4","key":"2242_CR7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/PAS.0000000000000564","volume":"40","author":"CN Prieto-Granada","year":"2016","unstructured":"Prieto-Granada CN, Wiesner T, Messina JL, Jungbluth AA, Chi P, Antonescu CR (2016) Loss of H3K27me3 expression is a highly sensitive marker for sporadic and radiation-induced MPNST. Am J Surg Pathol 40(4):479\u2013489","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2242_CR8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/modpathol.2015.134","volume":"29","author":"IM Schaefer","year":"2016","unstructured":"Schaefer IM, Fletcher CDM, Hornick JL (2016) Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. Mod Pathol 29(1):4\u201313","journal-title":"Mod Pathol"},{"issue":"5","key":"2242_CR9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrg.2016.13","volume":"17","author":"AP Feinberg","year":"2016","unstructured":"Feinberg AP, Koldobskiy MA, G\u00f6nd\u00f6r A (2016) Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet 17(5):284\u2013299","journal-title":"Nat Rev Genet"},{"issue":"2","key":"2242_CR10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/gcc.22128","volume":"53","author":"G Papp","year":"2014","unstructured":"Papp G, Krausz T, Stricker TP, Szendr\u00f6i M, Sapi Z (2014) SMARCB1 expression in epithelioid sarcoma is regulated by miR-206, miR-381, and miR-671-5p on both mRNA and protein levels. Genes Chromosomes Cancer 53(2):168\u2013176","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"2242_CR11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molcel.2013.10.030","volume":"53","author":"KJ Ferrari","year":"2014","unstructured":"Ferrari KJ, Scelfo A, Jammula S, Cuomo A, Barozzi I, St\u00fctzer A, Fischle W, Bonaldi T, Pasini D (2014) Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol Cell 53(1):49\u201362","journal-title":"Mol Cell"},{"issue":"5","key":"2242_CR12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ccr.2013.10.006","volume":"24","author":"S Bender","year":"2013","unstructured":"Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Hoifeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Seker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monaranu CM, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C, Cho YJ, Pfister SM (2013) Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant paediatric high-grade gliomas. Cancer Cell 24(5):660\u2013672","journal-title":"Cancer Cell"},{"issue":"6","key":"2242_CR13","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4149\/neo_2015_113","volume":"62","author":"WP He","year":"2015","unstructured":"He WP, Li Q, Zhou J, ZS H, Kung HF, Guan XY, Xie D, Yang GF (2015) Decreased expression of H3K27me3 in human ovarian carcinomas correlates with more aggressive tumor behaviour and poor patient survival. Neoplasma 62(6):932\u2013937","journal-title":"Neoplasma"},{"issue":"6","key":"2242_CR14","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/modpathol.2017.8","volume":"30","author":"KJ Busam","year":"2017","unstructured":"Busam KJ, Pulitzer MP, Coit DC, Arcila M, Leng D, Jungbluth AA, Wiesner T (2017) Reduced H3K27me3 expression in Merkel cell polyoma virus-positive tumors. Mod Pathol 30(6):877\u2013883","journal-title":"Mod Pathol"},{"issue":"3","key":"2242_CR15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/PAS.0000000000000769","volume":"41","author":"KJ Busam","year":"2017","unstructured":"Busam KJ, Shah KN, Gerami P, Sitzman T, Jungbluth AA, Kinsler V (2017) Reduced H3K27me3 expression is common in nodular melanomas of childhood associated with congenital melanocytic nevi but not in proliferative nodules. Am J Surg Pathol 41(3):396\u2013404","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"2242_CR16","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/ng.3095","volume":"46","author":"W Lee","year":"2014","unstructured":"Lee W, Teckie S, Wiesner T, Ran L, Prieto-Granada CN, Lin M, Zhu S, Cao Z, Liang Y, Sboner A, Tap WD, Fletcher JA, Huberman KH, Qin LX, Viale A, Singer S, Zheng D, Berger MF, Chen Y, Antonescu CR, Chi P (2014) PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet 46(11):1227\u20131232","journal-title":"Nat Genet"},{"issue":"6","key":"2242_CR17","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/modpathol.2016.45","volume":"29","author":"AHG Cleven","year":"2016","unstructured":"Cleven AHG, Al Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin B, de Vries MW, Warson KL, Torres KE, Wang WL, van Duinen SG, Hogendoorn PCW, Lazar AJ, Bovee JVMG (2016) Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Mod Pathol 29(6):582\u2013590","journal-title":"Mod Pathol"},{"issue":"1","key":"2242_CR18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2353\/ajpath.2007.060589","volume":"171","author":"S Jackowski","year":"2007","unstructured":"Jackowski S, Janusch M, Fiedler E, Marsch WC, Ulbrich EJ, Gaisbauer G, Dunst J, Kerjaschki D, Helmbold P (2007) Radiogenic lymphangiogenesis in the skin. Am J Pathol 171(1):338\u2013348","journal-title":"Am J Pathol"},{"issue":"4","key":"2242_CR19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/modpathol.2013.163","volume":"27","author":"W Shon","year":"2014","unstructured":"Shon W, Sukov WR, Jenkins SM, Folpe AL (2014) MYC amplification and overexpression in primary cutaneous angiosarcoma: a fluorescence in-situ hybridization and immunohistochemical study. Mod Pathol 27(4):509\u2013515","journal-title":"Mod Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-017-2242-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2242-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2242-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T23:57:03Z","timestamp":1659571023000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-017-2242-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["2242"],"URL":"https:\/\/doi.org\/10.1007\/s00428-017-2242-8","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]}}}