{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:53:11Z","timestamp":1771023191039,"version":"3.50.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00428-017-2249-1","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T10:21:15Z","timestamp":1510309275000},"page":"15-28","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Classification of eosinophilic disorders of the small and large intestine"],"prefix":"10.1007","volume":"472","author":[{"given":"Aoife J.","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Sheahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"2249_CR1","doi-asserted-by":"crossref","unstructured":"Conner JR, Kirsch R (2017) The pathology and causes of tissue eosinophilia in the gastrointestinal tract. Histopathology 71(2):177-199","DOI":"10.1111\/his.13228"},{"issue":"Suppl 1","key":"2249_CR2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/modpathol.2014.132","volume":"28","author":"RK Yantiss","year":"2015","unstructured":"Yantiss RK (2015) Eosinophils in the GI tract: how many is too many and what do they mean? Mod Pathol 28(Suppl 1):S7\u201321","journal-title":"Mod Pathol"},{"issue":"9","key":"2249_CR3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3109\/00365521003690251","volume":"45","author":"AJ Lucendo","year":"2010","unstructured":"Lucendo AJ (2010) Eosinophilic diseases of the gastrointestinal tract. Scand J Gastroenterol 45(9):1013\u20131021","journal-title":"Scand J Gastroenterol"},{"issue":"5","key":"2249_CR4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/gut.2006.107714","volume":"56","author":"J Ronkainen","year":"2007","unstructured":"Ronkainen J, Talley NJ, Aro P, Storskrubb T, Johansson SE, Lind T et al (2007) Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut 56(5):615\u2013620","journal-title":"Gut"},{"issue":"12","key":"2249_CR5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/adc.2006.100974","volume":"91","author":"S Cherian","year":"2006","unstructured":"Cherian S, Smith NM, Forbes DA (2006) Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia. Arch Dis Child 91(12):1000\u20131004","journal-title":"Arch Dis Child"},{"issue":"12","key":"2249_CR6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","volume":"3","author":"CA Liacouras","year":"2005","unstructured":"Liacouras CA, Spergel JM, Ruchelli E, Verma R, Mascarenhas M, Semeao E et al (2005) Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 3(12):1198\u20131206","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"2249_CR7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00535-008-2230-5","volume":"43","author":"HE Oh","year":"2008","unstructured":"Oh HE, Chetty R (2008) Eosinophilic gastroenteritis: a review. J Gastroenterol 43(10):741\u2013750","journal-title":"J Gastroenterol"},{"issue":"12","key":"2249_CR8","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1136\/gut.2005.072595","volume":"54","author":"S Al-Haddad","year":"2005","unstructured":"Al-Haddad S, Riddell RH (2005) The role of eosinophils in inflammatory bowel disease. Gut 54(12):1674\u20131675","journal-title":"Gut"},{"issue":"5","key":"2249_CR9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/gut.2008.165894","volume":"58","author":"BM Yan","year":"2009","unstructured":"Yan BM, Shaffer EA (2009) Primary eosinophilic disorders of the gastrointestinal tract. Gut 58(5):721\u2013732","journal-title":"Gut"},{"issue":"5","key":"2249_CR10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0169-4758(99)01620-8","volume":"16","author":"CA Behm","year":"2000","unstructured":"Behm CA, Ovington KS (2000) The role of eosinophils in parasitic helminth infections: insights from genetically modified mice. Parasitol Today 16(5):202\u2013209","journal-title":"Parasitol Today"},{"issue":"3","key":"2249_CR11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bpg.2007.12.008","volume":"22","author":"S Mueller","year":"2008","unstructured":"Mueller S (2008) Classification of eosinophilic gastrointestinal diseases. Best Pract Res Clin Gastroenterol 22(3):425\u2013440","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"3","key":"2249_CR12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/(SICI)1097-0185(199811)252:3<418::AID-AR10>3.0.CO;2-1","volume":"252","author":"M Kato","year":"1998","unstructured":"Kato M, Kephart GM, Talley NJ, Wagner JM, Sarr MG, Bonno M et al (1998) Eosinophil infiltration and degranulation in normal human tissue. Anat Rec 252(3):418\u2013425","journal-title":"Anat Rec"},{"issue":"11","key":"2249_CR13","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1136\/jcp.2005.031922","volume":"59","author":"S Mueller","year":"2006","unstructured":"Mueller S, Aigner T, Neureiter D, Stolte M (2006) Eosinophil infiltration and degranulation in oesophageal mucosa from adult patients with eosinophilic oesophagitis: a retrospective and comparative study on pathological biopsy. J Clin Pathol 59(11):1175\u20131180","journal-title":"J Clin Pathol"},{"key":"2249_CR14","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1572-0241.2003.07484.x","volume":"98","author":"D Schwab","year":"2003","unstructured":"Schwab D, M\u00fcller S, Aigner T, Neureiter D, Kirchner T, Hahn EG et al (2003) Functional and morphologic characterization of eosinophils in the lower intestinal mucosa of patients with food allergy. Eosinophils in Food Allergy. Am J Gastroenterol 98:1525\u20131534","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"2249_CR15","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/path.904","volume":"194","author":"M Jeziorska","year":"2001","unstructured":"Jeziorska M, Haboubi N, Schofield P, Woolley DE (2001) Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique. J Pathol 194(4):484\u2013492","journal-title":"J Pathol"},{"issue":"2","key":"2249_CR16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/PAS.0000000000000760","volume":"41","author":"KO Turner","year":"2017","unstructured":"Turner KO, Sinkre RA, Neumann WL, Genta RM (2017) Primary colonic eosinophilia and eosinophilic colitis in adults. Am J Surg Pathol 41(2):225\u2013233","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2249_CR17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2350\/10-07-0878-OA.1","volume":"14","author":"AG Saad","year":"2011","unstructured":"Saad AG (2011) Normal quantity and distribution of mast cells and eosinophils in the pediatric colon. Pediatr Dev Pathol 14(4):294\u2013300","journal-title":"Pediatr Dev Pathol"},{"issue":"6","key":"2249_CR18","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.humpath.2007.10.012","volume":"39","author":"AD Polydorides","year":"2008","unstructured":"Polydorides AD, Banner BF, Hannaway PJ, Yantiss RK (2008) Evaluation of site-specific and seasonal variation in colonic mucosal eosinophils. Hum Pathol 39(6):832\u2013836","journal-title":"Hum Pathol"},{"issue":"3","key":"2249_CR19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2350\/11-05-0130.1","volume":"9","author":"CW DeBrosse","year":"2006","unstructured":"DeBrosse CW, Case JW, Putnam PE, Collins MH, Rothenberg ME (2006) Quantity and distribution of eosinophils in the gastrointestinal tract of children. Pediatr Dev Pathol 9(3):210\u2013218","journal-title":"Pediatr Dev Pathol"},{"issue":"2","key":"2249_CR20","first-page":"110","volume":"9","author":"A Lowichik","year":"1996","unstructured":"Lowichik A, Weinberg AG (1996) A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod Pathol 9(2):110\u2013114","journal-title":"Mod Pathol"},{"issue":"4","key":"2249_CR21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/PAS.0000000000000370","volume":"39","author":"T Matsushita","year":"2015","unstructured":"Matsushita T, Maruyama R, Ishikawa N, Harada Y, Araki A, Chen D et al (2015) The number and distribution of eosinophils in the adult human gastrointestinal tract: a study and comparison of racial and environmental factors. Am J Surg Pathol 39(4):521\u2013527","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"2249_CR22","first-page":"363","volume":"10","author":"RR Pascal","year":"1997","unstructured":"Pascal RR, Gramlich TL, Parker KM, Gansler TS (1997) Geographic variations in eosinophil concentration in normal colonic mucosa. Mod Pathol 10(4):363\u2013365","journal-title":"Mod Pathol"},{"issue":"5","key":"2249_CR23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00281-012-0324-x","volume":"34","author":"S Aceves","year":"2012","unstructured":"Aceves S, Hirano I, Furuta GT, Collins MH (2012) Eosinophilic gastrointestinal diseases--clinically diverse and histopathologically confounding. Semin Immunopathol 34(5):715\u2013731","journal-title":"Semin Immunopathol"},{"issue":"31","key":"2249_CR24","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.3748\/wjg.v19.i31.5061","volume":"19","author":"SB Ingle","year":"2013","unstructured":"Ingle SB, Hinge Ingle CR (2013) Eosinophilic gastroenteritis: an unusual type of gastroenteritis. World J Gastroenterol 19(31):5061\u20135066","journal-title":"World J Gastroenterol"},{"issue":"2","key":"2249_CR25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12016-015-8489-4","volume":"50","author":"V Uppal","year":"2016","unstructured":"Uppal V, Kreiger P, Kutsch E (2016) Eosinophilic gastroenteritis and colitis: a comprehensive review. Clin Rev Allergy Immunol 50(2):175\u2013188","journal-title":"Clin Rev Allergy Immunol"},{"issue":"12","key":"2249_CR26","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.3748\/wjg.v9.i12.2813","volume":"9","author":"MJ Chen","year":"2003","unstructured":"Chen MJ, Chu CH, Lin SC, Shih SC, Wang TE (2003) Eosinophilic gastroenteritis: clinical experience with 15 patients. World J Gastroenterol 9(12):2813\u20132816","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2249_CR27","first-page":"70","volume":"88","author":"CM Lee","year":"1993","unstructured":"Lee CM, Changchien CS, Chen PC, Lin DY, Sheen IS, Wang CS et al (1993) Eosinophilic gastroenteritis: 10 years experience. Am J Gastroenterol 88(1):70\u201374","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"2249_CR28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cgh.2007.05.015","volume":"5","author":"NJ Talley","year":"2007","unstructured":"Talley NJ, Walker MM, Aro P, Ronkainen J, Storskrubb T, Hindley LA et al (2007) Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clin Gastroenterol Hepatol 5(10):1175\u20131183","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"2249_CR29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gtc.2007.01.003","volume":"36","author":"N Gonsalves","year":"2007","unstructured":"Gonsalves N (2007) Food allergies and eosinophilic gastrointestinal illness. Gastroenterol Clin N Am 36(1):75\u201391","journal-title":"Gastroenterol Clin N Am"},{"issue":"6","key":"2249_CR30","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/0046-8177(93)90248-F","volume":"24","author":"RD Odze","year":"1993","unstructured":"Odze RD, Bines J, Leichtner AM, Goldman H, Antonioli DA (1993) Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol 24(6):668\u2013674","journal-title":"Hum Pathol"},{"issue":"1","key":"2249_CR31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaci.2003.10.047","volume":"113","author":"ME Rothenberg","year":"2004","unstructured":"Rothenberg ME (2004) Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113(1):11\u201328","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2249_CR32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1756283X10392443","volume":"4","author":"AA Alfadda","year":"2011","unstructured":"Alfadda AA, Storr MA, Shaffer EA (2011) Eosinophilic colitis: epidemiology, clinical features, and current management. Therap Adv Gastroenterol 4(5):301\u2013309","journal-title":"Therap Adv Gastroenterol"},{"issue":"1","key":"2249_CR33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gut.31.1.54","volume":"31","author":"NJ Talley","year":"1990","unstructured":"Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR (1990) Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 31(1):54\u201358","journal-title":"Gut"},{"issue":"4","key":"2249_CR34","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1067\/mpd.2002.127663","volume":"141","author":"JR Guajardo","year":"2002","unstructured":"Guajardo JR, Plotnick LM, Fende JM, Collins MH, Putnam PE, Rothenberg ME (2002) Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry. J Pediatr 141(4):576\u2013581","journal-title":"J Pediatr"},{"issue":"9","key":"2249_CR35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11882-015-0558-5","volume":"15","author":"A Cianferoni","year":"2015","unstructured":"Cianferoni A, Spergel JM (2015) Eosinophilic esophagitis and gastroenteritis. Curr Allergy Asthma Rep 15(9):58","journal-title":"Curr Allergy Asthma Rep"},{"issue":"9","key":"2249_CR36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2165\/00128072-200204090-00002","volume":"4","author":"S Khan","year":"2002","unstructured":"Khan S, Orenstein SR (2002) Eosinophilic gastroenteritis: epidemiology, diagnosis and management. Paediatr Drugs 4(9):563\u2013570","journal-title":"Paediatr Drugs"},{"issue":"11","key":"2249_CR37","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.3748\/wjg.v13.i11.1758","volume":"13","author":"MY Yun","year":"2007","unstructured":"Yun MY, Cho YU, Park IS, Choi SK, Kim SJ, Shin SH et al (2007) Eosinophilic gastroenteritis presenting as small bowel obstruction: a case report and review of the literature. World J Gastroenterol 13(11):1758\u20131760","journal-title":"World J Gastroenterol"},{"issue":"2","key":"2249_CR38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/codi.12464","volume":"16","author":"AA Alfadda","year":"2014","unstructured":"Alfadda AA, Shaffer EA, Urbanski SJ, Storr MA (2014) Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study. Color Dis 16(2):123\u2013129","journal-title":"Color Dis"},{"issue":"1","key":"2249_CR39","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/j.crohns.2012.06.013","volume":"7","author":"L Fern\u00e1ndez Salazar","year":"2013","unstructured":"Fern\u00e1ndez Salazar L, Borrego Pintado H, Velayos Jim\u00e9nez B, Gonz\u00e1lez Hern\u00e1ndez JM (2013) Differential diagnosis and management of histologic eosinophilic colitis. J Crohns Colitis 7(1):e20\u2013e21","journal-title":"J Crohns Colitis"},{"issue":"5","key":"2249_CR40","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1157\/13094031","volume":"34","author":"H Inamura","year":"2006","unstructured":"Inamura H, Kashiwase Y, Morioka J, Suzuki K, Igarashi Y, Kurosawa M (2006) Accumulation of mast cells in the interstitium of eosinophilic colitis. Allergol Immunopathol (Madr) 34(5):228\u2013230","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"3","key":"2249_CR41","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000321812","volume":"83","author":"H Minematsu","year":"2011","unstructured":"Minematsu H, Hokama A, Makishi T, Arakaki K, Kinjo F, Fujita J (2011) Colonoscopic findings and pathologic characteristics of Strongyloides colitis: a case series. Digestion 83(3):210\u2013214","journal-title":"Digestion"},{"issue":"12","key":"2249_CR42","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s10620-005-3069-8","volume":"50","author":"P Tsibouris","year":"2005","unstructured":"Tsibouris P, Galeas T, Moussia M, Sotiropoulou M, Michopoulos S, Kralios N (2005) Two cases of eosinophilic gastroenteritis and malabsorption due to Enterobious vermicularis. Dig Dis Sci 50(12):2389\u20132392","journal-title":"Dig Dis Sci"},{"issue":"3","key":"2249_CR43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3346\/jkms.2003.18.3.429","volume":"18","author":"ST Hong","year":"2003","unstructured":"Hong ST, Lim HS, Kim DH, Kim SJ (2003) A case of gastroenteritis associated with gastric trichuriasis. J Korean Med Sci 18(3):429\u2013432","journal-title":"J Korean Med Sci"},{"issue":"3","key":"2249_CR44","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00000478-199503000-00011","volume":"19","author":"NI Walker","year":"1995","unstructured":"Walker NI, Croese J, Clouston AD, Parry M, Loukas A, Prociv P (1995) Eosinophilic enteritis in northeastern Australia. Pathology, association with Ancylostoma caninum, and implications. Am J Surg Pathol 19(3):328\u2013337","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2249_CR45","first-page":"53","volume":"17","author":"H Uzunismail","year":"2006","unstructured":"Uzunismail H, Hatemi I, Do\u011fusoy G, Akin O (2006) Dense eosinophilic infiltration of the mucosa preceding ulcerative colitis and mimicking eosinophilic colitis: report of two cases. Turk J Gastroenterol 17(1):53\u201357","journal-title":"Turk J Gastroenterol"},{"key":"2249_CR46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.mcg.0000190776.65526.da","volume":"40","author":"M Jim\u00e9nez-S\u00e1enz","year":"2006","unstructured":"Jim\u00e9nez-S\u00e1enz M, Gonz\u00e1lez-C\u00e1mpora R, Linares-Santiago E, Herrer\u00edas-Guti\u00e9rrez JM (2006) Bleeding colonic ulcer and eosinophilic colitis: a rare complication of nonsteroidal anti-inflammatory drugs. J Clin Gastroenterol 40:84\u201385","journal-title":"J Clin Gastroenterol"},{"issue":"6","key":"2249_CR47","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1399-3046.2006.00538.x","volume":"10","author":"SA Saeed","year":"2006","unstructured":"Saeed SA, Integlia MJ, Pleskow RG, Calenda KA, Rohrer RJ, Dayal Y et al (2006) Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis. Pediatr Transplant 10(6):730\u2013735","journal-title":"Pediatr Transplant"},{"issue":"2","key":"2249_CR48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/10401239509149034","volume":"7","author":"JW Friedberg","year":"1995","unstructured":"Friedberg JW, Frankenburg FR, Burk J, Johnson W (1995) Clozapine-caused eosinophilic colitis. Ann Clin Psychiatry 7(2):97\u201398","journal-title":"Ann Clin Psychiatry"},{"issue":"8932","key":"2249_CR49","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0140-6736(94)90782-X","volume":"344","author":"P Lange","year":"1994","unstructured":"Lange P, Oun H, Fuller S, Turney JH (1994) Eosinophilic colitis due to rifampicin. Lancet 344(8932):1296\u20131297","journal-title":"Lancet"},{"issue":"1","key":"2249_CR50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1528-1157.1992.tb02293.x","volume":"33","author":"VJ Anttila","year":"1992","unstructured":"Anttila VJ, Valtonen M (1992) Carbamazepine-induced eosinophilic colitis. Epilepsia 33(1):119\u2013121","journal-title":"Epilepsia"},{"issue":"2","key":"2249_CR51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0069477006286726","volume":"44","author":"M Jim\u00e9nez-S\u00e1enz","year":"2006","unstructured":"Jim\u00e9nez-S\u00e1enz M (2006) Naproxen: bleeding colonic ulcer, eosinophilic colitis. Clin-Alert 44(2):1\u20138","journal-title":"Clin-Alert"},{"issue":"4","key":"2249_CR52","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0002-9343(90)90386-R","volume":"89","author":"AJ Bridges","year":"1990","unstructured":"Bridges AJ, Marshall JB, Diaz-Arias AA (1990) Acute eosinophilic colitis and hypersensitivity reaction associated with naproxen therapy. Am J Med 89(4):526\u2013527","journal-title":"Am J Med"},{"issue":"3","key":"2249_CR53","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00004836-200004000-00007","volume":"30","author":"M Ahmad","year":"2000","unstructured":"Ahmad M, Soetikno RM, Ahmed A (2000) The differential diagnosis of eosinophilic esophagitis. J Clin Gastroenterol 30(3):242\u2013244","journal-title":"J Clin Gastroenterol"},{"issue":"10","key":"2249_CR54","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/00004836-200411000-00010","volume":"38","author":"DA Barbie","year":"2004","unstructured":"Barbie DA, Mangi AA, Lauwers GY (2004) Eosinophilic gastroenteritis associated with systemic lupus erythematosus. J Clin Gastroenterol 38(10):883\u2013886","journal-title":"J Clin Gastroenterol"},{"key":"2249_CR55","doi-asserted-by":"crossref","unstructured":"Roufosse FE, Goldman M, Cogan E (2007) Hypereosinophilic syndromes. Orphanet J Rare Dis","DOI":"10.1186\/1750-1172-2-37"},{"key":"2249_CR56","doi-asserted-by":"publisher","unstructured":"Bates WH (2012) Diagnosing eosinophilic colitis: histopathological pattern or nosological entity? Scientifica (Cairo). https:\/\/doi.org\/10.6064\/2012\/682576","DOI":"10.6064\/2012\/682576"},{"key":"2249_CR57","doi-asserted-by":"crossref","unstructured":"Naylor AR, Pollet JE (1985) Eosinophilic colitis. Dis Colon rectum 28(8):615\u2013618","DOI":"10.1007\/BF02554161"},{"key":"2249_CR58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/bmb\/ldr045","volume":"100","author":"AA Alfadda","year":"2011","unstructured":"Alfadda AA, Storr MA, Shaffer EA (2011) Eosinophilic colitis: an update on pathophysiology and treatment. Br Med Bull 100:59\u201372","journal-title":"Br Med Bull"},{"issue":"1","key":"2249_CR59","first-page":"5","volume":"3","author":"HS Winter","year":"1990","unstructured":"Winter HS, Antonioli DA, Fukagawa N, Marcial M, Goldman H (1990) Allergy-related proctocolitis in infants: diagnostic usefulness of rectal biopsy. Mod Pathol 3(1):5\u201310","journal-title":"Mod Pathol"},{"issue":"2","key":"2249_CR60","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-3476(95)70540-6","volume":"126","author":"RD Odze","year":"1995","unstructured":"Odze RD, Wershil BK, Leichtner AM, Antonioli DA (1995) Allergic colitis in infants. J Pediatr 126(2):163\u2013170","journal-title":"J Pediatr"},{"issue":"2","key":"2249_CR61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00000478-198602000-00001","volume":"10","author":"H Goldman","year":"1986","unstructured":"Goldman H, Proujansky R (1986) Allergic proctitis and gastroenteritis in children. Clinical and mucosal biopsy features in 53 cases. Am J Surg Pathol 10(2):75\u201386","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2249_CR62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1309\/AJCPE89ZPVJTSPWL","volume":"138","author":"IS Brown","year":"2012","unstructured":"Brown IS, Smith J, Rosty C (2012) Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients. Am J Clin Pathol 138(1):42\u201349","journal-title":"Am J Clin Pathol"},{"issue":"11","key":"2249_CR63","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.crohns.2014.05.003","volume":"8","author":"V Villanacci","year":"2014","unstructured":"Villanacci V, Antonelli E, Reboldi G, Salemme M, Casella G, Bassotti G (2014) Endoscopic biopsy samples of na\u00efve \u201ccolitides\u201d patients: role of basal plasmacytosis. J Crohns Colitis 8(11):1438\u20131443","journal-title":"J Crohns Colitis"},{"key":"2249_CR64","doi-asserted-by":"publisher","unstructured":"Bass JA, Friesen CA, Deacy AD, Neilan NA, Bracken JM, Shakhnovich V, et al (2015) Investigation of potential early histologic markers of pediatric inflammatory bowel disease. BMC Gastroenterol. https:\/\/doi.org\/10.1186\/s12876-015-0359-2","DOI":"10.1186\/s12876-015-0359-2"},{"issue":"2","key":"2249_CR65","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00004836-200302000-00006","volume":"36","author":"AT Carvalho","year":"2003","unstructured":"Carvalho AT, Elia CC, de Souza HS, Elias PR, Pontes EL, Lukashok HP et al (2003) Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease. J Clin Gastroenterol 36(2):120\u2013125","journal-title":"J Clin Gastroenterol"},{"issue":"5","key":"2249_CR66","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/00365520310008566","volume":"39","author":"X Xu","year":"2004","unstructured":"Xu X, Rivkind A, Pikarsky A, Pappo O, Bischoff SC, Levi-Schaffer F (2004) Mast cells and eosinophils have a potential profibrogenic role in Crohn disease. Scand J Gastroenterol 39(5):440\u2013447","journal-title":"Scand J Gastroenterol"},{"issue":"7","key":"2249_CR67","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/gut.31.7.791","volume":"31","author":"H Nolte","year":"1990","unstructured":"Nolte H, Spjeldnaes N, Kruse A, Windelborg B (1990) Histamine release from gut mast cells from patients with inflammatory bowel diseases. Gut 31(7):791\u2013794","journal-title":"Gut"},{"issue":"12","key":"2249_CR68","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gut.2005.066423","volume":"54","author":"M Lampinen","year":"2005","unstructured":"Lampinen M, R\u00f6nnblom A, Amin K, Kristjansson G, Rorsman F, Sangfelt P et al (2005) Eosinophil granulocytes are activated during the remission phase of ulcerative colitis. Gut 54(12):1714\u20131720","journal-title":"Gut"},{"issue":"12","key":"2249_CR69","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/codi.12725","volume":"16","author":"P Zezos","year":"2014","unstructured":"Zezos P, Patsiaoura K, Nakos A, Mpoumponaris A, Vassiliadis T, Giouleme O et al (2014) Severe eosinophilic infiltration in colonic biopsies predicts patients with ulcerative colitis not responding to medical therapy. Color Dis 16(12):420\u2013430","journal-title":"Color Dis"},{"issue":"6","key":"2249_CR70","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/00365520310000564","volume":"38","author":"M Tanaka","year":"2003","unstructured":"Tanaka M, Kusumi T, Oshitani N, Nishigami T, Iwao Y, Hatada Y et al (2003) Validity of simple mucosal biopsy criteria combined with endoscopy predicting patients with ulcerative colitis ultimately requiring surgery: a multicenter study. Scand J Gastroenterol 38(6):594\u2013598","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"2249_CR71","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/003655202753416885","volume":"37","author":"M Tanaka","year":"2002","unstructured":"Tanaka M, Saito H, Kusumi T, Shimoyama T, Fukuda S, Morita T et al (2002) Biopsy pathology predicts patients with ulcerative colitis subsequently requiring surgery. Scand J Gastroenterol 37(2):200\u2013205","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"2249_CR72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1078\/0344-0338-00367","volume":"199","author":"CA Rubio","year":"2003","unstructured":"Rubio CA (2003) A method for the detection of eosinophilic granulocytes in colonoscopic biopsies from IBD patients. Pathol Res Pract 199(3):145\u2013150","journal-title":"Pathol Res Pract"},{"issue":"10","key":"2249_CR73","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s11605-006-0055-1","volume":"11","author":"VR Velchuru","year":"2007","unstructured":"Velchuru VR, Khan MA, Hellquist HB, Studley JG (2007) Eosinophilic colitis. J Gastrointest Surg 11(10):1373\u20131375","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"2249_CR74","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/0016-5085(81)90274-2","volume":"80","author":"DM Martin","year":"1981","unstructured":"Martin DM, Goldman JA, Gilliam J, Nasrallah SM (1981) Gold-induced eosinophilic enterocolitis: response to oral cromolyn sodium. Gastroenterology 80(6):1567\u20131570","journal-title":"Gastroenterology"},{"issue":"3","key":"2249_CR75","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bpg.2007.09.001","volume":"22","author":"A Straumann","year":"2008","unstructured":"Straumann A (2008) Idiopathic eosinophilic gastrointestinal diseases in adults. Best Pract Res Clin Gastroenterol 22(3):481\u2013496","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"10","key":"2249_CR76","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","volume":"83","author":"PF Weller","year":"1994","unstructured":"Weller PF, Bubley GJ (1994) The idiopathic hypereosinophilic syndrome. Blood 83(10):2759\u20132779","journal-title":"Blood"},{"issue":"12","key":"2249_CR77","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1182\/blood-2003-01-0006","volume":"101","author":"AD Klion","year":"2003","unstructured":"Klion AD, Noel P, Akin C, Law MA, Gilliland DG, Cools J et al (2003) Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood 101(12):4660\u20134666","journal-title":"Blood"},{"issue":"2","key":"2249_CR78","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1182\/blood-2003-08-2798","volume":"103","author":"AD Klion","year":"2004","unstructured":"Klion AD, Robyn J, Akin C, Noel P, Brown M, Law M et al (2004) Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Blood 103(2):473\u2013478","journal-title":"Blood"},{"issue":"3","key":"2249_CR79","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00000478-198403000-00002","volume":"8","author":"K DeSchryver-Kecskemeti","year":"1984","unstructured":"DeSchryver-Kecskemeti K, Clouse RE (1984) A previously unrecognized subgroup of \u201ceosinophilic gastroenteritis\u201d. Association with connective tissue diseases. Am J Surg Pathol 8(3):171\u2013180","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2249_CR80","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0016-5085(92)91110-P","volume":"103","author":"RE Clouse","year":"1992","unstructured":"Clouse RE, Alpers DH, Hockenbery DM, DeSchryver-Kecskemeti K (1992) Pericrypt eosinophilic enterocolitis and chronic diarrhea. Gastroenterology 103(1):168\u2013176","journal-title":"Gastroenterology"},{"issue":"7","key":"2249_CR81","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/rheumatology\/40.7.763","volume":"40","author":"R Solans","year":"2001","unstructured":"Solans R, Bosch JA, P\u00e9rez-Bocanegra C, Selva A, Huguet P, Alijotas J et al (2001) Churg-Strauss syndrome: outcome and long-term follow-up of 32 patients. Rheumatology (Oxford) 40(7):763\u2013771","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"2249_CR82","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/gut.2004.049767","volume":"54","author":"M Weidenhiller","year":"2005","unstructured":"Weidenhiller M, M\u00fcller S, Schwab D, Hahn EG, Raithel M, Winterkamp S (2005) Microscopic (collagenous and lymphocytic) colitis triggered by food allergy. Gut 54(2):312\u2013313","journal-title":"Gut"},{"issue":"6","key":"2249_CR83","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/BF01295734","volume":"38","author":"LR Mills","year":"1993","unstructured":"Mills LR, Schuman BM, Thompson WO (1993) Lymphocytic colitis. A definable clinical and histological diagnosis. Dig Dis Sci 38(6):1147\u20131151","journal-title":"Dig Dis Sci"},{"issue":"5","key":"2249_CR84","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1172\/JCI111861","volume":"75","author":"GW Bo-Linn","year":"1985","unstructured":"Bo-Linn GW, Vendrell DD, Lee E, Fordtran JS (1985) An evaluation of the significance of microscopic colitis in patients with chronic diarrhea. J Clin Invest 75(5):1559\u20131569","journal-title":"J Clin Invest"},{"issue":"2","key":"2249_CR85","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0344-0338(00)80038-2","volume":"196","author":"S Ciani","year":"2000","unstructured":"Ciani S, Chuaqui B (2000) Histological features of resolving acute, non-complicated phlegmonous appendicitis. Pathol Res Pract 196(2):89\u201393","journal-title":"Pathol Res Pract"},{"issue":"5","key":"2249_CR86","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/00000478-199305000-00009","volume":"17","author":"DJ Dabbs","year":"1993","unstructured":"Dabbs DJ (1993) Eosinophilic and lymphoeosinophilic cholecystitis. Am J Surg Pathol 17(5):497\u2013501","journal-title":"Am J Surg Pathol"},{"key":"2249_CR87","doi-asserted-by":"publisher","unstructured":"Jawairia M, Shahzad G, Mustacchia P (2012) Eosinophilic gastrointestinal diseases: review and update. ISRN Gastroenterol. https:\/\/doi.org\/10.5402\/2012\/463689","DOI":"10.5402\/2012\/463689"},{"key":"2249_CR88","unstructured":"De Maeyer N, Kochuyt AM, Van Moerkercke W, Hiele M. Montelukast as a treatment modality for eosinophilic gastroenteritis. Acta Gastroenterol Belg 2011;74(4):570\u2013575"},{"issue":"6","key":"2249_CR89","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.jaci.2008.02.033","volume":"121","author":"ML Stein","year":"2008","unstructured":"Stein ML, Villanueva JM, Buckmeier BK, Yamada Y, Filipovich AH, Assa'ad AH et al (2008) Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J Allergy Clin Immunol 121(6):1473\u20131483","journal-title":"J Allergy Clin Immunol"},{"key":"2249_CR90","doi-asserted-by":"crossref","unstructured":"Foroughi S, Foster B, Kim N, Bernardino LB, Scott LM, Hamilton RG et al (2007) Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J Allergy Clin Immunol 120(3):594\u2013601","DOI":"10.1016\/j.jaci.2007.06.015"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-017-2249-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2249-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-017-2249-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T02:08:45Z","timestamp":1623809325000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-017-2249-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2249"],"URL":"https:\/\/doi.org\/10.1007\/s00428-017-2249-1","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,10]]},"assertion":[{"value":"29 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have complied with ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}