{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:12:26Z","timestamp":1792239146371,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00428-018-2292-6","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T05:18:59Z","timestamp":1515820739000},"page":"789-796","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Fumarate hydratase (FH) deficiency in uterine leiomyomas: recognition by histological features versus blind immunoscreening"],"prefix":"10.1007","volume":"472","author":[{"given":"Lisa","family":"Siegler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Erber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Burghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Brodkorb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafisa","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Stringfellow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias W.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,13]]},"reference":[{"issue":"1","key":"2292_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1136\/jmg.2005.033506","volume":"43","author":"MH Wei","year":"2006","unstructured":"Wei MH, Toure O, Glenn GM, Pithukpakorn M, Neckers L, Stolle C, Choyke P, Grubb R, Middelton L, Turner ML, Walther MM, Merino MJ, Zbar B, Linehan WM, Toro JR (2006) Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet 43(1):18\u201327. \n                    https:\/\/doi.org\/10.1136\/jmg.2005.033506","journal-title":"J Med Genet"},{"issue":"1","key":"2292_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1399-0004.2010.01486.x","volume":"79","author":"DL Smit","year":"2011","unstructured":"Smit DL, Mensenkamp AR, Badeloe S, Breuning MH, Simon MEH, van Spaendonck KY, Aalfs CM, Post JG, Shanley S, Krapels IPC, Hoefsloot LH, van Moorselaar RJA, Starink TM, Bayley JP, Frank J, van Steensel MAM, Menko FH (2011) Hereditary leiomyomatosis and renal cell cancer in families referred for fumarate hydratase germline mutation analysis. Clin Genet 79(1):49\u201359. \n                    https:\/\/doi.org\/10.1111\/j.1399-0004.2010.01486.x","journal-title":"Clin Genet"},{"issue":"6","key":"2292_CR3","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1073\/pnas.051633798","volume":"98","author":"V Launonen","year":"2001","unstructured":"Launonen V, Vierimaa O, Kiuru M, Isola J, Roth S, Pukkala E, Sistonen P, Herva R, Aaltonen LA (2001) Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A 98(6):3387\u20133392. \n                    https:\/\/doi.org\/10.1073\/pnas.051633798","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2292_CR4","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1046\/j.1523-1747.2003.12499.x","volume":"121","author":"A Martinez-Mir","year":"2003","unstructured":"Martinez-Mir A, Glaser B, S. Chuang G, Horev L, Waldman A, Engler DE, Gordon D, Spelman LJ, Hatzibougias I, Green J, Christiano AM, Zlotogorski A (2003) Germline fumarate hydratase mutations in families with multiple cutaneous and uterine leiomyomata. J Investig Dermatol 121(4):741\u2013744. \n                    https:\/\/doi.org\/10.1046\/j.1523-1747.2003.12499.x","journal-title":"J Investig Dermatol"},{"issue":"3","key":"2292_CR5","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jaad.2004.08.051","volume":"52","author":"GS Chuang","year":"2005","unstructured":"Chuang GS, Martinez-Mir A, Geyer A, Engler DE, Glaser B, Cserhalmi-Friedman PB, Gordon D, Horev L, Lukash B, Herman E, Cid MP, Brenner S, Landau M, Sprecher E, Garcia Muret MP, Christiano AM, Zlotogorski A (2005) Germline fumarate hydratase mutations and evidence for a founder mutation underlying multiple cutaneous and uterine leiomyomata. J Am Acad Dermatol 52(3):410\u2013416. \n                    https:\/\/doi.org\/10.1016\/j.jaad.2004.08.051","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"2292_CR6","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1001\/archdermatol.2008.517","volume":"144","author":"L Stewart","year":"2008","unstructured":"Stewart L, Glenn GM, Stratton P, Goldstein AM, Merino MJ, Tucker MA, Linehan WM, Toro JR (2008) Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer. Arch Dermatol 144(12):1584\u20131592. \n                    https:\/\/doi.org\/10.1001\/archdermatol.2008.517","journal-title":"Arch Dermatol"},{"key":"2292_CR7","unstructured":"OMIM, \n                    http:\/\/www.omim.org\/entry\/150800"},{"issue":"4","key":"2292_CR8","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/jmg.2010.085068","volume":"48","author":"B Gardie","year":"2011","unstructured":"Gardie B, Remenieras A, Kattygnarath D, Bombled J, Lefevre S, Perrier-Trudova V, Rustin P, Barrois M, Slama A, Avril MF, Bessis D, Caron O, Caux F, Collignon P, Coupier I, Cremin C, Dollfus H, Dugast C, Escudier B, Faivre L, Field M, Gilbert-Dussardier B, Janin N, Leport Y, Leroux D, Lipsker D, Malthieu F, McGilliwray B, Maugard C, Mejean A, Mortemousque I, Plessis G, Poppe B, Pruvost-Balland C, Rooker S, Roume J, Soufir N, Steinraths M, Tan MH, Theodore C, Thomas L, Vabres P, van Glabeke E, Meric JB, Verkarre V, Lenoir G, Joulin V, Deveaux S, Cusin V, Feunteun J, Teh BT, Paillerets BBd, Richard S, on behalf of the French National Cancer Institute \"Inherited predisposition to kidney cancer\" network (2011) Novel <em>FH<\/em> mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma. J Med Genet 48(4):226\u2013234. \n                    https:\/\/doi.org\/10.1136\/jmg.2010.085068","journal-title":"J Med Genet"},{"issue":"6","key":"2292_CR9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1136\/jmg.2005.036400","volume":"43","author":"HJ Lehtonen","year":"2006","unstructured":"Lehtonen HJ, Kiuru M, Ylisaukko-Oja SK, Salovaara R, Herva R, Koivisto PA, Vierimaa O, Aittom\u00e4ki K, Pukkala E, Launonen V, Aaltonen LA (2006) Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet 43(6):523\u2013526. \n                    https:\/\/doi.org\/10.1136\/jmg.2005.036400","journal-title":"J Med Genet"},{"issue":"1","key":"2292_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1365-2230.2004.01675.x","volume":"30","author":"I Chan","year":"2005","unstructured":"Chan I, Wong T, Martinez-Mir A, Christiano AM, McGrath JA (2005) Familial multiple cutaneous and uterine leiomyomas associated with papillary renal cell cancer. Clin Exp Dermatol 30(1):75\u201378. \n                    https:\/\/doi.org\/10.1111\/j.1365-2230.2004.01675.x","journal-title":"Clin Exp Dermatol"},{"key":"2292_CR11","doi-asserted-by":"crossref","unstructured":"Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet, 2002. 30(4): p. 406\u2013410","DOI":"10.1038\/ng849"},{"issue":"3","key":"2292_CR12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrc1013","volume":"3","author":"C Eng","year":"2003","unstructured":"Eng C, Kiuru M, Fernandez MJ, Aaltonen LA (2003) A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat Rev Cancer 3(3):193\u2013202. \n                    https:\/\/doi.org\/10.1038\/nrc1013","journal-title":"Nat Rev Cancer"},{"issue":"13","key":"2292_CR13","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1158\/1078-0432.CCR-13-0304","volume":"19","author":"WM Linehan","year":"2013","unstructured":"Linehan WM, Rouault TA (2013) Molecular pathways: fumarate hydratase-deficient kidney cancer\u2014targeting the Warburg effect in cancer. Clin Cancer Res 19(13):3345\u20133352. \n                    https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-0304","journal-title":"Clin Cancer Res"},{"issue":"4","key":"2292_CR14","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1097\/PAS.0000000000000127","volume":"38","author":"AM Udager","year":"2014","unstructured":"Udager AM, Alva A, Chen YB, Siddiqui J, Lagstein A, Tickoo SK, Reuter VE, Chinnaiyian AM, Mehra R (2014) Hereditary leiomyomatosis and renal cell carcinoma (HLRCC): a rapid autopsy report of metastatic renal cell carcinoma. Am J Surg Pathol 38(4):567\u2013577. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000127","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"2292_CR15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10689-011-9428-z","volume":"10","author":"HJ Lehtonen","year":"2011","unstructured":"Lehtonen HJ (2011) Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics. Familial Cancer 10(2):397\u2013411. \n                    https:\/\/doi.org\/10.1007\/s10689-011-9428-z","journal-title":"Familial Cancer"},{"key":"2292_CR16","unstructured":"OMIM, \n                    http:\/\/www.omim.org\/entry\/185470"},{"issue":"2","key":"2292_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1001\/archderm.141.2.199","volume":"141","author":"N Alam","year":"2005","unstructured":"Alam N et al (2005) Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome. Arch Dermatol 141(2):199\u2013206. \n                    https:\/\/doi.org\/10.1001\/archderm.141.2.199","journal-title":"Arch Dermatol"},{"issue":"2","key":"2292_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cancergencyto.2008.01.010","volume":"183","author":"T Ahvenainen","year":"2008","unstructured":"Ahvenainen T, Lehtonen HJ, Lehtonen R, Vahteristo P, Aittom\u00e4ki K, Baynam G, Dommering C, Eng C, Gruber SB, Gr\u00f6nberg H, Harvima R, Herva R, Hietala M, Kujala M, K\u00e4\u00e4ri\u00e4inen H, Sunde L, Vierimaa O, Pollard PJ, Tomlinson IPM, Bj\u00f6rck E, Aaltonen LA, Launonen V (2008) Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer. Cancer Genet Cytogenet 183(2):83\u201388. \n                    https:\/\/doi.org\/10.1016\/j.cancergencyto.2008.01.010","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"2292_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1086\/376435","volume":"73","author":"JR Toro","year":"2003","unstructured":"Toro JR, Nickerson ML, Wei MH, Warren MB, Glenn GM, Turner ML, Stewart L, Duray P, Tourre O, Sharma N, Choyke P, Stratton P, Merino M, Walther MCM, Linehan WM, Schmidt LS, Zbar B (2003) Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. Am J Hum Genet 73(1):95\u2013106. \n                    https:\/\/doi.org\/10.1086\/376435","journal-title":"Am J Hum Genet"},{"issue":"1","key":"2292_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/PAS.0b013e31825ec16f","volume":"37","author":"J Sanz-Ortega","year":"2013","unstructured":"Sanz-Ortega J, Vocke C, Stratton P, Linehan WM, Merino MJ (2013) Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome. Am J Surg Pathol 37(1):74\u201380. \n                    https:\/\/doi.org\/10.1097\/PAS.0b013e31825ec16f","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"2292_CR21","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1097\/PAS.0b013e318223ca01","volume":"35","author":"K Garg","year":"2011","unstructured":"Garg K, Tickoo SK, Soslow RA, Reuter VE (2011) Morphologic features of uterine leiomyomas associated with hereditary leiomyomatosis and renal cell carcinoma syndrome: a case report. Am J Surg Pathol 35(8):1235\u20131237. \n                    https:\/\/doi.org\/10.1097\/PAS.0b013e318223ca01","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"2292_CR22","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1097\/PAS.0000000000000520","volume":"39","author":"NM Joseph","year":"2015","unstructured":"Joseph NM, Solomon DA, Frizzell N, Rabban JT, Zaloudek C, Garg K (2015) Morphology and immunohistochemistry for 2SC and FH aid in detection of fumarate hydratase gene aberrations in uterine leiomyomas from young patients. Am J Surg Pathol 39(11):1529\u20131539. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000520","journal-title":"Am J Surg Pathol"},{"key":"2292_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2147\/IJNRD.S42097","volume":"7","author":"LS Schmidt","year":"2014","unstructured":"Schmidt LS, Linehan WM (2014) Hereditary leiomyomatosis and renal cell carcinoma. Int J Nephrol Renov Dis 7:253\u2013260","journal-title":"Int J Nephrol Renov Dis"},{"issue":"10","key":"2292_CR24","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1097\/PAS.0b013e31804375b8","volume":"31","author":"MJ Merino","year":"2007","unstructured":"Merino MJ, Torres-Cabala C, Pinto P, Marston Linehan W (2007) The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Am J Surg Pathol 31(10):1578\u20131585. \n                    https:\/\/doi.org\/10.1097\/PAS.0b013e31804375b8","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"2292_CR25","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1097\/PAS.0000000000000703","volume":"40","author":"M Miettinen","year":"2016","unstructured":"Miettinen M, Felisiak-Golabek A, Wasag B, Chmara M, Wang Z, Butzow R, Lasota J (2016) Fumarase-deficient uterine leiomyomas: an immunohistochemical, molecular genetic, and clinicopathologic study of 86 cases. Am J Surg Pathol 40(12):1661\u20131669. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000703","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"2292_CR26","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1038\/modpathol.2017.56","volume":"30","author":"JA Bennett","year":"2017","unstructured":"Bennett JA, Weigelt B, Chiang S, Selenica P, Chen YB, Bialik A, Bi R, Schultheis AM, Lim RS, Ng CKY, Morales-Oyarvide V, Young RH, Reuter VE, Soslow RA, Oliva E (2017) Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases. Mod Pathol 30(10):1476\u20131488. \n                    https:\/\/doi.org\/10.1038\/modpathol.2017.56","journal-title":"Mod Pathol"},{"issue":"1","key":"2292_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0672-1","volume":"16","author":"N M\u00e4kinen","year":"2017","unstructured":"M\u00e4kinen N, K\u00e4mpj\u00e4rvi K, Frizzell N, B\u00fctzow R, Vahteristo P (2017) Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors. Mol Cancer 16(1):101. \n                    https:\/\/doi.org\/10.1186\/s12943-017-0672-1","journal-title":"Mol Cancer"},{"issue":"5","key":"2292_CR28","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1097\/PAS.0000000000000163","volume":"38","author":"Y-B Chen","year":"2014","unstructured":"Chen Y-B, Brannon AR, Toubaji A, Dudas ME, Won HH, al-Ahmadie HA, Fine SW, Gopalan A, Frizzell N, Voss MH, Russo P, Berger MF, Tickoo SK, Reuter VE (2014) Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. Am J Surg Pathol 38(5):627\u2013637. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000163","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"2292_CR29","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1097\/PAS.0000000000000626","volume":"40","author":"B Buelow","year":"2016","unstructured":"Buelow B, Cohen J, Nagymanyoki Z, Frizzell N, Joseph NM, McCalmont T, Garg K (2016) Immunohistochemistry for 2-succinocysteine (2SC) and fumarate hydratase (FH) in cutaneous leiomyomas may aid in identification of patients with HLRCC (hereditary leiomyomatosis and renal cell carcinoma syndrome). Am J Surg Pathol 40(7):982\u2013988. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000626","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"2292_CR30","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1097\/DAD.0000000000000580","volume":"38","author":"M Llamas-Velasco","year":"2016","unstructured":"Llamas-Velasco M, Requena L, Adam J, Frizzell N, Hartmann A, Mentzel T (2016) Loss of fumarate hydratase and aberrant protein succination detected with S-(2-Succino)-cysteine staining to identify patients with multiple cutaneous and uterine leiomyomatosis and hereditary leiomyomatosis and renal cell cancer syndrome. Am J Dermatopathol 38(12):887\u2013891. \n                    https:\/\/doi.org\/10.1097\/DAD.0000000000000580","journal-title":"Am J Dermatopathol"},{"issue":"2","key":"2292_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s00428-015-1783-y","volume":"467","author":"P Martinek","year":"2015","unstructured":"Martinek P et al (2015) Genetic testing of leiomyoma tissue in women younger than 30 years old might provide an effective screening approach for the hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC). Virchows Arch 467(2):185\u2013191. \n                    https:\/\/doi.org\/10.1007\/s00428-015-1783-y","journal-title":"Virchows Arch"},{"issue":"5","key":"2292_CR32","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/PAS.0000000000000573","volume":"40","author":"WJ Harrison","year":"2016","unstructured":"Harrison WJ, Andrici J, Maclean F, Madadi-Ghahan R, Farzin M, Sioson L, Toon CW, Clarkson A, Watson N, Pickett J, Field M, Crook A, Tucker K, Goodwin A, Anderson L, Srinivasan B, Grossmann P, Martinek P, Ondi\u010d O, Hes O, Trpkov K, Clifton-Bligh RJ, Dwight T, Gill AJ (2016) Fumarate hydratase-deficient uterine leiomyomas occur in both the syndromic and sporadic settings. Am J Surg Pathol 40(5):599\u2013607. \n                    https:\/\/doi.org\/10.1097\/PAS.0000000000000573","journal-title":"Am J Surg Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-018-2292-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-018-2292-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-018-2292-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T07:21:21Z","timestamp":1547450481000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-018-2292-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,13]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["2292"],"URL":"https:\/\/doi.org\/10.1007\/s00428-018-2292-6","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,13]]},"assertion":[{"value":"6 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors confirm that the study has been performed in accordance with accepted principles of ethical and professional conduct for biomedical scientific research. Approval of the local academic ethics committee of the Friedrich-Alexander University Erlangen-N\u00fcrnberg (FAU) was obtained (ref. number 129_16Bc).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}