{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:07:39Z","timestamp":1773695259227,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00428-018-2330-4","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T09:30:25Z","timestamp":1520415025000},"page":"667-675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Histological activity score on baseline liver biopsy can predict non-response to steroids in patients with severe alcoholic hepatitis"],"prefix":"10.1007","volume":"472","author":[{"given":"Saggere Muralikrishna","family":"Shasthry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Vijayaraghavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"issue":"11","key":"2330_CR1","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1111\/j.1572-0241.1998.00587.x","volume":"93","author":"AJ McCullough","year":"1998","unstructured":"McCullough AJ, O'Connor JF (1998) Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 93(11):2022\u20132036","journal-title":"Am J Gastroenterol"},{"issue":"8981","key":"2330_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0140-6736(95)91685-7","volume":"346","author":"MR Teli","year":"1995","unstructured":"Teli MR, Day CP, Burt AD, Bennett MK, James OF (1995) Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 346(8981):987\u2013990","journal-title":"Lancet"},{"key":"2330_CR3","first-page":"70","volume":"225","author":"RP Adang","year":"1998","unstructured":"Adang RP, Wensing JW, Stockbr\u00fcgger RW (1998) Alcohol consumption and alcohol-related liver disease in the Netherlands. Scand J Gastroenterol Suppl 225:70\u201374","journal-title":"Scand J Gastroenterol Suppl"},{"key":"2330_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1365-2036.2004.01881.x","volume":"19","author":"S Tome","year":"2004","unstructured":"Tome S, Lucey MR (2004) Review article: Current management of alcoholic liver disease. Aliment Pharmacol Ther 19:707\u2013714","journal-title":"Aliment Pharmacol Ther"},{"key":"2330_CR5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0016-5085(78)90401-8","volume":"75","author":"WC Maddrey","year":"1978","unstructured":"Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr (1978) Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 75:193\u2013199","journal-title":"Gastroenterology"},{"key":"2330_CR6","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1136\/gut.2004.050781","volume":"54","author":"EH Forrest","year":"2005","unstructured":"Forrest EH, Evans CD, Stewart S, Phillips M, Oo YH, McAvoy N, Fisher NC, Singhal S, Brind A, Haydon G, O'Grady J, Day CP, Hayes PC, Murray LS, Morris AJ (2005) Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. Gut 54:1174\u20131179","journal-title":"Gut"},{"key":"2330_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1053\/j.gastro.2009.04.062","volume":"137","author":"A Louvet","year":"2009","unstructured":"Louvet A, Wartel F, Mathurin P et al (2009) Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor. Gastroenterology 137:541\u2013548","journal-title":"Gastroenterology"},{"key":"2330_CR8","doi-asserted-by":"publisher","first-page":"255e260","DOI":"10.1136\/gut.2010.224097","volume":"60","author":"P Mathurin","year":"2011","unstructured":"Mathurin P, O\u2019Grady J, Morgan TR et al (2011) Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 60:255e260","journal-title":"Gut"},{"issue":"6","key":"2330_CR9","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1002\/hep.21607","volume":"45","author":"A Louvet","year":"2007","unstructured":"Louvet A, Naveau S, Mathurin P et al (2007) The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 45(6):1348\u20131354","journal-title":"Hepatology"},{"issue":"5","key":"2330_CR10","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.jhep.2011.02.021","volume":"55","author":"RP Mookerjee","year":"2011","unstructured":"Mookerjee RP, Lackner C, Jalan R, Lackner C, Stauber R, Stadlbauer V, Deheragoda M, Aigelsreiter A, Jalan R (2011) The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis. J Hepatol 55(5):1103\u20131111","journal-title":"J Hepatol"},{"issue":"5","key":"2330_CR11","doi-asserted-by":"publisher","first-page":"1231-9.e1-6","DOI":"10.1053\/j.gastro.2014.01.018","volume":"146","author":"J Altamirano","year":"2014","unstructured":"Altamirano J, Miquel R, Katoonizadeh A et al (2014) A histologic scoring system for prognosis of patients with alcoholic hepatitis. Gastroenterology 146(5):1231-9.e1-6","journal-title":"Gastroenterology"},{"key":"2330_CR12","doi-asserted-by":"publisher","unstructured":"Rastogi A, Kumar A, Sarin SK et al (2011) Liver histology as predictor of outcome in patients with acute-on-chronic liver failure (ACLF). Virchows Arch 459(2):121\u2013127. https:\/\/doi.org\/10.1007\/s00428-011-1115-9","DOI":"10.1007\/s00428-011-1115-9"},{"issue":"26","key":"2330_CR13","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1056\/NEJMra0805786","volume":"360","author":"MR Lucey","year":"2009","unstructured":"Lucey MR, Mathurin P, Morgan TR (2009) Alcoholic hepatitis. N Engl J Med. 360(26):2758\u20132769","journal-title":"N Engl J Med."},{"key":"2330_CR14","doi-asserted-by":"crossref","unstructured":"Bone RC, Balk RA, Cerra FB et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. Chest 101(6):1644\u20131655","DOI":"10.1378\/chest.101.6.1644"},{"issue":"2","key":"2330_CR15","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s12072-010-9236-9","volume":"5","author":"Asian Pacific Association for the Study of the Liver (APASL) Working Party on Portal Hypertension","year":"2011","unstructured":"Asian Pacific Association for the Study of the Liver (APASL) Working Party on Portal Hypertension (2011) Diagnosis and management of acute variceal bleeding: Asian Pacific Association for Study of the liver recommendations. Hepatol Int 5(2):607\u2013624","journal-title":"Hepatol Int"},{"issue":"3","key":"2330_CR16","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1053\/j.gastro.2011.11.027","volume":"142","author":"V Garg","year":"2012","unstructured":"Garg V, Garg H, Khan A, Trehanpati N, Kumar A, Sharma BC, Sakhuja P, Sarin SK (2012) Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure. Gastroenterology 142(3):505\u2013512 e1","journal-title":"Gastroenterology"},{"issue":"1","key":"2330_CR17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1471-230X-13-55","volume":"13","author":"T Hardy","year":"2013","unstructured":"Hardy T, Wells C, Stewart SF et al (2013) White cell count and platelet count associate with histological alcoholic hepatitis in jaundiced harmful drinkers. BMC Gastroenterol 13(1):55. https:\/\/doi.org\/10.1186\/1471-230X-13-55","journal-title":"BMC Gastroenterol"},{"issue":"3","key":"2330_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1055\/s-2008-1040605","volume":"6","author":"RN MacSween","year":"1986","unstructured":"MacSween RN, Burt AD (1986) Histologic spectrum of alcoholic liver disease. Semin Liver Dis 6(3):221\u2013232","journal-title":"Semin Liver Dis"},{"key":"2330_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/hep.23258","volume":"51","author":"RS O\u2019Shea","year":"2010","unstructured":"O\u2019Shea RS, Dasarathy S, McCullough AJ (2010) Alcoholic liver disease, practice guidelines. Hepatology 51:307\u2013332","journal-title":"Hepatology"},{"issue":"4","key":"2330_CR20","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","volume":"12","author":"A Louvet","year":"2015","unstructured":"Louvet A, Mathurin P (2015) Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol 12(4):231\u2013242","journal-title":"Nat Rev Gastroenterol Hepatol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-018-2330-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-018-2330-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-018-2330-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T06:12:20Z","timestamp":1570860740000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-018-2330-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["2330"],"URL":"https:\/\/doi.org\/10.1007\/s00428-018-2330-4","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,7]]},"assertion":[{"value":"5 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Institutional review board acceptance was sought before enrolling the patients and the current study is part of the registered trial NCT01820208.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}