{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:21:14Z","timestamp":1777645274523,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00428-019-02634-5","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T10:47:54Z","timestamp":1564742874000},"page":"727-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Molecular profiling of clear cell adenocarcinoma of the urinary tract"],"prefix":"10.1007","volume":"475","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-3234","authenticated-orcid":false,"given":"Chieh-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Stehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Zehnder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin A.","family":"Pinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Kunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"2634_CR1","first-page":"790235","volume":"2015","author":"AK Venyo","year":"2015","unstructured":"Venyo AK (2015) Clear cell adenocarcinoma of the urethra: review of the literature. Int J Surg Oncol 2015:790235","journal-title":"Int J Surg Oncol"},{"key":"2634_CR2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.5858\/133.6.987","volume":"133","author":"AJ Adeniran","year":"2009","unstructured":"Adeniran AJ, Tamboli P (2009) Clear cell adenocarcinoma of the urinary bladder: a short review. Arch Pathol Lab Med 133:987\u2013991","journal-title":"Arch Pathol Lab Med"},{"key":"2634_CR3","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/00000478-200202000-00005","volume":"26","author":"E Oliva","year":"2002","unstructured":"Oliva E, Amin MB, Jimenez R, Young RH (2002) Clear cell carcinoma of the urinary bladder: a report and comparison of four tumors of mullerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. Am J Surg Pathol 26:190\u2013197","journal-title":"Am J Surg Pathol"},{"key":"2634_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4103\/0974-7796.84962","volume":"3","author":"S Sethi","year":"2011","unstructured":"Sethi S, Dhawan S, Chopra P (2011) Clear cell adenocarcinoma of urinary bladder: a case report and review. Urol Ann 3:151\u2013154","journal-title":"Urol Ann"},{"key":"2634_CR5","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1097\/PAS.0b013e31816b1020","volume":"32","author":"GX Tong","year":"2008","unstructured":"Tong GX, Weeden EM, Hamele-Bena D, Huan Y, Unger P, Memeo L, O\u2019Toole K (2008) Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis? Am J Surg Pathol 32:1380\u20131387","journal-title":"Am J Surg Pathol"},{"key":"2634_CR6","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.humpath.2009.10.011","volume":"41","author":"M Herawi","year":"2010","unstructured":"Herawi M, Drew PA, Pan CC, Epstein JI (2010) Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma. Hum Pathol 41:594\u2013601","journal-title":"Hum Pathol"},{"key":"2634_CR7","first-page":"225","volume":"6","author":"PJ Chor","year":"1993","unstructured":"Chor PJ, Gaum LD, Young RH (1993) Clear cell adenocarcinoma of the urinary bladder: report of a case of probable mullerian origin. Mod Pathol 6:225\u2013228","journal-title":"Mod Pathol"},{"key":"2634_CR8","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3109\/01443615.2015.1004526","volume":"35","author":"V Loizzi","year":"2015","unstructured":"Loizzi V, Cormio G, Leone L, Falagario M, Longo S, Resta L, Selvaggi L (2015) A rare case of primary clear-cell adenocarcinoma of the bladder arising from bladder endometriosis. J Obstet Gynaecol 35:758\u2013760","journal-title":"J Obstet Gynaecol"},{"key":"2634_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.humpath.2005.09.013","volume":"37","author":"A Hartmann","year":"2006","unstructured":"Hartmann A, Junker K, Dietmaier W, Schroder S, Lopez D, Hofstadter F, Blaszyk H (2006) Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma. Hum Pathol 37:117\u2013120","journal-title":"Hum Pathol"},{"key":"2634_CR10","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1158\/1078-0432.CCR-07-4147","volume":"14","author":"MT Sung","year":"2008","unstructured":"Sung MT, Zhang S, MacLennan GT, Lopez-Beltran A, Montironi R, Wang M, Tan PH, Cheng L (2008) Histogenesis of clear cell adenocarcinoma in the urinary tract: evidence of urothelial origin. Clin Cancer Res 14:1947\u20131955","journal-title":"Clin Cancer Res"},{"key":"2634_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1477-7819-10-33","volume":"10","author":"J Lu","year":"2012","unstructured":"Lu J, Xu Z, Jiang F, Wang Y, Hou Y, Wang C, Chen Q (2012) Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review. World J Surg Oncol 10:33","journal-title":"World J Surg Oncol"},{"key":"2634_CR12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.5114\/jcb.2015.52316","volume":"7","author":"S Lewis","year":"2015","unstructured":"Lewis S, Pal M, Bakshi G, Ghadi YG, Menon S, Murthy V, Mahantshetty U (2015) High-dose-rate brachytherapy - a novel treatment approach for primary clear cell adenocarcinoma of male urethra. J Contemp Brachytherapy 7:248\u2013251","journal-title":"J Contemp Brachytherapy"},{"key":"2634_CR13","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/S0046-8177(98)90015-6","volume":"29","author":"MZ Gilcrease","year":"1998","unstructured":"Gilcrease MZ, Delgado R, Vuitch F, Albores-Saavedra J (1998) Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison. Hum Pathol 29:1451\u20131456","journal-title":"Hum Pathol"},{"key":"2634_CR14","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ajpath.2013.11.023","volume":"184","author":"R Mehra","year":"2014","unstructured":"Mehra R, Vats P, Kalyana-Sundaram S, Udager AM, Roh M, Alva A, Pan J, Lonigro RJ, Siddiqui J, Weizer A, Lee C, Cao X, Wu YM, Robinson DR, Dhanasekaran SM, Chinnaiyan AM (2014) Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. Am J Pathol 184:584\u2013591","journal-title":"Am J Pathol"},{"key":"2634_CR15","doi-asserted-by":"crossref","unstructured":"Yang SR, Lin CY, Stehr H, Long SR, Kong CS, Berry GJ, Zehnder JL, Kunder CA (2017) Comprehensive genomic profiling of malignant effusions in patients with metastatic lung adenocarcinoma. J Mol Diagn","DOI":"10.1016\/j.jmoldx.2017.10.007"},{"key":"2634_CR16","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1128\/JCM.02315-16","volume":"55","author":"SK Tan","year":"2017","unstructured":"Tan SK, Milligan S, Sahoo MK, Taylor N, Pinsky BA (2017) Calibration of BK virus nucleic acid amplification testing to the 1st WHO international standard for BK virus. J Clin Microbiol 55:923\u2013930","journal-title":"J Clin Microbiol"},{"key":"2634_CR17","doi-asserted-by":"crossref","unstructured":"Saleem A, Brown RA, Higgins JPT, Troxell ML, Kunder CA, Pinsky BA, Zambrano E, Kao C-S (2018) A case report of pediatric clear cell carcinoma of the urinary bladder associated with polyomavirus. AJSP: Rev Rep","DOI":"10.1097\/PCR.0000000000000284"},{"key":"2634_CR18","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1038\/ncomms3185","volume":"4","author":"J Vinagre","year":"2013","unstructured":"Vinagre J, Almeida A, Populo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R, Prazeres H, Lima L, Melo M, da Rocha AG, Preto A, Castro P, Castro L, Pardal F, Lopes JM, Santos LL, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simoes M, Lima J, Maximo V, Soares P (2013) Frequency of TERT promoter mutations in human cancers. Nat Commun 4:2185","journal-title":"Nat Commun"},{"key":"2634_CR19","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nrc1753","volume":"5","author":"AG Bader","year":"2005","unstructured":"Bader AG, Kang S, Zhao L, Vogt PK (2005) Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5:921\u2013929","journal-title":"Nat Rev Cancer"},{"key":"2634_CR20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/sj.bjc.6602970","volume":"94","author":"B Karakas","year":"2006","unstructured":"Karakas B, Bachman KE, Park BH (2006) Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 94:455\u2013459","journal-title":"Br J Cancer"},{"key":"2634_CR21","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrclinonc.2018.28","volume":"15","author":"F Janku","year":"2018","unstructured":"Janku F, Yap TA, Meric-Bernstam F (2018) Targeting the PI3K pathway in cancer: are we making headway? Nat Rev Clin Oncol 15:273\u2013291","journal-title":"Nat Rev Clin Oncol"},{"key":"2634_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrc3860","volume":"15","author":"LM Thorpe","year":"2015","unstructured":"Thorpe LM, Yuzugullu H, Zhao JJ (2015) PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer 15:7\u201324","journal-title":"Nat Rev Cancer"},{"key":"2634_CR23","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/onc.2017.377","volume":"37","author":"GG Jinesh","year":"2018","unstructured":"Jinesh GG, Sambandam V, Vijayaraghavan S, Balaji K, Mukherjee S (2018) Molecular genetics and cellular events of K-Ras-driven tumorigenesis. Oncogene 37:839\u2013846","journal-title":"Oncogene"},{"key":"2634_CR24","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/nrc3106","volume":"11","author":"Y Pylayeva-Gupta","year":"2011","unstructured":"Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D (2011) RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 11:761\u2013774","journal-title":"Nat Rev Cancer"},{"key":"2634_CR25","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2147\/OTT.S89967","volume":"9","author":"C Massacesi","year":"2016","unstructured":"Massacesi C, Di Tomaso E, Urban P, Germa C, Quadt C, Trandafir L, Aimone P, Fretault N, Dharan B, Tavorath R, Hirawat S (2016) PI3K inhibitors as new cancer therapeutics: implications for clinical trial design. Onco Targets Ther 9:203\u2013210","journal-title":"Onco Targets Ther"},{"key":"2634_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.semcancer.2017.04.015","volume":"48","author":"JS O\u2019Donnell","year":"2018","unstructured":"O\u2019Donnell JS, Massi D, Teng MWL, Mandala M (2018) PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux. Semin Cancer Biol 48:91\u2013103","journal-title":"Semin Cancer Biol"},{"key":"2634_CR27","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1200\/JCO.2011.36.1196","volume":"30","author":"F Janku","year":"2012","unstructured":"Janku F, Wheler JJ, Westin SN, Moulder SL, Naing A, Tsimberidou AM, Fu S, Falchook GS, Hong DS, Garrido-Laguna I, Luthra R, Lee JJ, Lu KH, Kurzrock R (2012) PI3K\/AKT\/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 30:777\u2013782","journal-title":"J Clin Oncol"},{"key":"2634_CR28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.humpath.2015.09.021","volume":"48","author":"L Yan","year":"2016","unstructured":"Yan L, Salama ME, Lanciault C, Matsumura L, Troxell ML (2016) Polyomavirus large T antigen is prevalent in urothelial carcinoma post-kidney transplant. Hum Pathol 48:122\u2013131","journal-title":"Hum Pathol"},{"key":"2634_CR29","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/nature12965","volume":"507","author":"Cancer Genome Atlas Research N","year":"2014","unstructured":"Cancer Genome Atlas Research N (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507:315\u2013322","journal-title":"Nature"},{"key":"2634_CR30","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/cncr.29826","volume":"122","author":"JS Ross","year":"2016","unstructured":"Ross JS, Wang K, Khaira D, Ali SM, Fisher HA, Mian B, Nazeer T, Elvin JA, Palma N, Yelensky R, Lipson D, Miller VA, Stephens PJ, Subbiah V, Pal SK (2016) Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations. Cancer 122:702\u2013711","journal-title":"Cancer"},{"key":"2634_CR31","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.2353\/ajpath.2009.081000","volume":"174","author":"KT Kuo","year":"2009","unstructured":"Kuo KT, Mao TL, Jones S, Veras E, Ayhan A, Wang TL, Glas R, Slamon D, Velculescu VE, Kuman RJ, Shih IM (2009) Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am J Pathol 174:1597\u20131601","journal-title":"Am J Pathol"},{"key":"2634_CR32","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.ygyno.2006.05.029","volume":"103","author":"D Mayr","year":"2006","unstructured":"Mayr D, Hirschmann A, Lohrs U, Diebold J (2006) KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants. Gynecol Oncol 103:883\u2013887","journal-title":"Gynecol Oncol"},{"key":"2634_CR33","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/gcc.22507","volume":"57","author":"Y Shibuya","year":"2018","unstructured":"Shibuya Y, Tokunaga H, Saito S, Shimokawa K, Katsuoka F, Bin L, Kojima K, Nagasaki M, Yamamoto M, Yaegashi N, Yasuda J (2018) Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing. Genes Chromosomes Cancer 57:51\u201360","journal-title":"Genes Chromosomes Cancer"},{"key":"2634_CR34","doi-asserted-by":"publisher","first-page":"15266","DOI":"10.18632\/oncotarget.24555","volume":"9","author":"A Morikawa","year":"2018","unstructured":"Morikawa A, Hayashi T, Shimizu N, Kobayashi M, Taniue K, Takahashi A, Tachibana K, Saito M, Kawabata A, Iida Y, Ueda K, Saito M, Yanaihara N, Tanabe H, Yamada K, Takano H, Nureki O, Okamoto A, Akiyama T (2018) PIK3CA and KRAS mutations in cell free circulating DNA are useful markers for monitoring ovarian clear cell carcinoma. Oncotarget 9:15266\u201315274","journal-title":"Oncotarget"},{"key":"2634_CR35","doi-asserted-by":"publisher","unstructured":"Reis H, van der Vos KE, Niedworok C, Herold T, M\u00f3dos O, Szendr\u0151i A, Hager T, Ingenwerth M, Vis DJ, Behrendt MA, de Jong J, van der Heijden MS, Peyronnet B, Mathieu R, Wiesweg M, Ablat J, Okon K, Tolkach Y, Keresztes D, Nagy N, Bremmer F, Gaisa NT, Chlosta P, Kriegsmann J, Kovalszky I, Timar J, Kristiansen G, Radzun HJ, Kn\u00fcchel R, Schuler M, Black PC, R\u00fcbben H, Hadaschik BA, Schmid KW, van Rhijn BWG, Nyir\u00e1dy P, Szarvas T (2018) Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas. Int J Cancer. https:\/\/doi.org\/10.1002\/ijc.31547 [Epub ahead of print] PubMed PMID: 29672836.","DOI":"10.1002\/ijc.31547"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02634-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-019-02634-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02634-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T01:46:26Z","timestamp":1664070386000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-019-02634-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2634"],"URL":"https:\/\/doi.org\/10.1007\/s00428-019-02634-5","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,2]]},"assertion":[{"value":"26 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Author C. A. Kunder\u2019s spouse is an employee of Genentech. Other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}