{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:05:41Z","timestamp":1791432341145,"version":"4.3.3"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00428-019-02652-3","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T07:02:55Z","timestamp":1568012575000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["What\u2019s new in adipocytic neoplasia?"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-1673","authenticated-orcid":false,"given":"David","family":"Creytens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"2652_CR1","volume-title":"Tumours of Soft Tissue and Bone","author":"CDM Fletcher","year":"2013","unstructured":"Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (2013) World Health Organization Classification of Tumours. Pathology and Genetics. In: Tumours of Soft Tissue and Bone. IARC, Lyon"},{"key":"2652_CR2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/his.12267","volume":"64","author":"CDM Fletcher","year":"2014","unstructured":"Fletcher CDM (2014) The evolving classification of soft tissue tumours\u2014an update based on the new 2013 WHO classification. Histopathology 64:2\u201311","journal-title":"Histopathology"},{"key":"2652_CR3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/his.12311","volume":"64","author":"AP Dei Tos","year":"2014","unstructured":"Dei Tos AP (2014) Liposarcomas: diagnostic pitfalls and new insights. Histopathology 64:38\u201352","journal-title":"Histopathology"},{"key":"2652_CR4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00428-009-0815-x","volume":"456","author":"JM Coindre","year":"2010","unstructured":"Coindre JM, P\u00e9deutour F, Aurias A (2010) Well-differentiated and dedifferentiated liposarcomas. Virchows Arch 456:167\u2013179","journal-title":"Virchows Arch"},{"key":"2652_CR5","volume-title":"Tumours of Soft Tissue and Bone","author":"CDM Fletcher","year":"2002","unstructured":"Fletcher CDM, Unni KK, Mertens F (2002) World Health Organization Classification of Tumours. Pathology and Genetics. In: Tumours of Soft Tissue and Bone. IARC, Lyon"},{"key":"2652_CR6","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/PAS.0b013e3181e5dc49","volume":"34","author":"A Marino-Enriquez","year":"2010","unstructured":"Marino-Enriquez A, Fletcher CDM, Dal Cin P, Hornick JL (2010) Dedifferentiated liposarcoma with \u201chomologous\u201d lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol 34:1122\u20131131","journal-title":"Am J Surg Pathol"},{"key":"2652_CR7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/PAS.0b013e3181dbf2f7","volume":"34","author":"JM Boland","year":"2010","unstructured":"Boland JM, Weiss SW, Oliveira AM, Erickson-Johnson ML, Folpe AL (2010) Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases. Am J Surg Pathol 34:837\u2013843","journal-title":"Am J Surg Pathol"},{"key":"2652_CR8","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00000478-199409000-00006","volume":"18","author":"AP Dei Tos","year":"1994","unstructured":"Dei Tos AP, Mentzel T, Newman PL, Fletcher CD (1994) Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. Am J Surg Pathol 18:913\u2013921","journal-title":"Am J Surg Pathol"},{"key":"2652_CR9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/00313029800169066","volume":"30","author":"PW Allen","year":"1998","unstructured":"Allen PW, Strungs I, MacCormac LB (1998) Atypical subcutaneous fatty tumors: a review of 37 referred cases. Pathology 30:123\u2013135","journal-title":"Pathology"},{"key":"2652_CR10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1053\/adpa.2001.27911","volume":"5","author":"YC Cai","year":"2001","unstructured":"Cai YC, McMenamin ME, Rose G, Sandy CJ, Cree IA, Fletcher CD (2001) Primary liposarcoma of the orbit: a clinicopathologic study of seven cases. Ann Diagn Pathol 5:255\u2013266","journal-title":"Ann Diagn Pathol"},{"key":"2652_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/adpa.2002.32375","volume":"6","author":"AF Nascimento","year":"2002","unstructured":"Nascimento AF, McMenamin ME, Fletcher CD (2002) Liposarcomas\/atypical lipomatous tumors of the oral cavity: a clinicopathologic study of 23 cases. Ann Diagn Pathol 6:83\u201393","journal-title":"Ann Diagn Pathol"},{"key":"2652_CR12","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00428-004-1138-6","volume":"446","author":"T Mentzel","year":"2005","unstructured":"Mentzel T, Toenissen J, Rutten A, Schaller J (2005) Palmar atypical lipomatous tumor with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch 446:300\u2013304","journal-title":"Virchows Arch"},{"key":"2652_CR13","first-page":"70A","volume":"8","author":"AF Nascimento","year":"2005","unstructured":"Nascimento AF, Fletcher CDM (2005) Spindle cell liposarcoma\/atypical lipomatous tumor. A clinicopathologic study of 120 cases. Mod Pathol 8:70A","journal-title":"Mod Pathol"},{"issue":"2","key":"2652_CR14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PAS.0000000000000770","volume":"41","author":"A Marino-Enriquez","year":"2017","unstructured":"Marino-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CDM (2017) Atypical spindle cell lipomatous tumor: clnicopathologic characterization of 232 cases demonstrating a morphologic spectrum. Am J Surg Pathol 41(2):234\u2013244","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"2652_CR15","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1097\/PAS.0000000000000936","volume":"41","author":"D Creytens","year":"2017","unstructured":"Creytens D, Mentzel T, Ferdinande L, Lecoutere E, van Gorp J, Atanesyan L, de Groot K, Savola S, Van Roy N, Van Dorpe J, Flucke U (2017) \u201cAtypical\u201d pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical and molecular study of 21 cases, emphasizing its relationship to atypical spindle cell lipomatous tumor and suggesting a morphologic spectrum (\u2018atypical spindle cell\/pleomorphic lipomatous tumor\u2019). Am J Surg Pathol 41(11):1443\u20131455","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"2652_CR16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/PAS.0b013e3181963c9c","volume":"33","author":"R Alaggio","year":"2009","unstructured":"Alaggio R, Coffin CM, Weiss SW, Bridge JA, Issakov J, Oliveira AM, Folpe AL (2009) Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Am J Surg Pathol 33(5):645\u2013658","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"2652_CR17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/modpathol.2010.66","volume":"23","author":"T Mentzel","year":"2010","unstructured":"Mentzel T, Palmedo G, Kuhnen C (2010) Well-differentiated spindle cell liposarcoma (\u2018atypical spindle cell lipomatous tumor\u2019) does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical analysis of six cases. Mod Pathol 23(5):729\u2013736","journal-title":"Mod Pathol"},{"issue":"9","key":"2652_CR18","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/PAS.0b013e31829562ed","volume":"37","author":"AT Deyrup","year":"2013","unstructured":"Deyrup AT, Chibon F, Guillou L, Lagarde P, Coindre JM, Weiss SW (2013) Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. Am J Surg Pathol 37(9):1373\u20131378","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2652_CR19","first-page":"97","volume":"465","author":"D Creytens","year":"2014","unstructured":"Creytens D, van Gorp J, Savola S, Ferdinande L, Mentzel T, Libbrecht L (2014) Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. Virchows Arch 465(1):97\u2013108","journal-title":"Virchows Arch"},{"issue":"10","key":"2652_CR20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/pin.12719","volume":"68","author":"B Bahadir","year":"2018","unstructured":"Bahadir B, Behzatoglu K, Hacihasanoglu E, Koca SB, Sigirci BB, Tokat F (2018) Atypical spindle cell\/pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical, and molecular study of 20 cases. Pathol Int 68(10):550\u2013556","journal-title":"Pathol Int"},{"issue":"6","key":"2652_CR21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/jclinpath-2017-204975","volume":"71","author":"AJ McCarthy","year":"2018","unstructured":"McCarthy AJ, Chetty R (2018) Tumours of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component. J Clin Pathol 71(6):483\u2013492","journal-title":"J Clin Pathol"},{"key":"2652_CR22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.humpath.2017.11.023","volume":"74","author":"D Creytens","year":"2018","unstructured":"Creytens D, Mentzel T, Ferdinande L, van Gorp J, Van Dorpe J, Flucke U (2018) Atypical multivacuolated lipoblasts and atypical mitoses are not compatible with the diagnosis of spindle cell\/pleomorphic lipoma. Hum Pathol 74:188\u2013189","journal-title":"Hum Pathol"},{"key":"2652_CR23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.humpath.2018.04.032","volume":"81","author":"D Creytens","year":"2018","unstructured":"Creytens D, Mentzel T, Ferdinande L, van Gorp J, Van Dorpe J, Flucke U (2018) Atypical mitoses are present in otherwise classical pleomorphic lipomas\u2014reply. Hum Pathol 81:300\u2013302","journal-title":"Hum Pathol"},{"issue":"2","key":"2652_CR24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/PAS.0000000000001156","volume":"43","author":"D Creytens","year":"2019","unstructured":"Creytens D, Mentzel T, Ferdinande L, van Gorp J, Van Dorpe J, Flucke U (2019) \u201cFat-rich\u201d (spindle cell-poor) variants of atypical spindle cell lipomatous tumors show similar morphologic, immunohistochemical and molecular features as \u201cdysplastic lipomas\u201d: are they related lesions? Comment on Michal et al (2018). Am J Surg Pathol 43(2):288\u2013289","journal-title":"Am J Surg Pathol"},{"key":"2652_CR25","doi-asserted-by":"crossref","unstructured":"Creytens D, Mentzel T, Ferdinande L, van Gorp J, Van Dorpe J, Flucke U (2019) \u201cFat-rich\u201d (spindle cell-poor) variant of atypical spindle cell\/pleomorphic lipomatous tumor: striking mimic of \u201cclassical\u201d atypical lipomatous tumor\/well-differentiated liposarcoma. Int J Surg Pathol Epub ahead of print:106689691984656","DOI":"10.1177\/1066896919846561"},{"key":"2652_CR26","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1097\/PAS.0000000000001129","volume":"4211","author":"M Michal","year":"2018","unstructured":"Michal M, Agaimy A, Contreras AL, Svajdler M, Kazakov DV, Steiner P, Grossmann P, Martinek P, Hadravsky L, Michalova K, Svajdler P, Szep Z, Michal M, Fetsch JF (2018) Dysplastic lipoma: a distinctive atypical lipomatous neoplasm with anisocytosis, focal nuclear atypia, p53 overexpression, and a lack of MDM2 gene amplification by FISH: a report of 66 cases demonstrating occasional multifocality and a rare association with retinoblastoma. Am J Surg Pathol 4211:1530\u20131540","journal-title":"Am J Surg Pathol"},{"key":"2652_CR27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.anndiagpath.2017.04.012","volume":"29","author":"A Agaimy","year":"2017","unstructured":"Agaimy A (2017) Anisometric cell lipoma: insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant (\u201cfat-only\u201d) spindle cell lipoma. Ann Diagn Pathol 29:52\u201356","journal-title":"Ann Diagn Pathol"},{"issue":"suppl2","key":"2652_CR28","first-page":"17A","volume":"28","author":"HL Evans","year":"2015","unstructured":"Evans HL (2015) Subcutaneous minimally atypical lipomatous tumors with variable fat cell size\u2014a study of 13 cases. Mod Pathol 28(suppl2):17A","journal-title":"Mod Pathol"},{"key":"2652_CR29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.semdp.2019.02.006","volume":"36","author":"K Thway","year":"2019","unstructured":"Thway K (2019) Well-differentiated liposarcoma and dedifferentiated liposarcoma: an updated review. Sem Diagn Pathol 36:112\u2013121","journal-title":"Sem Diagn Pathol"},{"key":"2652_CR30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/1066896918809189","volume":"27","author":"D Creytens","year":"2019","unstructured":"Creytens D, Ferdinande L, van Gorp J, Van Dorpe J, Flucke U (2019) Atypical spindle cell lipomatous tumor with benign heterologous (metaplastic) cartilaginous differentiation. Int J Surg Pathol 27:521\u2013523","journal-title":"Int J Surg Pathol"},{"issue":"2","key":"2652_CR31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cancergencyto.2008.04.004","volume":"184","author":"A Italiano","year":"2008","unstructured":"Italiano A, Chambonniere ML, Attias R, Chibon F, Coindre JM, Pedeutour F (2008) Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas. Cancer Genet Cytogenet 184(2):99\u2013104","journal-title":"Cancer Genet Cytogenet"},{"key":"2652_CR32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/PAP.0000000000000204","volume":"25","author":"IM Schaefer","year":"2018","unstructured":"Schaefer IM, Hornick JL (2018) Diagnostic immunohistochemistry for soft tissue and bone tumors: an update. Adv Anat Pathol 25:400\u2013412","journal-title":"Adv Anat Pathol"},{"issue":"1","key":"2652_CR33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pathol.2017.07.007","volume":"50","author":"IM Schaefer","year":"2018","unstructured":"Schaefer IM, Fletcher CDM (2018) Recent advances in the diagnosis of soft tissue tumours. Pathology 50(1):37\u201348","journal-title":"Pathology"},{"issue":"1 Suppl","key":"2652_CR34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2350\/10-05-0836-PB.1","volume":"15","author":"CM Coffin","year":"2012","unstructured":"Coffin CM, Alaggio R (2012) Adipose and myxoid tumors of childhood and adolescence. Pediatr Dev Pathol 15(1 Suppl):239\u2013254","journal-title":"Pediatr Dev Pathol"},{"issue":"9","key":"2652_CR35","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/PAS.0b013e3182562bc1","volume":"36","author":"JM Boland","year":"2012","unstructured":"Boland JM, Colby TV, Folpe AP (2012) Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features. Am J Surg Pathol 36(9):1395\u20131403","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"2652_CR36","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/jclinpath-2014-202420","volume":"67","author":"D Creytens","year":"2014","unstructured":"Creytens D, van Gorp J, Ferdinande L, Van Roy N, Libbrecht L (2014) Array-based comparative genomic hybridization analysis of a pleomorphic myxoid liposarcoma. J Clin Pathol 67(9):834\u2013835","journal-title":"J Clin Pathol"},{"key":"2652_CR37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.semdp.2019.02.007","volume":"36","author":"WJ Anderson","year":"2019","unstructured":"Anderson WJ, Jo VY (2019) Pleomorphic liposarcoma: updates and current differential diagnosis. Semin Diagn Pathol 36:122\u2013128","journal-title":"Semin Diagn Pathol"},{"key":"2652_CR38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/j.semdp.2019.02.004","volume":"36","author":"J Putra","year":"2019","unstructured":"Putra J, Al-Ibraheemi A (2019) Adipocytic tumors in children: a contemporary review. Semin Diagn Pathol 36:95\u2013104","journal-title":"Semin Diagn Pathol"},{"key":"2652_CR39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1053\/j.semdp.2019.02.008","volume":"36","author":"D Creytens","year":"2019","unstructured":"Creytens D (2019) A contemporary review of myxoid adipocytic tumors. Semin Diagn Pathol 36:129\u2013141","journal-title":"Semin Diagn Pathol"},{"issue":"5","key":"2652_CR40","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00383-017-4063-x","volume":"33","author":"TJ Sinclair","year":"2017","unstructured":"Sinclair TJ, Thorson CM, Alvarez E, Tan S, Spunt SL, Chao SD (2017) Pleomorphic myxoid liposarcoma in an adolescent with li-Fraumeni syndrome. Pediatr Surg Int 33(5):631\u2013635","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"2652_CR41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/his.12913","volume":"69","author":"J Hofvander","year":"2016","unstructured":"Hofvander J, Jo VY, Ghanei I, Gisselsson D, Martensson E, Mertens F (2016) Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near-haploidization and loss of the RB1 gene. Histopathology 69(1):141\u2013147","journal-title":"Histopathology"},{"key":"2652_CR42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/j.semdp.2019.02.003","volume":"36","author":"EG Demicco","year":"2019","unstructured":"Demicco EG (2019) Molecular updates in adipocytic neoplasms. Sem Diagn Pathol 36:85\u201394","journal-title":"Sem Diagn Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02652-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-019-02652-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02652-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T21:08:03Z","timestamp":1624914483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-019-02652-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2652"],"URL":"https:\/\/doi.org\/10.1007\/s00428-019-02652-3","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739175814.793580998","asserted-by":"object"}]},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]},"assertion":[{"value":"28 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author has complied with all ethical standards as outlined on the Virchows Archives website.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author declares that he has no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}