{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:49:24Z","timestamp":1792536564697,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s00428-019-02680-z","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T05:41:27Z","timestamp":1573796487000},"page":"543-550","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinicopathologic features of Buschke-L\u00f6wenstein tumor: a multi-institutional analysis of 38 cases"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-7204","authenticated-orcid":false,"given":"Dongwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul S.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Feely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Umrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwajeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela S.","family":"Allende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti M.","family":"Karamchandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zaleski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Westerhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Alpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"2680_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/j.1365-2230.2008.02938.x","volume":"34","author":"E Erkek","year":"2009","unstructured":"Erkek E, Basar H, Bozdogan O et al (2009) Giant condyloma acuminata of Buschke\u2013Lowenstein: successful treatment with a combination of surgicalexcision, oral acitretin and topical imiquimod. Clin Exp Dermatol 34:366\u2013368","journal-title":"Clin Exp Dermatol"},{"key":"2680_CR2","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/01.dad.0000211528.87928.a8","volume":"28","author":"C Steffen","year":"2006","unstructured":"Steffen C (2006) The men behind the eponym \u2013 Abraham Buschke and LudwigLowenstein: giant condyloma (Buschke\u2013Loewenstein). Am J Dermatopathol 28:526\u2013536","journal-title":"Am J Dermatopathol"},{"key":"2680_CR3","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1007\/BF02234473","volume":"44","author":"LJ Trombetta","year":"2001","unstructured":"Trombetta LJ, Place RJ (2001) Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum 44:1878\u20131886","journal-title":"Dis Colon Rectum"},{"key":"2680_CR4","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/BF02052606","volume":"37","author":"QD Chu","year":"1994","unstructured":"Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ (1994) Giant condyloma acuminatum (Buschke\u2013Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum 37:950\u2013957","journal-title":"Dis Colon Rectum"},{"key":"2680_CR5","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/BF02554502","volume":"32","author":"C Creasman","year":"1989","unstructured":"Creasman C, Haas PA, Fox TA et al (1989) Malignant transformation of anorectal giant condyloma acuminatum (Buschke-Loewenstein tumor). Dis Colon Rectum 32:481\u2013487","journal-title":"Dis Colon Rectum"},{"key":"2680_CR6","doi-asserted-by":"crossref","unstructured":"Boshart M, zur Hausen H (1986) Human papillomaviruses in Buschke\u2013Lowensteintumors: physical state of the DNA and identification of a tandem duplication in the noncoding region of a human papillomavirus 6 subtype. J Virol 58: 963\u2013966.","DOI":"10.1128\/JVI.58.3.963-966.1986"},{"key":"2680_CR7","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1099\/0022-1317-73-12-3147","volume":"73","author":"A Rubben","year":"1992","unstructured":"Rubben A, Beaudenon S, Favre M et al (1992) Rearrangements of the upstream regulatory region of human papillomavirustype 6 can be found in both Buschke\u2013Lowenstein tumours and in condylomataacuminata. J Gen Virol 73:3147\u20133153","journal-title":"J Gen Virol"},{"key":"2680_CR8","doi-asserted-by":"crossref","unstructured":"Gissmann L, de Villiers EM, zur Hausen H (1982) Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer 29: 143\u2013146.","DOI":"10.1002\/ijc.2910290205"},{"key":"2680_CR9","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0090-4295(98)00351-3","volume":"53","author":"CL Haycox","year":"1999","unstructured":"Haycox CL, Kuypers J, Krieger JN (1999) Role of human papillomavirus typing in diagnosis and clinical decision making for a giant verrucous genital lesion. Urology 53:627\u2013630","journal-title":"Urology"},{"key":"2680_CR10","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00404-012-2670-2","volume":"288","author":"C Yang","year":"2013","unstructured":"Yang C, Liu S, Wang Z, Yang S (2013) Buschke-L\u00f6wenstein tumor in an old woman: cryotherapy and holmium laser treatment. Arch Gynecol Obstet 288:221\u2013223","journal-title":"Arch Gynecol Obstet"},{"key":"2680_CR11","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1001\/archderm.136.6.707","volume":"136","author":"A Geusau","year":"2000","unstructured":"Geusau A, Heinz-Peer G, Volc-Platzer B, Stingl G, Kirnbauer R (2000) Regression of deeply infiltrating giant condyloma (Buschke\u2013Lowenstein tumor) following long-term intralesional interferon alfa therapy. Arch Dermatol 136:707\u2013710","journal-title":"Arch Dermatol"},{"key":"2680_CR12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0090-4295(93)90288-L","volume":"42","author":"AK Ilkay","year":"1993","unstructured":"Ilkay AK, Chodak GW, Vogelsang NJ et al (1993) Buschke-Loewenstein tumor: therapeutic options including systemic chemotherapy. Urology 42:599\u2013601","journal-title":"Urology"},{"key":"2680_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000070963","volume":"207","author":"LM Heinzerling","year":"2003","unstructured":"Heinzerling LM, Kempf W, Kamarashev J, Hafner J, Nestle FO (2003) Treatment of verrucous carcinoma with imiquimod and CO2 laser ablation. Dermatology 207:119\u2013122","journal-title":"Dermatology"},{"key":"2680_CR14","doi-asserted-by":"crossref","unstructured":"Gholam P, Enk A, Hartschuh W (2009) Successful surgical management of giant condyloma acuminatum (Buschke-L\u00f6wenstein tumor) in the genitoanal region: a case report and evaluation of current therapies. Dermatology 218:56\u201359","DOI":"10.1159\/000165359"},{"key":"2680_CR15","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/his.13158","volume":"70","author":"N Zidar","year":"2017","unstructured":"Zidar N, Langner C, Odar K, Ho\u0161njak L, Kamar\u00e1dov\u00e1 K, Daum O, Pollheimer MJ, Ko\u0161orok P, Poljak M (2017) Anal verrucous carcinoma is not related to infection with human papillomaviruses and should be distinguished from giant condyloma (Buschke-L\u00f6wenstein tumour). Histopathology 70:938\u2013945","journal-title":"Histopathology"},{"key":"2680_CR16","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/S1479-666X(06)80114-9","volume":"4","author":"MG Tytherleigh","year":"2006","unstructured":"Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J (2006) Combined surgery and chemoradiation as a treatment for the Buschke-Lowenstein tumour. Surgeon 4:378\u2013383","journal-title":"Surgeon"},{"key":"2680_CR17","doi-asserted-by":"crossref","unstructured":"Nascimento AF, Granter SR, Cviko A, Yuan L, Hecht JL, Crum CP (2004) Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma? Am J Surg Pathol 28:638\u2013643","DOI":"10.1097\/00000478-200405000-00012"},{"key":"2680_CR18","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1038\/modpathol.2012.91","volume":"25","author":"M Del Pino","year":"2012","unstructured":"Del Pino M, Bleeker MCG, Quint WG et al (2012) Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma. Mod Pathol 25:1354\u20131363","journal-title":"Mod Pathol"},{"key":"2680_CR19","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1016\/j.humpath.2013.07.011","volume":"44","author":"KR Patel","year":"2013","unstructured":"Patel KR, Chernock RD, Zhang TR et al (2013) Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus. Hum Pathol 44:2385\u20132392","journal-title":"Hum Pathol"},{"key":"2680_CR20","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/jcmm.12211","volume":"18","author":"K Odar","year":"2014","unstructured":"Odar K, Kocjan BJ, Ho\u0161njak L, Gale N, Poljak M, Zidar N (2014) Verrucous carcinoma of the head and neck \u2013 not a human papillomavirus-related tumour? J Cell Mol Med 18:635\u2013645","journal-title":"J Cell Mol Med"},{"key":"2680_CR21","doi-asserted-by":"crossref","unstructured":"Tauber M, Monsel G, Bonnecarr\u00e8re L et al (2014) Unresectable perineal cuniculatum carcinoma: partial remission using systemic isotretinoin and interferon-\u03b12a therapy. Acta Derm Venereol 94:721\u2013722","DOI":"10.2340\/00015555-1852"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02680-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-019-02680-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02680-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:21:16Z","timestamp":1605313276000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-019-02680-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["2680"],"URL":"https:\/\/doi.org\/10.1007\/s00428-019-02680-z","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"22 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by Institutional Review Board of each participating institution.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}