{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T18:55:00Z","timestamp":1768676100080,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministry of Educatio","award":["0"],"award-info":[{"award-number":["0"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples and the technical approach to analyze the immunoglobulin genes was of amplifying rearranged variable region genes with the classical direct sequencing of the PCR products followed by cloning. Here, we studied the B cell Ig heavy-chain repertoires by next-generation sequencing (NGS) in 30 NMZL cases. Most of the cases were mutated (20\/28; 71.5%) with homologies to the respective germ line genes ranging from 85 to 97, 83%, whereas 8\/28 (28.5%) were unmutated. In addition, our results show that NMZL cases have a biased usage of specific immunoglobulin heavy-chain variable (IGHV) region genes. Moreover, we documented intraclonal diversity in all (100%) of the mutated cases and ongoing somatic hypermutations (SHM) have been confirmed by hundreds of reads. We analyzed the mutational pattern to detect and quantify antigen selection pressure and we found a positive selection in 4 cases, whereas in the remaining cases there was an unspecific stimulation. Finally, the disease-specific survival and the progression-free survival were significantly different between cases with mutated and unmutated IGHV genes, pointing out mutational status as a possible new biomarker in NMZL.<\/jats:p>","DOI":"10.1007\/s00428-019-02712-8","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T09:07:50Z","timestamp":1575450470000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications"],"prefix":"10.1007","volume":"477","author":[{"given":"Massimo","family":"Granai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Di Napoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Santi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Vergoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioia","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofya","family":"Kovalchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Cencini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Giulio","family":"Carta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Ziepert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Cevenini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Lazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Bellan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"2712_CR1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues (revised 4th Ed, Vol 2)","author":"SH Swerdlow","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL et al (2017) WHO classification of tumours of haematopoietic and lymphoid tissues (revised 4th Ed, Vol 2). IARC, Lyon"},{"key":"2712_CR2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.12688\/f1000research.13826.1","volume":"7","author":"F Bertoni","year":"2018","unstructured":"Bertoni F, Rossi D, Zucca E (2018) Recent advances in understanding the biology of marginal zone lymphoma. F1000Res 7:406","journal-title":"F1000Res"},{"issue":"Suppl 1","key":"2712_CR3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hon.2400","volume":"35","author":"M Raderer","year":"2017","unstructured":"Raderer M (2017) The multiple faces of marginal zone lymphomas. Hematol Oncol 35(Suppl 1):46\u201348","journal-title":"Hematol Oncol"},{"issue":"1-2","key":"2712_CR4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.beha.2016.11.001","volume":"30","author":"S Pileri","year":"2017","unstructured":"Pileri S, Ponzoni M (2017) Pathology of nodal marginal zone lymphomas. Best Pract Res Clin Haematol. Best Pract Res Clin Haematol 30(1-2):50\u201355","journal-title":"Best Pract Res Clin Haematol"},{"issue":"12","key":"2712_CR5","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1038\/leu.2016.226","volume":"30","author":"M Seifert","year":"2016","unstructured":"Seifert M, K\u00fcppers R (2016) Human memory B cells. Leukemia 30(12):2283\u20132292","journal-title":"Leukemia"},{"issue":"8","key":"2712_CR6","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1158\/1078-0432.CCR-15-1170","volume":"22","author":"V Bikos","year":"2016","unstructured":"Bikos V, Karypidou M, Stalika E et al (2016) An immunogenetic signature of ongoing antigen interactions in splenic marginal zone lymphoma expressing IGHV1-2*04 receptors. Clin Cancer Res 22(8):2032\u20132040","journal-title":"Clin Cancer Res"},{"issue":"2","key":"2712_CR7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jmoldx.2018.01.002","volume":"20","author":"R Ohgami","year":"2018","unstructured":"Ohgami R, Rosenwald A, Bagg A (2018) Next-generation sequencing for lymphomas. J Mol Diagn 20(2):163\u2013165","journal-title":"J Mol Diagn"},{"issue":"6","key":"2712_CR8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/bjh.13361","volume":"169","author":"J Schmidt","year":"2015","unstructured":"Schmidt J et al (2015) MYD88 L265P and CXCR4 mutations in lymphoplasmacytic lymphoma identify cases with high disease activity. Br J Haematol 169(6):795\u2013803","journal-title":"Br J Haematol"},{"issue":"3","key":"2712_CR9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00428-015-1858-9","volume":"468","author":"S Swerdlow","year":"2016","unstructured":"Swerdlow S, Kuzu I, Dogan A et al (2016) The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing. Virchows Arch 468(3):259\u2013275","journal-title":"Virchows Arch"},{"key":"2712_CR10","doi-asserted-by":"crossref","unstructured":"Kosmidis P, Bonzheim I, Dufke C et al (2017) Next generation sequencing of the clonal IGH rearrangement detects ongoing mutations and interfollicular trafficking in in situ follicular neoplasia. PLoS One 12(6):e0178503","DOI":"10.1371\/journal.pone.0178503"},{"issue":"12","key":"2712_CR11","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"J van Dongen","year":"2003","unstructured":"van Dongen J, Langerak A, Br\u00fcggemann M et al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17(12):2257\u20132317","journal-title":"Leukemia"},{"key":"2712_CR12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/ajcp\/aqv011","volume":"145","author":"T Amato","year":"2016","unstructured":"Amato T, Abate F, Piccaluga P et al (2016) Clonality analysis of immunoglobulin gene rearrangement by next-generation sequencing in endemic Burkitt lymphoma suggests antigen drive activation of BCR as opposed to sporadic Burkitt lymphoma. Am J Clin Pathol 145:116\u2013127","journal-title":"Am J Clin Pathol"},{"key":"2712_CR13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/978-1-61779-842-9_32","volume":"882","author":"E Alamyar","year":"2012","unstructured":"Alamyar E, Duroux P, Lefranc M et al (2012) IMGT(\u00ae) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT\/V-QUEST and IMGT\/highv-QUEST for NGS. Methods Mol Biol 882:569\u2013604","journal-title":"Methods Mol Biol"},{"key":"2712_CR14","doi-asserted-by":"crossref","first-page":"D1006","DOI":"10.1093\/nar\/gkn838","volume":"37","author":"M Lefranc","year":"2009","unstructured":"Lefranc M, Giudicelli V, Ginestoux C et al (2009) IMGT, the international immunogenetics information system. Nucleic Acids Res 37:D1006\u2013D1012","journal-title":"Nucleic Acids Res"},{"key":"2712_CR15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1309\/AJCP2G0VKTKPNPRR","volume":"144","author":"M Ambrosio","year":"2015","unstructured":"Ambrosio M, Rocca B, Ginori A et al (2015) A look into the evolution of Epstein-Barr virus\u2013induced lymphoproliferative disorders: a case study. Am J Clin Pathol 144:817\u2013822","journal-title":"Am J Clin Pathol"},{"key":"2712_CR16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00428-015-1814-8","volume":"467","author":"M Ambrosio","year":"2015","unstructured":"Ambrosio M, De Falco G, Rocca B et al (2015) Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity. Virchows Arch 467:471\u2013480","journal-title":"Virchows Arch"},{"key":"2712_CR17","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1182\/blood-2007-07-099564","volume":"111","author":"F Murray","year":"2008","unstructured":"Murray F, Darzentas N, Hadzidimitriou A et al (2008) Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 111:1524\u20131533","journal-title":"Blood"},{"key":"2712_CR18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2006-03-012948","volume":"109","author":"K Stamatopoulos","year":"2007","unstructured":"Stamatopoulos K, Belessi C, Moreno C et al (2007) Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 109:259\u2013270","journal-title":"Blood"},{"key":"2712_CR19","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1182\/blood-2006-10-051110","volume":"109","author":"R Bomben","year":"2007","unstructured":"Bomben R, Dal Bo M, Capello D et al (2007) Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study. Blood 109:2989\u20132998","journal-title":"Blood"},{"issue":"17","key":"2712_CR20","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1093\/nar\/gks457","volume":"40","author":"G Yaari","year":"2012","unstructured":"Yaari G, Uduman M, Kleinstein S (2012) Quantifying selection in high-throughput Immunoglobulin sequencing data sets. Nucleic Acids Res 40(17):e134","journal-title":"Nucleic Acids Res"},{"key":"2712_CR21","doi-asserted-by":"crossref","first-page":"W499","DOI":"10.1093\/nar\/gkr413","volume":"39","author":"M Uduman","year":"2011","unstructured":"Uduman M, Yaari G, Hershberg U et al (2011) Detecting selection in immunoglobulin sequences. Nucleic Acids Res 39:W499\u2013W504","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2712_CR22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2567.2005.02208.x","volume":"116","author":"B Bose","year":"2005","unstructured":"Bose B, Sinha S (2005) Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology 116(2):172\u2013183","journal-title":"Immunology"},{"issue":"12","key":"2712_CR23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1182\/blood-2017-03-771915","volume":"130","author":"C Thieblemont","year":"2017","unstructured":"Thieblemont C, Cascione L, Conconi A et al (2017) A MALT lymphoma prognostic index. Blood 130(12):1409\u20131417","journal-title":"Blood"},{"issue":"27","key":"2712_CR24","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","volume":"32","author":"B Cheson","year":"2014","unstructured":"Cheson B, Fisher R, Barrington S et al (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32(27):3059\u20133068","journal-title":"J Clin Oncol"},{"key":"2712_CR25","unstructured":"IBM Corp. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY. Released 2011."},{"issue":"3","key":"2712_CR26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1309\/AJCP5TYGBVW4ZITR","volume":"141","author":"J Schumacher","year":"2014","unstructured":"Schumacher J, Duncavage E, Mosbruger T et al (2014) A comparison of deep sequencing of TCRG rearrangements vs traditional capillary electrophoresis for assessment of clonality in T-Cell lymphoproliferative disorders. Am J Clin Pathol 141(3):348\u2013359","journal-title":"Am J Clin Pathol"},{"key":"2712_CR27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.12688\/f1000research.13567.1","volume":"7","author":"J Yam-Puc","year":"2018","unstructured":"Yam-Puc J, Zhang L, Zhang Y, Toellner K (2018) Role of B-cell receptors for B-cell development and antigen-induced differentiation. F1000Res 7:429","journal-title":"F1000Res"},{"key":"2712_CR28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/bs.ai.2016.11.002","volume":"133","author":"S Methot","year":"2017","unstructured":"Methot S, Di Noia J (2017) Molecular mechanisms of somatic hypermutation and class switch recombination. Adv Immunol 133:37\u201387","journal-title":"Adv Immunol"},{"key":"2712_CR29","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3389\/fimmu.2016.00546","volume":"7","author":"V Martin","year":"2016","unstructured":"Martin V, Wu Y, Townsend C et al (2016) Transitional B cells in early human B cell development - time to revisit the paradigm? Front Immunol 7:546","journal-title":"Front Immunol"},{"key":"2712_CR30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/path.5209","volume":"247","author":"A Xochelli","year":"2019","unstructured":"Xochelli A, Bikos V, Polychronidou E et al (2019) Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations. J Pathol 247:416\u2013421","journal-title":"J Pathol"},{"issue":"1","key":"2712_CR31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0002-9440(10)61691-4","volume":"159","author":"R Marasca","year":"2001","unstructured":"Marasca R, Vaccari P, Luppi M et al (2001) Immunoglobulin gene mutations and frequent use of VH1-69 and VH4-34 segments in hepatitis C virus-positive and hepatitis C virus-negative nodal marginal zone B-cell lymphoma. Am J Pathol 159(1):253\u2013261","journal-title":"Am J Pathol"},{"key":"2712_CR32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.coviro.2019.02.004","volume":"34","author":"F Chen","year":"2019","unstructured":"Chen F, Tzarum N, Wilson I et al (2019) VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design. Curr Opin Virol 34:149\u2013159","journal-title":"Curr Opin Virol"},{"issue":"4","key":"2712_CR33","first-page":"470","volume":"90","author":"A Traverse-Glehen","year":"2005","unstructured":"Traverse-Glehen A, Davi F, Ben Simon E et al (2005) Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection. Haematologica 90(4):470\u2013478","journal-title":"Haematologica"},{"issue":"3","key":"2712_CR34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood.V98.3.781","volume":"98","author":"A Conconi","year":"2001","unstructured":"Conconi A, Bertoni F, Pedrinis E et al (2001) Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes. Blood 98(3):781\u2013786","journal-title":"Blood"},{"issue":"5","key":"2712_CR35","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-3083.2012.02688.x","volume":"75","author":"A Warsame","year":"2012","unstructured":"Warsame A, Delabie J, Malecka A et al (2012) Monocytoid B cells: an enigmatic B cell subset showing evidence of extrafollicular immunoglobulin gene somatic hypermutation. Scand J Immunol 75(5):500\u2013509","journal-title":"Scand J Immunol"},{"issue":"10","key":"2712_CR36","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1182\/blood-2016-02-696757","volume":"128","author":"V Spina","year":"2016","unstructured":"Spina V, Khiabanian H, Messina M et al (2016) The genetics of nodal marginal zone lymphoma. Blood 128(10):1362\u20131373","journal-title":"Blood"},{"issue":"4","key":"2712_CR37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/path.4982","volume":"243","author":"A Agathangelidis","year":"2017","unstructured":"Agathangelidis A, Xochelli A, Stamatopoulos K et al (2017) A gene is known by the company it keeps: enrichment of TNFAIP3 gene aberrations in MALT lymphomas expressing IGHV4-34 antigen receptors. J Pathol 243(4):403\u2013406","journal-title":"J Pathol"},{"issue":"8","key":"2712_CR38","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1182\/blood.V94.8.2800.420a01_2800_2808","volume":"94","author":"K Stein","year":"1999","unstructured":"Stein K, Hummel M, Korbjuhn P et al (1999) Monocytoid B cells are distinct from splenic marginal zone cells and commonly derive from unmutated naive B cells and less frequently from postgerminal center B cells by polyclonal transformation. Blood 94(8):2800\u20132808","journal-title":"Blood"},{"issue":"21","key":"2712_CR39","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1182\/blood-2017-10-764373","volume":"131","author":"X Puente","year":"2018","unstructured":"Puente X, Jares P, Campo E (2018) Chronic lymphocytic leukemia and mantle cell lymphoma: crossroads of genetic and microenvironment interactions. Blood 131(21):2283\u20132296","journal-title":"Blood"},{"issue":"6","key":"2712_CR40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/ajcp\/aqx105","volume":"148","author":"T Amato","year":"2017","unstructured":"Amato T, Sall A, Di\u00e8ye T et al (2017) Preferential usage of specific immunoglobulin heavy chain variable region genes with unmutated profile and advanced stage at presentation are common features in patients with chronic lymphocytic leukemia from Senegal. Am J Clin Pathol 148(6):545\u2013554","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"2712_CR41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3324\/haematol.2018.207399","volume":"104","author":"I Del Giudice","year":"2019","unstructured":"Del Giudice I, Fo\u00e0 R (2019) Another step forward in the 20-year history of IGHV mutations in chronic lymphocytic leukemia. Haematologica 104(2):219\u2013221","journal-title":"Haematologica"},{"issue":"1","key":"2712_CR42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1182\/asheducation-2017.1.371","volume":"2017","author":"C Thieblemont","year":"2017","unstructured":"Thieblemont C (2017) Improved biological insight and influence on management in indolent lymphoma. Talk 3: update on nodal and splenic marginal zone lymphoma. Hematology Am Soc Hematol Educ Program 2017(1):371\u2013378","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"1-2","key":"2712_CR43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.beha.2016.08.026","volume":"30","author":"T Tadmor","year":"2017","unstructured":"Tadmor T, Polliack A (2017) Nodal marginal zone lymphoma: clinical features, diagnosis, management and treatment. Best Pract Res Clin Haematol 30(1-2):92\u201398","journal-title":"Best Pract Res Clin Haematol"},{"issue":"3","key":"2712_CR44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0609.2009.01301.x","volume":"83","author":"L Arcaini","year":"2009","unstructured":"Arcaini L, Lucioni M, Boveri E, Paulli M (2009 Sep) Nodal marginal zone lymphoma: current knowledge and future directions of an heterogeneous disease. Eur J Haematol 83(3):165\u2013174","journal-title":"Eur J Haematol"},{"issue":"7","key":"2712_CR45","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3109\/10428194.2015.1106535","volume":"57","author":"M van den Brand","year":"2016","unstructured":"van den Brand M, van der Velden WJ, Diets IJ, Ector GI, de Haan AF, Stevens WB, Hebeda KM, Groenen PJ, van Krieken HJ (2016) Clinical features of patients with nodal marginal zone lymphoma compared to follicular lymphoma: similar presentation, but differences in prognostic factors and rate of transformation. Leuk Lymphoma 57(7):1649\u20131656","journal-title":"Leuk Lymphoma"}],"updated-by":[{"DOI":"10.1007\/s00428-020-02794-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000}}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02712-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-019-02712-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-019-02712-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:21:31Z","timestamp":1606954891000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-019-02712-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2712"],"URL":"https:\/\/doi.org\/10.1007\/s00428-019-02712-8","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00428-020-02794-9","asserted-by":"object"}]},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,4]]},"assertion":[{"value":"22 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2020","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This error was caused due to the author\u2019s oversight and this does not change the views or the results presented in the manuscript","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This was a non-interventional study on archived tissue samples.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}