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Despite its relatively characteristic histology, it may sometimes mimic other lesions. Here, we report two female non-smoker patients diagnosed with low-grade mucoepidermoid carcinoma with oncocytic epithelium and prominent lymphoid (Warthin-like) stroma and with molecularly confirmed <jats:italic>MAML2<\/jats:italic> rearrangement. In addition, we screened a consecutive series of 114 Warthin tumour cases by means of <jats:italic>MAML2<\/jats:italic> break apart fluorescence in situ hybridization to assess its value in differential diagnosis. <jats:italic>MAML2<\/jats:italic> rearrangement was detected in both mucoepidermoid carcinoma cases, while all Warthin tumours were negative. Taking into account the literature data, Warthin-like mucoepidermoid carcinomas are more frequently observed in women, while a slight male predominance and smoking history are typical for Warthin tumour. In addition, the patients with Warthin-like mucoepidermoid carcinoma were significantly younger than those with Warthin tumour. To conclude, Warthin-like mucoepidermoid carcinoma may usually be suspected based on histology, while the diagnosis can be confirmed by means of molecular assays such as FISH. The investigation of <jats:italic>MAML2<\/jats:italic> status is particularly advised when Warthin tumour is considered in a young, non-smoking, female patient.<\/jats:p>","DOI":"10.1007\/s00428-020-02798-5","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T19:02:23Z","timestamp":1585422143000},"page":"393-400","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["MAML2 rearrangement as a useful diagnostic marker discriminating between Warthin tumour and Warthin-like mucoepidermoid carcinoma"],"prefix":"10.1007","volume":"477","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-3928","authenticated-orcid":false,"given":"Micha\u0142","family":"Bie\u0144kowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9529-2381","authenticated-orcid":false,"given":"Micha\u0142","family":"Kunc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-5713","authenticated-orcid":false,"given":"Mariola","family":"Iliszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9396-3273","authenticated-orcid":false,"given":"Alina","family":"Ku\u017aniacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-1320","authenticated-orcid":false,"given":"Micha\u0142","family":"Studniarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-2189","authenticated-orcid":false,"given":"Wojciech","family":"Biernat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"2798_CR1","volume-title":"WHO classification of head and neck Tumours","author":"A El-Naggar","year":"2017","unstructured":"El-Naggar A, Chan J, Grandis J, et al. 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