{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:01:08Z","timestamp":1790870468870,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Medical Science and Technology Program of Guangdong","award":["2017116204155117"],"award-info":[{"award-number":["2017116204155117"]}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2018001"],"award-info":[{"award-number":["A2018001"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313663"],"award-info":[{"award-number":["2018A030313663"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00428-020-02815-7","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T23:15:31Z","timestamp":1587683731000},"page":"573-579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Expression of potential therapeutic target SSTR2a in primary and metastatic non-keratinizing nasopharyngeal carcinoma"],"prefix":"10.1007","volume":"477","author":[{"given":"Lili","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,23]]},"reference":[{"key":"2815_CR1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s12253-018-0426-4","volume":"25","author":"A Zalatnai","year":"2018","unstructured":"Zalatnai A, Galambos E, Perj\u00e9si E (2018) Importance of immunohistochemical detection of somatostatin receptors. Pathol Oncol Res 25:521\u2013525","journal-title":"Pathol Oncol Res"},{"key":"2815_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/jnen\/nlx008","volume":"76","author":"C Boulagnon-Rombi","year":"2017","unstructured":"Boulagnon-Rombi C, Fleury C, Fichel C, Lefour S, Bressenot AM, Gauchotte G (2017) Immunohistochemical approach to the differential diagnosis of meningiomas and their mimics. J Neuropathol Exp Neurol 76:289\u2013298","journal-title":"J Neuropathol Exp Neurol"},{"key":"2815_CR3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/PAS.0000000000001205","volume":"43","author":"LL Tao","year":"2019","unstructured":"Tao LL, Huang YH, Chen YL, Yu GY, Yin WH (2019) SSTR2 is a useful diagnostic marker for follicular dendritic cells and their related tumors. Am J Surg Pathol 43:374\u2013381","journal-title":"Am J Surg Pathol"},{"key":"2815_CR4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1136\/jclinpath-2019-205913","volume":"72","author":"L Tao","year":"2019","unstructured":"Tao L, Chen Y, Huang Q, Yong J, Yan S, Huang Y (2019) Constant expression of somatostatin receptor 2a in minute pulmonary meningothelial-like nodules. J Clin Pathol 72:525\u2013528","journal-title":"J Clin Pathol"},{"key":"2815_CR5","doi-asserted-by":"publisher","first-page":"704","DOI":"10.2967\/jnumed.109.069765","volume":"51","author":"T Binderup","year":"2010","unstructured":"Binderup T, Knigge U, Loft A, Mortensen J, Pfeifer A, Federspiel B, Hansen PC, H\u00f8jgaard L, Kjaer A (2010) Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy,123I-MIBG scintigraphy, and 18F-FDG PET. J Nucl Med 51:704\u2013712","journal-title":"J Nucl Med"},{"key":"2815_CR6","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1172\/JCI117090","volume":"93","author":"A Kubota","year":"1994","unstructured":"Kubota A, Yamada Y, Kagimoto S, Shimatsu A, Imamura M, Tsuda K, Imura H, Seino S, Seino Y (1994) Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors. J Clin Invest 93:1321\u20131325","journal-title":"J Clin Invest"},{"key":"2815_CR7","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1097\/RLU.0b013e31827a216b","volume":"39","author":"N Naswa","year":"2014","unstructured":"Naswa N, Sharma P, Gupta SK, Karunanithi S, Reddy RM, Patnecha M, Lata S, Kumar R, Malhotra A, Bal C (2014) Dual tracer functional imaging of gastroenteropancreatic neuroendocrine tumors using 68Ga-DOTANOC PET-CT and 18F-FDG PET-CT: competitive or complimentary? Clin Nucl Med 39:e27\u2013e34","journal-title":"Clin Nucl Med"},{"key":"2815_CR8","doi-asserted-by":"publisher","first-page":"E75","DOI":"10.1002\/hed.24164","volume":"38","author":"LK Khor","year":"2016","unstructured":"Khor LK, Loi HY, Sinha AK, Tong KT, Goh BC, Loh KS, Lu SJ (2016) 68Ga-DOTA-peptide: a novel molecular biomarker for nasopharyngeal carcinoma. Head Neck 38:E75\u2013E80","journal-title":"Head Neck"},{"key":"2815_CR9","first-page":"66","volume-title":"WHO classification of head and neck tumors","author":"AK EI-Naggar","year":"2017","unstructured":"EI-Naggar AK (2017) In: JKC C, Grandis JR, Takata T, Slootweg PJ (eds) WHO classification of head and neck tumors, vol 9, 4th edn. IARC, Lyon, pp 66\u201368","edition":"4"},{"key":"2815_CR10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/PAS.0b013e31823d07f3","volume":"36","author":"M Korner","year":"2012","unstructured":"Korner M, Waser B, Schonbrunn A, Perren A, Reubi JC (2012) Somatostatin receptor subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting. Am J Surg Pathol 36:242\u2013252","journal-title":"Am J Surg Pathol"},{"key":"2815_CR11","doi-asserted-by":"publisher","first-page":"e1281","DOI":"10.1097\/MD.0000000000001281","volume":"94","author":"S Mehta","year":"2015","unstructured":"Mehta S, de Reuver PR, Gill P, Andrici J, D'Urso L, Mittal A, Pavlakis N, Clarke S, Samra JS, Gill AJ (2015) Somatostatin receptor SSTR-2a expression is a stronger predictor for survival than Ki-67 in pancreatic neuroendocrine tumors. Medicine (Baltimore) 94:e1281","journal-title":"Medicine (Baltimore)"},{"key":"2815_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.14310\/horm.2002.1357","volume":"11","author":"K Pazaitou-Panayiotou","year":"2012","unstructured":"Pazaitou-Panayiotou K, Tiensuu Janson E, Koletsa T, Kotoula V, Stridsberg M, Karkavelas G, Karayannopoulou G (2012) Somatostatin receptor expression in non-medullary thyroid carcinomas. Hormones 11:290\u2013296","journal-title":"Hormones"},{"key":"2815_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1385\/EP:11:1:57","volume":"11","author":"M Pilichowska","year":"2000","unstructured":"Pilichowska M, Kimura N, Schindler M, Suzuki A, Yoshida R, Nagura H (2000) Expression of somatostatin type 2A receptor correlates with estrogen receptor in human breast carcinoma. Endocr Pathol 11:57\u201367","journal-title":"Endocr Pathol"},{"key":"2815_CR14","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/his.13034","volume":"70","author":"M Lequoy","year":"2017","unstructured":"Lequoy M, Desbois-Mouthon C, Wendum D, Gupta V, Blachon JL, Scatton O, Dumont S, Mireille Bonnemaire M, Schmidlin F, Rosmorduc O, Fartoux L (2017) Somatostatin receptors in resected hepatocellular carcinoma: status and correlation with markers of poor prognosis. Histopathology 70:492\u2013498","journal-title":"Histopathology"},{"key":"2815_CR15","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1038\/bjc.2013.263","volume":"108","author":"J Zhao","year":"2013","unstructured":"Zhao J, Liang Q, Cheung KF, Kang W, Dong Y, Lung RW, Tong JH, Ka Fai To KF, Sung JJ, Yu J (2013) Somatostatin receptor 1, a novel EBV-driven CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer. Br J Cancer 108:2557\u20132564","journal-title":"Br J Cancer"},{"key":"2815_CR16","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1159\/000127025","volume":"62","author":"R Glaser","year":"1995","unstructured":"Glaser R, Kutz LA, MacCallum RC, Malarkey WB (1995) Hormonal modulation of Epstein-Barr virus replication. Neuroendocrinology 62:356\u2013361","journal-title":"Neuroendocrinology"},{"key":"2815_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8071032","volume":"8","author":"L Carideo","year":"2019","unstructured":"Carideo L, Prosperi D, Panzuto F, Magi L, Pratesi MS, Rinzivillo M, Annibale B, Signore A (2019) Role of combined [68Ga] Ga-DOTA-SST analogues and [18F] FDG PET\/CT in the management of GEP-NENs: a systematic review. J Clin Med 8:E1032","journal-title":"J Clin Med"},{"key":"2815_CR18","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s00428-002-0693-y","volume":"441","author":"KS Loh","year":"2002","unstructured":"Loh KS, Waser B, Tan LK, Ruan RS, Stauffer E, Reubi JC (2002) Somatostatin receptors in nasopharyngeal carcinoma. Virchows Arch 441:444\u2013448","journal-title":"Virchows Arch"},{"issue":"10","key":"2815_CR19","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1002\/cncr.11376","volume":"97","author":"G Pelosi","year":"2003","unstructured":"Pelosi G, Pasini F, Sonzogin A, Maffini F, Maisonneuve P, Iannucci A, Terzi A, De Manzoni G, Bresaola E, Viale G (2003) Prognostic implications of neuroendocrine differentiation and hormone production in patients with stage I non-small cell lung carcinoma. Cancer 97(10):2487\u20132497","journal-title":"Cancer"},{"issue":"44","key":"2815_CR20","doi-asserted-by":"publisher","first-page":"71727","DOI":"10.18632\/oncotarget.12327","volume":"7","author":"J Feng","year":"2016","unstructured":"Feng J, Sheng H, Zhu C, Qian X, Wan D, Su D, Chen X, Zhu L (2016) Correlations of neuroendocrine features with prognosis of non-small cell lung cancer. Oncotarget 7(44):71727\u201371736","journal-title":"Oncotarget"},{"issue":"12","key":"2815_CR21","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.bbamcr.2018.09.005","volume":"1865","author":"R Zhu","year":"2018","unstructured":"Zhu R, Yang X, Xue X, Shen M, Chen F, Chen X, Tsai Y, Keng PC, Chen Y, Lee SO, Chen Y (2018) Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer. Biochim Biophys Acta Mol Cell Res 1865(12):1878\u20131890","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"3","key":"2815_CR22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tranon.2017.01.011","volume":"10","author":"SS Yadav","year":"2017","unstructured":"Yadav SS, Li J, Stockert JA, Herzog B, O'Connor J, Garzon-Manco L, Parsons R, Tewari AK, Yadav KK (2017) Induction of neuroendocrine differentiation in prostate cancer cells by dovitinib (TKI-258) and its therapeutic implications. Transl Oncol 10(3):357\u2013366","journal-title":"Transl Oncol"},{"key":"2815_CR23","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1200\/JCO.2015.60.9347","volume":"33","author":"AW Lee","year":"2015","unstructured":"Lee AW, Ma BB, Ng WT, Chan AT (2015) Management of nasopharyngeal carcinoma: current practice and future perspective. J Clin Oncol 33:3356\u20133364","journal-title":"J Clin Oncol"},{"key":"2815_CR24","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/bjc.2017.357","volume":"117","author":"A Prawira","year":"2017","unstructured":"Prawira A, Oosting SF, Chen TW, Delos Santos KA, Saluja R, Wang L, Siu LL, Chan KKW, Hansen AR (2017) Systemic therapies for recurrent or metastatic nasopharyngeal carcinoma: a systematic review. Br J Cancer 117:1743\u20131752","journal-title":"Br J Cancer"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-020-02815-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-020-02815-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-020-02815-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T23:47:05Z","timestamp":1619135225000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-020-02815-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,23]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["2815"],"URL":"https:\/\/doi.org\/10.1007\/s00428-020-02815-7","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,23]]},"assertion":[{"value":"27 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Institutional Review Board of Peking University Shenzhen Hospital, and all patients provided written informed consent for the collection and publication of their medical information during the first visit to our hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}