{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:07:05Z","timestamp":1794344825544,"version":"4.9.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medical University of Gdansk","award":["02-0095\/07\/267"],"award-info":[{"award-number":["02-0095\/07\/267"]}]},{"name":"Medical University of Gdansk","award":["01-0424\/08\/267"],"award-info":[{"award-number":["01-0424\/08\/267"]}]},{"name":"Medical University of Gdansk","award":["02-0023\/07\/171"],"award-info":[{"award-number":["02-0023\/07\/171"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Salivary gland carcinomas represent a heterogeneous group of poorly characterized head and neck tumors. The purpose of this study was to evaluate <jats:italic>ALK<\/jats:italic> gene and protein aberrations in a large, well-characterized cohort of these tumors. A total of 182 salivary gland carcinomas were tested for anaplastic lymphoma kinase (ALK) positivity by immunohistochemistry (IHC) using the cut-off of 10% positive cells. ALK positive tumors were subjected to FISH analysis and followed by hybrid capture\u2013based next generation sequencing (NGS). Of the 182 tumors, 8 were ALK positive by IHC. Further analysis using hybrid capture NGS analysis revealed a novel <jats:italic>MYO18A<\/jats:italic> (Exon1-40)-<jats:italic>ALK<\/jats:italic> (exon 20-29) gene fusion in one case of intraductal carcinoma. Additional genomic analyses resulted in the detection of inactivating mutations in <jats:italic>BRAF<\/jats:italic> and <jats:italic>TP53<\/jats:italic>, as well as amplifications of <jats:italic>ERBB2<\/jats:italic> and <jats:italic>ALK<\/jats:italic>. <jats:italic>ALK<\/jats:italic> rearrangements are a rare entity in salivary gland carcinomas. We identified a potentially targetable novel <jats:italic>ALK<\/jats:italic> fusion in an intraductal carcinoma of minor salivary glands.<\/jats:p>","DOI":"10.1007\/s00428-020-02971-w","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T16:03:18Z","timestamp":1606320198000},"page":"933-941","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["ALK alterations in salivary gland carcinomas"],"prefix":"10.1007","volume":"478","author":[{"given":"Hanna","family":"Majewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Gorczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Czapiewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopika","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Lakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"Heuckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Laco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Andreasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Stodulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Iliszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Dziadziuszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Jassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas C.","family":"Heukamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-2189","authenticated-orcid":false,"given":"Wojciech","family":"Biernat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"2971_CR1","volume-title":"World Health Organization classification of head and neck tumours","author":"AK El-Naggar","year":"2017","unstructured":"El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (2017) World Health Organization classification of head and neck tumours. IARC, Lyon"},{"key":"2971_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1111\/j.1365-2559.2011.03777.x","volume":"58","author":"S Schwarz","year":"2011","unstructured":"Schwarz S, Stiegler C, Muller M, Ettl T, Brockhoff G, Zenk J, Agaimy A (2011) Salivary gland mucoepidermoid carcinoma is a clinically, morphologically and genetically heterogeneous entity: a clinicopathological study of 40 cases with emphasis on grading, histological variants and presence of the t(11;19) translocation. Histopathology 58:557\u2013570","journal-title":"Histopathology"},{"issue":"Suppl 1","key":"2971_CR3","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1007\/s12105-013-0462-z","volume":"7","author":"G Stenman","year":"2013","unstructured":"Stenman G (2013) Fusion oncogenes in salivary gland tumors: molecular and clinical consequences. Head Neck Pathol 7(Suppl 1):S12\u2013S19","journal-title":"Head Neck Pathol"},{"key":"2971_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.oraloncology.2008.03.012","volume":"45","author":"ID O'Neill","year":"2009","unstructured":"O'Neill ID (2009) t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma. Oral Oncol 45:2\u20139","journal-title":"Oral Oncol"},{"key":"2971_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00428-014-1701-8","volume":"466","author":"H Majewska","year":"2015","unstructured":"Majewska H, Skalova A, Stodulski D, Klimkova A, Steiner P, Stankiewicz C, Biernat W (2015) Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement. Virchows Arch 466:245\u2013254. https:\/\/doi.org\/10.1007\/s00428-014-1701-8","journal-title":"Virchows Arch"},{"key":"2971_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/PAS.0b013e3181d9efcc","volume":"34","author":"A Skalova","year":"2010","unstructured":"Skalova A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Starek I, Geierova M, Simpson RH, Passador-Santos F, Ryska A, Leivo I, Kinkor Z, Michal M (2010) Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol 34:599\u2013608","journal-title":"Am J Surg Pathol"},{"key":"2971_CR7","doi-asserted-by":"publisher","first-page":"18740","DOI":"10.1073\/pnas.0909114106","volume":"106","author":"M Persson","year":"2009","unstructured":"Persson M, Andren Y, Mark J, Horlings HM, Persson F, Stenman G (2009) Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A 106:18740\u201318744","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2971_CR8","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1158\/1078-0432.CCR-15-2867-T","volume":"22","author":"Y Mitani","year":"2016","unstructured":"Mitani Y, Liu B, Rao PH, Borra VJ, Zafereo M, Weber RS, Kies M, Lozano G, Futreal PA, Caulin C, El-Naggar AK (2016) Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clin Cancer Res 22:725\u2013733. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-2867-T","journal-title":"Clin Cancer Res"},{"key":"2971_CR9","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/gcc.20881","volume":"50","author":"CR Antonescu","year":"2011","unstructured":"Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, Perez-Ordonez B, Have C, Asa SL, Leong IT, Bradley G, Klieb H, Weinreb I (2011) EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosom Cancer 50:559\u2013570","journal-title":"Genes Chromosom Cancer"},{"key":"2971_CR10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1097\/PAS.0000000000000364","volume":"39","author":"A Skalova","year":"2015","unstructured":"Skalova A, Weinreb I, Hyrcza M, Simpson RH, Laco J, Agaimy A, Vazmitel M, Majewska H, Vanecek T, Talarcik P, Manajlovic S, Losito SN, Steiner P, Klimkova A, Michal M (2015) Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol 39:338\u2013348","journal-title":"Am J Surg Pathol"},{"key":"2971_CR11","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1126\/science.8122112","volume":"263","author":"SW Morris","year":"1994","unstructured":"Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263:1281\u20131284","journal-title":"Science"},{"key":"2971_CR12","doi-asserted-by":"publisher","first-page":"e110617","DOI":"10.1371\/journal.pone.0110617","volume":"9","author":"Y Wang","year":"2014","unstructured":"Wang Y, Wang S, Xu S, Qu J, Liu B (2014) Clinicopathologic features of patients with non-small cell lung cancer harboring the EML4-ALK fusion gene: a meta-analysis. PLoS One 9:e110617","journal-title":"PLoS One"},{"key":"2971_CR13","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/labinvest.2015.83","volume":"95","author":"C Walther","year":"2015","unstructured":"Walther C, Hofvander J, Nilsson J, Magnusson L, Domanski HA, Gisselsson D, Tayebwa J, Doyle LA, Fletcher CD, Mertens F (2015) Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing. Lab Investig 95:1071\u20131076","journal-title":"Lab Investig"},{"key":"2971_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1530\/ERC-14-0467","volume":"22","author":"G Park","year":"2015","unstructured":"Park G, Kim TH, Lee HO, Lim JA, Won JK, Min HS, Lee KE, Park DJ, Park YJ, Park WY (2015) Standard immunohistochemistry efficiently screens for anaplastic lymphoma kinase rearrangements in differentiated thyroid cancer. Endocr Relat Cancer 22:55\u201363","journal-title":"Endocr Relat Cancer"},{"key":"2971_CR15","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/PAS.0000000000000368","volume":"39","author":"A Chou","year":"2015","unstructured":"Chou A, Fraser S, Toon CW, Clarkson A, Sioson L, Farzin M, Cussigh C, Aniss A, O'Neill C, Watson N, Clifton-Bligh RJ, Learoyd DL, Robinson BG, Selinger CI, Delbridge LW, Sidhu SB, O'Toole SA, Sywak M, Gill AJ (2015) A detailed clinicopathologic study of ALK-translocated papillary thyroid carcinoma. Am J Surg Pathol 39:652\u2013659","journal-title":"Am J Surg Pathol"},{"key":"2971_CR16","doi-asserted-by":"publisher","first-page":"E66","DOI":"10.1002\/hed.23884","volume":"37","author":"SM Kim","year":"2015","unstructured":"Kim SM, Kim MJ, Jung HA, Sun JM, Choi YL, Ko YH, Park K, Baek CH, Son YI, Ahn MJ (2015) Presence of anaplastic lymphoma kinase translocation in sarcomatoid carcinoma of head and neck and treatment effect of crizotinib: a case series. Head Neck 37:E66\u2013E69","journal-title":"Head Neck"},{"key":"2971_CR17","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/gcc.22346","volume":"55","author":"MM Cajaiba","year":"2016","unstructured":"Cajaiba MM, Jennings LJ, Rohan SM, Perez-Atayde AR, Marino-Enriquez A, Fletcher JA, Geller JI, Leuer KM, Bridge JA, Perlman EJ (2016) ALK-rearranged renal cell carcinomas in children. Genes Chromosom Cancer 55:442\u2013451","journal-title":"Genes Chromosom Cancer"},{"key":"2971_CR18","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/s41467-017-01178-z","volume":"8","author":"MG Dalin","year":"2017","unstructured":"Dalin MG, Katabi N, Persson M, Lee KW, Makarov V, Desrichard A, Walsh LA, West L, Nadeem Z, Ramaswami D, Havel JJ, Kuo F, Chadalavada K, Nanjangud GJ, Ganly I, Riaz N, Ho AL, Antonescu CR, Ghossein R, Stenman G, Chan TA, Morris LGT (2017) Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. Nat Commun 8:1197. https:\/\/doi.org\/10.1038\/s41467-017-01178-z","journal-title":"Nat Commun"},{"key":"2971_CR19","doi-asserted-by":"publisher","unstructured":"Sasaki E, Masago K, Fujita S, Suzuki H, Hanai N, Hosoda W (2020) Salivary secretory carcinoma harboring a novel ALK fusion: expanding the molecular characterization of carcinomas beyond the ETV6 gene. Am J Surg Pathol. https:\/\/doi.org\/10.1097\/PAS.0000000000001471","DOI":"10.1097\/PAS.0000000000001471"},{"key":"2971_CR20","doi-asserted-by":"publisher","unstructured":"Rooper LM, Thompson LDR, Gagan J, Oliai BR, Weinreb I, Bishop JA (2020) Salivary intraductal carcinoma arising within intraparotid lymph node: a report of 4 cases with identification of a novel STRN-ALK fusion. Head Neck Pathol. https:\/\/doi.org\/10.1007\/s12105-020-01198-0","DOI":"10.1007\/s12105-020-01198-0"},{"key":"2971_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.humpath.2019.03.004","volume":"88","author":"S Dogan","year":"2019","unstructured":"Dogan S, Ng CKY, Xu B, Kumar R, Wang L, Edelweiss M, Scott SN, Zehir A, Drilon A, Morris LGT, Lee NY, Antonescu CR, Ho AL, Katabi N, Berger MF, Reis-Filho JS (2019) The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement. Hum Pathol 88:66\u201377. https:\/\/doi.org\/10.1016\/j.humpath.2019.03.004","journal-title":"Hum Pathol"},{"key":"2971_CR22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.5114\/pjp.2016.59223","volume":"67","author":"H Majewska","year":"2016","unstructured":"Majewska H, Skalova A, Weinreb I, Stodulski D, Hyrcza M, Stankiewicz C, Biernat W (2016) Giant cribriform adenocarcinoma of the tongue showing PRKD3 rearrangement. Pol J Pathol 67:84\u201390","journal-title":"Pol J Pathol"},{"key":"2971_CR23","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cancergen.2013.07.001","volume":"206","author":"A Marino-Enriquez","year":"2013","unstructured":"Marino-Enriquez A, Dal CP (2013) ALK as a paradigm of oncogenic promiscuity: different mechanisms of activation and different fusion partners drive tumors of different lineages. Cancer Genet 206:357\u2013373","journal-title":"Cancer Genet"},{"key":"2971_CR24","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1097\/JTO.0000000000000332","volume":"9","author":"M von Laffert","year":"2014","unstructured":"von Laffert M, Warth A, Penzel R, Schirmacher P, Kerr KM, Elmberger G, Schildhaus HU, Buttner R, Lopez-Rios F, Reu S, Kirchner T, Pauwels P, Specht K, Drecoll E, Hofler H, Aust D, Baretton G, Bubendorf L, Stallmann S, Fisseler-Eckhoff A, Soltermann A, Tischler V, Moch H, Penault-Llorca F, Hager H, Schaper F, Lenze D, Hummel M, Dietel M (2014) Multicenter immunohistochemical ALK-testing of non-small-cell lung cancer shows high concordance after harmonization of techniques and interpretation criteria. J Thorac Oncol 9:1685\u20131692","journal-title":"J Thorac Oncol"},{"key":"2971_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2217\/fon.13.184","volume":"10","author":"A Gorczynski","year":"2014","unstructured":"Gorczynski A, Prelowska M, Adam P, Czapiewski P, Biernat W (2014) ALK-positive cancer: still a growing entity. Future Oncol 10:305\u2013321. https:\/\/doi.org\/10.2217\/fon.13.184","journal-title":"Future Oncol"},{"key":"2971_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/his.12779","volume":"68","author":"K Loharamtaweethong","year":"2016","unstructured":"Loharamtaweethong K, Puripat N, Aoonjai N, Sutepvarnon A, Bandidwattanawong C (2016) Anaplastic lymphoma kinase (ALK) translocation in paediatric malignant peritoneal mesothelioma: a case report of novel ALK-related tumour spectrum. Histopathology 68:603\u2013607","journal-title":"Histopathology"},{"key":"2971_CR27","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/neuonc\/nov039","volume":"17","author":"TK Olsen","year":"2015","unstructured":"Olsen TK, Panagopoulos I, Meling TR, Micci F, Gorunova L, Thorsen J, Due-Tonnessen B, Scheie D, Lund-Iversen M, Krossnes B, Saxhaug C, Heim S, Brandal P (2015) Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity? Neuro-Oncology 17:1365\u20131373","journal-title":"Neuro-Oncology"},{"key":"2971_CR28","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/JTO.0b013e3182381535","volume":"7","author":"A McLeer-Florin","year":"2012","unstructured":"McLeer-Florin A, Moro-Sibilot D, Melis A, Salameire D, Lefebvre C, Ceccaldi F, de Fraipont F, Brambilla E, Lantuejoul S (2012) Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study. J Thorac Oncol 7:348\u2013354","journal-title":"J Thorac Oncol"},{"key":"2971_CR29","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.lungcan.2012.03.004","volume":"77","author":"HS Park","year":"2012","unstructured":"Park HS, Lee JK, Kim DW, Kulig K, Kim TM, Lee SH, Jeon YK, Chung DH, Heo DS (2012) Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients. Lung Cancer 77:288\u2013292","journal-title":"Lung Cancer"},{"key":"2971_CR30","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/PAS.0000000000000952","volume":"42","author":"I Weinreb","year":"2018","unstructured":"Weinreb I, Bishop JA, Chiosea SI, Seethala RR, Perez-Ordonez B, Zhang L, Sung YS, Chen CL, Assaad A, Oliai BR, Antonescu CR (2018) Recurrent RET gene rearrangements in intraductal carcinomas of salivary gland. Am J Surg Pathol 42:442\u2013452","journal-title":"Am J Surg Pathol"},{"key":"2971_CR31","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/PAS.0000000000001301","volume":"43","author":"A Skalova","year":"2019","unstructured":"Skalova A, Ptakova N, Santana T, Agaimy A, Ihrler S, Uro-Coste E, Thompson LDR, Bishop JA, Baneckova M, Rupp NJ, Morbini P, de Sanctis S, Schiavo-Lena M, Vanecek T, Michal M, Leivo I (2019) NCOA4-RET and TRIM27-RET are characteristic gene fusions in salivary intraductal carcinoma, including invasive and metastatic tumors: is \"intraductal\" correct? Am J Surg Pathol 43:1303\u20131313. https:\/\/doi.org\/10.1097\/PAS.0000000000001301","journal-title":"Am J Surg Pathol"},{"key":"2971_CR32","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1097\/PAS.0000000000001133","volume":"42","author":"A Skalova","year":"2018","unstructured":"Skalova A, Vanecek T, Uro-Coste E, Bishop JA, Weinreb I, Thompson LDR, de Sanctis S, Schiavo-Lena M, Laco J, Badoual C, Santana CT, Ptakova N, Baneckova M, Miesbauerova M, Michal M (2018) Molecular profiling of salivary gland intraductal carcinoma revealed a subset of tumors harboring NCOA4-RET and novel TRIM27-RET fusions: a report of 17 cases. Am J Surg Pathol 42:1445\u20131455. https:\/\/doi.org\/10.1097\/PAS.0000000000001133","journal-title":"Am J Surg Pathol"},{"key":"2971_CR33","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/gcc.22195","volume":"53","author":"I Weinreb","year":"2014","unstructured":"Weinreb I, Zhang L, Tirunagari LM, Sung YS, Chen CL, Perez-Ordonez B, Clarke BA, Skalova A, Chiosea SI, Seethala RR, Waggott D, Boutros PC, How C, Liu FF, Irish JC, Goldstein DP, Gilbert R, Ud DN, Assaad A, Hornick JL, Thompson LD, Antonescu CR (2014) Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. Genes Chromosom Cancer 53:845\u2013856","journal-title":"Genes Chromosom Cancer"},{"key":"2971_CR34","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1200\/JCO.2011.37.8588","volume":"30","author":"JC van Gaal","year":"2012","unstructured":"van Gaal JC, Flucke UE, Roeffen MH, de Bont ES, Sleijfer S, Mavinkurve-Groothuis AM, Suurmeijer AJ, van der Graaf WT, Versleijen-Jonkers YM (2012) Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: clinical and prognostic implications. J Clin Oncol 30:308\u2013315","journal-title":"J Clin Oncol"},{"key":"2971_CR35","doi-asserted-by":"publisher","first-page":"58903","DOI":"10.18632\/oncotarget.10368","volume":"7","author":"P Gasparini","year":"2016","unstructured":"Gasparini P, Casanova M, Villa R, Collini P, Alaggio R, Zin A, Bonvini P, Antonescu CR, Boldrini R, Caserini R, Moro M, Centonze G, Meazza C, Massimino M, Bergamaschi L, Luksch R, Chiaravalli S, Bisogno G, Zaffaroni N, Daidone MG, Sozzi G, Ferrari A (2016) Anaplastic lymphoma kinase aberrations correlate with metastatic features in pediatric rhabdomyosarcoma. Oncotarget 7:58903\u201358914","journal-title":"Oncotarget"},{"key":"2971_CR36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/JTO.0b013e3181fb7cd6","volume":"6","author":"M Salido","year":"2011","unstructured":"Salido M, Pijuan L, Martinez-Aviles L, Galvan AB, Canadas I, Rovira A, Zanui M, Martinez A, Longaron R, Sole F, Serrano S, Bellosillo B, Wynes MW, Albanell J, Hirsch FR, Arriola E (2011) Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer. J Thorac Oncol 6:21\u201327","journal-title":"J Thorac Oncol"},{"key":"2971_CR37","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/modpathol.2012.107","volume":"25","author":"WR Sukov","year":"2012","unstructured":"Sukov WR, Hodge JC, Lohse CM, Akre MK, Leibovich BC, Thompson RH, Cheville JC (2012) ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients. Mod Pathol 25:1516\u20131525","journal-title":"Mod Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-020-02971-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-020-02971-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-020-02971-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T22:09:16Z","timestamp":1620252556000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-020-02971-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2971"],"URL":"https:\/\/doi.org\/10.1007\/s00428-020-02971-w","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"assertion":[{"value":"2 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Prof Rafa\u0142 Dziadziuszko: Advisory board role for Pfizer, Novartis, Roche, Takeda, Merck, Seattle Genetics, and Foundation Medicine. Travel costs from Roche and AstraZeneca. Dr. Johannes Heuckmann is a full time employee of NEO New Oncology GmbH. Prof Jacek Jassem: Advisory board role for Boehringer, Astra Zeneca, BMS, and Merck. Other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Independent Bioethics Committee for Scientific Research at Medical University of Gda\u0144sk (Decision number: NKBBN\/4182015)","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}