{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:01:40Z","timestamp":1780923700243,"version":"3.54.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972520"],"award-info":[{"award-number":["81972520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472510"],"award-info":[{"award-number":["81472510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"crossref","award":["2020YFS0270"],"award-info":[{"award-number":["2020YFS0270"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"crossref"}]},{"name":"135 Project for Disciplines of Excellence\u2013Clinical Research Incubation Project, West China Hospital, Sichuan University","award":["2018HXFH011"],"award-info":[{"award-number":["2018HXFH011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00428-021-03076-8","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T01:02:47Z","timestamp":1616115767000},"page":"537-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Liposarcoma in children and young adults: a clinicopathologic and molecular study of 23 cases in one of the largest institutions of China"],"prefix":"10.1007","volume":"479","author":[{"given":"Ran","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhai","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-4121","authenticated-orcid":false,"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"3076_CR1","volume-title":"World Health Organization classification of tumours of soft tissue and bone","author":"CR Antonescu","year":"2020","unstructured":"Antonescu CR, Blay J-Y, Bovee JVMG, Bridge JA, Cunha IW, Dei Tos AP, Flanagan AM, Fletcher CDM, Folpe A, Hornick JL, Mertens F, Miettinen M, Nielsen GP, Oda Y, Yoshida A (2020) World Health Organization classification of tumours of soft tissue and bone, 5th edn. IARC Press, Lyon","edition":"5"},{"key":"3076_CR2","first-page":"484","volume-title":"Enzinger and Weiss\u2019s soft tissue tmors","author":"JR Goldblum","year":"2013","unstructured":"Goldblum JR, Folpe AL, Weiss SW (2013) Liposarcoma. In: Enzinger and Weiss\u2019s soft tissue tmors, 6th edn. Saunders, Philadelphia, pp 484\u2013523","edition":"6"},{"issue":"5","key":"3076_CR3","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/PAS.0b013e3181963c9c","volume":"33","author":"R Alaggio","year":"2009","unstructured":"Alaggio R, Coffin CM, Weiss SW, Bridge JA, Issakov J, Oliveira AM, Folpe AL (2009) Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Am J Surg Pathol 33(5):645\u2013658. https:\/\/doi.org\/10.1097\/PAS.0b013e3181963c9c","journal-title":"Am J Surg Pathol"},{"issue":"1 Suppl","key":"3076_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2350\/10-05-0836-PB.1","volume":"15","author":"CM Coffin","year":"2012","unstructured":"Coffin CM, Alaggio R (2012) Adipose and myxoid tumors of childhood and adolescence. Pediatr Dev Pathol 15(1 Suppl):239\u2013254. https:\/\/doi.org\/10.2350\/10-05-0836-PB.1","journal-title":"Pediatr Dev Pathol"},{"key":"3076_CR5","volume-title":"Pediatric soft tissue tumors: a clinical, pathological, and therapeutic approach","author":"CM Coffin","year":"1997","unstructured":"Coffin CM, Dehner LP, O'Shea PA (1997) Pediatric soft tissue tumors: a clinical, pathological, and therapeutic approach. Williams & Wilkins, Baltimore"},{"issue":"2","key":"3076_CR6","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1053\/j.semdp.2019.02.004","volume":"36","author":"J Putra","year":"2019","unstructured":"Putra J, Al-Ibraheemi A (2019) Adipocytic tumors in children: a contemporary review. Semin Diagn Pathol 36(2):95\u2013104. https:\/\/doi.org\/10.1053\/j.semdp.2019.02.004","journal-title":"Semin Diagn Pathol"},{"issue":"6","key":"3076_CR7","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/his.13957","volume":"75","author":"R Waters","year":"2019","unstructured":"Waters R, Horvai A, Greipp P, John I, Demicco EG, Dickson BC, Tanas MR, Larsen BT, Ud Din N, Creytens DH, Bahrami A, Doyle LA, Jo VY, Al-Ibraheemi A, Thway K, Jenkins SM, Siontis B, Folpe A, Fritchie K (2019) Atypical lipomatous tumour\/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged <\/= 40 years: a study of 116 patients. Histopathology 75(6):833\u2013842. https:\/\/doi.org\/10.1111\/his.13957","journal-title":"Histopathology"},{"issue":"5","key":"3076_CR8","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1080\/088800199276967","volume":"16","author":"A Ferrari","year":"1999","unstructured":"Ferrari A, Casanova M, Spreafico F, Luksch R, Terenziani M, Cefalo G, Massimino M, Gandola L, Navarria P, Fossati-Bellani F (1999) Childhood liposarcoma: a single-institutional twenty-year experience. Pediatr Hematol Oncol 16(5):415\u2013421. https:\/\/doi.org\/10.1080\/088800199276967","journal-title":"Pediatr Hematol Oncol"},{"issue":"7","key":"3076_CR9","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/pbc.23095","volume":"57","author":"WW Huh","year":"2011","unstructured":"Huh WW, Yuen C, Munsell M, Hayes-Jordan A, Lazar AJ, Patel S, Wang W-L, Barahmani N, Okcu MF, Hicks J, Debelenko L, Spunt SL (2011) Liposarcoma in children and young adults: a multi-institutional experience \u2020. Pediatr Blood Cancer 57(7):1142\u20131146. https:\/\/doi.org\/10.1002\/pbc.23095","journal-title":"Pediatr Blood Cancer"},{"issue":"10","key":"3076_CR10","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1002\/1097-0142(19931115)72:10<3114::aid-cncr2820721037>3.0.co;2-i","volume":"72","author":"MP La Quaglia","year":"1993","unstructured":"La Quaglia MP, Spiro SA, Ghavimi F, Hajdu SI, Meyers P, Exelby PR (1993) Liposarcoma in patients younger than or equal to 22 years of age. Cancer 72(10):3114\u20133119. https:\/\/doi.org\/10.1002\/1097-0142(19931115)72:10<3114::aid-cncr2820721037>3.0.co;2-i","journal-title":"Cancer"},{"issue":"1","key":"3076_CR11","doi-asserted-by":"publisher","first-page":"870910","DOI":"10.1155\/2012\/870910","volume":"2012","author":"EJ Stanelle","year":"2012","unstructured":"Stanelle EJ, Christison-Lagay ER, Sidebotham EL, Singer S, Antonescu CR, Meyers PA, La Quaglia MP (2012) Prognostic factors and survival in pediatric and adolescent liposarcoma. Sarcoma 2012(1):870910\u2013870916. https:\/\/doi.org\/10.1155\/2012\/870910","journal-title":"Sarcoma"},{"issue":"3","key":"3076_CR12","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/1097-0142(19830801)52:3<567::aid-cncr2820520332>3.0.co;2-4","volume":"52","author":"BM Shmookler","year":"1983","unstructured":"Shmookler BM, Enzinger FM (1983) Liposarcoma occurring in children. An analysis of 17 cases and review of the literature. Cancer 52(3):567\u2013574. https:\/\/doi.org\/10.1002\/1097-0142(19830801)52:3<567::aid-cncr2820520332>3.0.co;2-4","journal-title":"Cancer"},{"issue":"71","key":"3076_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.humpath.2017.06.015","volume":"71","author":"R Peng","year":"2018","unstructured":"Peng R, Chen H, Yang X, Zhang X, Zhang Z, He X, Zhang H (2018) A novel sclerosing atypical lipomatous tumor\/well-differentiated liposarcoma in a 7-year-old girl: report of a case with molecular confirmation. Hum Pathol 71(71):41\u201346. https:\/\/doi.org\/10.1016\/j.humpath.2017.06.015","journal-title":"Hum Pathol"},{"issue":"10","key":"3076_CR14","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1043\/1543-2165(2006)130[1448:Gostsr]2.0.Co;2","volume":"130","author":"JM Coindre","year":"2006","unstructured":"Coindre JM (2006) Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med 130(10):1448\u20131453. https:\/\/doi.org\/10.1043\/1543-2165(2006)130[1448:Gostsr]2.0.Co;2","journal-title":"Arch Pathol Lab Med"},{"issue":"9","key":"3076_CR15","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1097\/PAS.0b013e3181e92d0b","volume":"34","author":"H Zhang","year":"2010","unstructured":"Zhang H, Erickson-Johnson M, Wang X, Oliveira JL, Nascimento AG, Sim FH, Wenger DE, Zamolyi RQ, Pannain VL, Oliveira AM (2010) Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors. Am J Surg Pathol 34(9):1304\u20131311. https:\/\/doi.org\/10.1097\/PAS.0b013e3181e92d0b","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"3076_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1472-6890-13-32","volume":"13","author":"N Touqan","year":"2013","unstructured":"Touqan N, Diggle CP, Verghese ET, Perry S, Horgan K, Merchant W, Anwar R, Markham AF, Carr IM, Achuthan R (2013) An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas. BMC Clin Pathol 13(1):32. https:\/\/doi.org\/10.1186\/1472-6890-13-32","journal-title":"BMC Clin Pathol"},{"issue":"10","key":"3076_CR17","first-page":"533","volume":"54","author":"Z Ahmed","year":"2004","unstructured":"Ahmed Z, Shah HU, Yaqoob N, Muzaffar S (2004) Pleomorphic liposarcoma in a ten year old child. the. J Pak Med Assoc 54(10):533\u2013534","journal-title":"J Pak Med Assoc"},{"issue":"1","key":"3076_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/15513819609168665","volume":"16","author":"SZ Ali","year":"1996","unstructured":"Ali SZ, Teichberg S, Kahn E, Hajdu SI (1996) Intrathoracic pleomorphic liposarcoma in a child: study of an unusual case. Pediatr Pathol Lab Med 16(1):99\u2013105","journal-title":"Pediatr Pathol Lab Med"},{"issue":"7","key":"3076_CR19","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1097\/PAS.0b013e3182517b96","volume":"36","author":"JM Gardner","year":"2012","unstructured":"Gardner JM, Dandekar M, Thomas D, Goldblum JR, Weiss SW, Billings SD, Lucas DR, Mchugh JB, Patel RM (2012) Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. Am J Surg Pathol 36(7):1047\u20131051. https:\/\/doi.org\/10.1097\/PAS.0b013e3182517b96","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"3076_CR20","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1097\/PAS.0b013e318093f925","volume":"31","author":"HP Hahn","year":"2007","unstructured":"Hahn HP, Fletcher CD (2007) Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases. Am J Surg Pathol 31(12):1868\u20131874. https:\/\/doi.org\/10.1097\/PAS.0b013e318093f925","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"3076_CR21","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1524-4741.2010.00949.x","volume":"16","author":"KC Nandipati","year":"2010","unstructured":"Nandipati KC, Nerkar H, Satterfield J, Velagapudi M, Ruder U, Sung KJ (2010) Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. Breast J 16(5):537\u2013540. https:\/\/doi.org\/10.1111\/j.1524-4741.2010.00949.x","journal-title":"Breast J"},{"issue":"2","key":"3076_CR22","first-page":"173","volume":"121","author":"BR Pawel","year":"1997","unstructured":"Pawel BR, de Chadar\u00e9vian JP, Inniss S, Kalwinski P, Paul SR, Weintraub WH (1997) Mesenteric pleomorphic liposarcoma in an adolescent. Arch Pathol Lab Med 121(2):173\u2013176","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"3076_CR23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/jso.2930370410","volume":"37","author":"JT Plukker","year":"1988","unstructured":"Plukker JT, Joosten HJ, Rensing JB, Van Haelst UJ (1988) Primary liposarcoma of the mediastinum in a child. J Surg Oncol 37(4):257\u2013263. https:\/\/doi.org\/10.1002\/jso.2930370410","journal-title":"J Surg Oncol"},{"issue":"10","key":"3076_CR24","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1007\/s00247-011-2078-3","volume":"41","author":"DD Rasalkar","year":"2011","unstructured":"Rasalkar DD, Chow LT, Chu CW, Cheng FW, Li CK (2011) Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. Pediatr Radiol 41(10):1342\u20131345. https:\/\/doi.org\/10.1007\/s00247-011-2078-3","journal-title":"Pediatr Radiol"},{"issue":"4","key":"3076_CR25","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2350\/10-09-0918-CC.1","volume":"14","author":"E Rudzinski","year":"2011","unstructured":"Rudzinski E, Mawn L, Kuttesch J, Wushensky C, Wills M (2011) Orbital pleomorphic liposarcoma in an eight-year-old boy. Pediatr Dev Pathol 14(4):339\u2013344. https:\/\/doi.org\/10.2350\/10-09-0918-CC.1","journal-title":"Pediatr Dev Pathol"},{"issue":"1","key":"3076_CR26","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1007\/s00247-010-1797-1","volume":"40","author":"M Saeed","year":"2010","unstructured":"Saeed M, Plett S, Kim GE, Daldrup-Link H, Courtier J (2010) Radiological\u2013pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl. Pediatr Radiol 40(1):S68\u2013S70. https:\/\/doi.org\/10.1007\/s00247-010-1797-1","journal-title":"Pediatr Radiol"},{"issue":"11","key":"3076_CR27","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/pin.12104","volume":"63","author":"L Wang","year":"2013","unstructured":"Wang L, Ren W, Zhou X, Sheng W, Wang J (2013) Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. Pathol Int 63(11):523\u2013531. https:\/\/doi.org\/10.1111\/pin.12104","journal-title":"Pathol Int"},{"issue":"5","key":"3076_CR28","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1097\/RLU.0b013e3182478da8","volume":"37","author":"J Yang","year":"2012","unstructured":"Yang J, Codreanu I, Servaes S, Zhuang H (2012) Earlier detection of bone metastases from pleomorphic liposarcoma in a pediatric patient by FDG PET\/CT than planar 99mTc MDP bone scan. Clin Nucl Med 37(5):e104\u2013e107. https:\/\/doi.org\/10.1097\/RLU.0b013e3182478da8","journal-title":"Clin Nucl Med"},{"issue":"1","key":"3076_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5146\/tjpath.2019.01464","volume":"36","author":"M Ozsen","year":"2020","unstructured":"Ozsen M, Yalcinkaya U, Yazici Z, Sarisozen MB (2020) Lipomatous tumors in pediatric patients: a retrospective analysis of 50 cases. Turk Patoloji Derg 36(1):1\u201310. https:\/\/doi.org\/10.5146\/tjpath.2019.01464","journal-title":"Turk Patoloji Derg"},{"key":"3076_CR30","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/1097-0142(195909\/10)12:5<912::aid-cncr2820120510>3.0.co;2-g","volume":"12","author":"SL Kauffman","year":"1959","unstructured":"Kauffman SL, Stout AP (1959) Lipoblastic tumors of children. Cancer 12:912\u2013925. https:\/\/doi.org\/10.1002\/1097-0142(195909\/10)12:5<912::aid-cncr2820120510>3.0.co;2-g","journal-title":"Cancer"},{"issue":"1","key":"3076_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/path.1700680129","volume":"68","author":"CH Knowles","year":"1954","unstructured":"Knowles CH, Huggill PH (1954) Liposarcoma: with report of a case in a child. J Pathol Bacteriol 68(1):235\u2013245. https:\/\/doi.org\/10.1002\/path.1700680129","journal-title":"J Pathol Bacteriol"},{"key":"3076_CR32","first-page":"325","volume":"90","author":"P Cilotti","year":"1964","unstructured":"Cilotti P (1964) On a particular form of liposarcoma of the orbit with conspicuous morphological variations during its evolution. Ann Ottalmol Clin Ocul 90:325\u2013337","journal-title":"Ann Ottalmol Clin Ocul"},{"issue":"5","key":"3076_CR33","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1097\/00000478-200205000-00006","volume":"26","author":"S Gebhard","year":"2002","unstructured":"Gebhard S, Coindre JM, Michels JJ, Terrier P, Bertrand G, Trassard M, Taylor S, Ch\u00e2teau MC, Marqu\u00e8s B, Picot V, Guillou L (2002) Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 26(5):601\u2013616. https:\/\/doi.org\/10.1097\/00000478-200205000-00006","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"3076_CR34","doi-asserted-by":"publisher","first-page":"538085","DOI":"10.1155\/2011\/538085","volume":"2011","author":"J Haniball","year":"2011","unstructured":"Haniball J, Sumathi VP, Kindblom LG, Abudu A, Carter SR, Tillman RM, Jeys L, Spooner D, Peake D, Grimer RJ (2011) Prognostic factors and metastatic patterns in primary myxoid\/round-cell liposarcoma. Sarcoma 2011(1):538085\u2013538010. https:\/\/doi.org\/10.1155\/2011\/538085","journal-title":"Sarcoma"},{"issue":"8","key":"3076_CR35","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1450::AID-CNCR5>3.0.CO;2-G","volume":"77","author":"SE Kilpatrick","year":"2015","unstructured":"Kilpatrick SE, Doyon J, Choong PF, Sim FH, Nascimento AG (2015) The clinicopathologic spectrum of myxoid and round cell liposarcoma: a study of 95 cases. Cancer 77(8):1450\u20131458. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(19960415)77:8<1450::AID-CNCR5>3.0.CO;2-G","journal-title":"Cancer"},{"issue":"4","key":"3076_CR36","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1245\/s10434-011-2127-z","volume":"19","author":"LC Moreau","year":"2012","unstructured":"Moreau LC, Turcotte R, Ferguson P, Wunder J, Clarkson P, Masri B, Isler M, Dion N, Werier J, Ghert M, Deheshi B, (CANOOS) COOS (2012) Myxoid\\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases. Ann Surg Oncol 19(4):1081\u20131088. https:\/\/doi.org\/10.1245\/s10434-011-2127-z","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"3076_CR37","doi-asserted-by":"publisher","first-page":"218","DOI":"10.2350\/09-08-0694-OA.1","volume":"13","author":"LV Debelenko","year":"2010","unstructured":"Debelenko LV, Perez-Atayde AR, Dubois SG, Grier HE, Pai SY, Shamberger RC, Kozakewich HP (2010) p53+\/mdm2- atypical lipomatous tumor\/well-differentiated liposarcoma in young children: an early expression of Li\u2013Fraumeni syndrome. Pediatr Dev Pathol 13(3):218\u2013224. https:\/\/doi.org\/10.2350\/09-08-0694-OA.1","journal-title":"Pediatr Dev Pathol"},{"issue":"9","key":"3076_CR38","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/gcc.22754","volume":"58","author":"B Dadone-Montaudie","year":"2019","unstructured":"Dadone-Montaudie B, Burel-Vandenbos F, Soler C, Rosello O, Boyer C, Fabas T, Bianchini L, Pedeutour F (2019) Double minute chromosomes harboring MDM2 amplification in a pediatric atypical lipomatous tumor. Genes Chromosom Cancer 58(9):673\u2013679. https:\/\/doi.org\/10.1002\/gcc.22754","journal-title":"Genes Chromosom Cancer"},{"issue":"9","key":"3076_CR39","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1097\/PAS.0b013e3182562bc1","volume":"36","author":"JM Boland","year":"2012","unstructured":"Boland JM, Colby TV, Folpe AL (2012) Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features. Am J Surg Pathol 36(9):1395\u20131403. https:\/\/doi.org\/10.1097\/PAS.0b013e3182562bc1","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"3076_CR40","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1177\/1093526619889130","volume":"23","author":"BJ Kukull","year":"2020","unstructured":"Kukull BJ, Khalighi MA, Gundle KR, Hansford BG, Corless CL, Davis JL (2020) Low-grade osteosarcomatous dedifferentiation of an atypical lipomatous tumor in a pediatric patient. Pediatr Dev Pathol 23(3):240\u2013246. https:\/\/doi.org\/10.1177\/1093526619889130","journal-title":"Pediatr Dev Pathol"},{"issue":"4","key":"3076_CR41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00428-009-0835-6","volume":"455","author":"J Laco","year":"2009","unstructured":"Laco J, Mentzel T, Hornychova H, Kohout A, Jirousek Z, Ryska A (2009) Atypical lipomatous tumors of the tongue: report of six cases. Virchows Arch 455(4):383\u2013388. https:\/\/doi.org\/10.1007\/s00428-009-0835-6","journal-title":"Virchows Arch"},{"issue":"3","key":"3076_CR42","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.prp.2009.05.005","volume":"206","author":"S Okamoto","year":"2010","unstructured":"Okamoto S, Machinami R, Tanizawa T, Matsumoto S, Lee GH, Ishikawa Y (2010) Dedifferentiated liposarcoma with rhabdomyoblastic differentiation in an 8-year-old girl. Pathol Res Pract 206(3):191\u2013196. https:\/\/doi.org\/10.1016\/j.prp.2009.05.005","journal-title":"Pathol Res Pract"},{"key":"3076_CR43","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ijporl.2019.05.016","volume":"123","author":"CR Francom","year":"2019","unstructured":"Francom CR, Leoniak SM, Lovell MA, Herrmann BW (2019) Head and neck pleomorphic myxoid liposarcoma in a child with Li\u2013Fraumeni syndrome. Int J Pediatr Otorhinolaryngol 123:191\u2013194. https:\/\/doi.org\/10.1016\/j.ijporl.2019.05.016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"9","key":"3076_CR44","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1136\/jclinpath-2014-202420","volume":"67","author":"D Creytens","year":"2014","unstructured":"Creytens D, Van Gorp J, Ferdinande L, Van Roy N, Libbrecht L (2014) Array-based comparative genomic hybridization analysis of a pleomorphic myxoid liposarcoma. J Clin Pathol 67(9):834\u2013835. https:\/\/doi.org\/10.1136\/jclinpath-2014-202420","journal-title":"J Clin Pathol"},{"issue":"1","key":"3076_CR45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/his.12913","volume":"69","author":"J Hofvander","year":"2016","unstructured":"Hofvander J, Jo VY, Ghanei I, Gisselsson D, M\u00e5rtensson E, Mertens F (2016) Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near-haploidization and loss of the RB1 gene. Histopathology 69(1):141\u2013147. https:\/\/doi.org\/10.1111\/his.12913","journal-title":"Histopathology"},{"issue":"5","key":"3076_CR46","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00383-017-4063-x","volume":"33","author":"TJ Sinclair","year":"2017","unstructured":"Sinclair TJ, Thorson CM, Alvarez E, Tan S, Spunt SL, Chao SD (2017) Pleomorphic myxoid liposarcoma in an adolescent with Li\u2013Fraumeni syndrome. Pediatr Surg Int 33(5):631\u2013635. https:\/\/doi.org\/10.1007\/s00383-017-4063-x","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"3076_CR47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/1066896919878804","volume":"28","author":"SY Zare","year":"2020","unstructured":"Zare SY, Leivo M, Fadare O (2020) Recurrent pleomorphic myxoid liposarcoma in a patient with Li\u2013Fraumeni syndrome. Int J Surg Pathol 28(2):225\u2013228. https:\/\/doi.org\/10.1177\/1066896919878804","journal-title":"Int J Surg Pathol"},{"issue":"2","key":"3076_CR48","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s13555-011-0006-y","volume":"1","author":"S Goucha","year":"2011","unstructured":"Goucha S, Khaled A, Z\u00e9glaoui F, Rammeh S, Zermani R, Fazaa B (2011) Nevus lipomatosus cutaneous superficialis: report of eight cases. Dermatol Ther (Heidelb) 1(2):25\u201330. https:\/\/doi.org\/10.1007\/s13555-011-0006-y","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"6","key":"3076_CR49","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/pgp.0000000000000365","volume":"36","author":"B Tandon","year":"2017","unstructured":"Tandon B, Hagemann IS, Maluf HM, Pfeifer JD, Al-Kateb H (2017) Association of Li\u2013Fraumeni syndrome with small cell carcinoma of the ovary, hypercalcemic type and concurrent pleomorphic liposarcoma of the cervix. Int J Gynecol Pathol 36(6):593\u2013599. https:\/\/doi.org\/10.1097\/pgp.0000000000000365","journal-title":"Int J Gynecol Pathol"},{"issue":"15","key":"3076_CR50","first-page":"3237","volume":"55","author":"EA Strauss","year":"1995","unstructured":"Strauss EA, Hosler MR, Herzog P, Salhany K, Louie R, Felix CA (1995) Complex replication error causes p53 mutation in a Li\u2013Fraumeni family. Cancer Res 55(15):3237\u20133241","journal-title":"Cancer Res"},{"issue":"5","key":"3076_CR51","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.ejcts.2011.02.006","volume":"40","author":"X Sui","year":"2011","unstructured":"Sui X, Li Y, Zhao H, Wang J (2011) Giant liposarcoma of the esophagus with Li\u2013Fraumeni-like syndrome. Eur J Cardiothorac Surg 40(5):1253\u20131255. https:\/\/doi.org\/10.1016\/j.ejcts.2011.02.006","journal-title":"Eur J Cardiothorac Surg"},{"key":"3076_CR52","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/1471-2407-12-217","volume":"12","author":"K Kast","year":"2012","unstructured":"Kast K, Krause M, Schuler M, Friedrich K, Thamm B, Bier A, Distler W, Kruger S (2012) Late onset Li\u2013Fraumeni syndrome with bilateral breast cancer and other malignancies: case report and review of the literature. BMC Cancer 12:217. https:\/\/doi.org\/10.1186\/1471-2407-12-217","journal-title":"BMC Cancer"},{"issue":"1","key":"3076_CR53","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/s0165-4608(03)00031-1","volume":"145","author":"M Trkova","year":"2003","unstructured":"Trkova M, Foretova L, Kodet R, Hedvicakova P, Sedlacek Z (2003) A Li\u2013Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors. Cancer Genet Cytogenet 145(1):60\u201364. https:\/\/doi.org\/10.1016\/s0165-4608(03)00031-1","journal-title":"Cancer Genet Cytogenet"},{"issue":"8","key":"3076_CR54","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.joms.2007.09.015","volume":"66","author":"H Agir","year":"2008","unstructured":"Agir H, MacKinnon C, Tan ST (2008) Li\u2013Fraumeni syndrome: a case with 4 separate primary sarcomas and 5 sequential free flaps in the maxillofacial region. J Oral Maxillofac Surg 66(8):1714\u20131719. https:\/\/doi.org\/10.1016\/j.joms.2007.09.015","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"3076_CR55","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1001\/archophthalmol.2011.2432","volume":"130","author":"T Salam","year":"2012","unstructured":"Salam T, Salvi SM, Thaung C, Rose GE (2012) Orbital sarcoma in a young patient with Li\u2013Fraumeni syndrome. Arch Ophthalmol 130(5):662\u2013664. https:\/\/doi.org\/10.1001\/archophthalmol.2011.2432","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"3076_CR56","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ophtha.2009.08.017","volume":"117","author":"SN Madge","year":"2010","unstructured":"Madge SN, Tumuluri K, Strianese D, Bonavolonta P, Wilcsek G, Dodd TJ, Selva D (2010) Primary orbital liposarcoma. Ophthalmology 117(3):606\u2013614. https:\/\/doi.org\/10.1016\/j.ophtha.2009.08.017","journal-title":"Ophthalmology"},{"issue":"1","key":"3076_CR57","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/030089160509100121","volume":"91","author":"T Poli","year":"2005","unstructured":"Poli T, Lagana F, Caradonna L, Gobbi R, Corradi D, Sesenna E (2005) Primary orbital liposarcoma in Li\u2013Fraumeni cancer family syndrome: a case report. Tumori 91(1):96\u2013100","journal-title":"Tumori"},{"issue":"5","key":"3076_CR58","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1309\/ajcpn25njtounpnf","volume":"143","author":"EG Demicco","year":"2015","unstructured":"Demicco EG, Harms PW, Patel RM, Smith SC, Ingram D, Torres K, Carskadon SL, Camelo-Piragua S, McHugh JB, Siddiqui J, Palanisamy N, Lucas DR, Lazar AJ, Wang WL (2015) Extensive survey of STAT6 expression in a large series of mesenchymal tumors. Am J Clin Pathol 143(5):672\u2013682. https:\/\/doi.org\/10.1309\/ajcpn25njtounpnf","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"3076_CR59","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/modpathol.2013.164","volume":"27","author":"LA Doyle","year":"2014","unstructured":"Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL (2014) Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 27(3):390\u2013395. https:\/\/doi.org\/10.1038\/modpathol.2013.164","journal-title":"Mod Pathol"},{"issue":"5","key":"3076_CR60","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/his.12431","volume":"65","author":"C Koelsche","year":"2014","unstructured":"Koelsche C, Schweizer L, Renner M, Warth A, Jones DT, Sahm F, Reuss DE, Capper D, Knosel T, Schulz B, Petersen I, Ulrich A, Renker EK, Lehner B, Pfister SM, Schirmacher P, von Deimling A, Mechtersheimer G (2014) Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour. Histopathology 65(5):613\u2013622. https:\/\/doi.org\/10.1111\/his.12431","journal-title":"Histopathology"},{"issue":"4","key":"3076_CR61","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1097\/pas.0000000000000137","volume":"38","author":"A Yoshida","year":"2014","unstructured":"Yoshida A, Tsuta K, Ohno M, Yoshida M, Narita Y, Kawai A, Asamura H, Kushima R (2014) STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors. Am J Surg Pathol 38(4):552\u2013559. https:\/\/doi.org\/10.1097\/pas.0000000000000137","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"3076_CR62","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1097\/01.pas.0000170343.09562.39","volume":"29","author":"MB Binh","year":"2005","unstructured":"Binh MB, Sastre-Garau X, Guillou L, De PG, Terrier P, Lagac\u00e9 R, Aurias A, Hostein I, Coindre JM (2005) MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 29(10):1340\u20131347. https:\/\/doi.org\/10.1097\/01.pas.0000170343.09562.39","journal-title":"Am J Surg Pathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-021-03076-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-021-03076-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-021-03076-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T01:26:29Z","timestamp":1631928389000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-021-03076-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["3076"],"URL":"https:\/\/doi.org\/10.1007\/s00428-021-03076-8","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"assertion":[{"value":"7 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the West China Hospital Institutional Review Board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}