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Due to lack of reported metastases, in 30 cases described until now, the designation as low-grade cancer was so far solely based on demonstration of local tumor invasion and in a single case with perineural invasion. We herein describe the first documented case with local recurrence and hematogenous metastases.<\/jats:p>","DOI":"10.1007\/s00428-022-03374-9","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T16:02:32Z","timestamp":1656777752000},"page":"963-965","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["New entity of microsecretory adenocarcinoma of salivary glands: first case with recurrence and metastases \u2014 proof of malignancy"],"prefix":"10.1007","volume":"481","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-3794","authenticated-orcid":false,"given":"Philipp","family":"Jurmeister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Eisterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Rogatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ihrler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"3374_CR1","doi-asserted-by":"crossref","unstructured":"Bishop JA, Weinreb I, Swanson D, Westra WH, Qureshi HS, Sciubba J, u.\u00a0a. (2019) Microsecretory adenocarcinoma. Am J Surg Pathol 43:1023\u201332","DOI":"10.1097\/PAS.0000000000001273"},{"key":"3374_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.path.2020.10.003","volume":"14","author":"LM Rooper","year":"2021","unstructured":"Rooper LM (2021) Emerging entities in salivary pathology a practical review of sclerosing microcystic adenocarcinoma, microsecretory adenocarcinoma, and secretory myoepithelial carcinoma. Surg Pathol Clin 14:137\u2013150","journal-title":"Surg Pathol Clin"},{"key":"3374_CR3","doi-asserted-by":"crossref","unstructured":"Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A, u.\u00a0a. (2021) Microsecretory adenocarcinoma of salivary glands: an expanded series of 24 cases. Head Neck Pathol 15:1192\u2013201","DOI":"10.1007\/s12105-021-01331-7"},{"key":"3374_CR4","doi-asserted-by":"crossref","unstructured":"Bishop JA, Koduru P, Veremis BM, Oliai BR, Weinreb I, Rooper LM, u.\u00a0a. (2021) SS18 Break-apart fluorescence in situ hybridization is a practical and effective method for diagnosing microsecretory adenocarcinoma of salivary glands. Head Neck Pathol 15:723\u20136","DOI":"10.1007\/s12105-020-01280-7"},{"key":"3374_CR5","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/gcc.23020","volume":"61","author":"A Sk\u00e1lov\u00e1","year":"2022","unstructured":"Sk\u00e1lov\u00e1 A, Hyrcza MD, Vane\u010dek T, Ban\u011b\u010dkov\u00e1 M, Leivo I (2022) Fusion-positive salivary gland carcinomas. Genes Chromosomes Cancer 61:228\u2013243","journal-title":"Genes Chromosomes Cancer"},{"key":"3374_CR6","doi-asserted-by":"crossref","unstructured":"Kawakami F, Nagao T, Honda Y, Sakata J, Yoshida R, Nakayama H, u.\u00a0a. (2020) Microsecretory adenocarcinoma of the hard palate: a case report of a recently described entity. Pathol Int 70:781\u20135","DOI":"10.1111\/pin.12987"},{"key":"3374_CR7","doi-asserted-by":"crossref","unstructured":"Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, u.\u00a0a. (2021) Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult? Histopathology 79:779\u201390","DOI":"10.1111\/his.14421"},{"key":"3374_CR8","doi-asserted-by":"crossref","unstructured":"Sk\u00e1lov\u00e1 A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, u.\u00a0a. (2010) Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 Fusion Gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol 34:599\u2013608","DOI":"10.1097\/PAS.0b013e3181d9efcc"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-022-03374-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-022-03374-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-022-03374-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:09:18Z","timestamp":1670562558000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-022-03374-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3374"],"URL":"https:\/\/doi.org\/10.1007\/s00428-022-03374-9","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]},"assertion":[{"value":"16 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was waived as the article does not include any identifying information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}