{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:55:22Z","timestamp":1754261722772,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s00428-022-03455-9","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T15:02:41Z","timestamp":1670511761000},"page":"899-904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary pulmonary T-cell lymphoproliferative disorders with a limited-stage, low proliferative index, and unusual clinical behavior: two cases of a rare occurrence"],"prefix":"10.1007","volume":"482","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-3591","authenticated-orcid":false,"given":"Elena","family":"Sabattini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Bertuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Broccoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gazzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Mannu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Righi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Terragna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Melle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ambrosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano A.","family":"Pileri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"3455_CR1","volume-title":"WHO Classification of tumour of haematopoietic and lymphoid tissues, revised","author":"SH Swerdlow","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL et al (2017) WHO Classification of tumour of haematopoietic and lymphoid tissues, revised, 4th edn. IARC Press, Lyon","edition":"4"},{"issue":"7","key":"3455_CR2","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C (2022) Anagnostopoulos I et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 36(7):1720\u20131748. https:\/\/doi.org\/10.1038\/s41375-022-01620-2","journal-title":"Leukemia."},{"issue":"11","key":"3455_CR3","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1182\/blood.2022015851","volume":"140","author":"E Campo","year":"2022","unstructured":"Campo E, Jaffe ES, Cook JR et al (2022) The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood 140(11):1229\u20131253. https:\/\/doi.org\/10.1182\/blood.2022015851","journal-title":"Blood"},{"issue":"5","key":"3455_CR4","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/his.13286","volume":"71","author":"M Pizzi","year":"2017","unstructured":"Pizzi M, Agostinelli C, Righi S et al (2017) Aberrant expression of CD10 and BCL6 in mantle cell lymphoma. Histopathology 71(5):769\u2013777. https:\/\/doi.org\/10.1111\/his.13286","journal-title":"Histopathology"},{"issue":"10","key":"3455_CR5","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1038\/leu.2012.246","volume":"26","author":"AW Langerak","year":"2012","unstructured":"Langerak AW, Groenen PJ, Br\u00fcggemann M et al (2012) EuroClonality\/BIOMED-2 guidelines for interpretation and reporting of Ig\/TCR clonality testing in suspected lymphoproliferations. Leukemia. 26(10):2159\u201371. https:\/\/doi.org\/10.1038\/leu.2012.246","journal-title":"Leukemia."},{"issue":"8","key":"3455_CR6","doi-asserted-by":"publisher","first-page":"e432","DOI":"10.3324\/haematol.2020.249664","volume":"105","author":"V Tabanelli","year":"2020","unstructured":"Tabanelli V, Melle F, Motta G et al (2020) Evolutionary crossroads: morphological heterogeneity reflects divergent intra-clonal evolution in a case of high-grade B-cell lymphomas. Haematologica 105(8):e432\u2013e436. https:\/\/doi.org\/10.3324\/haematol.2020.249664","journal-title":"Haematologica"},{"issue":"4","key":"3455_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s11912-017-0582-9","volume":"19","author":"RF Sandell","year":"2017","unstructured":"Sandell RF, Boddicker RL, Feldman AL (2017) Genetic landscape and classification of peripheral T cell lymphomas. Curr Oncol Rep 19(4):28. https:\/\/doi.org\/10.1007\/s11912-017-0582-9","journal-title":"Curr Oncol Rep"},{"issue":"15","key":"3455_CR8","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1182\/blood-2018-09-872549","volume":"133","author":"TB Heavican","year":"2019","unstructured":"Heavican TB, Bouska A, Yu J et al (2019) Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma. Blood 133(15):1664\u20131676. https:\/\/doi.org\/10.1182\/blood-2018-09-872549","journal-title":"Blood"},{"issue":"12","key":"3455_CR9","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1038\/s41375-019-0473-1","volume":"33","author":"Y Watatani","year":"2019","unstructured":"Watatani Y, Sato Y, Miyoshi H et al (2019) Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Leukemia 33(12):2867\u20132883. https:\/\/doi.org\/10.1038\/s41375-019-0473-1","journal-title":"Leukemia"},{"key":"3455_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-319-99716-2_2","volume":"176","author":"J Iqbal","year":"2019","unstructured":"Iqbal J, Amador C, McKeithan TW, Chan WC (2019) Molecular and genomic landscape of peripheral T-cell lymphoma. Cancer Treat Res 176:31\u201368. https:\/\/doi.org\/10.1007\/978-3-319-99716-2_2","journal-title":"Cancer Treat Res"},{"issue":"4","key":"3455_CR11","doi-asserted-by":"publisher","first-page":"e148","DOI":"10.3324\/haematol.2016.158428","volume":"102","author":"MP Dobay","year":"2017","unstructured":"Dobay MP, Lemonnier F, Missiaglia E et al (2017) Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin. Haematologica 102(4):e148\u2013e151. https:\/\/doi.org\/10.3324\/haematol.2016.158428","journal-title":"Haematologica"},{"issue":"4","key":"3455_CR12","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1158\/2159-8290.cd-16-0330","volume":"7","author":"M McKinney","year":"2017","unstructured":"McKinney M, Moffitt AB, Gaulard P et al (2017) The genetic basis of hepatosplenic T-cell lymphoma. Cancer Discov 7(4):369\u2013379. https:\/\/doi.org\/10.1158\/2159-8290.cd-16-0330","journal-title":"Cancer Discov"},{"issue":"10","key":"3455_CR13","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/pai.0000000000000683","volume":"27","author":"S Fernandez-Pol","year":"2019","unstructured":"Fernandez-Pol S, Costa HA, Steiner DF et al (2019) High-throughput sequencing of subcutaneous panniculitis-like T-cell lymphoma reveals candidate pathogenic mutations. Appl Immunohistochem Mol Morphol 27(10):740\u2013748. https:\/\/doi.org\/10.1097\/pai.0000000000000683","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"25","key":"3455_CR14","doi-asserted-by":"publisher","first-page":"37636","DOI":"10.18632\/oncotarget.9400","volume":"7","author":"E Margolskee","year":"2016","unstructured":"Margolskee E, Jobanputra V, Jain P et al (2016) Genetic landscape of T- and NK-cell post-transplant lymphoproliferative disorders. Oncotarget 7(25):37636\u201337648. https:\/\/doi.org\/10.18632\/oncotarget.9400","journal-title":"Oncotarget"},{"issue":"8","key":"3455_CR15","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3109\/10428194.2012.663086","volume":"53","author":"H Shimura","year":"2012","unstructured":"Shimura H, Mori N, Wang YH, Okada M, Motoji T (2012) Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype. Leuk Lymphoma 53(8):1599\u20131609. https:\/\/doi.org\/10.3109\/10428194.2012.663086","journal-title":"Leuk Lymphoma"},{"issue":"19","key":"3455_CR16","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1056\/nejmoa1214514","volume":"368","author":"JE Maxson","year":"2013","unstructured":"Maxson JE, Gotlib J, Pollyea DA et al (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. Engl J Med 368(19):1781\u20131790. https:\/\/doi.org\/10.1056\/nejmoa1214514","journal-title":"Engl J Med"},{"issue":"3","key":"3455_CR17","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1182\/blood.v97.3.829","volume":"97","author":"M Germeshausen","year":"2001","unstructured":"Germeshausen M, Ballmaier M, Schulze H et al (2001) Granulocyte colony-stimulating factor receptor mutations in a patient with acute lymphoblastic leukemia secondary to severe congenital neutropenia. Case Rep Blood 97(3):829\u2013830. https:\/\/doi.org\/10.1182\/blood.v97.3.829","journal-title":"Case Rep Blood"},{"issue":"13","key":"3455_CR18","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","volume":"123","author":"JP Vaqu\u00e9","year":"2014","unstructured":"Vaqu\u00e9 JP, G\u00f3mez-L\u00f3pez G, Mons\u00e1lvez V et al (2014) PLCG1 mutations in cutaneous T-cell lymphomas. Blood 123(13):2034\u20132043. https:\/\/doi.org\/10.1182\/blood-2013-05-504308","journal-title":"Blood"},{"issue":"12","key":"3455_CR19","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1038\/ng.3444","volume":"47","author":"L Wang","year":"2015","unstructured":"Wang L, Ni X, Covington KR et al (2015) Genomic profiling of Sezary syndrome identifies alterations of key T cell signaling and differentiation genes. Nat Genet 47(12):1426\u20131434. https:\/\/doi.org\/10.1038\/ng.3444","journal-title":"Nat Genet"},{"issue":"1","key":"3455_CR20","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.3324\/haematol.2014.113696","volume":"100","author":"R Manso","year":"2015","unstructured":"Manso R, Rodr\u00edguez-Pinilla SM, Gonz\u00e1lez-Rinc\u00f3n J et al (2015) Recurrent presence of the PLCG1 S345F mutation in nodal peripheral T-cell lymphomas. Haematologica 100(1):e25-7. https:\/\/doi.org\/10.3324\/haematol.2014.113696","journal-title":"Haematologica"},{"issue":"11","key":"3455_CR21","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1182\/blood-2016-02-698977","volume":"128","author":"D Vallois","year":"2016","unstructured":"Vallois D, Dobay MP, Morin RD et al (2016) Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas. Blood 128(11):1490\u20131502. https:\/\/doi.org\/10.1182\/blood-2016-02-698977","journal-title":"Blood"},{"issue":"23","key":"3455_CR22","doi-asserted-by":"publisher","first-page":"4749","DOI":"10.1182\/blood-2012-11-465138","volume":"121","author":"M Neumann","year":"2013","unstructured":"Neumann M, Heesch S, Schlee C et al (2013) Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations. Blood 121(23):4749\u20134752. https:\/\/doi.org\/10.1182\/blood-2012-11-465138","journal-title":"Blood"},{"issue":"2","key":"3455_CR23","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41379-019-0376-8","volume":"33","author":"MA Laginestra","year":"2020","unstructured":"Laginestra MA, Cascione L, Motta G et al (2020) Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified. Mod Pathol 33(2):319. https:\/\/doi.org\/10.1038\/s41379-019-0376-8","journal-title":"Mod Pathol"},{"issue":"4","key":"3455_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/dad.0b013e31819f19bb","volume":"31","author":"H Beltraminelli","year":"2009","unstructured":"Beltraminelli H, Leinweber B, Kerl H, Cerroni L (2009) Primary cutaneous CD4+ small-\/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases. Am J Dermatopathol 31(4):317\u2013322. https:\/\/doi.org\/10.1097\/dad.0b013e31819f19bb","journal-title":"Am J Dermatopathol"},{"issue":"7","key":"3455_CR25","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3324\/haematol.2019.230961","volume":"105","author":"CR Soderquist","year":"2020","unstructured":"Soderquist CR, Patel N, Murty VV et al (2020) Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract. Haematologica 105(7):1895\u20131906. https:\/\/doi.org\/10.3324\/haematol.2019.230961","journal-title":"Haematologica"},{"issue":"2","key":"3455_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/his.13858","volume":"75","author":"KM Vroobel","year":"2019","unstructured":"Vroobel KM, O\u2019Connor S, Cunningham D et al (2019) Florid T follicular helper cell hyperplasia associated with extranodal marginal zone lymphoma: a diagnostic pitfall which may mimic T cell lymphoma. Case Rep, Histopathol 75(2):287\u2013290. https:\/\/doi.org\/10.1111\/his.13858","journal-title":"Case Rep, Histopathol"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-022-03455-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-022-03455-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-022-03455-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T09:07:33Z","timestamp":1683104853000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-022-03455-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["3455"],"URL":"https:\/\/doi.org\/10.1007\/s00428-022-03455-9","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"type":"print","value":"0945-6317"},{"type":"electronic","value":"1432-2307"}],"subject":[],"published":{"date-parts":[[2022,12,8]]},"assertion":[{"value":"8 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed patient consent was obtained from both patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed patient consent was obtained from both patients described.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed patient consent was obtained from both patients described.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}