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This session focused on newly recognized diseases and their diagnostic challenges. High-grade\/large B-cell lymphoma with 11q aberration (HG\/LBCL-11q) is defined by chromosome 11q-gains and telomeric loss. FISH analysis is recommended for the diagnosis. HG\/LBCL-11q can occur in the setting of immunodeficiency, including ataxia-telangiectasia, and predominates in children. The morphological spectrum of these cases is broader than previously thought with often Burkitt-like morphology and coarse apoptotic bodies. It has a Burkitt-like immunophenotype (CD10+, BCL6+, BCL2\u2212) but MYC expression is weak or negative, lacks <jats:italic>MYC<\/jats:italic> rearrangement, and is in contrast to Burkitt lymphoma 50% of the cases express LMO2. LBCL with <jats:italic>IRF4<\/jats:italic> rearrangement (LBCL-<jats:italic>IRF4<\/jats:italic>) occurs mainly in the pediatric population but also in adults. LBCL-<jats:italic>IRF4<\/jats:italic> has an excellent prognosis, with distinguishing molecular findings. <jats:italic>IRF4<\/jats:italic> rearrangements, although characteristic of this entity, are not specific and can be found in association with other chromosomal translocations in other large B-cell lymphomas. Other molecular subgroups discussed included primary bone diffuse large B-cell lymphoma (PB-DLBCL), which has distinctive clinical presentation and molecular findings, and B-acute lymphoblastic leukemia (B-ALL) with <jats:italic>IGH::MYC<\/jats:italic> translocation recently segregated from Burkitt lymphoma with TdT expression. This latter disorder has molecular features of precursor B-cells, often tetrasomy 1q and recurrent <jats:italic>NRAS<\/jats:italic> and <jats:italic>KRAS<\/jats:italic> mutations. In this report, novel findings, recommendations for diagnosis, open questions, and diagnostic challenges raised by the cases submitted to the workshop will be discussed.<\/jats:p>","DOI":"10.1007\/s00428-023-03590-x","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:01:46Z","timestamp":1691564506000},"page":"281-298","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Emerging entities: high-grade\/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP\/SH lymphoma workshop"],"prefix":"10.1007","volume":"483","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5365","authenticated-orcid":false,"given":"Leticia","family":"Quintanilla-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-899X","authenticated-orcid":false,"given":"Lorinda","family":"Soma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-6410","authenticated-orcid":false,"given":"Siok-Bian","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fina","family":"Climent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-2889","authenticated-orcid":false,"given":"Sarah L.","family":"Ondrejka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-7966","authenticated-orcid":false,"given":"Alberto","family":"Zamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-387X","authenticated-orcid":false,"given":"Andrew","family":"Wotherspoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-516X","authenticated-orcid":false,"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dirnhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"3590_CR1","volume-title":"WHO classification of tumours of haematopoetic and lymphoid tissues","author":"RD Gascoyne","year":"2017","unstructured":"Gascoyne RD, Campo E, Jaffe ES et al (2017) Diffuse large B-cell lymphoma, NOS. 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